IT1256237B - Procedimento per la preparazione di acyclovir - Google Patents
Procedimento per la preparazione di acyclovirInfo
- Publication number
- IT1256237B IT1256237B ITMI922951A ITMI922951A IT1256237B IT 1256237 B IT1256237 B IT 1256237B IT MI922951 A ITMI922951 A IT MI922951A IT MI922951 A ITMI922951 A IT MI922951A IT 1256237 B IT1256237 B IT 1256237B
- Authority
- IT
- Italy
- Prior art keywords
- preparation procedure
- acyclovir
- acyclovir preparation
- acetate
- trimethylsylation
- Prior art date
Links
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004150 aciclovir Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- XFEQOLXBMLXKDE-UHFFFAOYSA-N 2-(acetyloxymethoxy)ethyl acetate Chemical compound CC(=O)OCCOCOC(C)=O XFEQOLXBMLXKDE-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
E' descritto un procedimento per la preparazione di Acyclovir, comprendente il trattamento di guanina, opportunamente protetta per trimetilsilazione nelle posizioni 2, 6 e 9, con 2-acetossietossimetil acetato, seguito da rimozione dei gruppi trimetilsilici e da idrolisi basica del gruppo acetato.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI922951A IT1256237B (it) | 1992-12-23 | 1992-12-23 | Procedimento per la preparazione di acyclovir |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI922951A IT1256237B (it) | 1992-12-23 | 1992-12-23 | Procedimento per la preparazione di acyclovir |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI922951A0 ITMI922951A0 (it) | 1992-12-23 |
ITMI922951A1 ITMI922951A1 (it) | 1994-06-23 |
IT1256237B true IT1256237B (it) | 1995-11-29 |
Family
ID=11364529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI922951A IT1256237B (it) | 1992-12-23 | 1992-12-23 | Procedimento per la preparazione di acyclovir |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1256237B (it) |
-
1992
- 1992-12-23 IT ITMI922951A patent/IT1256237B/it active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITMI922951A0 (it) | 1992-12-23 |
ITMI922951A1 (it) | 1994-06-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19961230 |