CA2059403A1 - Utilisation de carragenines dans des compositions ophtalmiques a application topique - Google Patents

Utilisation de carragenines dans des compositions ophtalmiques a application topique

Info

Publication number
CA2059403A1
CA2059403A1 CA2059403A CA2059403A CA2059403A1 CA 2059403 A1 CA2059403 A1 CA 2059403A1 CA 2059403 A CA2059403 A CA 2059403A CA 2059403 A CA2059403 A CA 2059403A CA 2059403 A1 CA2059403 A1 CA 2059403A1
Authority
CA
Canada
Prior art keywords
carrageenans
compositions
topical ophthalmic
ophthalmic compositions
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2059403A
Other languages
English (en)
Other versions
CA2059403C (fr
Inventor
John C. Lang
Jamieson C. Keister
Paul J. T. Missel
Dimitri J. Stancioff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2059403A1 publication Critical patent/CA2059403A1/fr
Application granted granted Critical
Publication of CA2059403C publication Critical patent/CA2059403C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Composition ophtalmique topique qui comprend : un carraghénane à une concentration telle que la composition peut être administrée par gouttes et se gélifie dès l'instillation, dans un excipient ophtalmique.
CA002059403A 1991-01-15 1992-01-15 Utilisation de carragenines dans des compositions ophtalmiques a application topique Expired - Fee Related CA2059403C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64121491A 1991-01-15 1991-01-15
US641,214 1991-01-15

Publications (2)

Publication Number Publication Date
CA2059403A1 true CA2059403A1 (fr) 1992-07-16
CA2059403C CA2059403C (fr) 1999-03-09

Family

ID=24571428

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002059403A Expired - Fee Related CA2059403C (fr) 1991-01-15 1992-01-15 Utilisation de carragenines dans des compositions ophtalmiques a application topique

Country Status (7)

Country Link
US (1) US5403841A (fr)
EP (1) EP0495421B1 (fr)
JP (1) JP2594486B2 (fr)
AT (1) ATE141502T1 (fr)
CA (1) CA2059403C (fr)
DE (1) DE69212850T2 (fr)
DK (1) DK0495421T3 (fr)

Families Citing this family (332)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521222A (en) * 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
US5461081A (en) * 1989-09-28 1995-10-24 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
ES2118941T3 (es) * 1992-02-21 1998-10-01 Alcon Lab Inc Composiciones antiglaucoma topicas que comprenden inhibidores de anhidrasa carbonica y bloqueantes beta.
CA2141879A1 (fr) * 1992-09-17 1994-03-31 Thomas Robert Dean Composition inhibitrice a base d'anhydrase carbonique, utilisee comme topique
SE9301877D0 (sv) * 1993-06-02 1993-06-02 Kabi Pharmacia Ab In situ gel for therapeutic use
EP0708646A1 (fr) * 1994-05-06 1996-05-01 Alcon Laboratories, Inc. Utilisation de derives tocopheryle de vitamine e dans des compositions ophtalmiques
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
EP1057486A1 (fr) * 1995-11-17 2000-12-06 Alcon Laboratories, Inc. L'utilisation d'une combinaison de produits pharmacologiques dans le traitement du glaucome
FR2754712B1 (fr) 1996-10-17 1999-09-03 Merck Sharp Dohme Chibret Lab Compositions ophtalmiques
CH690814A5 (it) * 1996-11-04 2001-01-31 Applied Pharma Res Composizioni per uso topico contenenti polisaccaridi solfati.
ZA989513B (en) 1997-10-21 1999-04-21 Alcon Lab Inc Compositions containing histamine H2 agonists and methods of use in treating dry eye
US6174524B1 (en) 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
AU2183900A (en) 1998-12-24 2000-07-31 Alcon Laboratories, Inc. Ep4 receptor agonists for treatment of dry eye
AU2183800A (en) 1998-12-24 2000-07-31 Alcon Laboratories, Inc. Prostaglandin e agonists for treatment of dry eye
WO2000043395A1 (fr) 1999-01-25 2000-07-27 National Jewish Medical And Research Center Porphyrines substituees
MXPA02004349A (es) 1999-11-01 2003-09-22 Alcon Inc Composiciones farmaceuticas que contienen un farmaco antibiotico de fluoroquinolona y goma de xantano.
MXPA02004703A (es) 1999-11-09 2004-09-10 Alcon Inc Composiciones que contienen derivados de acido hidroxieicostetraenoico y metodos de uso para tratar trastornos de resequedad en los ojos.
AU1226001A (en) 1999-11-09 2001-06-06 Alcon Universal Limited Phospholipids of hydroxyeicosatetraenoic acid-like derivatives
BR0015423A (pt) 1999-11-09 2002-07-09 Alcon Inc Análogos de ácido 15-hidroxieicosatetraenóico interrompidos por heteroátomo e métodos de uso
WO2001034548A2 (fr) 1999-11-09 2001-05-17 Alcon Universal Ltd. Substitution par heteroatome en position 3 et deux homologues carbones de 15-hete et procedes d'utilisation
DE60020591T2 (de) 1999-11-09 2005-11-10 Alcon Inc. Benzenoidderivate von 15-hydroxyeicosatetraesäure und verfahren zur verwendung zur behandlung des trockenen auges
US6255343B1 (en) 1999-11-09 2001-07-03 Alcon Universal Ltd. 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use
US6552084B2 (en) 1999-11-09 2003-04-22 Alcon Universal Ltd. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
WO2001034550A2 (fr) 1999-11-09 2001-05-17 Alcon Universal Ltd. Analogues d'acide 15-hydroxyeicosatetraenoique presentant une stabilite metabolique amelioree et procedes d'utilisation de ces produits pour traiter des troubles de secheresse occulaire.
US6353012B1 (en) 1999-11-09 2002-03-05 Alcon Universal Ltd. 15-Hydroxyeicosatetraenoic acid-related compounds and methods of use
US6803385B2 (en) 1999-11-09 2004-10-12 Alcon, Inc. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
TR200201244T2 (tr) 1999-11-09 2002-08-21 Alcon, Inc. Göz kurumasının iyileştirilmesi için Lipoksin A4 ve analogları
WO2001034549A1 (fr) 1999-11-09 2001-05-17 Alcon Universal Ltd. Sels d'hydroxyeicosatetraenoate, compositions et procedes d'utilisation de ces dernieres pour traiter les troubles de secheresse occulaire.
TR200201251T2 (tr) 1999-11-09 2002-11-21 Alcon, Inc. Omega zinciri tadil edilmiş 15-hidroksieikosatetraenoik asit türevleri ve bunların göz kurumasının iyileştirilmesi için kullanım yöntemleri
US6458854B2 (en) 1999-11-09 2002-10-01 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
WO2001046134A1 (fr) 1999-12-22 2001-06-28 Alcon Universal Ltd. 6-KETO PROSTAGLANDINE F1α ET ANALOGUES DANS LE TRAITEMENT DE L'OEIL SEC
EP1305033B1 (fr) 2000-07-28 2004-10-20 Alcon, Inc Compositions pharmaceutiques contenant de la tobramycine et de la gomme de xanthane
AR031135A1 (es) 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
WO2002040056A2 (fr) 2000-11-06 2002-05-23 Alcon, Inc Produits viscoelastiques a base de carraghenanes utilises en chirurgie oculaire
US20030060447A1 (en) * 2002-04-24 2003-03-27 Mutlu Karakelle Non-aspirating transitional viscoelastics for use in surgery
BR0209883A (pt) 2001-05-21 2004-06-08 Alcon Inc Uso de inibidores da proteasoma para o tratamento de distúrbios do olho seco
BR0209965A (pt) 2001-05-21 2004-04-06 Alcon Inc Uso de inibidores de nf-kappab para tratar distúrbios do olho seco
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
BR0209882A (pt) * 2001-05-21 2004-06-08 Alcon Inc Método para o tratamento de distúrbios de olho seco
US7112588B2 (en) * 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
AU2002312194B8 (en) * 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US6750250B1 (en) 2001-07-12 2004-06-15 Alcon, Inc. 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders
US20040214754A1 (en) * 2001-10-03 2004-10-28 Ellis Edward J. Ophthalmic preparation containing glycomacropeptide
US20040220089A1 (en) * 2001-10-03 2004-11-04 Ellis Edward J. Ophthalmic preparation containing glycoprotein
US20060234944A1 (en) * 2001-10-23 2006-10-19 Oklahoma Medical Reseach Foundation Beta-secretase inhibitors and methods of use
JP4547152B2 (ja) * 2001-10-23 2010-09-22 オクラホマ メディカル リサーチ ファウンデーション β−セクレターゼ阻害剤および使用方法
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
AR038576A1 (es) * 2002-02-22 2005-01-19 Pharmacia Corp Formulaciones de drogas antibioticas oftalmicas que contienen un compuesto de ciclodextrina y cloruro de cetil piridinio
AU2003213210A1 (en) * 2002-02-22 2003-09-09 Pharmacia Corporation Ophthalmic formulation with gum system
SI1534286T1 (sl) 2002-07-29 2010-04-30 Rigel Pharmaceuticals Inc Postopki za zdravljenje ali prepreŽŤevanje avtoimunskih bolezni z 2,4-pirimidindiaminskimi spojinami
US8580851B2 (en) 2002-08-21 2013-11-12 Sucampo Ag Ophthalmic solution
AU2003303623A1 (en) * 2002-12-20 2004-07-29 Alcon, Inc. Treatment of dry eye by restoring 15-lipoxygenase activity to ocular surface cells
JP4741491B2 (ja) 2003-08-07 2011-08-03 ライジェル ファーマシューティカルズ, インコーポレイテッド 抗増殖剤としての2,4−ピリミジンジアミン化合物および使用
CA2536281C (fr) * 2003-08-21 2012-05-15 Sucampo Ag Composition ophtalmique
AU2005286774A1 (en) * 2004-09-17 2006-03-30 Comentis, Inc Amino-containing compounds which inhibit memapsin 2 beta-secretase activity and methods of use thereof
EP1797052A1 (fr) * 2004-09-17 2007-06-20 Comentis, Inc. Composes bicycliques inhibant l'activite de la beta-secretase et procedes d'utilisation associes
US9512125B2 (en) * 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
CA2604291A1 (fr) * 2005-04-08 2006-10-19 Comentis, Inc. Composes inhibant l'activite beta-secretase et leurs methodes d'utilisation
US8962643B2 (en) 2006-02-24 2015-02-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
TW200808375A (en) 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
CN101541783B (zh) 2006-06-30 2014-10-01 苏尼西斯制药有限公司 吡啶酮基pdk1抑制剂
ES2380551T3 (es) 2006-11-21 2012-05-16 Rigel Pharmaceuticals, Inc. Sales de profármaco de compuestos de 2,4-pirimidindiamina y sus usos
KR20080076667A (ko) * 2007-02-15 2008-08-20 주식회사 중외제약 요변성 약학 조성물
DK2170283T3 (en) 2007-06-22 2019-04-15 Univ Texas CREATION OF STABLE SUBMICRON Peptide OR PROTEIN PARTICLES BY THIN FILM FREEZING
CA2697166A1 (fr) * 2007-07-26 2009-01-29 Comentis, Inc. Composes qui inhibent l'activite de la beta-secretase et procedes d'utilisation de ceux-ci
KR20100059919A (ko) * 2007-09-24 2010-06-04 코멘티스, 인코포레이티드 치료를 위한 베타-세크레타제 억제제로서 (3-히드록시-4-아미노-부탄-2일)-3-(2-티아졸-2-일-피롤리딘-1-카르보닐) 벤즈아미드 유도체 및 관련 화합물
AU2008350907A1 (en) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
KR20100133980A (ko) * 2008-03-07 2010-12-22 썬 파마 어드밴스트 리서치 컴패니 리미티드 안약 조성물
RU2506083C2 (ru) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
US8618096B2 (en) * 2008-07-21 2013-12-31 The Regents Of The University Of California Prodrug compositions and methods for using the same in treating cancer and malaria
WO2010031056A2 (fr) 2008-09-15 2010-03-18 The Regents Of The University Of California Procédés et compositions pour moduler l’activité ire1, src, et abl
EP2382210B1 (fr) 2008-12-30 2017-03-01 Rigel Pharmaceuticals, Inc. Inhibiteurs de pyrimidinediamine kinase
MX2011007750A (es) 2009-01-23 2011-09-29 Rigel Pharmaceuticals Inc Composiciones y metodos para inhibicion de la ruta jak.
WO2010091198A1 (fr) 2009-02-06 2010-08-12 University Of Southern California Compositions thérapeutiques comprenant des monoterpènes
JP2012516187A (ja) * 2009-02-20 2012-07-19 マイクロ ラブズ リミテッド 貯蔵安定性プロスタグランジン製品
AU2010281404A1 (en) 2009-07-28 2012-02-09 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
AU2010284255B2 (en) 2009-08-17 2016-11-17 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
WO2011029046A1 (fr) 2009-09-04 2011-03-10 Biogen Idec Ma Inc. Inhibiteurs de tyrosine kinase de bruton
EP2485589A4 (fr) 2009-09-04 2013-02-06 Biogen Idec Inc Inhibiteurs hétéroaryles de btk
EP3070077B1 (fr) 2009-10-06 2018-11-28 Millennium Pharmaceuticals, Inc. Composés hétérocycliques utiles comme inhibiteurs de pdk1
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
EP2853262B1 (fr) 2009-10-26 2016-11-30 Sephoris Pharmaceuticals, LLC Traitement de l'érythème solaire utilisant des analgésiques et des antihistaminiques
CA2781056A1 (fr) 2009-11-16 2011-05-19 Rebecca Maglathlin Inhibiteurs de kinases
KR101849680B1 (ko) 2009-12-10 2018-04-17 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 아밀로이드 결합제
WO2011109635A1 (fr) 2010-03-03 2011-09-09 Neonc Technologies Inc. Compositions pharmaceutiques comprenant des monoterpènes
NZ718622A (en) 2010-03-30 2018-03-23 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
CA2837400C (fr) 2010-04-24 2017-12-12 Viamet Pharmaceuticals, Inc. Composes 5 (phenyle eventuellement substitue) pyridine 2 yl en tant qu'inhibiteurs de metalloenzyme
PT2598500T (pt) 2010-07-28 2021-07-22 Rigel Pharmaceuticals Inc Composições e métodos para a inibição da via jak
US20160038600A1 (en) 2012-08-03 2016-02-11 Neonc Technologies Inc. Pharmaceutical compositions comprising poh derivatives
CN110464718A (zh) 2010-08-27 2019-11-19 尼昂克技术公司 包含poh衍生物的药物组合物
EP2632903A4 (fr) 2010-10-28 2014-11-26 Viamet Pharmaceuticals Inc Composés inhibiteurs de métalloenzymes
EP2632898A4 (fr) 2010-10-29 2014-04-02 Biogen Idec Inc Inhibiteurs de tyrosine kinase hétérocycliques
JP5828343B2 (ja) 2010-11-13 2015-12-02 イノクリン ファーマシューティカルズ,インコーポレイテッド 金属酵素阻害化合物
CN103328452A (zh) 2010-12-13 2013-09-25 威尔金制药有限公司 金属酶抑制剂化合物
DK2651864T3 (en) 2010-12-17 2016-09-05 Neonc Tech Inc Methods and devices for use of isoperillylalkohol
AU2012217922B2 (en) 2011-02-14 2017-05-04 Allergan, Inc. Ester derivatives of bimatoprost compositions and methods
CA2828360A1 (fr) 2011-02-25 2012-08-30 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Analogues de chrysophaentine qui inhibent la proteine ftsz
CN103608028A (zh) 2011-04-28 2014-02-26 南加利福尼亚大学 人类髓源抑制性细胞癌症标记
CN103717602B (zh) 2011-05-17 2016-11-09 加利福尼亚大学董事会 激酶抑制剂
PL2710005T3 (pl) 2011-05-17 2017-07-31 Principia Biopharma Inc. Inhibitory kinazy tyrozynowej
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
WO2012162547A2 (fr) 2011-05-25 2012-11-29 Amylin Pharmaceuticals, Inc. Conjugués de deux hormones longue durée
EA024385B1 (ru) 2011-06-19 2016-09-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
CN105884743B (zh) 2011-06-19 2019-08-06 威尔金制药(Nc)有限公司 金属酶抑制剂化合物
KR101964195B1 (ko) 2011-06-23 2019-04-01 비아멧 파마슈티컬즈(엔씨), 인코포레이티드 금속효소 억제제 화합물
AU2012279154A1 (en) 2011-07-01 2014-02-20 The Regents Of The University Of California Herpes virus vaccine and methods of use
EP2751112B1 (fr) 2011-09-02 2019-10-09 The Regents of The University of California Pyrazolo[3,4-d]pyrimidines substituées et utilisations de celles-ci
WO2013063492A1 (fr) 2011-10-28 2013-05-02 Board Of Regents, The University Of Texas System Nouvelles compositions et procédés pour traiter le cancer
PT2788343T (pt) 2011-12-11 2018-06-01 Viamet Pharmaceuticals Nc Inc Compostos inibidores de metaloenzimas
IN2014DN06792A (fr) 2012-01-20 2015-05-22 Viamet Pharmaceuticals Inc
JP6231548B2 (ja) 2012-03-23 2017-11-15 マテオン セラピューティクス, インコーポレイテッド カテプシンの阻害のための組成物および方法
CN104379563B (zh) 2012-04-10 2018-12-21 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
WO2013173506A2 (fr) 2012-05-16 2013-11-21 Rigel Pharmaceuticals, Inc. Procédé de traitement d'une dégradation musculaire
EP2858500A4 (fr) 2012-06-08 2016-04-06 Biogen Ma Inc Inhibiteurs de la tyrosine kinase de bruton
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
CA2913736A1 (fr) 2012-06-11 2013-12-19 The Regents Of The University Of California Composes et procedes de traitement du cancer
US9090595B2 (en) 2012-08-27 2015-07-28 Allergan, Inc. Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes
WO2014035827A1 (fr) 2012-08-27 2014-03-06 Allergan, Inc. Épaississement réduit de la cornée centrale à l'aide de promédicaments esters hydrophiles de bêta-chlorocyclopentanes
RS58956B1 (sr) 2012-09-10 2019-08-30 Principia Biopharma Inc Jedinjenja pirazolopirimidina kao inhibitori kinaze
JP2015532287A (ja) 2012-09-26 2015-11-09 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア Ire1の調節
JP6465803B2 (ja) 2012-10-22 2019-02-06 シティ・オブ・ホープCity of Hope Etp誘導体
US9364462B2 (en) 2012-10-30 2016-06-14 The Regents Of The University Of California Alpha-1-adrenergic receptor agonist therapy
EP2953950B1 (fr) 2013-02-11 2021-01-13 The Regents of The University of California Compositions et méthodes de traitement de maladies neurodégénératives
EP2968296B1 (fr) 2013-03-12 2020-09-02 The Regents of the University of California Modulateurs de gamma-secrétase
WO2014143591A1 (fr) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition de la néovascularisation par inhibition simultanée de prostanoïde ip et des récepteurs ep4
WO2014143592A1 (fr) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition de la néovascularisation par inhibition des récepteurs de prostanoïde ip
JP2016519662A (ja) 2013-03-14 2016-07-07 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア K2pチャネルの調節
CA3123075C (fr) 2013-03-14 2023-09-19 The Regents Of The University Of California Agents mucolytiques thiosaccharidiques
KR102275112B1 (ko) 2013-03-14 2021-07-08 시티 오브 호프 5-브로모-인디루빈
BR112015023705A8 (pt) 2013-03-15 2020-03-17 Univ California compostos, composições farmacêuticas, usos de um composto, e método para síntese do composto da fórmula (ia)
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
EP2968297B1 (fr) 2013-03-15 2018-09-26 Verseon Corporation Composés aromatiques multisubstitués en tant qu'inhibiteurs de sérine protéase
SG10201707486XA (en) 2013-03-15 2017-10-30 Verseon Corp Halogenopyrazoles as inhibitors of thrombin
KR20150129735A (ko) 2013-03-15 2015-11-20 알러간, 인코포레이티드 렙틴 생성의 향상을 위한 비마토프로스트
JP6806562B2 (ja) 2013-03-15 2021-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア eIF2α経路の調節因子
WO2014146111A2 (fr) 2013-03-15 2014-09-18 The Regents Of The University Of California Composés antalgiques et leurs méthodes d'utilisation
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
WO2014190207A1 (fr) 2013-05-22 2014-11-27 The Regents Of The University Of California Inhibiteurs d'aurora kinase
US9795691B2 (en) 2013-06-24 2017-10-24 City Of Hope Chemically-linked nanoparticles
AU2014290202B2 (en) 2013-07-15 2018-11-15 Board Of Regents, The University Of Texas System Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain
WO2015026849A1 (fr) 2013-08-19 2015-02-26 The Regents Of The University Of California Composés et procédés pour traiter un trouble épileptique
JP2016530273A (ja) 2013-08-20 2016-09-29 シティ・オブ・ホープCity of Hope 癌を治療するためのhdac8阻害剤
WO2015031799A1 (fr) 2013-08-30 2015-03-05 The Regents Of The University Of California, A California Corporation Compositions contenant des nanocristaux scintillateurs et leurs procédés d'utilisation
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
KR102413253B1 (ko) 2013-12-11 2022-06-27 바이오젠 엠에이 인코포레이티드 종양, 신경 및 면역에서 인간 질환을 치료하는데 유용한 바이아릴 화합물
EP3080122B1 (fr) 2013-12-11 2018-10-31 Biogen MA Inc. Composes biaryles utiles dans le traitement de maladies humaines en oncologie, neurologie et immunologie
MX2016008418A (es) 2013-12-23 2017-01-11 Memorial Sloan Kettering Cancer Center Metodos y reactivos para el radiomarcaje.
PT2898888T (pt) * 2014-01-22 2019-07-16 Visufarma B V Composição que compreende iota-carragenina contra conjuntivite viral
WO2015116856A2 (fr) 2014-01-29 2015-08-06 City Of Hope Antagonistes du récepteur x de farnésoïde
CA2939219C (fr) 2014-02-11 2023-02-28 Mitokinin Llc Compositions et procedes les utilisant pour le traitement de maladie neurodegenerative et mitochondriale
US10287312B2 (en) 2014-02-14 2019-05-14 The Regents Of The University Of California Cyclic peroxides as prodrugs for selective delivery of agents
WO2015175075A1 (fr) 2014-02-20 2015-11-19 Allergan, Inc. Réduction de l'épaississement cornéen central par utilisation de promédicaments d'esters hydrophiles de bêta-chlorocyclopentanes
ES2841248T3 (es) 2014-02-21 2021-07-07 Principia Biopharma Inc Sales y forma sólida de un inhibidor de BTK
US20150259288A1 (en) 2014-03-14 2015-09-17 City Of Hope 5-bromo-indirubins
EP3128842B1 (fr) 2014-03-26 2023-07-26 City of Hope Traitement de cancers déficients en brca1 ou de cancers résistants
ES2908240T3 (es) 2014-04-07 2022-04-28 Univ California Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos
EA201692155A1 (ru) 2014-05-13 2017-04-28 Мемориал Слоун-Кеттеринг Кэнсэ Сентр МОДУЛЯТОРЫ Hsp70 И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
WO2015183794A1 (fr) 2014-05-27 2015-12-03 City Of Hope Complexes d'agonistes de tgr5 pour le traitement du diabète et du cancer
US10414814B2 (en) 2014-07-03 2019-09-17 City Of Hope Tumor-selective CTLA-4 antagonists
WO2016018917A2 (fr) 2014-07-28 2016-02-04 The Regents Of The University Of Califoria Compositions et procédés de fabrication d'acides nucléiques polymérisés
WO2016023036A1 (fr) 2014-08-08 2016-02-11 The Regents Of The University Of California Polymères peptidiques à haute densité
CN113620978A (zh) 2014-09-11 2021-11-09 加利福尼亚大学董事会 mTORC1抑制剂
PL3194411T3 (pl) 2014-09-15 2022-06-20 The Regents Of The University Of California Analogi nukleotydów
JP2017528486A (ja) 2014-09-17 2017-09-28 ヴァーセオン コーポレイション セリンプロテアーゼ阻害剤としてのピラゾリル置換ピリドン化合物
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
US10011600B2 (en) 2014-09-25 2018-07-03 Araxes Pharma Llc Methods and compositions for inhibition of Ras
WO2016049524A1 (fr) 2014-09-25 2016-03-31 Araxes Pharma Llc Inhibiteurs de protéines mutantes kras g12c
AU2015327817B2 (en) 2014-10-02 2020-04-23 Allergan, Inc. Ester prodrugs of gamma-lactams and their use
PT3233103T (pt) 2014-12-18 2021-01-18 Principia Biopharma Inc Tratamento de pênfigo
US10689423B2 (en) 2015-01-13 2020-06-23 City Of Hope CTLA4-binding protein peptide-linker masks
AU2016206475B2 (en) 2015-01-16 2021-11-04 City Of Hope Cell penetrating antibodies
US10227333B2 (en) 2015-02-11 2019-03-12 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
CN107613768B (zh) 2015-02-12 2020-10-20 NeOnc技术股份有限公司 包含紫苏醇衍生物的药物组合物
CA2977135C (fr) 2015-02-25 2023-08-22 The Regents Of The University Of California Agonistes de recepteur 5ht pour le traitement de troubles
CA2977521C (fr) 2015-02-27 2024-03-19 Curtana Pharmaceuticals, Inc. Composes d'uree 1-(aryle)-3-(heteroaryle) et utilisation comme inhibiteurs du facteur olig2
CN107531687A (zh) 2015-02-27 2018-01-02 加利福尼亚大学董事会 能够实现软骨复壮的小分子
HUE060104T2 (hu) 2015-02-27 2023-01-28 Verseon Int Corporation Szubsztituált pirazol vegyületek mint szerinproteázinhibitorok
CA2981504C (fr) 2015-03-30 2023-10-24 City Of Hope Complexes a interverrouillage mecanique
CA2981530A1 (fr) 2015-04-10 2016-10-13 Araxes Pharma Llc Composes quinazoline substitues et leurs procedes d'utilisation
EP3283462B1 (fr) 2015-04-15 2020-12-02 Araxes Pharma LLC Inhibiteurs tricycliques condensés de kras et procédés pour les utiliser
AU2016247858B2 (en) 2015-04-17 2020-10-15 Ludwig Institute For Cancer Research Ltd. PLK4 inhibitors
JP6704000B2 (ja) 2015-04-24 2020-06-03 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア Ror1−ror2結合のモジュレーター
CA2986030A1 (fr) 2015-05-15 2016-11-24 City Of Hope Compositions de recepteur d'antigene chimerique
US10787664B2 (en) 2015-05-26 2020-09-29 City Of Hope Compounds of chemically modified oligonucleotides and methods of use thereof
MA42510A (fr) 2015-06-10 2018-06-06 Biogen Ma Inc Formes et compositions d'inhibiteurs biaryles de la tyrosine kinase de bruton
WO2016201169A1 (fr) 2015-06-10 2016-12-15 City Of Hope Compositions et méthodes de traitement au moyen de polysaccharides zwittérioniques
MA42242A (fr) 2015-06-24 2018-05-02 Principia Biopharma Inc Inhibiteurs de la tyrosine kinase
WO2017004357A1 (fr) 2015-07-02 2017-01-05 City Of Hope Composés et compositions comprenant des oligodésoxynucléotides phosphorothioés, et procédés d'utilisation associés
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3719016A1 (fr) 2015-08-04 2020-10-07 Rigel Pharmaceuticals, Inc. Composés de benzazole et procédés de fabrication et d'utilisation des composés
CN108135958B (zh) 2015-08-06 2022-03-04 希望之城 细胞穿透蛋白-抗体缀合物及其使用方法
WO2017040693A1 (fr) 2015-08-31 2017-03-09 The Regents Of The University Of California Composés antiviraux à spectre large et leurs utilisations
WO2017040982A1 (fr) 2015-09-02 2017-03-09 The Regents Of The University Of California Ligands her3 et utilisations de ceux-ci
CN108349900A (zh) 2015-09-04 2018-07-31 希望之城 雄激素受体拮抗剂
US11253521B2 (en) 2015-09-25 2022-02-22 Ludwig Institute For Cancer Research Ltd 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
US10689356B2 (en) 2015-09-28 2020-06-23 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058915A1 (fr) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibiteurs de protéines mutantes kras g12c
EP3356359B1 (fr) 2015-09-28 2021-10-20 Araxes Pharma LLC Inhibiteurs de protéines kras portant la mutation g12c
US10730867B2 (en) 2015-09-28 2020-08-04 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10875842B2 (en) 2015-09-28 2020-12-29 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
JP7038045B2 (ja) 2015-10-15 2022-03-17 シティ・オブ・ホープ ホスホロチオエート化オリゴデオキシヌクレオチドを含む化合物及び組成物、ならびにその使用方法
EP3364977A4 (fr) 2015-10-19 2019-09-04 Araxes Pharma LLC Méthode de criblage d'inhibiteurs de ras
US10662218B2 (en) 2015-10-23 2020-05-26 Erx Pharmaceuticals, Inc. Analogs of celastrol
KR20180101329A (ko) 2015-10-23 2018-09-12 선에시스 파마슈티컬스 인코포레이티드 암 치료에 사용하기 위한 헤테로시클릭 pdk1 억제제
US11058700B2 (en) 2015-10-28 2021-07-13 City Of Hope Macrocyclic lactones and uses thereof as modulators of purinergic receptors
US10414757B2 (en) 2015-11-16 2019-09-17 Araxes Pharma Llc 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
US20190119259A1 (en) 2015-12-10 2019-04-25 City Of Hope Cell penetrating cyanine-coupled antibodies
AU2016379444B2 (en) 2015-12-24 2021-04-29 The Regents Of The University Of California CFTR regulators and methods of use thereof
KR20180101416A (ko) 2015-12-24 2018-09-12 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Cftr 조절제 및 이의 이용 방법
AU2016380349B2 (en) 2015-12-30 2020-10-29 Nqp 1598, Ltd. Metalloenzyme inhibitor compounds
WO2017120198A1 (fr) 2016-01-05 2017-07-13 The Regents Of The University Of California Amphophiles de benzothiazole
US10519442B2 (en) 2016-02-11 2019-12-31 City Of Hope Twist signaling inhibitor compositions and methods of using the same
EP3430017B1 (fr) 2016-03-17 2023-01-25 The Regents of The University of California Compositions et méthodes pour traiter les parasitoses
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
EP3458448B1 (fr) 2016-04-25 2021-06-23 Forma Therapeutics, Inc. Inhibiteurs de fasn pour utilisation dans le traitement de la stéatohépatite non alcoolique
EP3448519A4 (fr) 2016-04-29 2020-01-22 Board Of Regents, The University Of Texas System Liants de récepteur sigma
TWI763668B (zh) 2016-05-05 2022-05-11 美商嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808914A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
UA121354C2 (uk) 2016-05-12 2020-05-12 Анакор Фармасутікалз, Інк. Нові сполуки для лікування паразитарних захворювань
US10918648B2 (en) 2016-05-26 2021-02-16 The Regents Of The University Of California Estrogen receptor modulator combinations
JP7065840B2 (ja) 2016-06-27 2022-05-12 ライジェル ファーマシューティカルズ, インコーポレイテッド 2,4-ジアミノ-ピリミジン化合物ならびに該化合物の作製法および使用法
KR102515813B1 (ko) 2016-06-29 2023-03-30 프린시피아 바이오파마, 인코퍼레이티드 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제
WO2018013609A2 (fr) 2016-07-11 2018-01-18 The Regents The University Of California Nanoparticules synthétiques de mélanine et leurs utilisations
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
WO2018017153A1 (fr) 2016-07-21 2018-01-25 Biogen Ma Inc. Formes de succinate et compositions d'inhibiteurs de tyrosine kinase de bruton
US10179787B2 (en) 2016-07-29 2019-01-15 Flx Bio, Inc. Chemokine receptor modulators and uses thereof
US11542261B2 (en) 2016-08-17 2023-01-03 Children's Hospital Medical Center Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
US11254667B2 (en) 2016-08-17 2022-02-22 Children's Hospital Medical Center Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
WO2018039612A1 (fr) 2016-08-26 2018-03-01 The Regents Of The University Of California Compositions et méthodes favorisant la croissance des cheveux au moyen d'inhibiteurs de mpc1
JP7063885B2 (ja) 2016-09-13 2022-05-09 ザ ジャクソン ラボラトリー 標的にされた増大するdna脱メチル化
CA3036852A1 (fr) 2016-09-15 2018-03-22 City Of Hope Derives dithio etp
US10849955B2 (en) 2016-09-28 2020-12-01 City Of Hope Methods of treating pancreatic cancer using GPCR antagonists
EP3519402A1 (fr) 2016-09-29 2019-08-07 Araxes Pharma LLC Inhibiteurs de protéines mutantes kras g12c
US10377743B2 (en) 2016-10-07 2019-08-13 Araxes Pharma Llc Inhibitors of RAS and methods of use thereof
JP7170634B2 (ja) 2016-10-26 2022-11-14 ライジェル ファーマシューティカルズ, インコーポレイテッド Irak阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法
WO2018081294A1 (fr) 2016-10-26 2018-05-03 Rigel Pharmaceuticals, Inc. Composés pyrazole amide en tant qu'inhibiteurs d'irak
US10646540B2 (en) 2016-11-18 2020-05-12 City Of Hope Peptide inhibitors of twist
JP7144411B2 (ja) 2016-11-30 2022-09-29 ネオンク テクノロジーズ インク. ペリリルアルコール-3-ブロモピルベート複合体及びがんの治療方法
JP7191828B2 (ja) 2016-12-15 2022-12-19 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア がん治療のための組成物および方法
WO2018125799A2 (fr) 2016-12-29 2018-07-05 Viamet Pharmaceuticals (Bermuda), Ltd. Composés inhibiteurs des métalloenzymes
KR20190129034A (ko) 2016-12-29 2019-11-19 세레니티 테라퓨틱스 (버뮤다), 리미티드 금속효소 억제제 화합물
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
US11358959B2 (en) 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
US11274093B2 (en) 2017-01-26 2022-03-15 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
CN110382482A (zh) 2017-01-26 2019-10-25 亚瑞克西斯制药公司 稠合的杂-杂二环化合物及其使用方法
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
JP2020521741A (ja) 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー がんの処置のための化合物およびその使用の方法
CN110831933A (zh) 2017-05-25 2020-02-21 亚瑞克西斯制药公司 喹唑啉衍生物作为突变kras、hras或nras的调节剂
CA3063440A1 (fr) 2017-05-25 2018-11-29 Araxes Pharma Llc Inhibiteurs covalents de kras
WO2018237145A1 (fr) 2017-06-21 2018-12-27 Mitokinin, Inc. Compositions et méthodes les utilisant pour le traitement d'une maladie neurodégénérative et mitochondriale
CA3068305A1 (fr) 2017-06-29 2019-01-03 Rigel Pharmaceuticals, Inc. Inhibiteurs de kinases et leurs procedes de fabrication et d'utilisation
WO2019006371A1 (fr) 2017-06-30 2019-01-03 City Of Hope Compositions et procédés de modulation de l'activité macrophage
US11389460B2 (en) 2017-09-15 2022-07-19 City Of Hope Methods and compositions for treating endometrial cancer
WO2019067015A1 (fr) 2017-09-29 2019-04-04 City Of Hope Récepteurs d'antigènes chimériques et anticorps bispécifiques pour le traitement du lymphome à cellules du manteau
EP3688028A2 (fr) 2017-09-29 2020-08-05 Genentech, Inc. Complexes d'antibiotiques peptidiques et leurs méthodes d'utilisation
US11260048B2 (en) 2017-10-03 2022-03-01 The Schepens Eye Research Institute, Inc. Compounds and compositions for inhibiting retinal pigment epithelium degeneration and methods using the same
CA3078942A1 (fr) 2017-10-10 2019-04-18 Syros Pharmaceuticals, Inc. Composes de pyrrolotriazine et procedes d'inhibition de kinases tam
US11618780B2 (en) 2017-10-20 2023-04-04 City Of Hope Composition and method for activating latent human immunodeficiency virus (HIV)
UY37956A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
AU2018358160B2 (en) 2017-11-02 2023-03-16 Abbvie Inc. Modulators of the integrated stress pathway
BR112020008817B8 (pt) 2017-11-02 2023-10-03 Abbvie Inc Compostos moduladores da via de estresse integrada
UY37957A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
BR112020008827A2 (pt) 2017-11-02 2020-10-20 Calico Life Sciences Llc moduladores da via de estresse integrada
UY37958A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
CA3080964A1 (fr) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulateurs de la voie de reponse integree au stress
JP2021501781A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
AU2018360854B2 (en) 2017-11-02 2023-03-30 Abbvie Inc. Modulators of the integrated stress pathway
JP2021502345A (ja) 2017-11-06 2021-01-28 ラプト・セラピューティクス・インコーポレイテッド 抗がん剤
US20210292410A1 (en) 2017-12-07 2021-09-23 Morphosys Ag Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment
JP7292299B2 (ja) 2017-12-07 2023-06-16 アンプリックス ファーマシューティカルズ,インク. 複素環式の置換ピリジン誘導体である抗真菌薬
WO2019126037A1 (fr) 2017-12-19 2019-06-27 City Of Hope Arncr transactivateurs et arng modifiés et leurs utilisations
AU2019209470A1 (en) 2018-01-16 2020-08-13 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
AU2019209475A1 (en) 2018-01-16 2020-08-20 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
RU2020128176A (ru) 2018-01-26 2022-03-02 Рапт Терапьютикс, Инк. Модуляторы рецепторов хемокинов и их применение
WO2019157195A1 (fr) 2018-02-08 2019-08-15 Neonc Technologies, Inc Procédés de perméabilisation de la barrière hémato-encéphalique
EP3765459A1 (fr) 2018-03-13 2021-01-20 Shire Human Genetic Therapies, Inc. Imidazopyridines substituées en tant qu'inhibiteurs de la kallicréine plasmatique et leurs utilisations
JP7427655B2 (ja) 2018-04-27 2024-02-05 スプルース バイオサイエンシーズ,インク. 精巣副腎残存腫瘍および卵巣副腎残存腫瘍を処置するための方法
JP7381492B2 (ja) 2018-05-01 2023-11-15 レヴォリューション・メディスンズ,インコーポレイテッド Mtor阻害剤としてのc26-連結ラパマイシン類似体
WO2019212990A1 (fr) 2018-05-01 2019-11-07 Revolution Medicines, Inc. Analogues de rapamycine liés à c40, c28 et c32 en tant qu'inhibiteurs de mtor
EP3788044B1 (fr) 2018-05-03 2023-08-09 Rigel Pharmaceuticals, Inc. Composés inhibiteurs de rip1 et leurs procédés de fabrication et d'utilisation
EA202092581A1 (ru) 2018-05-03 2021-04-08 Ригел Фармасьютикалз, Инк. Соединения, ингибирующие rip1, а также способы их получения и применения
EP3787618A4 (fr) 2018-05-04 2022-05-04 Cirius Therapeutics, Inc. Analogues de thiazolidinedione pour le traitement de nafld et de maladies métaboliques
JP2021527051A (ja) 2018-06-05 2021-10-11 ラプト・セラピューティクス・インコーポレイテッド ピラゾロ−ピリミジン−アミノ−シクロアルキル化合物及びその治療的使用
SG11202012820PA (en) 2018-06-21 2021-01-28 Calico Life Sciences Llc Protein tyrosine phosphatase inhibitors and methods of use thereof
CA3104653A1 (fr) 2018-06-25 2020-01-02 Amplyx Pharmaceuticals, Inc. Derives de pyridine substitues par un noyau heterocyclique et un groupe amino
US20210221864A1 (en) 2018-08-24 2021-07-22 City Of Hope Masked cytokine conjugates
TWI771621B (zh) 2018-10-11 2022-07-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
WO2020092845A1 (fr) 2018-11-01 2020-05-07 Rigel Pharmaceuticals, Inc. Modes de réalisation d'un procédé et d'une composition permettant de traiter la leucémie myéloïde aiguë
MX2021004517A (es) 2018-11-01 2021-11-04 Lynk Pharmaceuticals Co Ltd Inhibidores de cinasa de janus 1 triciclicos y composiciones y metodos de los mismos.
CN114025844B (zh) 2019-03-14 2022-07-26 卡里科生命科学有限责任公司 蛋白酪氨酸磷酸酶抑制剂及其使用方法
PE20220572A1 (es) 2019-04-30 2022-04-20 Calico Life Sciences Llc Moduladores de la via integrada del estres
EP3968979A4 (fr) 2019-05-15 2023-03-01 Bexson Biomedical, Inc. Formulation de kétamine pour injection sous-cutanée
US20200377518A1 (en) 2019-05-29 2020-12-03 Rigel Pharmaceuticals, Inc. Method of preventing and treating thrombosis
MX2022001596A (es) 2019-08-08 2022-03-11 Rigel Pharmaceuticals Inc Compuestos y metodos para tratar sindrome de liberacion de citocinas.
MX2022001890A (es) 2019-08-14 2022-04-26 Rigel Pharmaceuticals Inc Metodo para bloquear o mejorar el sindrome de liberacion de citocinas.
CA3152264A1 (fr) 2019-08-30 2021-03-04 Rigel Pharmaceuticals, Inc. Composes de pyrazole, formulations de ceux-ci, et procede d'utilisation des composes et/ou des formulations
JOP20220056A1 (ar) 2019-09-06 2023-01-30 Rigel Pharmaceuticals Inc مركبات rip1 تثبيطية وطرق عملها واستخدامها
US11479543B2 (en) 2019-09-06 2022-10-25 Rigel Pharmaceuticals, Inc. Heterocyclic RIP1 kinase inhibitors
EP4031566A1 (fr) 2019-09-18 2022-07-27 Novartis AG Protéines de fusion nkg2d et leurs utilisations
WO2021055589A1 (fr) 2019-09-18 2021-03-25 Shire Human Genetic Therapies, Inc. Inhibiteurs hétéroaryles de la kallicréine plasmatique
CN114728962A (zh) 2019-09-18 2022-07-08 武田药品工业有限公司 血浆激肽释放酶抑制剂及其用途
CN115298184A (zh) 2019-11-07 2022-11-04 里格尔药品股份有限公司 杂环rip1抑制化合物
WO2021097339A1 (fr) 2019-11-13 2021-05-20 Rapt Therapeutics, Inc. Formes cristallines d'un antagoniste du récepteur de chimiokine c-c de type 4 et leurs utilisations
EP4077291A1 (fr) 2019-12-18 2022-10-26 Calico Life Sciences LLC Inhibiteurs de protéine tyrosine phosphatase et leurs méthodes d'utilisation
AU2021276656A1 (en) 2020-05-19 2022-11-24 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
KR20230053611A (ko) 2020-08-18 2023-04-21 사이빈 아이알엘 리미티드 펜에틸아민 유도체, 조성물, 및 사용 방법
JP2023548605A (ja) 2020-11-02 2023-11-17 トレセラ コーポレーション デオキシシチジンキナーゼ阻害剤の結晶形態およびその使用
JP2023551145A (ja) 2020-11-18 2023-12-07 ベクソン バイオメディカル,インク. 医薬化合物の錯化剤塩製剤
US20240058344A1 (en) 2020-12-18 2024-02-22 Cornell University Methods of treating neurodegenerative disorders and stat3-linked cancers using suppressors of electron leak
US20220288047A1 (en) 2021-03-03 2022-09-15 Rigel Pharmaceuticals, Inc. Method for treating a disease or condition using a pyrazole compound or formulation thereof
TW202300490A (zh) 2021-03-11 2023-01-01 美商雷傑製藥公司 雜環rip1激酶抑制劑
US11918582B2 (en) 2021-03-15 2024-03-05 Rapt Therapeutics, Inc. Pyrazole pyrimidine compounds and uses thereof
EP4308228A1 (fr) 2021-03-17 2024-01-24 Takeda Pharmaceutical Company Limited Inhibiteurs de la kallicréine plasmatique
CN117355523A (zh) 2021-03-17 2024-01-05 武田药品工业株式会社 血浆激肽释放酶的多环抑制剂
WO2022197763A1 (fr) 2021-03-17 2022-09-22 Shire Human Genetic Therapies, Inc. Inhibiteurs de la kallicréine plasmatique
EP4308230A1 (fr) 2021-03-17 2024-01-24 Takeda Pharmaceutical Company Limited Inhibiteurs hétéroaryle de la kallicréine plasmatique
CN117396473A (zh) 2021-03-17 2024-01-12 武田药品工业株式会社 血浆激肽释放酶的咪唑并吡啶基抑制剂
WO2023156450A1 (fr) 2022-02-15 2023-08-24 Cybin Irl Limited Compositions de phénéthylamine thérapeutique et procédés d'utilisation
WO2023156453A1 (fr) 2022-02-15 2023-08-24 Cybin Irl Limited Dérivés de phénétylamine, compositions et procédés d'utilisation
WO2023183377A1 (fr) 2022-03-23 2023-09-28 Rigel Pharmaceuticals, Inc. Composés pyrimid-2-yl-pyrazole utilisés en tant qu'inhibiteurs d'irak
US20230312568A1 (en) 2022-03-31 2023-10-05 Rigel Pharmaceuticals, Inc. Tricyclic irak inhibitors
US20230322741A1 (en) 2022-04-06 2023-10-12 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
CN114504550B (zh) * 2022-04-18 2022-08-19 中山大学中山眼科中心 一种包含甲硝唑的眼用凝胶及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014335A (en) * 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4136178A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Locust bean gum therapeutic compositions
US4136177A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US4565821A (en) * 1983-03-21 1986-01-21 The Texas A&M University System Method and ophthalmic composition for treating ocular hypertension and glaucoma with butyrophenones
GB8318403D0 (en) * 1983-07-07 1983-08-10 Sutherland I W Gel-forming polysaccharides
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
GB8628068D0 (en) * 1986-11-24 1986-12-31 Unilever Plc Aqueous gel comprising carrageenan
EP0375299A1 (fr) * 1988-12-19 1990-06-27 Merck & Co. Inc. Mélanges d'inhibiteurs ACE et CA pour le traitement du glaucome
JPH02291619A (ja) * 1989-04-28 1990-12-03 Mitsubishi Kasei Corp 透明タッチパネル
FR2653021A1 (fr) * 1989-10-17 1991-04-19 Merck Sharp & Dohme Composition ophtalmique aqueuse liquide a transition de phase liquide-gel.
JPH0458418A (ja) * 1990-06-26 1992-02-25 Hitachi Aic Inc タッチパネル

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JPH06116137A (ja) 1994-04-26
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DE69212850D1 (de) 1996-09-26
JP2594486B2 (ja) 1997-03-26
DK0495421T3 (da) 1996-12-09
CA2059403C (fr) 1999-03-09
EP0495421A1 (fr) 1992-07-22
ATE141502T1 (de) 1996-09-15
US5403841A (en) 1995-04-04

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