ES2118941T3 - Composiciones antiglaucoma topicas que comprenden inhibidores de anhidrasa carbonica y bloqueantes beta. - Google Patents
Composiciones antiglaucoma topicas que comprenden inhibidores de anhidrasa carbonica y bloqueantes beta.Info
- Publication number
- ES2118941T3 ES2118941T3 ES93906084T ES93906084T ES2118941T3 ES 2118941 T3 ES2118941 T3 ES 2118941T3 ES 93906084 T ES93906084 T ES 93906084T ES 93906084 T ES93906084 T ES 93906084T ES 2118941 T3 ES2118941 T3 ES 2118941T3
- Authority
- ES
- Spain
- Prior art keywords
- compositions
- carbonic
- anhidrase
- topics
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBEN COMPOSICIONES FARMACEUTICAS OFTALMICAS, UTILES PARA CONTROLAR LA ELEVADA PRESION INTRAOCULAR, RELACIONADA CON EL GLAUCOMA Y LA HIPERTENSION OCULAR. LAS COMPOSICIONES COMPRENDEN UNA COMBINACION DE UN INACTIVADOR BETA Y UN INHIBIDOR DE ANHIDRASA CARBONICA, PARA REDUCIR LA PRODUCCION DE HUMOR ACUOSO, PREFERENTEMENTE FORMULADO COMO UNA SUSPENSION QUE TIENE UN PH ENTRE UN 6''8 Y UN 7''8. ESTAS COMPOSICIONES PUEDEN CONTENER ADICIONALMENTE UN POLIMERO ANIONICO MUCOMIMETICO Y/O UN SUSTRATO PORTADOR DE UN MEDICAMENTE FINAMENTE DIVIDIDO, PARA PROPORCIONAR LIBERACION SOSTENIDA. TAMBIEN SE DESCRIBE UN METODO PARA CONTROLAR LA PRESION INTRAOCULAR ELEVADA CON ESTAS COMPOSICIONES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83986992A | 1992-02-21 | 1992-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2118941T3 true ES2118941T3 (es) | 1998-10-01 |
Family
ID=25280847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93906084T Expired - Lifetime ES2118941T3 (es) | 1992-02-21 | 1993-02-19 | Composiciones antiglaucoma topicas que comprenden inhibidores de anhidrasa carbonica y bloqueantes beta. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0625903B1 (es) |
JP (2) | JP2965267B2 (es) |
AT (1) | ATE169499T1 (es) |
AU (1) | AU677577B2 (es) |
CA (1) | CA2129037C (es) |
DE (1) | DE69320329T2 (es) |
DK (1) | DK0625903T3 (es) |
ES (1) | ES2118941T3 (es) |
HK (1) | HK1009941A1 (es) |
WO (1) | WO1993016701A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG84487A1 (en) | 1991-04-17 | 2001-11-20 | Merck & Co Inc | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist |
US6316443B1 (en) | 1994-08-04 | 2001-11-13 | Merck & Co., Inc. | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist |
US6071904A (en) * | 1996-12-11 | 2000-06-06 | Alcon Laboratories, Inc. | Process for manufacturing ophthalmic suspensions |
CA2294343A1 (en) * | 1997-06-26 | 1999-01-07 | Merck & Co., Inc. | Method for optimizing retinal and optic nerve health |
WO1999037292A2 (en) * | 1998-01-23 | 1999-07-29 | Merck Sharp & Dohme B.V. | Carbonic anhydrase inhibitor for increasing oxygen tension in the optic nerve and retina |
US6291506B1 (en) | 1998-08-04 | 2001-09-18 | Wisconsin Alumni Research Foundation | Method of reducing retinal ganglion cell degeneration |
TWI290470B (en) * | 1999-12-01 | 2007-12-01 | Sankyo Co | The composition for treating glaucoma |
EP1568382B1 (en) * | 2002-11-18 | 2013-11-06 | Santen Pharmaceutical Co., Ltd. | REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND beta-BLOCKER |
US9649300B2 (en) * | 2013-08-28 | 2017-05-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Inhibition of WNT, TGF beta and Hippo signaling pathways to treat cancer, organ fibrosis and metabolic disorders |
MX2019007434A (es) | 2016-12-21 | 2019-08-16 | Biotheryx Inc | Derivados de tienopirrol para uso en seleccion como diana de proteinas, composiciones, metodos y usos de los mismos. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3655663A (en) * | 1969-04-21 | 1972-04-11 | Burton K Wasson | 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles |
US4911920A (en) * | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
US4797413A (en) * | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
US4863922A (en) * | 1984-12-12 | 1989-09-05 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
EP0189690B1 (en) * | 1984-12-12 | 1989-03-01 | Merck & Co. Inc. | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them |
US4731368A (en) * | 1986-12-08 | 1988-03-15 | Merck & Co., Inc. | Thienopyridine sulfonamides and their ophthalmological formulation |
US4751231A (en) * | 1987-09-16 | 1988-06-14 | Merck & Co., Inc. | Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents |
EP0309028A3 (en) * | 1987-09-16 | 1990-06-27 | Merck & Co. Inc. | Substituted thieno(2,3-b)furan-2-sulfonamides as antiglaucoma agents |
US4946859A (en) * | 1989-07-31 | 1990-08-07 | Merck & Co., Inc. | 4-(2-methyl-2-hydroxypropylamino)-5,6-dihydrothieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide |
US5153192A (en) * | 1990-04-09 | 1992-10-06 | Alcon Laboratories, Inc. | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
IE911192A1 (en) * | 1990-04-12 | 1991-10-23 | Merck & Co Inc | Substituted aromatic sulfonamides as antiglaucoma agents |
JP2594486B2 (ja) * | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
CA2064160C (en) * | 1991-03-27 | 1998-08-11 | Paul J. T. Missel | Use of combinations of gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
RO113612B1 (ro) * | 1991-04-17 | 1998-09-30 | Merck & Co Inc | Compozitie oftalmica |
-
1993
- 1993-02-19 ES ES93906084T patent/ES2118941T3/es not_active Expired - Lifetime
- 1993-02-19 DE DE69320329T patent/DE69320329T2/de not_active Expired - Fee Related
- 1993-02-19 AT AT93906084T patent/ATE169499T1/de not_active IP Right Cessation
- 1993-02-19 AU AU37257/93A patent/AU677577B2/en not_active Ceased
- 1993-02-19 DK DK93906084T patent/DK0625903T3/da active
- 1993-02-19 WO PCT/US1993/001487 patent/WO1993016701A2/en active IP Right Grant
- 1993-02-19 JP JP5514967A patent/JP2965267B2/ja not_active Expired - Fee Related
- 1993-02-19 EP EP93906084A patent/EP0625903B1/en not_active Expired - Lifetime
- 1993-02-19 CA CA002129037A patent/CA2129037C/en not_active Expired - Fee Related
-
1998
- 1998-02-25 JP JP10044090A patent/JPH10324640A/ja active Pending
- 1998-09-24 HK HK98110893A patent/HK1009941A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69320329T2 (de) | 1998-12-24 |
CA2129037C (en) | 1998-03-24 |
AU3725793A (en) | 1993-09-13 |
ATE169499T1 (de) | 1998-08-15 |
AU677577B2 (en) | 1997-05-01 |
WO1993016701A3 (en) | 1994-01-06 |
JPH07504899A (ja) | 1995-06-01 |
HK1009941A1 (en) | 1999-06-11 |
EP0625903A1 (en) | 1994-11-30 |
DE69320329D1 (de) | 1998-09-17 |
JPH10324640A (ja) | 1998-12-08 |
WO1993016701A2 (en) | 1993-09-02 |
JP2965267B2 (ja) | 1999-10-18 |
DK0625903T3 (da) | 1999-05-10 |
EP0625903B1 (en) | 1998-08-12 |
CA2129037A1 (en) | 1993-09-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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