ATE169499T1 - Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker - Google Patents
Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blockerInfo
- Publication number
- ATE169499T1 ATE169499T1 AT93906084T AT93906084T ATE169499T1 AT E169499 T1 ATE169499 T1 AT E169499T1 AT 93906084 T AT93906084 T AT 93906084T AT 93906084 T AT93906084 T AT 93906084T AT E169499 T1 ATE169499 T1 AT E169499T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrase
- inhibitors
- compositions containing
- containing carbon
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000002876 beta blocker Substances 0.000 title abstract 2
- 229940097320 beta blocking agent Drugs 0.000 title abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title 1
- 102000004867 Hydro-Lyases Human genes 0.000 title 1
- 108090001042 Hydro-Lyases Proteins 0.000 title 1
- 230000001384 anti-glaucoma Effects 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- 230000004406 elevated intraocular pressure Effects 0.000 abstract 2
- 229940122072 Carbonic anhydrase inhibitor Drugs 0.000 abstract 1
- 206010018307 Glaucoma and ocular hypertension Diseases 0.000 abstract 1
- 229920006318 anionic polymer Polymers 0.000 abstract 1
- 210000001742 aqueous humor Anatomy 0.000 abstract 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83986992A | 1992-02-21 | 1992-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE169499T1 true ATE169499T1 (de) | 1998-08-15 |
Family
ID=25280847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93906084T ATE169499T1 (de) | 1992-02-21 | 1993-02-19 | Topische antiglaukoma zusammensetzungen, enthaltend karbonhydrasehemmer und beta-blocker |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0625903B1 (de) |
| JP (2) | JP2965267B2 (de) |
| AT (1) | ATE169499T1 (de) |
| AU (1) | AU677577B2 (de) |
| CA (1) | CA2129037C (de) |
| DE (1) | DE69320329T2 (de) |
| DK (1) | DK0625903T3 (de) |
| ES (1) | ES2118941T3 (de) |
| WO (1) | WO1993016701A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG84487A1 (en) | 1991-04-17 | 2001-11-20 | Merck & Co Inc | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist |
| US6316443B1 (en) | 1994-08-04 | 2001-11-13 | Merck & Co., Inc. | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist |
| US6071904A (en) * | 1996-12-11 | 2000-06-06 | Alcon Laboratories, Inc. | Process for manufacturing ophthalmic suspensions |
| WO1999000133A1 (en) * | 1997-06-26 | 1999-01-07 | Merck & Co., Inc. | Method for optimizing retinal and optic nerve health |
| DE69928771T2 (de) * | 1998-01-23 | 2006-09-07 | Einar Stefansson | Carbonische anhydrase inhibitor zur steigerung des sauerstoffdrucks im sehnerv und retina |
| WO2000007584A2 (en) * | 1998-08-04 | 2000-02-17 | Wisconsin Alumni Research Foundation | Method of reducing retinal ganglion cell degeneration |
| JP4000505B2 (ja) * | 1999-12-01 | 2007-10-31 | 第一三共株式会社 | 緑内障を治療するための併用剤 |
| US7972612B2 (en) | 2002-11-18 | 2011-07-05 | Santen Pharmaceutical Co., Ltd. | Remedy for glaucoma comprising Rho kinase inhibitor and β-blocker |
| WO2015031109A1 (en) * | 2013-08-28 | 2015-03-05 | University Of Pittsburgh-Of The Common Wealth System Of Higher Education | Inhibition of wnt, tgf beta and hippo signaling pathways to treat cancer, organ fibrosis and metabolic disorders |
| KR20190093205A (ko) | 2016-12-21 | 2019-08-08 | 바이오테릭스, 인코포레이티드 | 단백질 표적화에 사용하기 위한 티에노피롤 유도체, 조성물, 방법 및 이의 용도 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655663A (en) * | 1969-04-21 | 1972-04-11 | Burton K Wasson | 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles |
| US4911920A (en) * | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| US4797413A (en) * | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
| US4863922A (en) * | 1984-12-12 | 1989-09-05 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
| DE3568431D1 (en) * | 1984-12-12 | 1989-04-06 | Merck & Co Inc | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them |
| US4731368A (en) * | 1986-12-08 | 1988-03-15 | Merck & Co., Inc. | Thienopyridine sulfonamides and their ophthalmological formulation |
| US4751231A (en) * | 1987-09-16 | 1988-06-14 | Merck & Co., Inc. | Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents |
| EP0309028A3 (de) * | 1987-09-16 | 1990-06-27 | Merck & Co. Inc. | Substituierte Thieno[2,3-b]furan-2-sulfonamide als Antiglaukommittel |
| US4946859A (en) * | 1989-07-31 | 1990-08-07 | Merck & Co., Inc. | 4-(2-methyl-2-hydroxypropylamino)-5,6-dihydrothieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide |
| US5153192A (en) * | 1990-04-09 | 1992-10-06 | Alcon Laboratories, Inc. | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
| IE911192A1 (en) * | 1990-04-12 | 1991-10-23 | Merck & Co Inc | Substituted aromatic sulfonamides as antiglaucoma agents |
| JP2594486B2 (ja) * | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
| JP2536806B2 (ja) * | 1991-03-27 | 1996-09-25 | アルコン ラボラトリーズ インコーポレイテッド | ゲル化多糖類と微粉砕された薬剤担体とを組み合わせた局部眼科用組成物 |
| WO1992018124A1 (en) * | 1991-04-17 | 1992-10-29 | Merck & Co., Inc. | OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF A CARBONIC ANHYDRASE INHIBITOR AND A β-ADRENERGIC ANTAGONIST |
-
1993
- 1993-02-19 EP EP93906084A patent/EP0625903B1/de not_active Expired - Lifetime
- 1993-02-19 ES ES93906084T patent/ES2118941T3/es not_active Expired - Lifetime
- 1993-02-19 WO PCT/US1993/001487 patent/WO1993016701A2/en not_active Ceased
- 1993-02-19 DK DK93906084T patent/DK0625903T3/da active
- 1993-02-19 DE DE69320329T patent/DE69320329T2/de not_active Expired - Fee Related
- 1993-02-19 JP JP5514967A patent/JP2965267B2/ja not_active Expired - Fee Related
- 1993-02-19 CA CA002129037A patent/CA2129037C/en not_active Expired - Fee Related
- 1993-02-19 AT AT93906084T patent/ATE169499T1/de not_active IP Right Cessation
- 1993-02-19 AU AU37257/93A patent/AU677577B2/en not_active Ceased
-
1998
- 1998-02-25 JP JP10044090A patent/JPH10324640A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69320329D1 (de) | 1998-09-17 |
| CA2129037C (en) | 1998-03-24 |
| WO1993016701A3 (en) | 1994-01-06 |
| CA2129037A1 (en) | 1993-09-02 |
| AU677577B2 (en) | 1997-05-01 |
| WO1993016701A2 (en) | 1993-09-02 |
| JPH07504899A (ja) | 1995-06-01 |
| JPH10324640A (ja) | 1998-12-08 |
| ES2118941T3 (es) | 1998-10-01 |
| JP2965267B2 (ja) | 1999-10-18 |
| AU3725793A (en) | 1993-09-13 |
| HK1009941A1 (en) | 1999-06-11 |
| EP0625903A1 (de) | 1994-11-30 |
| EP0625903B1 (de) | 1998-08-12 |
| DK0625903T3 (da) | 1999-05-10 |
| DE69320329T2 (de) | 1998-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |