PT2598500T - Composições e métodos para a inibição da via jak - Google Patents
Composições e métodos para a inibição da via jakInfo
- Publication number
- PT2598500T PT2598500T PT117458588T PT11745858T PT2598500T PT 2598500 T PT2598500 T PT 2598500T PT 117458588 T PT117458588 T PT 117458588T PT 11745858 T PT11745858 T PT 11745858T PT 2598500 T PT2598500 T PT 2598500T
- Authority
- PT
- Portugal
- Prior art keywords
- inhibition
- compositions
- methods
- jak pathway
- jak
- Prior art date
Links
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36857010P | 2010-07-28 | 2010-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2598500T true PT2598500T (pt) | 2021-07-22 |
Family
ID=44504225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117458588T PT2598500T (pt) | 2010-07-28 | 2011-07-27 | Composições e métodos para a inibição da via jak |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US8343954B2 (pt) |
| EP (1) | EP2598500B1 (pt) |
| JP (2) | JP6073221B2 (pt) |
| KR (1) | KR101937495B1 (pt) |
| CN (1) | CN103201280B (pt) |
| AR (2) | AR082408A1 (pt) |
| AU (1) | AU2011282742B2 (pt) |
| BR (1) | BR112013001632B1 (pt) |
| CA (1) | CA2804199C (pt) |
| DK (1) | DK2598500T3 (pt) |
| EA (1) | EA201390015A1 (pt) |
| ES (1) | ES2880622T3 (pt) |
| IL (1) | IL223855A (pt) |
| MX (2) | MX347331B (pt) |
| PL (1) | PL2598500T3 (pt) |
| PT (1) | PT2598500T (pt) |
| RU (1) | RU2672100C2 (pt) |
| TW (1) | TWI582090B (pt) |
| WO (1) | WO2012015972A1 (pt) |
| ZA (1) | ZA201300388B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070203161A1 (en) * | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| NZ594323A (en) | 2009-01-23 | 2013-05-31 | Rigel Pharmaceuticals Inc | Compositions and methods for inhibition of the jak pathway |
| KR101937495B1 (ko) | 2010-07-28 | 2019-01-10 | 리겔 파마슈티칼스, 인크. | Ｊａｋ 경로의 억제를 위한 조성물 및 방법 |
| ES2658395T3 (es) | 2012-04-04 | 2018-03-09 | Rigel Pharmaceuticals, Inc. | Inhibidores de proteína cinasa C y usos de los mismos |
| US20130310340A1 (en) * | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
| CA2899281C (en) * | 2013-01-25 | 2022-05-31 | Rigel Pharmaceuticals, Inc. | Pyrimidinediamine compounds for use in treating or preventing autoimmune alopecia |
| JP6421170B2 (ja) | 2013-03-14 | 2018-11-07 | ライジェル ファーマシューティカルズ， インコーポレイテッド | プロテインキナーゼｃ阻害剤およびその使用 |
| WO2016090079A1 (en) * | 2014-12-05 | 2016-06-09 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| WO2016100452A2 (en) * | 2014-12-17 | 2016-06-23 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| WO2017007658A1 (en) * | 2015-07-07 | 2017-01-12 | Rigel Pharmaceuticals, Inc. | A combination for immune mediated cancer treatment |
| WO2019040706A1 (en) * | 2017-08-24 | 2019-02-28 | Aclaris Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATING VITILIGO |
| ES2925450T3 (es) * | 2017-11-06 | 2022-10-18 | Bristol Myers Squibb Co | Compuestos de isofuranona útiles como inhibidores de HPK1 |
| CA3104745A1 (en) * | 2018-05-24 | 2019-11-28 | Astrazeneca Ab | Fumarate salt of 5-((5-methyl-2-((3,4,5-trimethylphenyl)amino)pyrimidin-4-yl)amino)-benzo[d]oxazol-2(3h)-one |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| CN110078633B (zh) * | 2019-05-24 | 2021-05-11 | 爱斯特（成都）生物制药股份有限公司 | 一种4-氟-3-甲氧基-5-甲基苯胺盐酸盐制备方法 |
| CN115697993A (zh) * | 2020-05-29 | 2023-02-03 | 南京正大天晴制药有限公司 | 作为axl抑制剂的嘧啶类化合物 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| ES2055280T3 (es) | 1989-12-04 | 1994-08-16 | Searle & Co | Sistema monocapa para la administracion transdermica de farmacos. |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| EP0495421B1 (en) | 1991-01-15 | 1996-08-21 | Alcon Laboratories, Inc. | Use of carrageenans in topical ophthalmic compositions |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| WO1993011938A1 (en) | 1991-12-18 | 1993-06-24 | Minnesota Mining And Manufacturing Company | Multilayered barrier structures |
| ATE132381T1 (de) | 1992-01-29 | 1996-01-15 | Voelkl Franz Ski | Ballspielschläger, insbesondere tennisschläger |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| US5700904A (en) | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| EP1534286B1 (en) | 2002-07-29 | 2009-12-09 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
| DK1656372T3 (da) * | 2003-07-30 | 2013-07-01 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme |
| CA2591948C (en) | 2005-01-19 | 2013-11-12 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| EP1883302A4 (en) * | 2005-05-03 | 2009-05-20 | Rigel Pharmaceuticals Inc | JAK KINASE HEMMER AND ITS USE |
| ZA200710206B (en) * | 2005-06-08 | 2009-12-30 | Rigel Pharmaceuticals Inc | Compositions and methods for inhibition of the JAK path-way |
| US20070203161A1 (en) * | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US8393954B2 (en) | 2006-12-29 | 2013-03-12 | Cfph, Llc | Top performers |
| WO2008118822A1 (en) * | 2007-03-23 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2009063240A1 (en) * | 2007-11-16 | 2009-05-22 | Arrow Therapeutics Limited | 2,4-diaminopyrimidine derivatives useful as inhibitors of aurora kinase |
| NZ594323A (en) * | 2009-01-23 | 2013-05-31 | Rigel Pharmaceuticals Inc | Compositions and methods for inhibition of the jak pathway |
| KR101937495B1 (ko) * | 2010-07-28 | 2019-01-10 | 리겔 파마슈티칼스, 인크. | Ｊａｋ 경로의 억제를 위한 조성물 및 방법 |
| JP6129155B2 (ja) * | 2011-04-12 | 2017-05-17 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 同種移植片拒絶反応を抑制する方法 |
-
2011
- 2011-07-27 KR KR1020137004970A patent/KR101937495B1/ko active IP Right Grant
- 2011-07-27 RU RU2015122016A patent/RU2672100C2/ru active
- 2011-07-27 EP EP11745858.8A patent/EP2598500B1/en active Active
- 2011-07-27 CA CA2804199A patent/CA2804199C/en active Active
- 2011-07-27 DK DK11745858.8T patent/DK2598500T3/da active
- 2011-07-27 BR BR112013001632-9A patent/BR112013001632B1/pt not_active IP Right Cessation
- 2011-07-27 PT PT117458588T patent/PT2598500T/pt unknown
- 2011-07-27 CN CN201180036682.6A patent/CN103201280B/zh active Active
- 2011-07-27 MX MX2013000757A patent/MX347331B/es active IP Right Grant
- 2011-07-27 JP JP2013521954A patent/JP6073221B2/ja not_active Expired - Fee Related
- 2011-07-27 PL PL11745858T patent/PL2598500T3/pl unknown
- 2011-07-27 AU AU2011282742A patent/AU2011282742B2/en not_active Ceased
- 2011-07-27 WO PCT/US2011/045609 patent/WO2012015972A1/en active Application Filing
- 2011-07-27 US US13/192,344 patent/US8343954B2/en active Active
- 2011-07-27 EA EA201390015A patent/EA201390015A1/ru unknown
- 2011-07-27 ES ES11745858T patent/ES2880622T3/es active Active
- 2011-07-28 TW TW100126853A patent/TWI582090B/zh not_active IP Right Cessation
- 2011-07-28 AR ARP110102733A patent/AR082408A1/es active IP Right Grant
-
2012
- 2012-11-26 US US13/685,433 patent/US9067925B2/en not_active Ceased
- 2012-12-25 IL IL223855A patent/IL223855A/en active IP Right Grant
-
2013
- 2013-01-15 ZA ZA2013/00388A patent/ZA201300388B/en unknown
- 2013-01-18 MX MX2020009397A patent/MX2020009397A/es unknown
-
2015
- 2015-05-29 US US14/725,932 patent/US9611260B2/en active Active
- 2015-10-20 US US14/918,353 patent/USRE47396E1/en active Active
-
2016
- 2016-11-14 JP JP2016221423A patent/JP2017061518A/ja not_active Withdrawn
-
2017
- 2017-02-22 US US15/439,705 patent/US9920041B2/en active Active
-
2018
- 2018-02-08 US US15/892,224 patent/US10479783B2/en active Active
-
2019
- 2019-10-17 US US16/656,461 patent/US11174251B2/en active Active
-
2020
- 2020-09-02 AR ARP200102456A patent/AR119882A2/es unknown
-
2021
- 2021-10-05 US US17/494,370 patent/US20220024907A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL263729A (en) | Preparations and methods for removing biofilms | |
| HK1163076A1 (zh) | 抑制 途徑的組合物和方法 | |
| HRP20180829T1 (hr) | Spojevi tioacetata, pripravci i postupci za uporabu | |
| ZA201300388B (en) | Compositions and methods for inhibition of the jak pathway | |
| IL225672A0 (en) | Methods and compositions for polymerase inhibition | |
| ZA201301329B (en) | Novel compounds and compositions for the inhibition of nampt | |
| EP2536756A4 (en) | HSA-RELATED COMPOSITIONS AND USE PROCESSES | |
| EP2584897A4 (en) | COMPOSITIONS CONTAINING RESVERATROL AND METHODS OF USE | |
| SG11201400668SA (en) | Wnt compositions and therapeutic uses of such compositions | |
| EP2603202A4 (en) | COMPOSITIONS AND METHOD FOR THE TREATMENT OF TAUOPATHIES | |
| HK1222128A1 (zh) | 用於製備氣霧劑的方法和組合物 | |
| EP2596112A4 (en) | ACETYCYSTEIN COMPOSITIONS AND USE METHOD THEREFOR | |
| EP2858648A4 (en) | METHODS AND COMPOSITIONS FOR INHIBITING PIN1 | |
| EP2663576A4 (en) | NEW WNT COMPOSITIONS AND THERAPEUTIC APPLICATIONS OF SUCH COMPOSITIONS | |
| EP2539444A4 (en) | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE | |
| HK1162483A1 (zh) | 抑制激酶通路的組合物和方法 | |
| ZA201302952B (en) | Fungicidal compositions and methods of use | |
| HK1254904B (zh) | 用於改變xlhed表型的組合物和方法 | |
| EP2637501A4 (en) | FUNGICIDES AND METHODS OF USE THEREOF | |
| GB2499769A8 (en) | Composition for inhibiting the growth of mammalianhair |