BR0015423A - Análogos de ácido 15-hidroxieicosatetraenóico interrompidos por heteroátomo e métodos de uso - Google Patents

Análogos de ácido 15-hidroxieicosatetraenóico interrompidos por heteroátomo e métodos de uso

Info

Publication number
BR0015423A
BR0015423A BR0015423-7A BR0015423A BR0015423A BR 0015423 A BR0015423 A BR 0015423A BR 0015423 A BR0015423 A BR 0015423A BR 0015423 A BR0015423 A BR 0015423A
Authority
BR
Brazil
Prior art keywords
methods
analogues
heteroatom
interrupted
hydroxyeicosatetraenoic acid
Prior art date
Application number
BR0015423-7A
Other languages
English (en)
Inventor
Raymond E Conrow
Peter G Klimko
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of BR0015423A publication Critical patent/BR0015423A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/54—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated

Abstract

Patente de Invenção: "ANáLOGOS DE áCIDO 15-HIDROXIEICOSATE-TRAENóICO INTERROMPIDOS POR HETEROáTOMO E MéTODOS DE USO". São descritos derivados de ácido hidroxieicosatetraenóico (HETE) interrompidos por heteroátomos e métodos de seu uso para tratar olhos secos.
BR0015423-7A 1999-11-09 2000-10-23 Análogos de ácido 15-hidroxieicosatetraenóico interrompidos por heteroátomo e métodos de uso BR0015423A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16438399P 1999-11-09 1999-11-09
PCT/US2000/029235 WO2001034129A2 (en) 1999-11-09 2000-10-23 Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and methods of use

Publications (1)

Publication Number Publication Date
BR0015423A true BR0015423A (pt) 2002-07-09

Family

ID=22594245

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015423-7A BR0015423A (pt) 1999-11-09 2000-10-23 Análogos de ácido 15-hidroxieicosatetraenóico interrompidos por heteroátomo e métodos de uso

Country Status (20)

Country Link
US (3) US6331566B1 (pt)
EP (1) EP1227809B1 (pt)
JP (1) JP2003513910A (pt)
KR (1) KR20020040848A (pt)
CN (1) CN1382046A (pt)
AR (1) AR031536A1 (pt)
AT (1) ATE292464T1 (pt)
AU (1) AU776258B2 (pt)
BR (1) BR0015423A (pt)
CA (1) CA2386623A1 (pt)
DE (1) DE60019322T2 (pt)
ES (1) ES2235966T3 (pt)
HK (1) HK1045260B (pt)
MX (1) MXPA02004702A (pt)
PL (1) PL356092A1 (pt)
PT (1) PT1227809E (pt)
TR (1) TR200201249T2 (pt)
TW (2) TW200718423A (pt)
WO (1) WO2001034129A2 (pt)
ZA (1) ZA200202278B (pt)

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* Cited by examiner, † Cited by third party
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US20030109508A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
US20030109488A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
AU2003235454A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
AU2003221707A1 (en) * 2002-06-14 2003-12-31 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
US20030232858A1 (en) * 2002-06-14 2003-12-18 Barker Ronnie C. Use of hydroxyeicosatetraenoic acid compounds to treat dry mouth
WO2004026406A1 (en) * 2002-09-20 2004-04-01 Alcon, Inc. Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
KR20090088854A (ko) * 2006-09-13 2009-08-20 다케다 야쿠힌 고교 가부시키가이샤 2-6-(3-아미노-피페리딘-엘-일)-3-메틸-2,4-디옥소-3,4-디하이드로-2h-피리미딘-1-일메틸-4-플루오로-벤조니트릴의 용도
ITUB20153104A1 (it) * 2015-08-13 2017-02-13 Sooft Italia S P A Contrada Molino 17 68333 Montegiorgio Fm Composizione ed uso di collirio a base di inositolo per migliorare l'accomodazione visiva dei pazienti
EP3776635B1 (en) * 2018-04-04 2022-12-07 Basf Se Cleavable additives for use in a method of making a semiconductor substrate

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US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
AU546872B2 (en) 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
US4421748A (en) 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
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US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
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ATE132366T1 (de) 1990-05-29 1996-01-15 Boston Ocular Res Zusammensetzung zur behandlung von dry eye erkrankungen
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ATE141502T1 (de) 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
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Also Published As

Publication number Publication date
TR200201249T2 (tr) 2002-09-23
US6331566B1 (en) 2001-12-18
ZA200202278B (en) 2003-05-28
CA2386623A1 (en) 2001-05-17
MXPA02004702A (es) 2004-09-10
TWI268776B (en) 2006-12-21
DE60019322T2 (de) 2005-09-08
ATE292464T1 (de) 2005-04-15
US20010051648A1 (en) 2001-12-13
WO2001034129A2 (en) 2001-05-17
WO2001034129A3 (en) 2001-12-13
HK1045260A1 (en) 2002-11-22
ES2235966T3 (es) 2005-07-16
PL356092A1 (en) 2004-06-14
AR031536A1 (es) 2003-09-24
TW200718423A (en) 2007-05-16
EP1227809A2 (en) 2002-08-07
DE60019322D1 (de) 2005-05-12
AU8031500A (en) 2001-06-06
US20020002196A1 (en) 2002-01-03
HK1045260B (zh) 2005-06-10
US6441035B2 (en) 2002-08-27
EP1227809B1 (en) 2005-04-06
CN1382046A (zh) 2002-11-27
KR20020040848A (ko) 2002-05-30
PT1227809E (pt) 2005-06-30
US6436994B2 (en) 2002-08-20
JP2003513910A (ja) 2003-04-15
AU776258B2 (en) 2004-09-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.