BRPI0310060B8 - sistema automatizado para isolar, amplificar e detectar uma seqüência de ácido nucléico alvo ou uma proteína - Google Patents

sistema automatizado para isolar, amplificar e detectar uma seqüência de ácido nucléico alvo ou uma proteína

Info

Publication number
BRPI0310060B8
BRPI0310060B8 BRPI0310060A BR0310060A BRPI0310060B8 BR PI0310060 B8 BRPI0310060 B8 BR PI0310060B8 BR PI0310060 A BRPI0310060 A BR PI0310060A BR 0310060 A BR0310060 A BR 0310060A BR PI0310060 B8 BRPI0310060 B8 BR PI0310060B8
Authority
BR
Brazil
Prior art keywords
amplifying
isolating
detecting
acid sequence
nucleic acid
Prior art date
Application number
BRPI0310060A
Other languages
English (en)
Other versions
BRPI0310060B1 (pt
BR0310060A (pt
Inventor
Thomas Bradley
Collis Matthew
Fort Thomas
Hansen Timothy
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Publication of BR0310060A publication Critical patent/BR0310060A/pt
Publication of BRPI0310060B1 publication Critical patent/BRPI0310060B1/pt
Publication of BRPI0310060B8 publication Critical patent/BRPI0310060B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G01N2035/00366—Several different temperatures used
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403—Sample carriers with closing or sealing means
    • G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1053—General features of the devices using the transfer device for another function for separating part of the liquid, e.g. filters, extraction phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Abstract

"sistema automatizado para isolar, amplificar e detectar uma seqüência de ácido nucléico alvo". são apresentados um sistema e um método para preparar e testar ácidos nucléicos objetivados. o sistema integra uma pipeta (522), extrator (516), leitora (502) de ensaio, e outros componentes, incluindo um braço (524) de robô articulado seletivamente submisso (scara) . essa integração sinérgica de ferramentas de diagnóstico previamente separadas cria um sistema e método de modo que um mínimo de intervenção humana é exigido. o sistema resultante provê um método substancialmente mais exato e preciso de se isolar, amplificar e detectar ácidos nucléicos objetivados para o diagnóstico de doenças.
BRPI0310060A 2002-05-17 2003-05-19 sistema automatizado para isolar, amplificar e detectar uma seqüência de ácido nucléico alvo ou uma proteína BRPI0310060B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38085902P 2002-05-17 2002-05-17
PCT/US2003/015602 WO2003097808A2 (en) 2002-05-17 2003-05-19 Automated system for isolating, amplyifying and detecting a target nucleic acid sequence

Publications (3)

Publication Number Publication Date
BR0310060A BR0310060A (pt) 2005-02-15
BRPI0310060B1 BRPI0310060B1 (pt) 2017-01-31
BRPI0310060B8 true BRPI0310060B8 (pt) 2021-07-27

Family

ID=29550028

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0310060A BRPI0310060B8 (pt) 2002-05-17 2003-05-19 sistema automatizado para isolar, amplificar e detectar uma seqüência de ácido nucléico alvo ou uma proteína

Country Status (14)

Country Link
US (4) US20040029260A1 (pt)
EP (1) EP1506413B1 (pt)
JP (1) JP4532264B2 (pt)
KR (1) KR20050008720A (pt)
CN (2) CN103399162B (pt)
AU (1) AU2003233555B2 (pt)
BR (1) BRPI0310060B8 (pt)
CA (1) CA2483694C (pt)
ES (1) ES2594333T3 (pt)
MX (1) MXPA04011083A (pt)
NO (1) NO20045307L (pt)
RU (1) RU2004137103A (pt)
WO (1) WO2003097808A2 (pt)
ZA (1) ZA200409089B (pt)

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CN103399162A (zh) 2013-11-20
US20120282603A1 (en) 2012-11-08
BRPI0310060B1 (pt) 2017-01-31
US9696328B2 (en) 2017-07-04
CN1653338A (zh) 2005-08-10
CN103399162B (zh) 2016-04-27
CA2483694A1 (en) 2003-11-27
ES2594333T3 (es) 2016-12-19
JP2005525816A (ja) 2005-09-02
BR0310060A (pt) 2005-02-15
US20090155808A1 (en) 2009-06-18
MXPA04011083A (es) 2005-02-14
EP1506413A4 (en) 2005-08-17
WO2003097808A9 (en) 2004-02-19
RU2004137103A (ru) 2005-11-20
EP1506413B1 (en) 2016-07-06
WO2003097808A3 (en) 2004-07-15
WO2003097808A2 (en) 2003-11-27
US20110200991A1 (en) 2011-08-18
KR20050008720A (ko) 2005-01-21
AU2003233555B2 (en) 2009-11-26
EP1506413A2 (en) 2005-02-16
ZA200409089B (en) 2005-02-08
JP4532264B2 (ja) 2010-08-25
CA2483694C (en) 2016-04-19
US20040029260A1 (en) 2004-02-12
AU2003233555A1 (en) 2003-12-02
NO20045307L (no) 2004-12-03

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