ATE259068T1 - Vorrichtung zur handhabung von mikroflüssigkeitsmengen - Google Patents
Vorrichtung zur handhabung von mikroflüssigkeitsmengenInfo
- Publication number
- ATE259068T1 ATE259068T1 AT97108726T AT97108726T ATE259068T1 AT E259068 T1 ATE259068 T1 AT E259068T1 AT 97108726 T AT97108726 T AT 97108726T AT 97108726 T AT97108726 T AT 97108726T AT E259068 T1 ATE259068 T1 AT E259068T1
- Authority
- AT
- Austria
- Prior art keywords
- microdispenser
- liquid
- pressure
- reservoir
- coupled
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
- G01F1/05—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects
- G01F1/34—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure
- G01F1/48—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by measuring pressure or differential pressure the pressure or differential pressure being created by a capillary element
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F3/00—Measuring the volume flow of fluids or fluent solid material wherein the fluid passes through the meter in successive and more or less isolated quantities, the meter being driven by the flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00378—Piezo-electric or ink jet dispensers
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
- G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1039—Micropipettes, e.g. microcapillary tubes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1041—Ink-jet like dispensers
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65645596A | 1996-05-31 | 1996-05-31 | |
US4186197P | 1997-04-08 | 1997-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE259068T1 true ATE259068T1 (de) | 2004-02-15 |
Family
ID=26718622
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97108726T ATE259068T1 (de) | 1996-05-31 | 1997-05-30 | Vorrichtung zur handhabung von mikroflüssigkeitsmengen |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0810438B1 (de) |
JP (2) | JP4095135B2 (de) |
AT (1) | ATE259068T1 (de) |
DE (1) | DE69727422T2 (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6203759B1 (en) | 1996-05-31 | 2001-03-20 | Packard Instrument Company | Microvolume liquid handling system |
US6521187B1 (en) * | 1996-05-31 | 2003-02-18 | Packard Instrument Company | Dispensing liquid drops onto porous brittle substrates |
US6537817B1 (en) | 1993-05-31 | 2003-03-25 | Packard Instrument Company | Piezoelectric-drop-on-demand technology |
US6158269A (en) * | 1995-07-13 | 2000-12-12 | Bayer Corporation | Method and apparatus for aspirating and dispensing sample fluids |
DE19802367C1 (de) | 1997-02-19 | 1999-09-23 | Hahn Schickard Ges | Mikrodosiervorrichtungsarray und Verfahren zum Betreiben desselben |
AU6963798A (en) * | 1997-04-08 | 1998-10-30 | Packard Instrument Company Inc. | Microvolume liquid handling system |
US6902703B2 (en) | 1999-05-03 | 2005-06-07 | Ljl Biosystems, Inc. | Integrated sample-processing system |
US6838051B2 (en) | 1999-05-03 | 2005-01-04 | Ljl Biosystems, Inc. | Integrated sample-processing system |
US6121049A (en) * | 1997-12-05 | 2000-09-19 | Bayer Corporation | Method of verifying aspirated volume in automatic diagnostic system |
DE19754000A1 (de) | 1997-12-05 | 1999-06-17 | Max Planck Gesellschaft | Vorrichtung und Verfahren zur elektrisch ausgelösten Mikrotropfenabgabe mit einem Dispensierkopf |
US6060320A (en) * | 1997-12-05 | 2000-05-09 | Bayer Corporation | Method of verifying aspirated volume in automatic diagnostic system |
US6063339A (en) * | 1998-01-09 | 2000-05-16 | Cartesian Technologies, Inc. | Method and apparatus for high-speed dot array dispensing |
US7470547B2 (en) | 2003-07-31 | 2008-12-30 | Biodot, Inc. | Methods and systems for dispensing sub-microfluidic drops |
IL123210A0 (en) | 1998-02-06 | 1998-09-24 | Gombinsky Moshe | A device and system for the collection of magnetic particles |
FR2776389B1 (fr) * | 1998-03-20 | 2000-06-16 | Fondation Jean Dausset Ceph | Dispositif automatique de realisation d'echantillons en vue de la mise en oeuvre de reactions chimiques ou biologiques en milieu liquide |
DE19815400C2 (de) * | 1998-04-06 | 2002-02-07 | Max Planck Gesellschaft | Vorrichtung zur Probenaufnahme aus polymeren Trägermaterialien |
US6296811B1 (en) * | 1998-12-10 | 2001-10-02 | Aurora Biosciences Corporation | Fluid dispenser and dispensing methods |
AU5126400A (en) * | 1999-05-03 | 2000-11-17 | Ljl Biosystems, Inc. | Integrated sample-processing system |
DE19934896A1 (de) * | 1999-07-24 | 2001-01-25 | Max Planck Gesellschaft | Pipettierkopf für Parallelpipettierer |
CA2384520A1 (en) * | 1999-09-14 | 2001-03-22 | Pharmacopeia, Inc. | Flow control elements for use in liquid dispensers |
DE19946525A1 (de) * | 1999-09-28 | 2001-05-03 | Fraunhofer Ges Forschung | Vorrichtung zur Aufnahme und Abgabe kleinster Flüssigkeitsmengen |
DE10017105A1 (de) * | 2000-04-06 | 2001-10-11 | Basf Ag | Verfahren und Vorrichtung zur Herstellung von Biopolymer-Feldern |
US7163660B2 (en) | 2000-05-31 | 2007-01-16 | Infineon Technologies Ag | Arrangement for taking up liquid analytes |
US6852291B1 (en) | 2000-10-11 | 2005-02-08 | Innovadyne Technologies, Inc. | Hybrid valve apparatus and method for fluid handling |
US7135146B2 (en) | 2000-10-11 | 2006-11-14 | Innovadyne Technologies, Inc. | Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device |
CH695544A5 (de) * | 2000-11-17 | 2006-06-30 | Tecan Trading Ag | Vorrichtung zur Abgabe bzw. Aufnahme/Abgabe von Flüssigkeitsproben. |
US20020106308A1 (en) * | 2001-02-02 | 2002-08-08 | Zweifel Ronald A. | Microdrop dispensing apparatus |
US6983636B2 (en) | 2002-01-25 | 2006-01-10 | Innovadyne Technologies, Inc. | Apparatus and method for assessing the liquid flow performances through a small dispensing orifice |
JP2003254983A (ja) * | 2002-03-05 | 2003-09-10 | Sakae:Kk | 液面検知装置及びこれを用いた自動分析装置 |
US6932502B2 (en) * | 2002-05-01 | 2005-08-23 | Hewlett-Packard Development Company, L.P. | Mixing apparatus |
US20040029260A1 (en) | 2002-05-17 | 2004-02-12 | Hansen Timothy R. | Automated system for isolating, amplifying and detecting a target nucleic acid sequence |
DE10225931A1 (de) * | 2002-06-11 | 2003-12-24 | Basf Ag | Reaktorsystem zur parallelen Durchführung chemischer Reaktionen, insbesondere Polymerisationsreaktionen |
JP4077256B2 (ja) * | 2002-07-09 | 2008-04-16 | 株式会社マイクロジェット | 吐出装置および注入装置 |
DE10255595A1 (de) * | 2002-11-26 | 2004-06-03 | Cybio Ag | Mehrkanaldosiervorrichtung mit automatischer Kalibrierung |
US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
US8307722B2 (en) * | 2005-05-19 | 2012-11-13 | Universal Bio Research Co., Ltd. | Method of detecting dispensed quantity, and liquid suction monitoring dispensing apparatus |
DE102005060862B3 (de) * | 2005-12-20 | 2007-06-28 | Stratec Biomedical Systems Ag | Verfahren und Vorrichtung zur Beurteilung eines Dosiervorgangs |
JP2007315949A (ja) * | 2006-05-26 | 2007-12-06 | Toshiba Corp | 自動分析装置 |
US8015939B2 (en) | 2006-06-30 | 2011-09-13 | Asml Netherlands B.V. | Imprintable medium dispenser |
JP4957957B2 (ja) * | 2006-11-15 | 2012-06-20 | 横河電機株式会社 | 液体供給装置 |
WO2008089449A2 (en) | 2007-01-19 | 2008-07-24 | Biodot, Inc. | Systems and methods for high speed array printing and hybridization |
US9304141B2 (en) | 2007-04-18 | 2016-04-05 | Becton, Dickinson And Company | Method and apparatus for determing dispense volume |
DE102008016513B4 (de) * | 2008-03-31 | 2012-12-20 | Bartels Mikrotechnik Gmbh | Vorrichtung und Verfahren zum exakten Dosieren von Flüssigkeiten |
JP5274124B2 (ja) * | 2008-07-02 | 2013-08-28 | ベックマン コールター, インコーポレイテッド | 分注装置 |
KR101093686B1 (ko) * | 2008-10-29 | 2011-12-15 | 한국기계연구원 | 중공형 액추에이터 구동방식 액적 디스펜싱 장치 |
DE102009050782B4 (de) | 2008-10-29 | 2020-06-10 | Korea Institute Of Machinery & Materials | Hohle, Aktuator-getriebene Tröpfchenabgabevorrichtung |
EP2213364A1 (de) * | 2009-01-30 | 2010-08-04 | Albert-Ludwigs-Universität Freiburg | Phasenleitermuster für Flüssigkeitsmanipulation |
JP5034016B2 (ja) * | 2009-01-30 | 2012-09-26 | 矢部川電気工業株式会社 | 流体移送装置、流体移送方法、プログラム、及び、記録媒体 |
KR20110046935A (ko) | 2009-10-29 | 2011-05-06 | 포항공과대학교 산학협력단 | 액적 토출 장치 |
DK2665557T3 (da) | 2011-01-21 | 2020-04-06 | Biodot Inc | Piezoelektrisk dispenser med en langsgående transducer og udskifteligt kapillærrør |
FR2978064B1 (fr) * | 2011-07-18 | 2016-02-19 | Interlab | Procede et dispositif de distribution gravimetrique et en serie de solution. |
JP5453375B2 (ja) * | 2011-11-07 | 2014-03-26 | 株式会社東芝 | 自動分析装置 |
EP2802848A4 (de) * | 2012-01-11 | 2015-11-04 | Siemens Healthcare Diagnostics | Flüssigkeitstransfersysteme und verfahren zur kalibrierung davon |
AU2013337608B2 (en) * | 2012-11-01 | 2017-07-20 | Leica Biosystems Melbourne Pty Ltd | A fluid transport system |
JP2013061356A (ja) * | 2013-01-08 | 2013-04-04 | Toshiba Corp | 自動分析装置 |
FR3047067B1 (fr) * | 2016-01-22 | 2019-07-05 | Elvesys | Systeme de mesure de debit d'un liquide et son utilisation |
US10814062B2 (en) * | 2017-08-31 | 2020-10-27 | Becton, Dickinson And Company | Reservoir with low volume sensor |
US20210077991A1 (en) * | 2017-12-19 | 2021-03-18 | Siemens Healthcare Diagnostics Inc. | Probe apparatus, assemblies, and methods for aspirating and dispensing liquids |
US11320295B2 (en) * | 2019-04-26 | 2022-05-03 | Festo Se & Co. Kg | Dosing unit and method for dosing a liquid |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60107744U (ja) * | 1983-12-26 | 1985-07-22 | オリンパス光学工業株式会社 | 分注機 |
JPS60145345U (ja) * | 1984-03-07 | 1985-09-26 | 株式会社島津製作所 | 液体試料注入器 |
CA1252173A (en) * | 1984-07-19 | 1989-04-04 | Thomas C. Jessop | Apparatus and method for detecting liquid penetration by a container used for aspirating and dispensing the liquid |
SE448031B (sv) * | 1985-06-18 | 1987-01-12 | Scomas Ab | Forfarande och apparat for indikering av avkenning av pipetteringspositioner vid en testplatta |
IT1181735B (it) * | 1985-11-19 | 1987-09-30 | Chemila Srl | Sensore di livello di liquidi,utilizzato in una stazione automatica per la preparazione di dosaggi immunologici |
JPS6315121A (ja) * | 1986-07-07 | 1988-01-22 | Tosoh Corp | 液定量取出し装置 |
CA1302979C (en) * | 1986-10-24 | 1992-06-09 | Richard W. Hanaway | Multiple pipette sampler |
AU603617B2 (en) * | 1986-11-17 | 1990-11-22 | Abbott Laboratories | Apparatus and process for reagent fluid dispensing and printing |
JPH01234144A (ja) * | 1988-03-15 | 1989-09-19 | Nagao Saito | 超音波加工振動装置 |
JPH087222B2 (ja) * | 1990-01-18 | 1996-01-29 | 持田製薬株式会社 | 自動分注希釈装置 |
JP3246752B2 (ja) * | 1991-02-13 | 2002-01-15 | オリンパス光学工業株式会社 | 分注ノズル洗浄装置 |
US5133392A (en) * | 1991-04-10 | 1992-07-28 | Eastman Kodak Company | Liquid injection using container bottom sensing |
US5370842A (en) * | 1991-11-29 | 1994-12-06 | Canon Kabushiki Kaisha | Sample measuring device and sample measuring system |
JPH07213926A (ja) * | 1994-02-03 | 1995-08-15 | Hitachi Koki Co Ltd | ピペット |
JPH07243949A (ja) * | 1994-03-03 | 1995-09-19 | Olympus Optical Co Ltd | 医療用分析機の分注ノズル洗浄装置 |
JPH07287021A (ja) * | 1994-04-19 | 1995-10-31 | Hitachi Ltd | 自動分注装置 |
JP3532626B2 (ja) * | 1994-10-07 | 2004-05-31 | アロカ株式会社 | 攪拌ノズル装置 |
-
1997
- 1997-05-30 DE DE69727422T patent/DE69727422T2/de not_active Expired - Lifetime
- 1997-05-30 AT AT97108726T patent/ATE259068T1/de not_active IP Right Cessation
- 1997-05-30 EP EP97108726A patent/EP0810438B1/de not_active Expired - Lifetime
- 1997-06-02 JP JP14392197A patent/JP4095135B2/ja not_active Expired - Lifetime
-
2007
- 2007-11-28 JP JP2007307569A patent/JP4783776B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP4783776B2 (ja) | 2011-09-28 |
JPH10114394A (ja) | 1998-05-06 |
EP0810438B1 (de) | 2004-02-04 |
EP0810438A3 (de) | 1998-09-30 |
JP4095135B2 (ja) | 2008-06-04 |
DE69727422D1 (de) | 2004-03-11 |
DE69727422T2 (de) | 2004-07-01 |
EP0810438A2 (de) | 1997-12-03 |
JP2008145434A (ja) | 2008-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |