BR9910574A - Compostos tendo derivado de ácido glicurÈnico e derivado de glicosamina em sua estrutura, método para a produção dos compostos, e uso dos compostos - Google Patents

Compostos tendo derivado de ácido glicurÈnico e derivado de glicosamina em sua estrutura, método para a produção dos compostos, e uso dos compostos

Info

Publication number
BR9910574A
BR9910574A BR9910574-8A BR9910574A BR9910574A BR 9910574 A BR9910574 A BR 9910574A BR 9910574 A BR9910574 A BR 9910574A BR 9910574 A BR9910574 A BR 9910574A
Authority
BR
Brazil
Prior art keywords
cir
compounds
derived
glucosamine
production
Prior art date
Application number
BR9910574-8A
Other languages
English (en)
Inventor
Nobuaki Yatsuka
Nobuyuki Sato
Shigeru Moriyama
Tadakazu Tamai
Masazumi Nishikawa
Original Assignee
Maruha Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12042598A external-priority patent/JP4301591B2/ja
Priority claimed from JP27389598A external-priority patent/JP4301602B2/ja
Application filed by Maruha Corp filed Critical Maruha Corp
Publication of BR9910574A publication Critical patent/BR9910574A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Patente de Invenção: "COMPOSTOS TENDO DERIVADO DE áCIDO GLICURÈNICO E DERIVADO DE GLICOSAMINA EM SUA ESTRUTURA, MéTODO PARA A PRODUçãO DOS COMPOSTOS, E USO DOS COMPOSTOS"<D>. A presente invenção refere-se a compostos da seguinte fórmula geral (1) tendo um derivado de ácido glicurónico e um derivado de glicosamina em sua estrutura, sais e solvatos farmacologicamente aceitáveis dos compostos, ou solvatos dos sais, um método para a produção dos compostos (1), uma composição farmacêutica contendo os compostos (1), polímeros tendo pelo menos um dos compostos (1) como uma estrutura de cadeia lateral, um agente de revestimento contendo o composto (1) ou o polímero como um dos ingredientes ativos, e produtos moldados, órgãos artificiais, dispositivos médicos, e equipamento para o cultivo celular, que foi produzido usando o polímero e/ou o agente de revestimento.
BR9910574-8A 1998-04-30 1999-04-30 Compostos tendo derivado de ácido glicurÈnico e derivado de glicosamina em sua estrutura, método para a produção dos compostos, e uso dos compostos BR9910574A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12042598A JP4301591B2 (ja) 1998-04-30 1998-04-30 新規な血小板粘着凝集抑制物質、その製造法およびその用途
JP27389598A JP4301602B2 (ja) 1998-09-28 1998-09-28 血管内皮細胞増殖促進剤
PCT/JP1999/002306 WO1999057301A1 (fr) 1998-04-30 1999-04-30 Composes dont la structure comporte des derives d'acide glucuronique et des derives de glucosamine, leur procede de preparation et d'utilisation

Publications (1)

Publication Number Publication Date
BR9910574A true BR9910574A (pt) 2001-09-11

Family

ID=26458012

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910574-8A BR9910574A (pt) 1998-04-30 1999-04-30 Compostos tendo derivado de ácido glicurÈnico e derivado de glicosamina em sua estrutura, método para a produção dos compostos, e uso dos compostos

Country Status (12)

Country Link
US (1) US6613897B1 (pt)
EP (1) EP1074631B1 (pt)
KR (1) KR100530196B1 (pt)
CN (1) CN1185352C (pt)
AT (1) ATE302785T1 (pt)
AU (1) AU758575C (pt)
BR (1) BR9910574A (pt)
CA (1) CA2330388A1 (pt)
DE (1) DE69926876T2 (pt)
NO (1) NO20005402L (pt)
RU (1) RU2218922C2 (pt)
WO (1) WO1999057301A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4450456B2 (ja) 1999-09-27 2010-04-14 株式会社マルハニチロ水産 皮脂産生抑制剤
US7507723B2 (en) * 2000-07-07 2009-03-24 Seikagaku Corporation Hyaluronic acid oligosaccharide fractions and drugs containing the same
DE60114724T2 (de) * 2000-07-18 2006-06-01 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Blutflussverbesserer und Mittel zur Vorbeugung oder Heilung von Thrombose
WO2004043509A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
WO2006083328A2 (en) * 2004-09-15 2006-08-10 Massachusetts Institute Of Technology Biologically active surfaces and methods of their use
US20070099867A1 (en) * 2005-05-24 2007-05-03 Glycoscience Laboratories, Inc. Pharmaceutical agent containing hyaluronan as an active ingredient
JP2009091248A (ja) * 2006-01-17 2009-04-30 Toshitsu Kagaku Kenkyusho:Kk 外傷性神経障害および／または運動機能障害の治療薬
WO2008068854A1 (ja) 2006-12-05 2008-06-12 Glycoscience Laboratories, Inc. 変形性関節症の治療剤
US8114466B2 (en) * 2007-01-03 2012-02-14 Boston Scientific Scimed, Inc. Methods of applying coating to the inside surface of a stent
US8080260B2 (en) 2008-02-13 2011-12-20 The Cleveland Clinic Foundation Molecular enhancement of extracellular matrix and methods of use
EP2300042A4 (en) 2008-04-30 2012-05-02 Cleveland Clinic Foundation COMPOSITIONS AND METHODS FOR TREATING URINARY INCONTINENCE
CZ302503B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
CZ2012136A3 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CZ304140B6 (cs) 2012-09-27 2013-11-13 Contipro Biotech S.R.O. Enzym hyaluronan-lyáza, zpusob jeho výroby, pouzití a zpusob prípravy nízkomolekulárního hyaluronanu
CZ2012842A3 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CZ305153B6 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ2015398A3 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
CN106518934B (zh) * 2016-11-21 2019-05-03 苏州大学 不饱和透明质酸奇数寡糖的制备方法
CN110183499B (zh) * 2019-06-26 2020-07-21 苏州鸿洋医药科技有限公司 一种不饱和透明质酸四糖
KR20210028544A (ko) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033474B2 (ja) 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法
GB8504025D0 (en) 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
CS264719B1 (cs) * 1987-03-06 1989-09-12 Galatik Antonin Farmakologický přípravek na báze derivátu kyseliny hyaluronovej
GB8713747D0 (en) 1987-06-12 1987-07-15 Unilever Plc Skin treatment composition
IT1217458B (it) 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
JPH0673103A (ja) * 1991-11-27 1994-03-15 Lignyte Co Ltd ヒアルロン酸高分子複合体及びその製造方法
IT1260154B (it) 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5585361A (en) * 1994-06-07 1996-12-17 Genzyme Corporation Methods for the inhibition of platelet adherence and aggregation
HU219815B (hu) 1995-02-07 2001-08-28 Fidia Advanced Biopolymers S.R.L. Eljárás tárgyak hialuronsavval, hialuronsavszármazékokkal és félszintetikus polimerekkel történő bevonására
US5733893A (en) * 1995-03-15 1998-03-31 Washington University Method of identifying molecules that regulate FGF activity

Also Published As

Publication number Publication date
CN1303443A (zh) 2001-07-11
AU758575C (en) 2003-11-20
DE69926876D1 (de) 2005-09-29
AU3627499A (en) 1999-11-23
WO1999057301A1 (fr) 1999-11-11
NO20005402D0 (no) 2000-10-26
KR100530196B1 (ko) 2005-11-22
AU758575B2 (en) 2003-03-27
ATE302785T1 (de) 2005-09-15
DE69926876T2 (de) 2006-06-14
CA2330388A1 (en) 1999-11-11
NO20005402L (no) 2000-12-18
KR20010043168A (ko) 2001-05-25
CN1185352C (zh) 2005-01-19
EP1074631A2 (en) 2001-02-07
EP1074631A4 (en) 2002-01-30
US6613897B1 (en) 2003-09-02
WO1999057301A8 (fr) 2000-01-06
RU2218922C2 (ru) 2003-12-20
EP1074631B1 (en) 2005-08-24

Similar Documents

Publication Publication Date Title
BR9910574A (pt) Compostos tendo derivado de ácido glicurÈnico e derivado de glicosamina em sua estrutura, método para a produção dos compostos, e uso dos compostos
PT1087934E (pt) Compostos de eter de aminociclo-hexilo e as suas utilizacoes
MD1233C2 (ro) Derivaţi de eritromicină, procedeu de preparare a lor şi compoziţie farmaceutică pe baza acestora
BG104441A (en) Cyclic amine derivatives and their use as drugs
ATE150462T1 (de) Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
PT1003504E (pt) Compostos quimicos
ES2191260T3 (es) Derivados de la imidazolidin-4-ona utiles como agentes anticancerosos.
ATE534656T1 (de) Neue oligosaccharide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE69326231D1 (de) Cholesterinspiegelsenkendes mittel
YU56302A (sh) Derivati 8,8a-dihidro-indeno/1,2-d/taizola, koji su supstituisani u 8a-položaju,postupak za njihovu proizvodnju i njihova primena kod leka npr.kao anorektičnog sredstva
ATE146473T1 (de) Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
ATE89547T1 (de) Dopamin-vorlaeufer.
DK0992509T3 (da) Nye makrolid-derivater
ATE240306T1 (de) Benzothiadiazinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
FI935800A0 (fi) Antidepressiva och mot Parkisons sjukdom verksamma foereningar
ATE178332T1 (de) Benzothiadiazinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zuzammensetzungen
DE3686979D1 (de) Cephemverbindungen und verfahren zu ihrer herstellung.
IT1301968B1 (it) Derivati di eritromicina ad attivita&#39; antibiotica
DE69734678D1 (de) 6-0-substitutierte eryththromycin-verbindungen und verfahrenen zu ihrer herstellung
EP1219296A4 (en) SEBUM PRODUCTION INHIBITORS
DE69105786T2 (de) Harnstoffderivate, deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen.
PL320105A1 (en) Novel heterocyclic compounds, method of obtaining them, their application as a drug and in production of drugs and as a pharmaceutic agent
TR200003451T2 (tr) Pirimidin-Aminometil-Piridin Türevleri, Hazırlanmaları ve helikobakter bakterinin kontrolünde kullanımları
ITMI950132A1 (it) Derivati tiolici ad attivita&#39; inibitrice delle metallopeptidasi
IT1215340B (it) Derivati di esteri dell&#39;acido immidazol-1-il-carbossilico, procedimenti per la loro preparazione e composizioni fungicide che contengono il derivato come componente attivo.

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]