BR112013025753A8 - Métodos para aprimoramento do rendimento de produto e produção em um micro-organismo através da adição de aceptores de elétrons alternativos - Google Patents
Métodos para aprimoramento do rendimento de produto e produção em um micro-organismo através da adição de aceptores de elétrons alternativosInfo
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- BR112013025753A8 BR112013025753A8 BR112013025753A BR112013025753A BR112013025753A8 BR 112013025753 A8 BR112013025753 A8 BR 112013025753A8 BR 112013025753 A BR112013025753 A BR 112013025753A BR 112013025753 A BR112013025753 A BR 112013025753A BR 112013025753 A8 BR112013025753 A8 BR 112013025753A8
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
- C12P7/10—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01054—Formate C-acetyltransferase (2.3.1.54), i.e. pyruvate formate-lyase or PFL
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Wood Science & Technology (AREA)
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- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
MÉTODOS PARA APRIMORAMENTO DO RENDIMENTO DE PRODUTO E PRODUÇÃO EM UM MICRO-ORGANISMO ATRAVÉS DA ADIÇÃO DE ACEPTORES DE ELÉTRONS ALTERNATIVOS A presente invenção proporciona vias metabólicas para reduzir ou eliminar a produção de glicerol e aumentar a formação de produto. Mais especificamente, a invenção proporciona um micro-organismo recombinante compreendendo uma deleção de uma ou mais enzimas nativas que atuam para produzir glicerol e/ou regular a síntese de glicerol e uma ou mais enzimas nativas e/ou heterólogas que atuam em uma ou mais vias metabólicas sintéticas para converter uma fonte de carboidratos, tal como lignocelulose, a um produto, tal como o etanol, em que as uma ou mais enzimas nativas e/ou heterólogas estão na condição ativa, suprarregulada ou infrarregulada. A invenção também proporciona um micro-organismo recombinante compreendendo uma ou mais enzimas heterólogas que atuam para regular a síntese de glicerol e uma ou mais enzimas nativas e/ou heterólogas que atuam em uma ou mais vias metabólicas sintéticas para converter uma fonte de carboidrato a etanol, em que as referidas uma ou mais enzimas nativas e/ou heterólogas estão na condição ativada, suprarregulada ou infrarregulada.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR122019017739-2A BR122019017739B1 (pt) | 2011-04-05 | 2012-04-05 | Micro-organismo recombinante compreendendo uma deleção de enzimas nativas que atuam para produzir glicerol e/ou regular a síntese de glicerol e vias metabólicas sintéticas para converter uma fonte de carboidrato a etanol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161472085P | 2011-04-05 | 2011-04-05 | |
PCT/US2012/032443 WO2012138942A1 (en) | 2011-04-05 | 2012-04-05 | Methods for the improvement of product yield and production in a microorganism through the addition of alternate electron acceptors |
Publications (2)
Publication Number | Publication Date |
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BR112013025753A2 BR112013025753A2 (pt) | 2018-04-10 |
BR112013025753A8 true BR112013025753A8 (pt) | 2018-06-12 |
Family
ID=45952666
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122019017739-2A BR122019017739B1 (pt) | 2011-04-05 | 2012-04-05 | Micro-organismo recombinante compreendendo uma deleção de enzimas nativas que atuam para produzir glicerol e/ou regular a síntese de glicerol e vias metabólicas sintéticas para converter uma fonte de carboidrato a etanol |
BR112013025753A BR112013025753A8 (pt) | 2011-04-05 | 2012-04-05 | Métodos para aprimoramento do rendimento de produto e produção em um micro-organismo através da adição de aceptores de elétrons alternativos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122019017739-2A BR122019017739B1 (pt) | 2011-04-05 | 2012-04-05 | Micro-organismo recombinante compreendendo uma deleção de enzimas nativas que atuam para produzir glicerol e/ou regular a síntese de glicerol e vias metabólicas sintéticas para converter uma fonte de carboidrato a etanol |
Country Status (8)
Country | Link |
---|---|
US (4) | US8956851B2 (pt) |
EP (2) | EP3483279A1 (pt) |
CN (2) | CN103649321B (pt) |
BR (2) | BR122019017739B1 (pt) |
CA (2) | CA3227563A1 (pt) |
DK (1) | DK2694662T3 (pt) |
WO (1) | WO2012138942A1 (pt) |
ZA (1) | ZA201307441B (pt) |
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2012
- 2012-04-05 BR BR122019017739-2A patent/BR122019017739B1/pt active IP Right Grant
- 2012-04-05 WO PCT/US2012/032443 patent/WO2012138942A1/en active Application Filing
- 2012-04-05 CN CN201280025218.1A patent/CN103649321B/zh active Active
- 2012-04-05 CN CN201910530568.7A patent/CN110423705A/zh active Pending
- 2012-04-05 EP EP18197527.7A patent/EP3483279A1/en not_active Withdrawn
- 2012-04-05 CA CA3227563A patent/CA3227563A1/en active Pending
- 2012-04-05 CA CA2832279A patent/CA2832279C/en active Active
- 2012-04-05 DK DK12713845.1T patent/DK2694662T3/da active
- 2012-04-05 EP EP12713845.1A patent/EP2694662B1/en active Active
- 2012-04-05 BR BR112013025753A patent/BR112013025753A8/pt not_active Application Discontinuation
- 2012-04-05 US US14/110,075 patent/US8956851B2/en active Active
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- 2013-10-04 ZA ZA2013/07441A patent/ZA201307441B/en unknown
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EP2694662A1 (en) | 2014-02-12 |
US20150232863A1 (en) | 2015-08-20 |
US8956851B2 (en) | 2015-02-17 |
US20140186930A1 (en) | 2014-07-03 |
ZA201307441B (en) | 2016-05-25 |
WO2012138942A1 (en) | 2012-10-11 |
EP3483279A1 (en) | 2019-05-15 |
CN110423705A (zh) | 2019-11-08 |
EP2694662B1 (en) | 2020-01-08 |
CA2832279A1 (en) | 2012-10-11 |
BR112013025753A2 (pt) | 2018-04-10 |
US20220098600A1 (en) | 2022-03-31 |
CN103649321A (zh) | 2014-03-19 |
BR122019017739B1 (pt) | 2021-06-22 |
US11034967B2 (en) | 2021-06-15 |
US9719098B2 (en) | 2017-08-01 |
CN103649321B (zh) | 2019-07-16 |
US20170356000A1 (en) | 2017-12-14 |
CA2832279C (en) | 2024-03-05 |
DK2694662T3 (da) | 2020-03-02 |
CA3227563A1 (en) | 2012-10-11 |
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