BR112014026206A2 - sistemas e métodos celulares para melhorar a síntese de ácidos graxos através da expressão da desidrogenase - Google Patents
sistemas e métodos celulares para melhorar a síntese de ácidos graxos através da expressão da desidrogenaseInfo
- Publication number
- BR112014026206A2 BR112014026206A2 BR112014026206A BR112014026206A BR112014026206A2 BR 112014026206 A2 BR112014026206 A2 BR 112014026206A2 BR 112014026206 A BR112014026206 A BR 112014026206A BR 112014026206 A BR112014026206 A BR 112014026206A BR 112014026206 A2 BR112014026206 A2 BR 112014026206A2
- Authority
- BR
- Brazil
- Prior art keywords
- dehydrogenase
- methods
- fatty acid
- expression
- native
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01044—Phosphogluconate dehydrogenase (decarboxylating) (1.1.1.44)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/99—Oxidoreductases acting on the CH-OH group of donors (1.1) with other acceptors (1.1.99)
- C12Y101/99006—D-2-Hydroxy-acid dehydrogenase (1.1.99.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
Abstract
resumo patente de invenção: "sistemas e métodos celulares para melhorar a síntese de ácidos graxos através da expressão da desidrogenase". a presente invenção refere-se a métodos para a produção de lipídeos, tais como produtos de ácidos graxos em células hospedeiras recombinantes, modificadas para expressar um gene não nativo que codifica uma desidrogenase. os microrganismos recombinantes são capazes de se proliferar a uma taxa mais elevada em comparação com microrganismos que não expressam um gene não nativo da desidrogenase, e culturas de microrganismos que são modificados para a produção de lipídeos e que expressam uma desidrogenase não nativa, produz mais lipídeo do que as culturas de microrganismos de controle que não incluem um gene não nativo da desidrogenase. 22811359v1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/453,235 US9181568B2 (en) | 2012-04-23 | 2012-04-23 | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
PCT/US2012/067901 WO2013162648A1 (en) | 2012-04-23 | 2012-12-05 | Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014026206A2 true BR112014026206A2 (pt) | 2017-07-18 |
Family
ID=49380459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014026206A BR112014026206A2 (pt) | 2012-04-23 | 2012-12-05 | sistemas e métodos celulares para melhorar a síntese de ácidos graxos através da expressão da desidrogenase |
Country Status (13)
Country | Link |
---|---|
US (1) | US9181568B2 (pt) |
EP (1) | EP2841585B1 (pt) |
JP (2) | JP6209590B2 (pt) |
CN (1) | CN104126013B (pt) |
AU (1) | AU2012378148B2 (pt) |
BR (1) | BR112014026206A2 (pt) |
CA (1) | CA2871373C (pt) |
IL (1) | IL234810A (pt) |
MX (1) | MX337128B (pt) |
MY (1) | MY172288A (pt) |
SG (1) | SG11201406546UA (pt) |
WO (1) | WO2013162648A1 (pt) |
ZA (1) | ZA201407306B (pt) |
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SG11201402672VA (en) * | 2011-11-28 | 2014-06-27 | Solazyme Inc | Genetically engineered microbial strains including prototheca lipid pathway genes |
CN104968788A (zh) | 2012-12-07 | 2015-10-07 | 索拉兹米公司 | 包括原始小球藻脂质途径基因的基因工程化微生物菌株 |
US9896691B2 (en) * | 2013-05-03 | 2018-02-20 | Board Of Regents, The University Of Texas System | Compositions and methods for lipid production |
EP3194424A1 (en) * | 2014-09-15 | 2017-07-26 | Matrix Genetics, LLC | Cyanobacteria having improved photosynthetic activity |
US20160097029A1 (en) * | 2014-10-06 | 2016-04-07 | Morgan State University | Engineered cyanobacteria with enhanced salt tolerance |
WO2017079308A2 (en) * | 2015-11-02 | 2017-05-11 | Synthetic Genomics, Inc. | Algal mutants with increased lipid productivity |
JP6734112B2 (ja) * | 2016-05-10 | 2020-08-05 | 花王株式会社 | 脂質の製造方法 |
CN107460217B (zh) * | 2016-06-05 | 2019-12-13 | 中国石油化工股份有限公司 | 一种混合培养制备微藻油脂的方法 |
JP2018047147A (ja) * | 2016-09-23 | 2018-03-29 | 株式会社三共 | スロットマシン |
JP2018047145A (ja) * | 2016-09-23 | 2018-03-29 | 株式会社三共 | スロットマシン |
JP2018047146A (ja) * | 2016-09-23 | 2018-03-29 | 株式会社三共 | スロットマシン |
JP2018047144A (ja) * | 2016-09-23 | 2018-03-29 | 株式会社三共 | スロットマシン |
JP2018061577A (ja) * | 2016-10-11 | 2018-04-19 | 株式会社三共 | スロットマシン |
WO2019236819A1 (en) * | 2018-06-07 | 2019-12-12 | Cargill, Incorporated | Methods and genetically modified cells for producing c8 fatty acids and fatty acid chain products |
MX2021004477A (es) * | 2018-10-17 | 2021-06-04 | Perfect Day Inc | Componentes recombinantes y composiciones para usarse en productos alimenticios. |
CN113066533B (zh) * | 2021-04-02 | 2023-04-04 | 欧蒙医学诊断(中国)有限公司 | 一种mNGS病原体数据分析方法 |
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-
2012
- 2012-04-23 US US13/453,235 patent/US9181568B2/en active Active
- 2012-12-05 CN CN201280070199.4A patent/CN104126013B/zh not_active Expired - Fee Related
- 2012-12-05 JP JP2015508935A patent/JP6209590B2/ja not_active Expired - Fee Related
- 2012-12-05 BR BR112014026206A patent/BR112014026206A2/pt not_active Application Discontinuation
- 2012-12-05 EP EP12875170.8A patent/EP2841585B1/en active Active
- 2012-12-05 MY MYPI2014002993A patent/MY172288A/en unknown
- 2012-12-05 WO PCT/US2012/067901 patent/WO2013162648A1/en active Application Filing
- 2012-12-05 SG SG11201406546UA patent/SG11201406546UA/en unknown
- 2012-12-05 CA CA2871373A patent/CA2871373C/en not_active Expired - Fee Related
- 2012-12-05 MX MX2014012810A patent/MX337128B/es active IP Right Grant
- 2012-12-05 AU AU2012378148A patent/AU2012378148B2/en active Active
-
2014
- 2014-09-23 IL IL234810A patent/IL234810A/en active IP Right Grant
- 2014-10-08 ZA ZA2014/07306A patent/ZA201407306B/en unknown
-
2017
- 2017-02-10 JP JP2017022740A patent/JP2017123852A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US9181568B2 (en) | 2015-11-10 |
ZA201407306B (en) | 2015-11-25 |
IL234810A (en) | 2016-09-29 |
EP2841585B1 (en) | 2020-03-25 |
JP2015517811A (ja) | 2015-06-25 |
MY172288A (en) | 2019-11-20 |
CA2871373A1 (en) | 2013-10-31 |
EP2841585A4 (en) | 2016-09-28 |
JP6209590B2 (ja) | 2017-10-04 |
CN104126013B (zh) | 2019-05-14 |
CA2871373C (en) | 2016-07-19 |
MX337128B (es) | 2016-02-12 |
WO2013162648A1 (en) | 2013-10-31 |
EP2841585A1 (en) | 2015-03-04 |
AU2012378148A1 (en) | 2014-11-13 |
JP2017123852A (ja) | 2017-07-20 |
US20130280793A1 (en) | 2013-10-24 |
MX2014012810A (es) | 2015-01-22 |
AU2012378148B2 (en) | 2016-11-24 |
SG11201406546UA (en) | 2014-11-27 |
CN104126013A (zh) | 2014-10-29 |
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