BR0011407A - Molécula de ácido nucléico isolada, polipeptìdeo de fusão, composição, vetor, sistema de vetor, sistema de vetor hospedeiro, métodos de produzir um polipeptìdeo de fusão. - Google Patents

Molécula de ácido nucléico isolada, polipeptìdeo de fusão, composição, vetor, sistema de vetor, sistema de vetor hospedeiro, métodos de produzir um polipeptìdeo de fusão.

Info

Publication number
BR0011407A
BR0011407A BR0011407-3A BR0011407A BR0011407A BR 0011407 A BR0011407 A BR 0011407A BR 0011407 A BR0011407 A BR 0011407A BR 0011407 A BR0011407 A BR 0011407A
Authority
BR
Brazil
Prior art keywords
fusion polypeptide
vector
vector system
modified
nucleic acid
Prior art date
Application number
BR0011407-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Nicholas J Papadopoulos
Samuel Davis
George D Yancopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22480568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0011407(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR0011407A publication Critical patent/BR0011407A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
BR0011407-3A 1999-06-08 2000-05-23 Molécula de ácido nucléico isolada, polipeptìdeo de fusão, composição, vetor, sistema de vetor, sistema de vetor hospedeiro, métodos de produzir um polipeptìdeo de fusão. BR0011407A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13813399P 1999-06-08 1999-06-08
PCT/US2000/014142 WO2000075319A1 (en) 1999-06-08 2000-05-23 Modified chimeric polypeptides with improved pharmacokinetic properties

Publications (1)

Publication Number Publication Date
BR0011407A true BR0011407A (pt) 2002-04-02

Family

ID=22480568

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0011407-3A BR0011407A (pt) 1999-06-08 2000-05-23 Molécula de ácido nucléico isolada, polipeptìdeo de fusão, composição, vetor, sistema de vetor, sistema de vetor hospedeiro, métodos de produzir um polipeptìdeo de fusão.
BRPI0011407A BRPI0011407B8 (pt) 1999-06-08 2000-05-23 molécula de ácido nucléico quimérica, polipeptídeo de fusão, vetor de expressão, sistema de vetor hospedeiro, e, métodos de produzir um polipeptídeo de fusão

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0011407A BRPI0011407B8 (pt) 1999-06-08 2000-05-23 molécula de ácido nucléico quimérica, polipeptídeo de fusão, vetor de expressão, sistema de vetor hospedeiro, e, métodos de produzir um polipeptídeo de fusão

Country Status (32)

Country Link
EP (2) EP1544299B1 (enExample)
JP (2) JP4723140B2 (enExample)
KR (1) KR100659477B1 (enExample)
CN (3) CN103349781B (enExample)
AT (2) ATE293164T1 (enExample)
AU (2) AU779303B2 (enExample)
BE (1) BE2013C029I2 (enExample)
BR (2) BR0011407A (enExample)
CA (1) CA2376379C (enExample)
CY (2) CY1108883T1 (enExample)
CZ (2) CZ303656B6 (enExample)
DE (2) DE60019415T2 (enExample)
DK (2) DK1183353T3 (enExample)
ES (2) ES2319305T3 (enExample)
FR (1) FR13C0028I2 (enExample)
HR (1) HRP20010908B1 (enExample)
HU (3) HU229156B1 (enExample)
IL (3) IL146890A0 (enExample)
LT (1) LTC1183353I2 (enExample)
LU (1) LU92195I2 (enExample)
ME (2) ME00024B (enExample)
MX (1) MXPA01012630A (enExample)
NO (4) NO330775B1 (enExample)
NZ (1) NZ515913A (enExample)
PL (1) PL208247B1 (enExample)
PT (2) PT1544299E (enExample)
RS (1) RS50073B (enExample)
RU (1) RU2265661C2 (enExample)
SK (1) SK287332B6 (enExample)
UA (1) UA74146C2 (enExample)
WO (1) WO2000075319A1 (enExample)
ZA (1) ZA200110068B (enExample)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710174B2 (en) 2001-09-13 2004-03-23 Isis Pharmaceuticals, Inc. Antisense inhibition of vascular endothelial growth factor receptor-1 expression
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US7087411B2 (en) * 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US6833349B2 (en) * 1999-06-08 2004-12-21 Regeneron Pharmaceuticals, Inc. Methods of treating inflammatory skin diseases
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
JP4669984B2 (ja) 2001-01-19 2011-04-13 ベジェニクス リミテッド 腫瘍画像化のターゲットとしてのF1t4(VEGFR−3)および抗腫瘍療法
US6734017B2 (en) 2001-09-28 2004-05-11 Isis Pharmaceuticals, Inc. Antisense modulation of vascular endothelial growth factor receptor-2 expression
ES2362648T3 (es) 2002-05-04 2011-07-08 Acorda Therapeutics, Inc. Composiciones y métodos para promover la proyección neuronal.
DK1608685T3 (da) 2003-03-28 2007-06-11 Regeneron Pharma VEGF antagonister til behandlingen af diabetes
EP3211084B1 (en) 2003-05-16 2019-03-27 Acorda Therapeutics, Inc. Proteoglycan degrading mutants for treatment of cns
JP5399612B2 (ja) * 2003-05-16 2014-01-29 アコーダ セラピューティクス、インク. Cnsを治療するための融合タンパク質
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
WO2004106378A2 (en) * 2003-05-28 2004-12-09 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection by using vegf antagonists
US7186699B2 (en) 2003-06-03 2007-03-06 Cell Genesys, Inc. Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
WO2004110490A2 (en) * 2003-06-06 2004-12-23 Regeneron Pharmaceuticals, Inc. Use of vegf inhibitors for tumor regression
US7399612B2 (en) 2003-06-30 2008-07-15 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
AR046510A1 (es) * 2003-07-25 2005-12-14 Regeneron Pharma Composicion de un antagonista de vegf y un agente anti-proliferativo
US20050112061A1 (en) * 2003-08-06 2005-05-26 Jocelyn Holash Use of a VEGF antagonist in combination with radiation therapy
AU2005244933B2 (en) 2004-05-18 2011-08-04 Acorda Therapeutics, Inc. Methods of purifying chondroitinase and stable formulations thereof
DK1767546T3 (da) 2004-06-08 2012-04-23 Chengdu Kanghong Biotechnologies Co Ltd Angiogenese-inhiberende kimært protein og dets anvendelse
MXPA06014421A (es) 2004-06-10 2007-05-04 Regeneron Pharma Uso de inhibidores de vegf para el tratamiento de cancer humano.
CN1968709A (zh) * 2004-06-18 2007-05-23 瑞泽恩制药公司 用于治疗恶性胸腔积液的vegf抑制剂
CN1997386B (zh) 2004-07-30 2012-05-30 瑞泽恩制药公司 通过阻断vegf介导的活性来治疗i型糖尿病的方法
EP1804835B9 (en) * 2004-09-13 2010-09-29 Genzyme Corporation Multimeric constructs
FR2878749B1 (fr) * 2004-12-03 2007-12-21 Aventis Pharma Sa Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives
CA2621047A1 (en) 2005-02-02 2006-08-24 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a vegf inhibitor
US20060217311A1 (en) 2005-03-25 2006-09-28 Daniel Dix VEGF antagonist formulations
JP5189985B2 (ja) 2005-09-26 2013-04-24 アコーダ セラピューティクス、インク. コンドロイチナーゼabci変異体を用いた組成物およびその使用方法
CA2630839C (en) 2005-12-16 2017-01-17 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with dll4 antagonists
FR2895258B1 (fr) 2005-12-22 2008-03-21 Aventis Pharma Sa Combinaison comprenant de la combretastatine et des agents anticancereux
US8216575B2 (en) 2006-03-31 2012-07-10 Chengdu Kanghong Biotechnologies Co., Ltd. Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
CN100502945C (zh) * 2006-03-31 2009-06-24 成都康弘生物科技有限公司 Vegf受体融合蛋白在治疗眼睛疾病中的应用
PT2944306T (pt) 2006-06-16 2021-02-15 Regeneron Pharma Formulações antagonistas de vegf adequadas para administração intravitreal
HUE028379T2 (en) 2006-09-29 2016-12-28 Oncomed Pharm Inc Preparations and procedures for the diagnosis and treatment of cancer
CA3086902C (en) 2006-10-10 2021-11-09 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
FR2918279B1 (fr) * 2007-07-05 2010-10-22 Aventis Pharma Sa Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan
CN101575379B (zh) * 2008-05-09 2012-05-30 上海抗体药物国家工程研究中心有限公司 可溶性vegfr双功能融合受体、其制备方法及用途
ES2836948T3 (es) 2008-11-03 2021-06-28 Molecular Partners Ag Proteínas de unión que inhiben la interacción del receptor de VEGF-A
CN101838329A (zh) * 2009-03-18 2010-09-22 嘉和生物药业有限公司 抗血管新生融合蛋白
TR201818814T4 (tr) 2009-10-16 2019-01-21 Oncomed Pharm Inc Dll4 antagonist antikorlarının ve anti-hipertansif ajanların terapötik kombinasyonu ve kullanımı.
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制vegf-a受體交互作用的經修飾結合性蛋白質
ES2652508T3 (es) 2010-08-06 2018-02-02 Genzyme Corporation Composiciones de antagonistas de VEGF y sus usos
US20140080153A1 (en) * 2011-01-07 2014-03-20 Chugai Seiyaku Kabushiki Kaisha Method for improving physical properties of antibody
EP3763379A1 (en) 2011-01-13 2021-01-13 Regeneron Pharmaceuticals, Inc. Use of a vegf antagonist to treat angiogenic eye disorders
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
KR101397088B1 (ko) 2011-06-10 2014-05-19 강원대학교산학협력단 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물
JO3370B1 (ar) * 2011-11-10 2019-03-13 Regeneron Pharma طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
JP6138815B2 (ja) * 2011-12-01 2017-05-31 エーピー バイオサイエンシーズ, インコーポレイテッド 補体経路およびvegf経路に対するタンパク質インヒビターおよびそれらの使用方法
CN103304668B (zh) * 2012-03-12 2015-10-28 江苏健德生物药业有限公司 Ultra-VEGF-trap免疫融合蛋白、其制备方法及其应用
PL2846836T3 (pl) 2012-05-07 2020-01-31 Allergan, Inc. Sposób leczenia amd u pacjentów opornych na terapię anty- vegf
WO2014006113A1 (en) 2012-07-03 2014-01-09 Sanofi Method of treating cancer by effective amounts of aflibercept
TW201438736A (zh) 2012-11-14 2014-10-16 Regeneron Pharma 以dll4拮抗劑治療卵巢癌之方法
HUE048687T2 (hu) 2013-02-18 2020-08-28 Vegenics Pty Ltd Ligandum kötõ molekulák és alkalmazásaik
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
CN104193828B (zh) * 2013-09-12 2017-04-05 北京韩美药品有限公司 同时阻断her2和vegfr信号通路的重组融合蛋白
CN105960247A (zh) 2013-11-05 2016-09-21 阿勒根公司 用抗vegf darpin治疗眼病的方法
CA2947456C (en) 2014-05-12 2023-03-14 Formycon Ag Pre-filled plastic syringe containing a vegf antagonist
MX375557B (es) 2014-07-18 2025-03-06 Sanofi Sa Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer.
JP2016036322A (ja) * 2014-08-11 2016-03-22 日本化薬株式会社 血管新生因子と結合するキメラタンパク質
CA2970315C (en) 2014-12-11 2023-08-22 Bayer Healthcare Llc Use of anti-vegf agents to treat lesions in macular degeneration patients
GB201503453D0 (en) 2015-03-01 2015-04-15 Jain Arjun Endothelin-1"sponge"
TWI870789B (zh) 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
WO2017046140A1 (en) 2015-09-18 2017-03-23 Bayer Pharma Aktiengesellschaft Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
WO2017065559A1 (ko) 2015-10-15 2017-04-20 (주)알테오젠 Igg fc 도메인을 가지는 융합 단백질의 생산방법
KR101936049B1 (ko) * 2015-10-15 2019-01-08 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 생산방법
KR102854749B1 (ko) 2015-11-18 2025-09-04 에스아이오2 메디컬 프로덕츠, 엘엘씨 안과 제제용 제약 패키지
MX2018006171A (es) 2015-11-18 2018-12-19 Formycon Ag Jeringa de plastico precargada que contiene un antagonista de vegf.
EP4556023A3 (en) 2015-11-18 2025-10-15 Formycon AG Pre-filled pharmaceutical package comprising a liquid formulation of a vegf-antagonist
WO2017084616A1 (en) * 2015-11-19 2017-05-26 Zhuhai Tairuishang Biopharm Ltd. Methods and compositions for binding vegf
KR102261636B1 (ko) 2015-12-03 2021-06-07 리제너론 파마슈티칼스 인코포레이티드 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
US10576128B2 (en) 2016-01-26 2020-03-03 Formycon Ag Liquid formulation of a VEGF antagonist
JPWO2018070390A1 (ja) 2016-10-12 2019-08-22 第一三共株式会社 抗robo4抗体と他剤を含む組成物
US11135266B2 (en) 2016-11-21 2021-10-05 Just-Evotec Biologics, Inc. Aflibercept formulations and uses thereof
WO2018215580A1 (en) 2017-05-24 2018-11-29 Formycon Ag Method for sterilizing prefilled plastic syringes containing a vegf antagonist
US20200237997A1 (en) 2017-05-24 2020-07-30 Formycon Ag Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
CA3063995A1 (en) 2017-05-24 2018-11-29 Sio2 Medical Products, Inc. Sterilizable pharmaceutical package for ophthalmic formulations
TW201904610A (zh) 2017-06-14 2019-02-01 德商拜耳製藥公司 用於治療新生血管型青光眼之非抗體vegf拮抗劑
WO2019020777A1 (en) 2017-07-26 2019-01-31 Formycon Ag LIQUID FORMULATION OF A VEGF ANTAGONIST
CN111344410B (zh) 2017-08-17 2023-09-15 济世易为生物有限公司 从宿主细胞半乳糖凝集素和其他污染物中纯化糖基化蛋白的方法
MY202872A (en) 2017-11-20 2024-05-28 Just Evotec Biologics Inc Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof
CR20200282A (es) 2017-11-27 2021-02-18 4D Molecular Therapeutics Inc Cápsides variantes de virus adenoasociados y su uso para inhibir la angiogénesis
CN111465407A (zh) 2017-11-30 2020-07-28 瑞泽恩制药公司 使用vegf拮抗剂治疗生血管性眼病
AU2018385394B2 (en) * 2017-12-13 2024-05-02 Regeneron Pharmaceuticals, Inc. Devices and systems for chromatography column bed support management and related methods
BR112020015074A2 (pt) * 2018-01-26 2020-12-08 The Regents Of The University Of California Métodos e composições para tratamento de transtornos angiogênicos com uso de agentes anti-vegf
BR112020017872A2 (pt) 2018-03-02 2020-12-22 Kodiak Sciences Inc. Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos
JOP20200275A1 (ar) 2018-05-10 2020-11-02 Regeneron Pharma صيغ تحتوي على بروتين اندماج لمستقبلvegf مرتفعة التركيز
TW202016125A (zh) * 2018-05-10 2020-05-01 美商再生元醫藥公司 用於定量及調節蛋白質黏度之系統與方法
US11519020B2 (en) 2018-05-25 2022-12-06 Regeneron Pharmaceuticals, Inc. Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
CN111378044B (zh) 2018-12-28 2022-07-15 长春金赛药业有限责任公司 抗体融合蛋白、制备方法及其应用
WO2020229584A1 (en) 2019-05-16 2020-11-19 Formycon Ag Method for reducing methionine oxidation in recombinant proteins
JP2022546082A (ja) 2019-09-03 2022-11-02 アムジエン・インコーポレーテツド 薬物送達のための注入デバイス及び注入デバイスのためのパッケージ
AU2020348947B2 (en) 2019-09-16 2025-11-27 Amgen Inc. Method for external sterilization of drug delivery device
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
CA3168512A1 (en) 2019-11-25 2021-06-03 Napoleone Ferrara Long-acting vegf inhibitors for intraocular neovascularization
MY193353A (en) * 2019-12-06 2022-10-06 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
MX2022006751A (es) 2019-12-06 2022-08-19 Regeneron Pharma Minitrampas de vegf y metodos de uso de las mismas.
MX2022010177A (es) 2020-02-24 2022-09-12 Amgen Inc Envases y sistemas para su uso durante la esterilizacion externa de dispositivos de administracion de farmacos.
CN115803009A (zh) 2020-05-08 2023-03-14 瑞泽恩制药公司 用于治疗眼病和癌症的vegf阱和微阱及方法
WO2022231930A1 (en) 2021-04-26 2022-11-03 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
EP4145456A1 (en) 2021-09-06 2023-03-08 Bayer AG Prediction of a change related to a macular fluid
WO2023092324A1 (zh) 2021-11-24 2023-06-01 苏州光度生物科技有限公司 多特异性配体结合分子及其应用
KR102764987B1 (ko) 2022-08-02 2025-02-12 주식회사 파노로스바이오사이언스 변형된 융합 단백질 및 이의 용도
KR20250065646A (ko) 2022-09-16 2025-05-13 치루 파머수티컬 컴퍼니 리미티드 안정적인 고농도 자가완충식 약물 조성물
WO2025033876A1 (ko) * 2023-08-04 2025-02-13 주식회사 파노로스바이오사이언스 변형된 융합 단백질과 scFv의 결합체 및 이의 용도
WO2025213011A1 (en) 2024-04-05 2025-10-09 Amgen Inc. Method of assessing stopper movement in a drug delivery device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506466D0 (en) * 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US6100071A (en) * 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production

Also Published As

Publication number Publication date
CN103349781A (zh) 2013-10-16
CZ302689B6 (cs) 2011-09-07
JP5273746B2 (ja) 2013-08-28
HK1043388A1 (en) 2002-09-13
HK1185798A1 (en) 2014-02-28
MXPA01012630A (es) 2002-07-22
HU230159B1 (hu) 2015-09-28
ATE417928T1 (de) 2009-01-15
CY1108883T1 (el) 2014-07-02
NO332559B1 (no) 2012-10-29
AU2005201365A1 (en) 2005-04-28
EP1183353B1 (en) 2005-04-13
NO20100656L (no) 2002-02-08
DE60019415T2 (de) 2006-03-09
PT1183353E (pt) 2005-06-30
CZ303656B6 (cs) 2013-01-30
DE60041159D1 (de) 2009-01-29
JP2003501089A (ja) 2003-01-14
SK17522001A3 (sk) 2003-04-01
BRPI0011407B8 (pt) 2021-05-25
ATE293164T1 (de) 2005-04-15
HK1132653A1 (en) 2010-03-05
CN101433715A (zh) 2009-05-20
CY2013019I1 (el) 2015-11-04
IL146890A0 (en) 2002-08-14
CA2376379A1 (en) 2000-12-14
PL208247B1 (pl) 2011-04-29
CN1369009A (zh) 2002-09-11
LTPA2013009I1 (lt) 2013-06-25
CY2013019I2 (el) 2015-11-04
HU229156B1 (en) 2013-09-30
NO2022060I1 (no) 2022-12-21
HRP20010908B1 (en) 2006-05-31
PT1544299E (pt) 2009-03-18
CN103349781B (zh) 2015-04-01
EP1183353A1 (en) 2002-03-06
DE60019415D1 (de) 2005-05-19
IL190234A0 (en) 2008-11-03
CZ20014387A3 (cs) 2002-10-16
NO2013010I2 (no) 2013-05-15
JP2011024595A (ja) 2011-02-10
IL146890A (en) 2008-07-08
CN100523187C (zh) 2009-08-05
PL352246A1 (en) 2003-08-11
SK287332B6 (sk) 2010-07-07
KR20020019070A (ko) 2002-03-09
ZA200110068B (en) 2002-12-06
ME00024B (me) 2010-02-10
YU86901A (sh) 2004-05-12
WO2000075319A1 (en) 2000-12-14
BRPI0011407B1 (pt) 2018-09-25
FR13C0028I2 (fr) 2014-05-16
NO330775B1 (no) 2011-07-11
HUS1300052I1 (hu) 2016-08-29
ES2237429T3 (es) 2005-08-01
UA74146C2 (uk) 2005-11-15
HRP20010908A2 (en) 2005-04-30
FR13C0028I1 (fr) 2013-06-14
EP1544299B1 (en) 2008-12-17
LU92195I2 (fr) 2013-07-15
BE2013C029I2 (enExample) 2019-03-06
EP1544299A1 (en) 2005-06-22
NZ515913A (en) 2004-01-30
AU779303B2 (en) 2005-01-13
CA2376379C (en) 2007-08-07
NO2013010I1 (no) 2013-06-17
JP4723140B2 (ja) 2011-07-13
RS50073B (sr) 2009-01-22
CN101433715B (zh) 2013-04-17
AU2005201365B2 (en) 2007-08-09
DK1544299T3 (da) 2009-03-23
MEP3208A (xx) 2010-02-10
NO20016036D0 (no) 2001-12-10
HUP0201515A3 (en) 2004-12-28
NO20016036L (no) 2002-02-08
KR100659477B1 (ko) 2006-12-20
RU2265661C2 (ru) 2005-12-10
HUP0201515A2 (en) 2002-08-28
LTC1183353I2 (lt) 2023-02-27
AU5040400A (en) 2000-12-28
DK1183353T3 (da) 2005-08-08
ES2319305T3 (es) 2009-05-06

Similar Documents

Publication Publication Date Title
BR0011407A (pt) Molécula de ácido nucléico isolada, polipeptìdeo de fusão, composição, vetor, sistema de vetor, sistema de vetor hospedeiro, métodos de produzir um polipeptìdeo de fusão.
ATE352626T1 (de) Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
BR0007414A (pt) Expressão e exportação de proteìnas antiobesidade como proteìnas de fusão fc
DE69533923D1 (de) Cytokinin-designiertes lerk-5
BR0113921A (pt) ácidos nucléicos e polipeptìdeos receptores
AU9174398A (en) Peptides
BR9612359A (pt) Derivado covalente de uma proteína ob composição polipeptídeo quimérico sequência de ácido nucleico vetor de express o replicável célula hospedeira e métodos associados aos mesmos
BR0009393A (pt) Polipeptìdeo, sequência de ácido nucleico isolada, construção de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, método para a produção do polipeptìdeo, uso de um polipeptìdeo, e, composição detergente
BR0214350A (pt) Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso
DE69836092D1 (de) Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen
DE69634640D1 (de) Mutierte alpha-amylase enzyme mit erhöhter stabilität
ATE368682T1 (de) Als 2f1 bezeichnetes rezeptorprotein
AU6542598A (en) Site protected protein modification
WO2002062999A3 (en) Proteins and nucleic acids encoding same
DE69511399D1 (de) Isolierte, von mage-3 abgeleitete peptide, welche mit hla-a2 molekülen komplexieren
WO2002059315A3 (en) Human nucleic acids and polypeptides and methods of use thereof
WO2001025438A3 (en) Ifn-alpha homologues
WO2002046409A3 (en) Proteins and nucleic acids encoding same
FI962268L (fi) Homologinen, rekombinanttinen vasta-aineilmentämisjärjestelmä rottien tai hiirien soluille
EP0522070A4 (en) Molecular cloning of the genes responsible for collagenase production from -i(clostridium histolyticum)
DE69834565D1 (de) Schnell erzeugung von stabilen säugertier-zellinien mit gewinnung eines hohen gehalts von recombinanten proteine
WO1994028132A3 (en) Opioid receptors: compositions and methods
WO2003021265A8 (en) Genetic construct intracellular monitoring system
DK1144666T3 (da) Replikationsdeficient baculovirusekspressionssystem
DE60139113D1 (de) 18477, eine menschliche proteinkinase und deren verwendung

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 37, 24, 25 DA LPI 9279/06

B12B Appeal against refusal [chapter 12.2 patent gazette]
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: REAPRESENTAR A PETICAO NO 020120017630 DE 01/03/2012.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 25/09/2018, OBSERVADAS AS CONDICOES LEGAIS.

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI NO 52402.004205/2021-78 ORIGEM: 31O VF DO RIO DE JANEIRO PROCESSO NO: 5031304-25.2021.4.02.5101 NULIDADE DE ATO ADMINISTRATIVO AUTOR: LIBBS FARMACEUTICA LTDA. REU(S): REGENERON PHARMACEUTICALS, INC. E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/05/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 23/05/2020