BG63047B1 - Азациклохексапептиди - Google Patents

Азациклохексапептиди Download PDF

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Publication number
BG63047B1
BG63047B1 BG99999A BG9999995A BG63047B1 BG 63047 B1 BG63047 B1 BG 63047B1 BG 99999 A BG99999 A BG 99999A BG 9999995 A BG9999995 A BG 9999995A BG 63047 B1 BG63047 B1 BG 63047B1
Authority
BG
Bulgaria
Prior art keywords
haa
compound
last
description
sequence
Prior art date
Application number
BG99999A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG99999A (bg
Inventor
James Balkovec
Frances Bouffard
Regina Black
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63047(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of BG99999A publication Critical patent/BG99999A/bg
Publication of BG63047B1 publication Critical patent/BG63047B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Chemical Vapour Deposition (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG99999A 1993-03-16 1995-09-13 Азациклохексапептиди BG63047B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds
PCT/US1994/002580 WO1994021677A1 (en) 1993-03-16 1994-03-10 Aza cyclohexapeptide compounds

Publications (2)

Publication Number Publication Date
BG99999A BG99999A (bg) 1996-04-30
BG63047B1 true BG63047B1 (bg) 2001-02-28

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99999A BG63047B1 (bg) 1993-03-16 1995-09-13 Азациклохексапептиди

Country Status (33)

Country Link
US (3) US5378804A (ru)
EP (1) EP0620232B1 (ru)
JP (1) JP2568474B2 (ru)
KR (1) KR100329693B1 (ru)
CN (1) CN1098274C (ru)
AT (1) ATE186736T1 (ru)
AU (1) AU668804B2 (ru)
BG (1) BG63047B1 (ru)
BR (2) BR9406009A (ru)
CA (1) CA2118757C (ru)
CZ (1) CZ286235B6 (ru)
DE (2) DE69421639T2 (ru)
DK (1) DK0620232T3 (ru)
ES (1) ES2139043T3 (ru)
FI (1) FI109542B (ru)
GR (1) GR3031872T3 (ru)
HK (1) HK1008674A1 (ru)
HR (1) HRP940161B1 (ru)
HU (2) HU217614B (ru)
IL (1) IL108892A (ru)
LU (1) LU90875I2 (ru)
LV (1) LV12574B (ru)
NL (1) NL300076I2 (ru)
NO (2) NO318372B1 (ru)
NZ (1) NZ263360A (ru)
PL (1) PL179261B1 (ru)
RO (1) RO113246B1 (ru)
RU (1) RU2122548C1 (ru)
SI (1) SI9420013B (ru)
SK (1) SK282527B6 (ru)
UA (1) UA59329C2 (ru)
WO (1) WO1994021677A1 (ru)
ZA (1) ZA941807B (ru)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
JP3118466B2 (ja) * 1994-08-23 2000-12-18 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルリポペプチドの側鎖誘導体の改良製造方法
JP3657989B2 (ja) * 1994-09-16 2005-06-08 メルク エンド カンパニー インコーポレーテッド アザシクロヘキサペプチド化合物
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
ATE206054T1 (de) * 1995-01-26 2001-10-15 Merck & Co Inc Neue fungizide cyclohexapeptide
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
WO1997017365A1 (en) * 1995-11-09 1997-05-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
PE63998A1 (es) * 1996-04-19 1998-10-30 Merck & Co Inc Composiciones anti-fungosas
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
CZ88499A3 (cs) * 1996-09-12 1999-10-13 Merck And Co., Inc. Kombinace látek s antifungálním účinkem
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
CA2380176A1 (en) * 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
WO2005018743A1 (en) * 2003-07-22 2005-03-03 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
CN1950396A (zh) * 2004-02-24 2007-04-18 联邦科学技术研究组织 抗真菌肽
EP1785432A1 (en) 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
WO2008012310A1 (en) 2006-07-26 2008-01-31 Sandoz Ag Caspofungin formulations
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
AU2008269140A1 (en) 2007-06-26 2008-12-31 Merck Sharp & Dohme Corp. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
WO2009158034A1 (en) * 2008-06-25 2009-12-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin free of caspofungin impurity a
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
US20120190815A1 (en) * 2009-08-06 2012-07-26 Tianhui Xu Azacyclohexapeptide or its pharmaceutical acceptable salt, preparing method and use thereof
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
AU2011304408B2 (en) 2010-09-20 2015-01-15 Xellia Pharmaceuticals Aps Caspofungin composition
WO2012041218A1 (zh) * 2010-09-29 2012-04-05 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
US8877777B2 (en) * 2010-09-30 2014-11-04 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
EP2661441A4 (en) * 2011-01-03 2015-04-08 Biocon Ltd PROCESS FOR THE PREPARATION OF ACETATE CASPOFUNGIN AND ITS INTERMEDIATES
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
SI2680873T1 (sl) 2011-03-03 2017-12-29 Cidara Therapeutics, Inc. Protiglivna sredstva in njihova uporaba
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
CA2833206A1 (en) 2011-04-28 2012-11-01 Unitris Biopharma Co., Ltd. Intermediate for synthesizing caspofungin and preparation method therefor
HUE063336T2 (hu) 2012-03-19 2024-01-28 Cidara Therapeutics Inc Adagolási rend echinokandin osztályba tartozó vegyületekhez
ES2607646T3 (es) * 2012-11-20 2017-04-03 Fresenius Kabi Usa, Llc Formulaciones de acetato de caspofungina
CN112110991A (zh) * 2014-12-24 2020-12-22 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
US9675659B2 (en) 2015-08-21 2017-06-13 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
EP3399995A4 (en) 2016-01-08 2019-08-21 Cidara Therapeutics, Inc. METHODS FOR PREVENTING AND TREATING PNEUMOCYSTIS INFECTIONS
JP7224916B2 (ja) 2016-03-16 2023-02-20 シダラ セラピューティクス インコーポレーテッド 真菌感染の処置のための投薬レジメン
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BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
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Also Published As

Publication number Publication date
HRP940161B1 (en) 2001-04-30
JP2568474B2 (ja) 1997-01-08
KR100329693B1 (ko) 2002-08-14
FI109542B (fi) 2002-08-30
HK1008674A1 (en) 1999-05-14
CZ235895A3 (en) 1996-02-14
BR1100273A (pt) 1999-10-13
HRP940161A2 (en) 1996-08-31
SI9420013A (en) 1996-08-31
NO318372B1 (no) 2005-03-14
NO953648L (no) 1995-11-15
DK0620232T3 (da) 2000-03-13
DE10299013I2 (de) 2009-11-19
EP0620232B1 (en) 1999-11-17
HUT73496A (en) 1996-08-28
HU9502703D0 (en) 1995-11-28
DE69421639D1 (de) 1999-12-23
NZ263360A (en) 1997-08-22
NL300076I2 (nl) 2002-04-02
SK113695A3 (en) 1996-02-07
RU2122548C1 (ru) 1998-11-27
ATE186736T1 (de) 1999-12-15
NO953648D0 (no) 1995-09-15
IL108892A0 (en) 1994-06-24
US5792746A (en) 1998-08-11
PL310634A1 (en) 1995-12-27
FI954327A (fi) 1995-09-14
NO2005020I1 (no) 2005-09-13
ZA941807B (en) 1994-10-13
HU211890A9 (en) 1995-12-28
BR9406009A (pt) 1995-12-26
AU5783294A (en) 1994-09-22
CA2118757A1 (en) 1994-09-17
NL300076I1 (nl) 2002-03-01
US5514650A (en) 1996-05-07
CA2118757C (en) 2002-05-14
JPH06321986A (ja) 1994-11-22
US5378804A (en) 1995-01-03
CN1119441A (zh) 1996-03-27
BG99999A (bg) 1996-04-30
AU668804B2 (en) 1996-05-16
CN1098274C (zh) 2003-01-08
LV12574B (en) 2001-04-20
WO1994021677A1 (en) 1994-09-29
EP0620232A1 (en) 1994-10-19
KR960701092A (ko) 1996-02-24
RO113246B1 (ro) 1998-05-29
FI954327A0 (fi) 1995-09-14
HU217614B (hu) 2000-03-28
ES2139043T3 (es) 2000-02-01
SI9420013B (sl) 2002-12-31
UA59329C2 (ru) 2003-09-15
LU90875I2 (en) 2002-03-04
IL108892A (en) 1998-07-15
LV12574A (en) 2000-11-20
GR3031872T3 (en) 2000-02-29
CZ286235B6 (cs) 2000-02-16
NO2005020I2 (no) 2008-12-01
SK282527B6 (sk) 2002-10-08
DE69421639T2 (de) 2000-06-08
DE10299013I1 (de) 2003-01-23
PL179261B1 (pl) 2000-08-31

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