BG103454A - Противопаразитни пиразоли - Google Patents

Противопаразитни пиразоли

Info

Publication number
BG103454A
BG103454A BG103454A BG10345499A BG103454A BG 103454 A BG103454 A BG 103454A BG 103454 A BG103454 A BG 103454A BG 10345499 A BG10345499 A BG 10345499A BG 103454 A BG103454 A BG 103454A
Authority
BG
Bulgaria
Prior art keywords
alkyl
hydrogen
halo
cycloalkyl group
bromo
Prior art date
Application number
BG103454A
Other languages
English (en)
Other versions
BG64127B1 (bg
Inventor
Bernard BANKS
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625290.3A external-priority patent/GB9625290D0/en
Priority claimed from GBGB9702235.4A external-priority patent/GB9702235D0/en
Priority claimed from GBGB9712045.5A external-priority patent/GB9712045D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of BG103454A publication Critical patent/BG103454A/bg
Publication of BG64127B1 publication Critical patent/BG64127B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

Съединенията намират приложение в състава на противопаразитни средства. Те имат формула, в която R1е 2,4,6-тризаместен фенил или 3,5-дизаместен пиридин-2-ил; R3 е С1-С4 алкил, евентуално заместен с хидрокси или с един или повече хало, циано, С1-С5 алканоил или фенил; R5 е водород, С1-С4 алкил, амино или хало; R2 и R4 са независими един от друг и поотделно означават водород, С1-С4 алкил, флуоро, хлоро или бромо, или заедно с въглеродния атом, към който са прикачени, образуват С3-С6 циклоалкилова група; R6 и R8 са независими един от друг и поотделно означават водород, С1-С4 алкил, флуоро, хлоро или бромо, или, когато R2 и R4 не образуват частот циклоалкилова група, R2 и R6 заедно с въглеродните атоми, към които са прикачени, могат да образуват С5-С7 циклоалкилова група; и R7 е водород, С1-С4 алкил, евентуално заместен с един или повече хало, или С1-С4 алкокси. Изобретението се отнася и до техни фармацевтично, ветеринарно или аграрно приемливи соли или солвати.
BG103454A 1996-12-05 1999-06-01 Противопаразитни пиразоли BG64127B1 (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9625290.3A GB9625290D0 (en) 1996-12-05 1996-12-05 Parasiticidal agents
GBGB9702235.4A GB9702235D0 (en) 1997-02-04 1997-02-04 Parasiticidal agents
GBGB9712045.5A GB9712045D0 (en) 1997-06-10 1997-06-10 Parasiticidal agents
PCT/EP1997/006697 WO1998024767A1 (en) 1996-12-05 1997-11-25 Parasiticidal pyrazoles

Publications (2)

Publication Number Publication Date
BG103454A true BG103454A (bg) 2000-01-31
BG64127B1 BG64127B1 (bg) 2004-01-30

Family

ID=27268619

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103454A BG64127B1 (bg) 1996-12-05 1999-06-01 Противопаразитни пиразоли

Country Status (40)

Country Link
US (2) US6075043A (bg)
EP (1) EP0946515B1 (bg)
JP (2) JP3950483B2 (bg)
KR (1) KR100354311B1 (bg)
CN (1) CN1106386C (bg)
AR (1) AR013879A1 (bg)
AT (1) ATE233736T1 (bg)
AU (1) AU720705B2 (bg)
BG (1) BG64127B1 (bg)
BR (1) BR9713565A (bg)
CA (1) CA2273951C (bg)
CO (1) CO5031251A1 (bg)
CZ (1) CZ295295B6 (bg)
DE (1) DE69719547T2 (bg)
DK (1) DK0946515T3 (bg)
DZ (1) DZ2360A1 (bg)
EA (1) EA002278B1 (bg)
ES (1) ES2191870T3 (bg)
HK (1) HK1029111A1 (bg)
HR (1) HRP970663B1 (bg)
HU (1) HUP0000544A3 (bg)
ID (1) ID21556A (bg)
IL (1) IL129866A (bg)
IS (1) IS1982B (bg)
MA (1) MA24414A1 (bg)
MY (1) MY117021A (bg)
NO (2) NO313518B1 (bg)
NZ (1) NZ335611A (bg)
OA (1) OA11055A (bg)
PA (1) PA8442101A1 (bg)
PE (1) PE20199A1 (bg)
PL (1) PL190926B1 (bg)
PT (1) PT946515E (bg)
RS (1) RS49720B (bg)
SK (1) SK285203B6 (bg)
TN (1) TNSN97197A1 (bg)
TW (1) TW524667B (bg)
UA (1) UA60321C2 (bg)
UY (2) UY24798A1 (bg)
WO (1) WO1998024767A1 (bg)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
GB9801851D0 (en) * 1998-01-29 1998-03-25 Pfizer Ltd Parasiticidal agents
GB9810354D0 (en) * 1998-05-14 1998-07-15 Pfizer Ltd Heterocycles
GB9811050D0 (en) * 1998-05-22 1998-07-22 Pfizer Ltd Pyrazoles
AR021608A1 (es) * 1998-12-11 2002-07-31 Merial Ltd Represion de artropodos en animales
US6531501B1 (en) 1998-12-11 2003-03-11 Aventis Cropscience, S.A. Control of arthropods in animals
GB9916052D0 (en) * 1999-07-08 1999-09-08 Pfizer Ltd Anthelmintic compositions
CA2393197C (en) 1999-12-02 2009-03-03 Aventis Cropscience S.A. Control of arthropods in animals with 1-arylpyrazoles
WO2003076409A1 (en) * 2002-03-14 2003-09-18 Syngenta Participations Ag Derivatives of 1-phenyl-3-phenylpyrazole as herbicides
CH697663B1 (de) * 2003-01-07 2009-01-15 Lanxess Deutschland Gmbh Pyrazolylalkine.
WO2005023773A1 (en) * 2003-09-04 2005-03-17 Pfizer Limited Process for the preparation of substituted aryl pyrazoles
GB0329314D0 (en) * 2003-12-18 2004-01-21 Pfizer Ltd Substituted arylpyrazoles
US7514464B2 (en) * 2003-12-18 2009-04-07 Pfizer Limited Substituted arylpyrazoles
CA2560510C (en) 2004-03-18 2009-10-13 Pfizer Inc. N-(1-arylpyrazol-4yl) sulfonamides and their use as parasiticides
US20080146643A1 (en) * 2005-06-15 2008-06-19 Pfizer Limited Combination
US20070149464A1 (en) * 2005-06-15 2007-06-28 Pfizer Inc. Combination
US20080176865A1 (en) * 2005-06-15 2008-07-24 Pfizer Limited Substituted arylpyrazoles
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
ATE456557T1 (de) * 2005-06-15 2010-02-15 Pfizer Ltd Substituierte arylpyrazole zur verwendung gegen parasiten
US20080293726A1 (en) 2005-07-06 2008-11-27 Sepracor Inc. Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
EP1783114A1 (en) * 2005-11-03 2007-05-09 Novartis AG N-(hetero)aryl indole derivatives as pesticides
DE102006061538A1 (de) 2006-12-27 2008-07-03 Bayer Healthcare Ag Kombinationsprodukt zur Bekämpfung von Parasiten an Tieren
DE102006061537A1 (de) 2006-12-27 2008-07-03 Bayer Healthcare Ag Mittel zur Bekämpfung von Parasiten an Tieren
AU2011236510A1 (en) 2010-04-08 2012-10-11 Zoetis Llc Substituted 3,5- di phenyl - isoxazoline derivatives as insecticides and acaricides
JP5409968B2 (ja) 2010-08-05 2014-02-05 ゾエティス・エルエルシー 駆虫剤としてのイソオキサゾリン誘導体
EP2619189B1 (en) 2010-09-24 2020-04-15 Zoetis Services LLC Isoxazoline oximes as antiparasitic agents
BR112013023068B8 (pt) 2011-03-10 2022-11-22 Zoetis Llc Derivados de isoxazolina espirocíclica, seu uso e seu processo de preparação, e composições veterinárias
JP5824573B2 (ja) 2011-03-22 2015-11-25 ゾエティス・エルエルシー 抗寄生虫薬としてのイソオキサゾリン誘導体
US9925167B2 (en) 2011-06-30 2018-03-27 Hansen-Ab Gmbh Agents for the control of parasites on animals
AU2013215368A1 (en) 2012-02-03 2014-08-21 Zoetis Services Llc Dihydrofuran azetidine derivatives as antiparasitic agents
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
BR112014027805A2 (pt) 2012-05-09 2017-06-27 Zoetis Llc derivados de azetidina como agentes antiparasitários
BR112015013491B1 (pt) 2012-12-12 2021-03-30 Zoetis Services Llc Composição veterinária ectoparasítica injetável e uso da mesma
RS65380B1 (sr) 2017-08-24 2024-04-30 Novo Nordisk As Glp-1 kompozicije i njihova upotreba
CN111116478B (zh) * 2019-12-18 2021-10-26 浙江金伯士药业有限公司 一种兽用抗生素维吉霉素中间体的制备方法
US20230093542A1 (en) 2020-02-18 2023-03-23 Novo Nordisk A/S Glp-1 compositions and uses thereof
CN115894374A (zh) * 2023-02-16 2023-04-04 广州佳途科技股份有限公司 一种氟甲腈的制备方法及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658725A1 (de) * 1976-12-24 1978-07-06 Bayer Ag Mittel zur bekaempfung von tierischen ektoparasiten mit stark ausgepraegter residualwirkung
US4479968A (en) 1980-10-17 1984-10-30 The Wellcome Foundation Ltd. Control of ectoparasitic infestations of pigs
GB2086302A (en) * 1980-10-24 1982-05-12 Bone Cravens Ltd Prefill Valve System
GB8531485D0 (en) * 1985-12-20 1986-02-05 May & Baker Ltd Compositions of matter
US5232940A (en) * 1985-12-20 1993-08-03 Hatton Leslie R Derivatives of N-phenylpyrazoles
US5547974A (en) * 1985-12-20 1996-08-20 Rhone-Poulenc Agriculture Ltd. Derivatives of N-phenylpyrazoles
GB8713769D0 (en) * 1987-06-12 1987-07-15 May & Baker Ltd Compositions of matter
GB8713768D0 (en) * 1987-06-12 1987-07-15 May & Baker Ltd Compositions of matter
GB8613914D0 (en) * 1986-06-07 1986-07-09 Coopers Animal Health Liquid formulations
EP0273862B1 (de) * 1986-12-05 1991-07-10 Ciba-Geigy Ag Ektoparasitizide nicht-wässrige Pour-on-Flüssigformulierung
DE3706993A1 (de) * 1987-03-05 1988-09-15 Bayer Ag 5-amino-3-halogenalkyl-1-aryl-pyrazole
SE455750B (sv) 1987-06-11 1988-08-01 Ericsson Telefon Ab L M Digitalt tidsmultiplext mobiltelefonisystem med ett effektivt utnyttjande av varje tidsram
GB9120641D0 (en) * 1991-09-27 1991-11-06 Ici Plc Heterocyclic compounds
ZA94170B (en) * 1993-01-20 1995-03-15 Soltec Res Pty Ltd Ectoparasiticidal formulation
AUPM437194A0 (en) * 1994-03-11 1994-03-31 Commonwealth Scientific And Industrial Research Organisation Pesticide formulation
ATE267248T1 (de) 1995-08-11 2004-06-15 Novozymes As Neuartige lipolytische enzyme
GB9601128D0 (en) * 1995-08-11 1996-03-20 Pfizer Ltd Parasiticidal compounds
JPH0987111A (ja) * 1995-09-27 1997-03-31 Sumitomo Chem Co Ltd 害虫駆除用毒餌剤
FR2739255B1 (fr) * 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
ATE236883T1 (de) * 1995-12-19 2003-04-15 Bayer Cropscience Sa Neue 1-aryl pyrazol derivate und ihre verwendung als schädlingsbekämpfungsmittel
GR1002899B (el) * 1996-03-29 1998-05-11 Rhone Merieux Περιλαιμιο κατα ψυλλων και κροτωνων για σκυλους και γατες, με βαση ν-φαινυλπυραζολη
IE970215A1 (en) * 1996-03-29 1997-10-08 Rhone Merieux Direct pour-on skin solution for antiparasitic use in cattle¹and sheep
IE80657B1 (en) * 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
GR970100096A (el) * 1996-03-29 1997-11-28 Merial Εξωτερικη διαταξη κατα των παρασιτων για βοοειδη με βαση τη ν-φαινυλπυραζολη, ειδικα σκουλαρικια.
TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
US7100379B2 (en) * 2003-08-14 2006-09-05 Samsung Electronics Co., Ltd. Water supply control apparatus and method for ice maker

Also Published As

Publication number Publication date
OA11055A (en) 2002-03-07
KR100354311B1 (ko) 2002-09-28
RS49720B (sr) 2007-12-31
SK285203B6 (sk) 2006-08-03
NO313518B1 (no) 2002-10-14
MA24414A1 (fr) 1998-07-01
CN1106386C (zh) 2003-04-23
SK74099A3 (en) 2001-02-12
NO992732L (no) 1999-08-05
EA199900447A1 (ru) 2000-02-28
UY24923A1 (es) 1998-09-01
CN1258282A (zh) 2000-06-28
EP0946515A1 (en) 1999-10-06
HUP0000544A2 (hu) 2000-06-28
EP0946515B1 (en) 2003-03-05
HK1029111A1 (en) 2001-03-23
IS5050A (is) 1999-05-11
JP2007211016A (ja) 2007-08-23
AU720705B2 (en) 2000-06-08
IS1982B (is) 2005-01-14
JP2000505812A (ja) 2000-05-16
BG64127B1 (bg) 2004-01-30
YU25299A (sh) 2002-10-18
DE69719547T2 (de) 2003-10-02
EA002278B1 (ru) 2002-02-28
UA60321C2 (uk) 2003-10-15
CA2273951A1 (en) 1998-06-11
PT946515E (pt) 2003-06-30
US6268509B1 (en) 2001-07-31
PE20199A1 (es) 1999-03-05
ATE233736T1 (de) 2003-03-15
HRP970663B1 (en) 2003-10-31
IL129866A0 (en) 2000-02-29
TNSN97197A1 (fr) 2005-03-15
HRP970663A2 (en) 1998-10-31
DZ2360A1 (fr) 2002-12-28
CZ195199A3 (cs) 2000-08-16
CO5031251A1 (es) 2001-04-27
PL333922A1 (en) 2000-01-31
JP3950483B2 (ja) 2007-08-01
HUP0000544A3 (en) 2002-01-28
AR013879A1 (es) 2001-01-31
CA2273951C (en) 2003-04-01
KR20000057432A (ko) 2000-09-15
DE69719547D1 (de) 2003-04-10
US6075043A (en) 2000-06-13
ES2191870T3 (es) 2003-09-16
UY24798A1 (es) 2000-09-29
NO992736D0 (no) 1999-06-04
MY117021A (en) 2004-04-30
NZ335611A (en) 2001-01-26
TW524667B (en) 2003-03-21
PA8442101A1 (es) 2000-05-24
AU5485998A (en) 1998-06-29
BR9713565A (pt) 2000-03-14
IL129866A (en) 2004-05-12
DK0946515T3 (da) 2003-07-14
ID21556A (id) 1999-06-24
PL190926B1 (pl) 2006-02-28
WO1998024767A1 (en) 1998-06-11
CZ295295B6 (cs) 2005-06-15
NO992732D0 (no) 1999-06-04

Similar Documents

Publication Publication Date Title
BG103454A (bg) Противопаразитни пиразоли
TW369526B (en) Diazabicyclic neurokinin antagonists
MY105092A (en) Triazole antifungal agents.
TW229140B (bg)
MY105494A (en) Triazole antifungal agents.
ES8306093A1 (es) Procedimiento de preparacion de derivados aminoalcoil heterociclicos farmaceuticamente activos.
TW276255B (bg)
BG100815A (bg) Инсектицидни n-/заместени-арилметил/-4-/бис/заместени фенил/ метил/ пиперидини
TW427982B (en) Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them
ES8601220A1 (es) Procedimiento de preparacion de nuevas sales de derivados organofosforados
IL114785A0 (en) Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
PL339143A1 (en) Tetrahydro-gamma-carbolynes
AU581438B2 (en) Substituted pyrrolidinones, processes for their preparation and pharmaceutical compositions
ES8307260A1 (es) Procedimiento para la obtencion de derivados de trifluormetil-fenoxifenil-silicio.
GB2311780A (en) Piperazine-2,5-dione derivatives as modulators of multidrug resistance
ATE133939T1 (de) Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung
IL71201A (en) Bactericidal compositions for plant protection containing quinolonecarboxylic acid derivatives and certain such novel compounds
NZ304438A (en) Substituted triazole derivatives and antifungal compositions
ZA854683B (en) New 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidines,their preparation and pharmaceutical compositions containing these compounds
TW372964B (en) Substituted 2-phenylpyridines, compositions containing same, processes for preparing same and their uses
BG106784A (bg) 3-(4,5-дихидроизоксазол-5-ил) бензоилпиразоли
HUP9901988A2 (hu) 2,2'-bi(1H-pirrol)-vegyületet tartalmazó szinergetikus immunszuppresszív készítmény
ES8607265A1 (es) Un procedimiento para la preparacion de nuevos derivados de aminoalcoholes
BG104037A (bg) Производни на 6-пиролидин-2-илпириндини, тяхното получаване и използването им в терапията
CA2276463A1 (en) Substituted 4-benzoyl-pyrazoles