ATE133939T1 - Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung - Google Patents

Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung

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Publication number
ATE133939T1
ATE133939T1 AT93400841T AT93400841T ATE133939T1 AT E133939 T1 ATE133939 T1 AT E133939T1 AT 93400841 T AT93400841 T AT 93400841T AT 93400841 T AT93400841 T AT 93400841T AT E133939 T1 ATE133939 T1 AT E133939T1
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Austria
Prior art keywords
indan
nhr5
trion
dione
derivatives
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AT93400841T
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English (en)
Inventor
De Sevricourt Michel Cugnon
Catherine Dacquet
Michel Finet
Marquer Florence Le
Max Robba
Norbert Olivier Tembo
Sylvie Yannic-Arnoult
Jean-Luc Torregrosa
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Innothera Lab Sa
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Publication of ATE133939T1 publication Critical patent/ATE133939T1/de

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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AT93400841T 1992-04-03 1993-04-01 Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung ATE133939T1 (de)

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AT93400841T ATE133939T1 (de) 1992-04-03 1993-04-01 Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung

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US (2) US5648381A (de)
EP (2) EP0566445B1 (de)
JP (2) JPH06508375A (de)
AT (2) ATE133938T1 (de)
DE (2) DE69301494T2 (de)
ES (2) ES2084459T3 (de)
WO (2) WO1993020046A1 (de)

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JPH06508375A (ja) * 1992-04-03 1994-09-22 イノテラ インダン−１，３−ジオンおよびインダン−１，２，３−トリオンの誘導体、それらの調製方法およびそれらの治療上の使用
FR2710639B1 (fr) * 1993-10-01 1995-12-22 Innothera Lab Sa Dérivés d'indane cétoniques, leur procédé d'obtention, leur application thérapeutique.
FR2710644B1 (fr) * 1993-10-01 1995-12-22 Innothera Lab Sa Dérivés d'indane cétoniques et de leurs analogues hétérocycliques et leur utilisation thérapeutique.
FR2710641B1 (fr) * 1993-10-01 1995-12-22 Innothera Lab Sa Dérivés d'indane triones et d'hydrazides et leur application thérapeutique.
FR2738150B1 (fr) * 1995-09-01 1997-10-31 Synthelabo Utilisation de la sulphasalazine et de ses metabolites pour la fabrication d'un medicament utile dans le traitement de l'insuffisance veineuse et des ulceres veineux
FR2742151B1 (fr) * 1995-12-12 1998-03-06 Innothera Lab Sa Utilisation de derives de bicycles mono ou dicetoniques, nouveaux composes obtenus et leur application en therapeutique
US6013674A (en) * 1997-06-02 2000-01-11 Eli Lilly And Company Cell adhesion inhibitors
US9795584B2 (en) 2013-07-30 2017-10-24 University Of South Florida Treating an atypical protein kinase C enzyme abnormality
WO2015027702A1 (zh) * 2013-09-02 2015-03-05 北京英力科技发展有限公司 环戊二酮肟酯及其应用
CN104910053B (zh) * 2014-06-09 2017-09-12 北京英力科技发展有限公司 不对称二肟酯化合物及其制造方法与应用
WO2016082304A1 (zh) * 2014-11-28 2016-06-02 北京英力科技发展有限公司 一种光固化阻焊油墨
IT201900008301A1 (it) 2019-06-06 2020-12-06 Epi C S R L Modulatori di sirtuine
CN111991377B (zh) * 2020-09-23 2022-03-22 唐怡庭 一种茚酮衍生物在制备治疗脓毒症药物中的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280185A (en) * 1965-10-01 1966-10-18 American Home Prod 3-substituted 1, 2, 4-cyclopentanetrione, 1-thiosemicarbazones
DE2127982A1 (en) * 1971-06-05 1972-12-14 Boehringer Mannheim Gmbh, 6800 Mannheim Virustatic indane-1,3-dione-2,2-derivs - from indanedione and two reagents or from diethylphthalate and methylsulphones
FR2567754B1 (fr) * 1984-07-20 1987-05-29 Cortial Application therapeutique d'aminomethylene-2 indanediones-1,3 substituees sur l'azote
FR2593501B1 (fr) * 1986-01-29 1988-05-06 Panmedica Sa Nouveaux derives bis (r-oxyimino)-5,7 dihydro-6,7 (5h) dibenzo (a,c) cycloheptene, leurs procedes de preparation et leur application comme medicaments
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones
JPH06508375A (ja) * 1992-04-03 1994-09-22 イノテラ インダン−１，３−ジオンおよびインダン−１，２，３−トリオンの誘導体、それらの調製方法およびそれらの治療上の使用

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Publication number Publication date
ATE133938T1 (de) 1996-02-15
WO1993020045A1 (fr) 1993-10-14
DE69301494D1 (de) 1996-03-21
EP0566445B1 (de) 1996-02-07
JPH06508375A (ja) 1994-09-22
US5648381A (en) 1997-07-15
DE69301494T2 (de) 1996-10-17
EP0566445A1 (de) 1993-10-20
EP0566446B1 (de) 1996-02-07
ES2084459T3 (es) 1996-05-01
DE69301493D1 (de) 1996-03-21
EP0566446A1 (de) 1993-10-20
WO1993020046A1 (fr) 1993-10-14
US5571843A (en) 1996-11-05
ES2084458T3 (es) 1996-05-01
DE69301493T2 (de) 1996-11-07
JPH06508374A (ja) 1994-09-22

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