DE69207194T2 - Verfahren zur Herstellung von Bacchatin III und von Desacetyl-10-Bacchatin III Derivate - Google Patents

Verfahren zur Herstellung von Bacchatin III und von Desacetyl-10-Bacchatin III Derivate

Info

Publication number
DE69207194T2
DE69207194T2 DE69207194T DE69207194T DE69207194T2 DE 69207194 T2 DE69207194 T2 DE 69207194T2 DE 69207194 T DE69207194 T DE 69207194T DE 69207194 T DE69207194 T DE 69207194T DE 69207194 T2 DE69207194 T2 DE 69207194T2
Authority
DE
Germany
Prior art keywords
bacchatin
iii
preparation
desacetyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69207194T
Other languages
English (en)
Other versions
DE69207194D1 (de
Inventor
Augustin Hittinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of DE69207194D1 publication Critical patent/DE69207194D1/de
Publication of DE69207194T2 publication Critical patent/DE69207194T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69207194T 1991-07-10 1992-07-08 Verfahren zur Herstellung von Bacchatin III und von Desacetyl-10-Bacchatin III Derivate Expired - Lifetime DE69207194T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9108673A FR2678930B1 (fr) 1991-07-10 1991-07-10 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
PCT/FR1992/000649 WO1993001179A1 (fr) 1991-07-10 1992-07-08 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Publications (2)

Publication Number Publication Date
DE69207194D1 DE69207194D1 (de) 1996-02-08
DE69207194T2 true DE69207194T2 (de) 1996-09-05

Family

ID=9414931

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69207194T Expired - Lifetime DE69207194T2 (de) 1991-07-10 1992-07-08 Verfahren zur Herstellung von Bacchatin III und von Desacetyl-10-Bacchatin III Derivate

Country Status (25)

Country Link
US (1) US5578739A (de)
EP (2) EP0522958A1 (de)
JP (1) JP3085710B2 (de)
KR (1) KR100206458B1 (de)
AT (1) ATE132145T1 (de)
AU (1) AU662346B2 (de)
CA (1) CA2111319C (de)
CZ (1) CZ281288B6 (de)
DE (1) DE69207194T2 (de)
DK (1) DK0593641T3 (de)
ES (1) ES2081120T3 (de)
FI (1) FI109792B (de)
FR (1) FR2678930B1 (de)
GR (1) GR3018543T3 (de)
HU (1) HU217115B (de)
IE (1) IE73637B1 (de)
MX (1) MX9204029A (de)
NO (2) NO302521B1 (de)
NZ (1) NZ243491A (de)
PL (1) PL169780B1 (de)
RU (1) RU2088578C1 (de)
SK (1) SK281560B6 (de)
WO (1) WO1993001179A1 (de)
YU (1) YU49175B (de)
ZA (1) ZA925098B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
CA2111527C (en) * 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
FR2718135B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation d'hydroxy-7 taxanes.
US5580899A (en) * 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
FR2740451B1 (fr) 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
ATE234800T1 (de) 1997-08-21 2003-04-15 Univ Florida State Verfahren zur synthese von taxanen
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
CA2317728A1 (en) * 1998-01-14 1999-07-22 Bristol-Myers Squibb Company Novel crystalline complexes of baccatin iii with imidazole, 2-methylimidazole or isopropanol
PT1082316E (pt) 1998-05-01 2004-11-30 Napro Biotherapeutics Inc Processos e intermediarios uteis para a sintese de paclitaxel a partir de c-7,c-10-di-cbz-bacatina iii
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
IT1319168B1 (it) * 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
EP2389948A1 (de) 2006-03-23 2011-11-30 Novartis AG Antitumorzellenantigen-Antikörper-Therapeutika
DE102008013929B3 (de) * 2008-03-12 2009-04-09 Wieland-Werke Ag Verdampferrohr mit optimierten Hinterschneidungen am Nutengrund
CN101531645B (zh) * 2009-04-29 2012-08-22 深圳万乐药业有限公司 一种多西他赛的合成方法
BR112014031421A2 (pt) 2012-06-15 2017-06-27 Brigham & Womens Hospital Inc composições para tratamento de câncer e métodos para produção das mesmas
US10426753B2 (en) 2014-04-03 2019-10-01 Invictus Oncology Pvt. Ltd. Supramolecular combinatorial therapeutics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Also Published As

Publication number Publication date
ATE132145T1 (de) 1996-01-15
CZ3194A3 (en) 1994-04-13
NZ243491A (en) 1995-05-26
RU2088578C1 (ru) 1997-08-27
WO1993001179A1 (fr) 1993-01-21
YU49175B (sh) 2004-07-15
ES2081120T3 (es) 1996-02-16
DE69207194D1 (de) 1996-02-08
HU9400062D0 (en) 1994-05-30
FI940075A (fi) 1994-01-07
NO934485L (no) 1993-12-08
NO302521B1 (no) 1998-03-16
CA2111319C (fr) 2003-04-08
MX9204029A (es) 1993-01-01
SK281560B6 (sk) 2001-05-10
IE73637B1 (en) 1997-06-18
US5578739A (en) 1996-11-26
FR2678930B1 (fr) 1995-01-13
AU2328092A (en) 1993-02-11
IE922234A1 (en) 1993-01-13
PL169780B1 (pl) 1996-08-30
FR2678930A1 (fr) 1993-01-15
DK0593641T3 (da) 1996-01-29
EP0593641A1 (de) 1994-04-27
SK1794A3 (en) 1994-11-09
HUT66018A (en) 1994-08-29
JP3085710B2 (ja) 2000-09-11
FI940075A0 (fi) 1994-01-07
GR3018543T3 (en) 1996-03-31
NO934485D0 (no) 1993-12-08
CZ281288B6 (cs) 1996-08-14
EP0593641B1 (de) 1995-12-27
YU68792A (sh) 1995-10-03
AU662346B2 (en) 1995-08-31
CA2111319A1 (fr) 1993-01-21
FI109792B (fi) 2002-10-15
HU217115B (hu) 1999-11-29
ZA925098B (en) 1993-04-28
JPH06509082A (ja) 1994-10-13
EP0522958A1 (de) 1993-01-13
KR100206458B1 (ko) 1999-07-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

R071 Expiry of right

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