BG101209A - Хиполипидемични 1,4-бензотиазепин-1,1-диоксиди - Google Patents
Хиполипидемични 1,4-бензотиазепин-1,1-диоксидиInfo
- Publication number
- BG101209A BG101209A BG101209A BG10120997A BG101209A BG 101209 A BG101209 A BG 101209A BG 101209 A BG101209 A BG 101209A BG 10120997 A BG10120997 A BG 10120997A BG 101209 A BG101209 A BG 101209A
- Authority
- BG
- Bulgaria
- Prior art keywords
- hypolipidemic
- hypolipidemic compounds
- new
- compounds
- hiperlipidemic
- Prior art date
Links
- 230000000055 hyoplipidemic effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретението се отнася до нови хиполипидемични бензотиазепиндиоксиди с формуладо метод и нови междинни продукти за получаването им, до фармацевтичнисъстави, които ги съдържат, и до приложението им в медицината, по-специално при профилактика и лечението на хиперлипидемични състояния като атеросклероза.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28852794A | 1994-08-10 | 1994-08-10 | |
PCT/GB1995/001884 WO1996005188A1 (en) | 1994-08-10 | 1995-08-09 | Hypolipidemic 1,4-benzothiazepine-1,1-dioxides |
Publications (2)
Publication Number | Publication Date |
---|---|
BG101209A true BG101209A (bg) | 1997-08-29 |
BG62048B1 BG62048B1 (bg) | 1999-01-29 |
Family
ID=23107516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG101209A BG62048B1 (bg) | 1994-08-10 | 1997-02-07 | Хиполипидемични 1,4-бензотиазепин-1,1-диоксиди |
Country Status (31)
Country | Link |
---|---|
US (1) | US5910494A (bg) |
EP (2) | EP1203769A1 (bg) |
JP (1) | JP2935756B2 (bg) |
KR (1) | KR100354288B1 (bg) |
CN (1) | CN1059673C (bg) |
AP (1) | AP720A (bg) |
AT (1) | ATE226946T1 (bg) |
AU (1) | AU696073B2 (bg) |
BG (1) | BG62048B1 (bg) |
BR (1) | BR9508586A (bg) |
CA (1) | CA2197099A1 (bg) |
CZ (1) | CZ37397A3 (bg) |
DE (1) | DE69528704T2 (bg) |
DK (1) | DK0775126T3 (bg) |
EE (1) | EE9700028A (bg) |
ES (1) | ES2185711T3 (bg) |
FI (1) | FI970531A0 (bg) |
HK (1) | HK1003936A1 (bg) |
HU (1) | HUT77129A (bg) |
IL (1) | IL114877A (bg) |
IS (1) | IS4418A (bg) |
MX (1) | MX9700890A (bg) |
NO (1) | NO308131B1 (bg) |
NZ (1) | NZ290911A (bg) |
OA (1) | OA10597A (bg) |
PL (1) | PL184512B1 (bg) |
PT (1) | PT775126E (bg) |
RU (1) | RU2156245C2 (bg) |
SK (1) | SK17797A3 (bg) |
WO (1) | WO1996005188A1 (bg) |
ZA (1) | ZA956647B (bg) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
GB9423172D0 (en) * | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
GB9704208D0 (en) * | 1997-02-28 | 1997-04-16 | Glaxo Group Ltd | Chemical compounds |
DK0864582T3 (da) * | 1997-03-14 | 2003-09-29 | Aventis Pharma Gmbh | Hypolidemiske 1,4-benzothiazepin-1,1-dioxider |
GB9800428D0 (en) | 1998-01-10 | 1998-03-04 | Glaxo Group Ltd | Chemical compounds |
EA004877B1 (ru) | 1998-12-23 | 2004-08-26 | Джи.Ди.Сирл Ллс | Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний |
CZ20012342A3 (cs) | 1998-12-23 | 2001-12-12 | G. D. Searle Llc | Kombinace inhibitorů transportu ľlučové kyseliny v ileu a derivátů kyseliny fibrové pro kardiovaskulární indikace |
JP2002533409A (ja) | 1998-12-23 | 2002-10-08 | ジー.ディー.サール エルエルシー | 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤および胆汁酸隔離剤の組み合わせ |
HUP0201972A3 (en) | 1998-12-23 | 2005-06-28 | G D Searle Llc Chicago | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
EA009466B1 (ru) | 1998-12-23 | 2007-12-28 | Джи.Ди. Сирл Ллс | Ингибитор белка, переносящего эфир холестерила |
AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
US6489366B1 (en) | 1998-12-23 | 2002-12-03 | G. D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
KR20020000139A (ko) * | 1999-02-12 | 2002-01-04 | 추후제출 | 회장 담즙산 수송 및 타우로콜산염 흡수의 억제제로서의활성을 보유하는 신규한 1,2-벤조티아제핀 |
DE19916108C1 (de) * | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
GB9914745D0 (en) * | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
FR2796070B1 (fr) | 1999-07-06 | 2003-02-21 | Lipha | Derives de benzodiazepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparation |
SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
JP2003528830A (ja) | 2000-03-10 | 2003-09-30 | ファルマシア・コーポレーション | テトラヒドロベンゾチエピン類の製造方法 |
US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
US20020183307A1 (en) * | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
WO2002053548A1 (en) * | 2000-12-27 | 2002-07-11 | Banyu Pharmaceutical Co.,Ltd. | Benzothiazepine derivatives |
GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
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US6852753B2 (en) | 2002-01-17 | 2005-02-08 | Pharmacia Corporation | Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
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US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
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GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
CA2557576C (en) * | 2004-02-27 | 2010-02-09 | Asahi Kasei Pharma Corporation | Novel benzothiazepine and benzothiepine compounds |
US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
JP2012509891A (ja) | 2008-11-26 | 2012-04-26 | サティオゲン ファーマシューティカルズ,インク. | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
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CA3158184A1 (en) | 2019-12-04 | 2021-08-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
AR120676A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
TW202134222A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途 |
JP2023537285A (ja) | 2020-08-03 | 2023-08-31 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
WO2022101379A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
AU2021390172A1 (en) | 2020-12-04 | 2023-06-22 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
US20240173333A1 (en) | 2022-11-03 | 2024-05-30 | Albireo Ab | Treating Alagille Syndrome (ALGS) |
WO2024121434A1 (en) | 2022-12-09 | 2024-06-13 | Albireo Ab | Asbt inhibitors in the treatment of renal diseases |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3362962A (en) * | 1964-01-24 | 1968-01-09 | Hoffmann La Roche | Certain benzothiazepine derivatives |
US4564612A (en) * | 1983-04-22 | 1986-01-14 | Takeda Chemical Industries, Ltd. | Condensed, seven-membered ring compounds and their use |
GB9111376D0 (en) * | 1991-05-25 | 1991-07-17 | Boots Co Plc | Therapeutic agents |
GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
US5276025A (en) * | 1992-09-09 | 1994-01-04 | Merck & Co., Inc. | Heterobicyclic sulfonamides |
IL108634A0 (en) * | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
ZA941003B (en) * | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
PT781278E (pt) * | 1994-09-13 | 2001-08-30 | Monsanto Co | Novas benzotiepinas com actividade inibidora do transporte de acido biliar ileal e da remocao do taurocolato |
GB9423172D0 (en) * | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
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1995
- 1995-08-08 ZA ZA9506647A patent/ZA956647B/xx unknown
- 1995-08-09 MX MX9700890A patent/MX9700890A/es unknown
- 1995-08-09 WO PCT/GB1995/001884 patent/WO1996005188A1/en active IP Right Grant
- 1995-08-09 EE EE9700028A patent/EE9700028A/xx unknown
- 1995-08-09 AU AU44260/96A patent/AU696073B2/en not_active Ceased
- 1995-08-09 AT AT95927877T patent/ATE226946T1/de not_active IP Right Cessation
- 1995-08-09 US US08/793,040 patent/US5910494A/en not_active Expired - Fee Related
- 1995-08-09 SK SK177-97A patent/SK17797A3/sk unknown
- 1995-08-09 ES ES95927877T patent/ES2185711T3/es not_active Expired - Lifetime
- 1995-08-09 EP EP02003711A patent/EP1203769A1/en not_active Withdrawn
- 1995-08-09 JP JP8507116A patent/JP2935756B2/ja not_active Expired - Lifetime
- 1995-08-09 EP EP95927877A patent/EP0775126B1/en not_active Expired - Lifetime
- 1995-08-09 NZ NZ290911A patent/NZ290911A/en unknown
- 1995-08-09 AP APAP/P/1997/000920A patent/AP720A/en active
- 1995-08-09 IL IL11487795A patent/IL114877A/xx active IP Right Grant
- 1995-08-09 KR KR1019970700845A patent/KR100354288B1/ko not_active IP Right Cessation
- 1995-08-09 DK DK95927877T patent/DK0775126T3/da active
- 1995-08-09 CZ CZ97373A patent/CZ37397A3/cs unknown
- 1995-08-09 PL PL95318496A patent/PL184512B1/pl unknown
- 1995-08-09 BR BR9508586A patent/BR9508586A/pt not_active Application Discontinuation
- 1995-08-09 CA CA002197099A patent/CA2197099A1/en not_active Abandoned
- 1995-08-09 RU RU97104002/04A patent/RU2156245C2/ru active
- 1995-08-09 CN CN95195419A patent/CN1059673C/zh not_active Expired - Fee Related
- 1995-08-09 PT PT95927877T patent/PT775126E/pt unknown
- 1995-08-09 HU HU9700408A patent/HUT77129A/hu active IP Right Revival
- 1995-08-09 DE DE69528704T patent/DE69528704T2/de not_active Expired - Fee Related
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1997
- 1997-01-24 IS IS4418A patent/IS4418A/is unknown
- 1997-02-06 OA OA60961A patent/OA10597A/en unknown
- 1997-02-07 NO NO970585A patent/NO308131B1/no not_active IP Right Cessation
- 1997-02-07 BG BG101209A patent/BG62048B1/bg unknown
- 1997-02-07 FI FI970531A patent/FI970531A0/fi unknown
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1998
- 1998-04-15 HK HK98103105A patent/HK1003936A1/xx not_active IP Right Cessation
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