FR2724169B1 - Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant - Google Patents

Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Info

Publication number
FR2724169B1
FR2724169B1 FR9410660A FR9410660A FR2724169B1 FR 2724169 B1 FR2724169 B1 FR 2724169B1 FR 9410660 A FR9410660 A FR 9410660A FR 9410660 A FR9410660 A FR 9410660A FR 2724169 B1 FR2724169 B1 FR 2724169B1
Authority
FR
France
Prior art keywords
phenylimidazolidines
medicaments
substituted
novel
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9410660A
Other languages
English (en)
Other versions
FR2724169A1 (fr
Inventor
Andre Claussner
Francois Coubet
Jean Georges Teutsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR9410660A priority Critical patent/FR2724169B1/fr
Priority to TW083111272A priority patent/TW521073B/zh
Priority to IL11190894A priority patent/IL111908A/xx
Priority to MA23750A priority patent/MA23423A1/fr
Priority to US08/669,419 priority patent/US5750553A/en
Priority to AU14573/95A priority patent/AU687152B2/en
Priority to DK95906361T priority patent/DK0738263T3/da
Priority to PT95906361T priority patent/PT738263E/pt
Priority to CN95191761A priority patent/CN1113873C/zh
Priority to KR1019960703612A priority patent/KR100372065B1/ko
Priority to PCT/FR1995/000004 priority patent/WO1995018794A1/fr
Priority to BR9506457A priority patent/BR9506457A/pt
Priority to ES95906361T priority patent/ES2156204T3/es
Priority to CA002180379A priority patent/CA2180379A1/fr
Priority to JP7518337A priority patent/JPH09507241A/ja
Priority to AT95906361T priority patent/ATE200281T1/de
Priority to HU9601836A priority patent/HUT76299A/hu
Priority to DE69520560T priority patent/DE69520560T2/de
Priority to EP95906361A priority patent/EP0738263B1/fr
Publication of FR2724169A1 publication Critical patent/FR2724169A1/fr
Priority to FI962754A priority patent/FI112475B/fi
Application granted granted Critical
Publication of FR2724169B1 publication Critical patent/FR2724169B1/fr
Priority to GR20010400704T priority patent/GR3035853T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9410660A 1994-01-05 1994-09-06 Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant Expired - Fee Related FR2724169B1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR9410660A FR2724169B1 (fr) 1994-09-06 1994-09-06 Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
TW083111272A TW521073B (en) 1994-01-05 1994-12-05 New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
IL11190894A IL111908A (en) 1994-01-05 1994-12-07 Optionally substituted phenylimidazolidines, their preparation process and intermediates, and method of inducing antiandrogenic activity in warmblooded animals
MA23750A MA23423A1 (fr) 1994-01-05 1995-01-03 Nouvelles phenyllimidazolidines eventuellement substituees, leur procede et des intermidiaires de preparation, leur application comme medicaments et compositions pharmaceutiques les renfermant
AT95906361T ATE200281T1 (de) 1994-01-05 1995-01-04 Substituerte phenylimidazolidine mit antiandrogener aktivität
DK95906361T DK0738263T3 (da) 1994-01-05 1995-01-04 Substituerede phenylimidazolidiner med antiandrogen aktivitet
PT95906361T PT738263E (pt) 1994-01-05 1995-01-04 Novas fenilimidazolidinas eventualmente substituidas processos e intermediarios para a sua preparacao sua aplicacao como medicamentos e composicoes farmaceuticas que as contem
CN95191761A CN1113873C (zh) 1994-01-05 1995-01-04 新的任选取代的苯基咪唑烷、中间体及其制备方法,作为药物的应用和含有它们的药物组合
KR1019960703612A KR100372065B1 (ko) 1994-01-05 1995-01-04 신규임의치환페닐이미다졸리딘,중간체및그의제조방법,그의약제로서의용도및그를함유하는제약조성물
PCT/FR1995/000004 WO1995018794A1 (fr) 1994-01-05 1995-01-04 Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US08/669,419 US5750553A (en) 1994-01-05 1995-01-04 Optionally substituted phenylimidazolidines, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them
ES95906361T ES2156204T3 (es) 1994-01-05 1995-01-04 Fenilimidazolidinas sustituidas con actividad antiandrogena.
CA002180379A CA2180379A1 (fr) 1994-01-05 1995-01-04 Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
JP7518337A JPH09507241A (ja) 1994-01-05 1995-01-04 新規な置換されていてもよいフェニルイミダゾリジン類、それらの製造法及び中間体、それらの薬剤としての用途並びにそれらを含有する製薬組成物
AU14573/95A AU687152B2 (en) 1994-01-05 1995-01-04 Novel optionally substituted phenylimidazolidines, intermediates and process for their preparation, their use as drugs and pharmaceutical compositions containing them
HU9601836A HUT76299A (en) 1994-01-05 1995-01-04 Substituted phenylimidazolidines, process for their preparation, and pharmaceutical compositions containing them
DE69520560T DE69520560T2 (de) 1994-01-05 1995-01-04 Substituerte phenylimidazolidine mit antiandrogener aktivität
EP95906361A EP0738263B1 (fr) 1994-01-05 1995-01-04 Phenylimidazolidines substituees a activite antiandrogene
BR9506457A BR9506457A (pt) 1994-01-05 1995-01-04 Novas fenilimidazolidinas eventualmente substituídas seu processo e intermediários de preparação sua aplicação como medicamentos e as composições farmacêuticas que os contêm
FI962754A FI112475B (fi) 1994-01-05 1996-07-04 Uusia, mahdollisesti substituoituja fenyyli-imidatsolidiineja, menetelmä niiden valmistamiseksi, niiden käyttö lääkkeinä ja niitä käsittävät farmaseuttiset koostumukset
GR20010400704T GR3035853T3 (en) 1994-01-05 2001-05-11 Novel optionally substituted phenylimidazolidines, intermediates and process for their preparation, their use as drugs and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9410660A FR2724169B1 (fr) 1994-09-06 1994-09-06 Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
FR2724169A1 FR2724169A1 (fr) 1996-03-08
FR2724169B1 true FR2724169B1 (fr) 1997-01-03

Family

ID=9466726

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9410660A Expired - Fee Related FR2724169B1 (fr) 1994-01-05 1994-09-06 Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Country Status (1)

Country Link
FR (1) FR2724169B1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2579514A1 (fr) * 2004-09-10 2006-03-23 Janssen Pharmaceutica N.V. Derives d'imidazolidine-2-one en tant que modulateurs selectifs du recepteur androgenique
FR2880276A1 (fr) * 2005-01-05 2006-07-07 Lefebvre Dominique Caparros Utilisation des anti-androgenes dans le traitement des comportements agressifs ou impulsifs induits par des maladies du systeme nerveux central

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1032258B (de) * 1956-12-20 1958-06-19 Kali Chemie Ag Verfahren zur Herstellung von in 5-Stellung mono- und disubstituierten 1-Aryl-hydantoinen
GB997037A (en) * 1962-03-19 1965-06-30 Ici Ltd New hydrantoin derivatives
DK123717B (da) * 1968-11-25 1972-07-24 Sumitomo Chemical Co 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning.
JPS5136332B1 (fr) * 1970-12-09 1976-10-07
US4093444A (en) * 1973-05-22 1978-06-06 Pepro, Societe Pour Le Developpement Et La Vente De Specialites Chimiques Hydantoin derivatives and methods for regulating plant-growth
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
DE2540872A1 (de) * 1975-09-13 1977-03-24 Basf Ag Hydantoin-derivate
JPS52113965A (en) * 1976-03-22 1977-09-24 Nippon Soda Co Ltd Hydantoin derivatives, their preparation, fungicides for agriculture a nd gardening use containing the same
JPS53112875A (en) * 1977-03-15 1978-10-02 Sumitomo Chem Co Ltd 1-chlorocarbonylmethyl-3-(3,5-dichlorophenyl)hydantoin, its preparation and industrial bactericide containing the same
JPS53124267A (en) * 1977-04-06 1978-10-30 Sumitomo Chem Co Ltd 1-alkoxyacyl-3-(3,5-dihalogenophenyl)hydantoin derivatives, their preparation and bactericides for agricultural and horticultural uses containing the same as active agent
JPS5427564A (en) * 1977-08-02 1979-03-01 Sumitomo Chem Co Ltd 1-branched alkylcarbonyl-3-(3,5-dihalogenophenyl) hydantoins, their preparation, and bactericides for pomicultural and horticultural uses containing the same as active agent.
MC1220A1 (fr) * 1977-10-28 1979-07-20 Hoffmann La Roche Nouveaux derives d'imidazolidine
FI801184A (fi) * 1979-04-24 1980-10-25 Hoffmann La Roche Foerfarande foer framstaellning av imidazolidinderivat
BE884897R (fr) * 1980-08-22 1981-02-23 Hoffmann La Roche Preparations pharmaceutiques
US4753957A (en) * 1981-09-28 1988-06-28 Rohm And Haas Company Substituted 2,4-imidazolidinediones and fungicidal compositions
EP0091596B1 (fr) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Hydantoins, préparation et application
FR2619381B1 (fr) * 1987-08-13 1989-12-08 Roussel Uclaf Nouvelles imidazolidines substituees par un radical hydroxymethyle et un radical phenyl substitue, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant et un intermediaire pour leur preparation
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2671348B1 (fr) * 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
FR2724169A1 (fr) 1996-03-08

Similar Documents

Publication Publication Date Title
FR2694290B1 (fr) Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
MA26630A1 (fr) 4-phenylpyperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2780057B1 (fr) Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26687A1 (fr) 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2744449B1 (fr) Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
MA24529A1 (fr) Pyrazolopyrimidinones nouvelles, procede pour leur preparation et compositions les contenant .
MA26622A1 (fr) Pyrazolopyrimidinones nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26472A1 (fr) Derives de n-hydroxy-b-sulfonylpropionamide, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26559A1 (fr) Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation
FR2665453B1 (fr) Polylactides purifies, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2715402B1 (fr) Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
MA23395A1 (fr) Procede de preparation de nouvelles formulations
HUP9802393A3 (en) Benzothiazolone derivatives, their use, pharmaceutical compositions containing them, process for the preparation thereof and intermediates
FR2750988B1 (fr) Nouveaux derives de 2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2644787B1 (fr) Nouveaux steroides 21 aminosubstitues, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
FI960316A (fi) Oksatiolaanit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE03996B1 (et) Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
MA23663A1 (fr) Procede de preparation de formulations pharmaceutiques
FR2747680B1 (fr) Nouveaux steroides, leur application a titre de medicaments, leur procede de preparation, les intermediaires de ce procede et les compositions pharmaceutiques les renfermant
MA26583A1 (fr) Derives de benzamide nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2791980B1 (fr) Pyrido-thieno-diazepines, leur procede de preparation, et les compositions pharmaceutiques les contenant
FR2815346B1 (fr) Nouveaux composes aminotriazolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2733498B1 (fr) Nouveaux composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2761992B1 (fr) Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2724169B1 (fr) Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Legal Events

Date Code Title Description
CA Change of address
CD Change of name or company name
TP Transmission of property
TP Transmission of property
ST Notification of lapse

Effective date: 20070531