ES2156204T3 - Fenilimidazolidinas sustituidas con actividad antiandrogena. - Google Patents

Fenilimidazolidinas sustituidas con actividad antiandrogena.

Info

Publication number
ES2156204T3
ES2156204T3 ES95906361T ES95906361T ES2156204T3 ES 2156204 T3 ES2156204 T3 ES 2156204T3 ES 95906361 T ES95906361 T ES 95906361T ES 95906361 T ES95906361 T ES 95906361T ES 2156204 T3 ES2156204 T3 ES 2156204T3
Authority
ES
Spain
Prior art keywords
pct
halogen
optionally substituted
phenylimidazolidins
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95906361T
Other languages
English (en)
Inventor
Andre Claussner
Francois Goubet
Jean-Georges Teutsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9400042A external-priority patent/FR2715402B1/fr
Priority claimed from FR9410660A external-priority patent/FR2724169B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2156204T3 publication Critical patent/ES2156204T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A LOS PRODUCTOS DE FORMULA GENERAL (I), EN LA QUE Z{SUB,1} Y Z{SUB,2} IDENTICOS O DIFERENTES REPRESENTAN CIANO, NITRO, HALOGENO, TRIFLUORMETILO O CARBOXI LIBRE ESTERIFICADO, EL GRUPO -A-B ES ELEGIDO ENTRE LOS RADICALES (A) Y (B) EN LOS QUE X REPRESENTA OXIGENO O AZUFRE, R{SUB,3J} REPRESENTA R{SUB,3} CON LA EXCEPCION DEL VALOR DEL HIDROGENO, R{SUB,3} ES ELEGIDO ENTRE LOS SIGUIENTES RADICALES: HIDROGENO; ALQUILO, ALCENILO, ALQUINILO, ARILO O ARILALQUILO, EVENTUALMENTE SUSTITUIDOS, Y REPRESENTA OXIGENO O AZUFRE O NH, R{SUB,4} Y R{SUB,5} IDENTICOS O DIFERENTES, REPRESENTAN PARTICULARMENTE ALQUILO SUSTITUIDO POR HIDROXILO, CON LA EXCEPCION DE LOS PRODUCTOS EN LOS QUE R{SUB,4} Y R{SUB,5} IDENTICOS O DIFERENTES REPRESENTAN HIDROGENO O UN RADICAL ALQUILO (C{SUB,1-12}) EVENTUALMENTE SUSTITUIDO POR UNO O VARIOS ATOMOS DE HALOGENO O R{SUB,4} Y R{SUB,5} REPRESENTAN UN RADICAL CICLOALQUILO (C{SUB,1-17}) O UNO DE R{SUB,4} O R{SUB,5} REPRESENTA METILO, EL OTRO HIDROXIMETILO, Y REPRESENTA OXIGENO O NH, -A-B- REPRESENTA (C), Z{SUB,1} ES UN RADICAL 4-NITRO Y Z{SUB,2} UN RADICAL 3CF{SUB,3}.
ES95906361T 1994-01-05 1995-01-04 Fenilimidazolidinas sustituidas con actividad antiandrogena. Expired - Lifetime ES2156204T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9400042A FR2715402B1 (fr) 1994-01-05 1994-01-05 Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR9410660A FR2724169B1 (fr) 1994-09-06 1994-09-06 Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ES2156204T3 true ES2156204T3 (es) 2001-06-16

Family

ID=26230882

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95906361T Expired - Lifetime ES2156204T3 (es) 1994-01-05 1995-01-04 Fenilimidazolidinas sustituidas con actividad antiandrogena.

Country Status (20)

Country Link
US (1) US5750553A (es)
EP (1) EP0738263B1 (es)
JP (1) JPH09507241A (es)
KR (1) KR100372065B1 (es)
CN (1) CN1113873C (es)
AT (1) ATE200281T1 (es)
AU (1) AU687152B2 (es)
BR (1) BR9506457A (es)
CA (1) CA2180379A1 (es)
DE (1) DE69520560T2 (es)
DK (1) DK0738263T3 (es)
ES (1) ES2156204T3 (es)
FI (1) FI112475B (es)
GR (1) GR3035853T3 (es)
HU (1) HUT76299A (es)
IL (1) IL111908A (es)
MA (1) MA23423A1 (es)
PT (1) PT738263E (es)
TW (1) TW521073B (es)
WO (1) WO1995018794A1 (es)

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Also Published As

Publication number Publication date
CN1141631A (zh) 1997-01-29
FI962754A (fi) 1996-07-04
IL111908A0 (en) 1995-03-15
FI962754A0 (fi) 1996-07-04
CA2180379A1 (fr) 1995-07-13
EP0738263A1 (fr) 1996-10-23
DE69520560D1 (de) 2001-05-10
IL111908A (en) 2003-05-29
ATE200281T1 (de) 2001-04-15
GR3035853T3 (en) 2001-08-31
AU1457395A (en) 1995-08-01
DK0738263T3 (da) 2001-06-18
MA23423A1 (fr) 1995-10-01
BR9506457A (pt) 1997-10-07
EP0738263B1 (fr) 2001-04-04
TW521073B (en) 2003-02-21
CN1113873C (zh) 2003-07-09
FI112475B (fi) 2003-12-15
US5750553A (en) 1998-05-12
PT738263E (pt) 2001-08-30
DE69520560T2 (de) 2001-09-13
AU687152B2 (en) 1998-02-19
HUT76299A (en) 1997-07-28
JPH09507241A (ja) 1997-07-22
WO1995018794A1 (fr) 1995-07-13
KR100372065B1 (ko) 2003-05-12
HU9601836D0 (en) 1996-09-30

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