AU2019316103B2 - Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy - Google Patents

Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy

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Publication number
AU2019316103B2
AU2019316103B2 AU2019316103A AU2019316103A AU2019316103B2 AU 2019316103 B2 AU2019316103 B2 AU 2019316103B2 AU 2019316103 A AU2019316103 A AU 2019316103A AU 2019316103 A AU2019316103 A AU 2019316103A AU 2019316103 B2 AU2019316103 B2 AU 2019316103B2
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Prior art keywords
antibody
oligonucleotide
transferrin receptor
muscle
complex
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Application number
AU2019316103A
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English (en)
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AU2019316103A1 (en
Inventor
Mohammed T. QATANANI
Romesh R. Subramanian
Timothy Weeden
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Dyne Therapeutics Inc
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Dyne Therapeutics Inc
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Priority to AU2026203763A priority Critical patent/AU2026203763A1/en
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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AU2019316103A 2018-08-02 2019-08-02 Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy Active AU2019316103B2 (en)

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US201862713933P 2018-08-02 2018-08-02
US62/713,933 2018-08-02
PCT/US2019/044990 WO2020028864A1 (en) 2018-08-02 2019-08-02 Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy

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