AU2008334945C1 - Compositions and methods for producing isoprene - Google Patents

Compositions and methods for producing isoprene Download PDF

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Publication number
AU2008334945C1
AU2008334945C1 AU2008334945A AU2008334945A AU2008334945C1 AU 2008334945 C1 AU2008334945 C1 AU 2008334945C1 AU 2008334945 A AU2008334945 A AU 2008334945A AU 2008334945 A AU2008334945 A AU 2008334945A AU 2008334945 C1 AU2008334945 C1 AU 2008334945C1
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AU
Australia
Prior art keywords
cells
isoprene
polypeptide
nucleic acid
isoprene synthase
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Ceased
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AU2008334945A
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English (en)
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AU2008334945B2 (en
AU2008334945A1 (en
AU2008334945B8 (en
Inventor
Zachary Quinn Beck
Marguerite Cervin
Gopal K. Chotani
Frank J. Feher
Richard J. La Duca
Joseph C. Mcauliffe
Andrei Miasnikov
Michael Charles Miller
Alex Nielson
Caroline Peres
Aaron S. Puhala
Karl J. Sanford
Fernando Valle
Gregory M. Whited
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goodyear Tire and Rubber Co
Danisco US Inc
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Goodyear Tire and Rubber Co
Danisco US Inc
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Publication of AU2008334945A1 publication Critical patent/AU2008334945A1/en
Priority to AU2013201497A priority Critical patent/AU2013201497B2/en
Publication of AU2008334945B2 publication Critical patent/AU2008334945B2/en
Application granted granted Critical
Publication of AU2008334945B8 publication Critical patent/AU2008334945B8/en
Publication of AU2008334945C1 publication Critical patent/AU2008334945C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1022Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1229Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01036Mevalonate kinase (2.7.1.36)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01033Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y402/00Carbon-oxygen lyases (4.2)
    • C12Y402/03Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027Isoprene synthase (4.2.3.27)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y503/00Intramolecular oxidoreductases (5.3)
    • C12Y503/03Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03002Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/30Fuel from waste, e.g. synthetic alcohol or diesel

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2008334945A 2007-12-13 2008-12-15 Compositions and methods for producing isoprene Ceased AU2008334945C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013201497A AU2013201497B2 (en) 2007-12-13 2013-03-13 Compositions and methods for producing isoprene

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1357407P 2007-12-13 2007-12-13
US61/013,574 2007-12-13
PCT/US2008/086869 WO2009076676A2 (en) 2007-12-13 2008-12-15 Compositions and methods for producing isoprene

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013201497A Division AU2013201497B2 (en) 2007-12-13 2013-03-13 Compositions and methods for producing isoprene

Publications (4)

Publication Number Publication Date
AU2008334945A1 AU2008334945A1 (en) 2009-06-18
AU2008334945B2 AU2008334945B2 (en) 2013-06-27
AU2008334945B8 AU2008334945B8 (en) 2013-07-04
AU2008334945C1 true AU2008334945C1 (en) 2013-09-05

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AU2008334945A Ceased AU2008334945C1 (en) 2007-12-13 2008-12-15 Compositions and methods for producing isoprene

Country Status (13)

Country Link
US (5) US8288148B2 (https=)
EP (2) EP3354740A1 (https=)
JP (3) JP6049982B2 (https=)
KR (1) KR20100118973A (https=)
CN (2) CN105368764B (https=)
AU (1) AU2008334945C1 (https=)
BR (1) BRPI0823506A8 (https=)
CA (1) CA2709107A1 (https=)
DK (1) DK2235190T3 (https=)
MX (1) MX2010006576A (https=)
RU (1) RU2545699C2 (https=)
SG (2) SG191671A1 (https=)
WO (1) WO2009076676A2 (https=)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8609385B2 (en) 2007-05-01 2013-12-17 Zuvachem, Inc. Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
CN105368764B (zh) 2007-12-13 2019-03-12 丹尼斯科美国公司 用于生产异戊二烯的组合物和方法
WO2009132220A2 (en) 2008-04-23 2009-10-29 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
JP5624980B2 (ja) * 2008-06-30 2014-11-12 ザ・グッドイヤー・タイヤ・アンド・ラバー・カンパニーThe Goodyeartire & Rubber Company 再生資源に由来するイソプレンの重合体
MX318543B (es) * 2008-07-02 2014-03-18 Danisco Us Inc Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
EP2344629B1 (en) 2008-09-15 2018-01-24 Danisco US Inc. Systems using cell culture for production of isoprene
CA2737082A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
CA2737223A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
WO2010031062A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
MY161071A (en) 2008-12-30 2017-04-14 Danisco Us Inc Methods of producing isoprene and a co-product
US8324442B2 (en) * 2009-03-03 2012-12-04 Amyris, Inc. Microbial derived isoprene and methods for making the same
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
TW201120213A (en) 2009-06-17 2011-06-16 Danisco Us Inc Polymerization of isoprene from renewable resources
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用dxp及mva途徑之改良之異戊二烯製造
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
US20110039323A1 (en) * 2009-08-14 2011-02-17 Eric Lawrence Singsaas Isoprene Production
DK2480660T5 (da) 2009-09-23 2020-11-09 Danisco Us Inc Hidtil ukendte glycosylhydrolaseenzymer og anvendelser heraf
US8569562B2 (en) 2009-12-18 2013-10-29 Danisco Us Inc. Purification of isoprene from renewable resources
BR112012015117A2 (pt) 2009-12-22 2019-09-24 Danisco Us Inc "biorreator de membrana para produção aumentada de gás isopreno"
WO2011076261A1 (en) 2009-12-22 2011-06-30 Global Bioenergies Process for the production of isoprenol from mevalonate employing a diphosphomevalonate decarboxylase
AU2010333801B2 (en) 2009-12-23 2015-12-17 Danisco Us Inc. Methods for improving the efficiency of simultaneous saccharification and fermentation reactions
SG196782A1 (en) 2009-12-23 2014-02-13 Danisco Us Inc Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl)
KR101814648B1 (ko) * 2010-05-05 2018-01-04 게노마티카 인코포레이티드 부타디엔을 생합성하기 위한 미생물 및 방법
US8933282B2 (en) 2010-06-17 2015-01-13 Danisco Us Inc. Fuel compositions comprising isoprene derivatives
CA2807558A1 (en) 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
CA2816306A1 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
CN102559769B (zh) * 2010-12-20 2014-07-30 中国科学院青岛生物能源与过程研究所 一种制备异戊二烯的重组细胞及其制备方法
JP2014502844A (ja) 2010-12-22 2014-02-06 ダニスコ・ユーエス・インク 組み換え細胞による五炭糖の生物学的生産
BR112013018316A2 (pt) 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg
US20140051129A1 (en) * 2011-02-23 2014-02-20 Syngenta Participations Ag Potentiation of enzymatic saccharification
JP6290626B2 (ja) 2011-03-17 2018-03-14 ダニスコ・ユーエス・インク 糖化プロセスにおける粘度を低下させる方法
CN103492561A (zh) 2011-03-17 2014-01-01 丹尼斯科美国公司 纤维素酶组合物和使用相同组合物用于改善木质纤维素生物质转化成可发酵糖的方法
BR112013027555A2 (pt) 2011-04-29 2021-08-10 Danisco Us Inc. células recombinantes capazes de maior produção de isopreno, mevalonato e isoprenoides e método para produzir isopreno, mevalonato e isoprenoides
SG194691A1 (en) 2011-04-29 2013-12-30 Danisco Us Inc Production of mevalonate, isoprene, and isoprenoids using genes encodingpolypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities
US9169486B2 (en) 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
BR112014002661A2 (pt) 2011-08-04 2019-09-24 Danisco Us Inc produção de isopreno, precursores de isoprenoide, e isoprenoides com o uso de acetoacetil-coa sintase
BR112014002405A2 (pt) 2011-08-04 2017-04-04 Novozymes As polopeptídeo e polinucleotídeo isolados, composição, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, planta transgênica, parte da planta ou célula de planta, métodos para produzir um polipeptídeo e uma proteína, e, processos para degradar um material celulóssico, para produzir um produto de fermentação, e para fermentar um material celulósico
WO2013022799A1 (en) 2011-08-05 2013-02-14 Danisco Us Inc. PRODUCTION OF ISOPRENOIDS UNDER NEUTRAL pH CONDITIONS
KR20140070605A (ko) 2011-09-16 2014-06-10 게노마티카 인코포레이티드 알켄을 생산하기 위한 유기체 및 방법
WO2013052914A2 (en) * 2011-10-07 2013-04-11 Danisco Us Inc. Methods for increasing microbial production of isoprene, isoprenoids, and isoprenoid precursor molecules using glucose and acetate co-metabolism
BR112014008278A2 (pt) 2011-10-07 2017-04-18 Danisco Us Inc utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno
EP2766492B1 (en) 2011-10-11 2018-06-06 Metabolic Explorer Fermentative production of prenol
EP2771460B1 (en) 2011-10-27 2017-04-26 Danisco US Inc. Isoprene synthase variants with improved solubility for production of isoprene
EP2794891A2 (en) 2011-12-20 2014-10-29 Scientist of Fortune S.A. Production of 1,3-dienes by enzymatic conversion of 3-hydroxyalk-4-enoates and/or 3-phosphonoxyalk-4-enoates
JP2015510392A (ja) 2011-12-23 2015-04-09 ダニスコ・ユーエス・インク 低減したispa活性を有する宿主細胞を用いるイソプレン産生増強法
US8865442B2 (en) 2011-12-23 2014-10-21 Danisco Us Inc. Production of isoprene under reduced oxygen inlet levels
US20140128645A1 (en) * 2011-12-23 2014-05-08 The Goodyear Tire & Rubber Company Enhanced production of isoprene using marine bacterial cells
WO2013096863A1 (en) * 2011-12-23 2013-06-27 The Regents Of The University Of California Constructs and methods for improved isoprene biosynthesis
US9315831B2 (en) 2012-03-30 2016-04-19 Danisco Us Inc. Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
WO2013150100A1 (en) 2012-04-05 2013-10-10 Global Bioenergies Method for the enzymatic production of isoprenol using mevalonate as a substrate
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
US8741613B2 (en) * 2012-05-16 2014-06-03 Glycos Biotechnologies, Inc. Microorganisms and processes for the production of isoprene
CN104471061B (zh) * 2012-05-30 2018-06-22 株式会社普利司通 异戊二烯合酶和其编码基因以及用于产生异戊二烯单体的方法
US8962296B2 (en) 2012-05-30 2015-02-24 Bridgestone Corporation Isoprene synthase and gene encoding the same, and method for producing isoprene monomer
US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
US8703455B2 (en) 2012-08-29 2014-04-22 Scientist of Fourtune, S.A. Production of volatile dienes by enzymatic dehydration of light alkenols
CN104919038A (zh) 2012-10-23 2015-09-16 积水化学工业株式会社 重组细胞以及异戊二烯的生产方法
WO2014076232A2 (en) * 2012-11-19 2014-05-22 Novozymes A/S Isopropanol production by recombinant hosts using an hmg-coa intermediate
US20160002672A1 (en) 2012-12-21 2016-01-07 Danisco Us Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway
KR20150100666A (ko) * 2012-12-27 2015-09-02 세키스이가가쿠 고교가부시키가이샤 재조합 세포, 및 이소프렌의 생산 방법
BR112015021003A2 (pt) * 2013-03-07 2017-07-18 Calysta Inc composições e métodos para a produção biológica de isopreno.
CA2905265A1 (en) * 2013-03-14 2014-10-02 President And Fellows Of Harvard College Genetically modified bacteria
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
WO2014156997A1 (ja) 2013-03-29 2014-10-02 味の素株式会社 発酵ガス中のイソプレンの回収方法および精製イソプレンの製造方法
SG11201508186XA (en) 2013-04-10 2015-11-27 Danisco Us Inc Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
CN103233044B (zh) * 2013-05-27 2014-08-06 青岛蔚蓝生物集团有限公司 一种异戊二烯的生产方法及其生产菌株
CN103232986B (zh) * 2013-05-27 2014-06-18 青岛蔚蓝生物集团有限公司 一种异戊二烯生产方法
WO2014205355A2 (en) 2013-06-21 2014-12-24 Danisco Us Inc. Compositions and methods for clostridial transformation
RU2013146377A (ru) 2013-10-17 2015-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ ИЗОПРЕНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Bacillus
MY172689A (en) 2013-11-22 2019-12-10 Ajinomoto Kk Modified isoprene synthase
WO2015080273A1 (ja) 2013-11-28 2015-06-04 味の素株式会社 イソプレンモノマーの製造方法
US10648004B2 (en) 2014-02-20 2020-05-12 Danisco Us Inc. Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
RU2014112066A (ru) 2014-03-28 2015-10-10 Адзиномото Ко., Инк. Способ получения мономерного изопрена
WO2016015021A1 (en) 2014-07-24 2016-01-28 The Regents Of The University Of California Oxidative starch degradation by a new family of pmos
CN112279744B (zh) 2014-11-26 2023-08-15 维索利斯有限公司 用于生物学衍生的甲羟戊酸转化的方法
JP6720433B2 (ja) * 2015-02-18 2020-07-08 誠司 仲亀 イソプレンの製造方法
CN106554933A (zh) * 2015-09-30 2017-04-05 中国科学院上海生命科学研究院 异戊二烯基因工程生产菌及其应用
WO2017132924A1 (zh) * 2016-02-04 2017-08-10 中国科学院微生物研究所 一种用于生物合成异戊二烯和异戊烯的酶及其突变体
CN107365758B (zh) * 2016-05-12 2021-03-05 山东常青藤生物科技有限公司 五碳平台化合物合成基因及其应用
WO2018203947A2 (en) 2017-02-06 2018-11-08 Zymergen Inc. Engineered biosynthetic pathways for production of tyramine by fermentation
WO2018147446A1 (ja) * 2017-02-10 2018-08-16 味の素株式会社 イソプレノイド化合物の製造方法
CN110268058B (zh) * 2017-02-27 2023-11-21 积水化学工业株式会社 重组细胞、重组细胞的制备方法以及异戊二烯或萜烯的生产方法
CN110914416B (zh) 2017-04-27 2023-07-21 加州大学董事会 产生大麻素和大麻素衍生物的微生物和方法
US11452967B2 (en) 2017-07-17 2022-09-27 Zymergen Inc. Metal-organic framework materials
JP2020536993A (ja) 2017-10-05 2020-12-17 ザイマージェン インコーポレイテッド 光学的に透明なポリイミド
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
WO2020069142A1 (en) 2018-09-26 2020-04-02 Demetrix, Inc. Optimized expression systems for expressing berberine bridge enzyme and berberine bridge enzyme-like polypeptides
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
ES2944837T3 (es) 2018-11-08 2023-06-26 Sutro Biopharma Inc Cepas de E. coli con citoplasma oxidativo
CN109482064A (zh) * 2018-11-22 2019-03-19 中国科学院北京综合研究中心 医疗废物焚烧烟气汞和二噁英深度处理系统
WO2020181091A1 (en) 2019-03-05 2020-09-10 Bp Corporation North America Inc. Fatty acyl-acp reductases and their uses
CA3140079A1 (en) 2019-05-22 2020-11-26 Demetrix, Inc. Optimized cannabinoid synthase polypeptides
AU2020349513A1 (en) 2019-09-18 2022-05-05 Demetrix, Inc. Optimized tetrahydrocannabinolic acid (THCA) synthase polypeptides
WO2021183448A1 (en) 2020-03-09 2021-09-16 Demetrix, Inc. Optimized olivetolic acid cyclase polypeptides
US12351850B2 (en) * 2020-04-30 2025-07-08 Sutro Biopharma, Inc. Methods of producing full-length antibodies using E. coli
CN113774092B (zh) * 2021-09-27 2022-11-08 哈尔滨工业大学(深圳) 一种由环境废水合成异戊二烯的方法
CN116121288B (zh) * 2023-03-27 2023-09-01 广东省科学院微生物研究所(广东省微生物分析检测中心) 一组克隆恶臭假单胞菌大片段dna的载体及其应用
CN118475621A (zh) 2023-06-19 2024-08-09 杭州恩和生物科技有限公司 生产7-脱氢胆固醇的融合多肽及其使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002550A2 (de) * 1996-07-15 1998-01-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrobielle erzeugung von isopren

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1344713A (en) * 1915-12-02 1920-06-29 Westinghouse Electric & Mfg Co Reactance-coil
DE1793254A1 (de) * 1968-08-23 1971-12-16 Bayer Ag Verfahren zur Gewinnung von Cyclopenten,Isopren und einem Diolefinstrom aus C?-Crackbenzinschnitten
CA1338400C (en) 1983-08-31 1996-06-18 David H. Gelfand Recombinant fungal cellulases
US5380831A (en) * 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
DE3338269A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen Verfahren zur gewinnung von isopren aus einem c(pfeil abwaerts)5(pfeil abwaerts)-kohlenwasserstoffgemisch
GB8407828D0 (en) 1984-03-27 1984-05-02 Ontario Research Foundation In situ preparation
US4570029A (en) 1985-03-04 1986-02-11 Uop Inc. Process for separating isoprene
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
DE3650202T3 (de) 1985-08-29 2004-06-03 Genencor International, Inc., South San Francisco Expression von heterologen Polypeptiden in filamentösen Pilzen, Verfahren zu deren Herstellung und Vektoren zu deren Herstellung.
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4846872A (en) * 1986-08-11 1989-07-11 Fujisawa Pharmaceutical Co., Ltd. Herbicide
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5545816A (en) * 1990-03-02 1996-08-13 Amoco Corporation Phytoene biosynthesis in genetically engineered hosts
US5306862A (en) * 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
WO1992010581A1 (en) * 1990-12-10 1992-06-25 Genencor International, Inc. IMPROVED SACCHARIFICATION OF CELLULOSE BY CLONING AND AMPLIFICATION OF THE β-GLUCOSIDASE GENE OF TRICHODERMA REESEI
RU2027760C1 (ru) * 1991-02-01 1995-01-27 Казанский институт биологии Способ получения жидких углеводородов
TW261517B (https=) * 1991-11-29 1995-11-01 Mitsubishi Shozi Kk
WO1995004134A1 (en) 1993-08-02 1995-02-09 Genencor International, Inc. Method of reducing complex carbohydrates in fermentation products
US5861271A (en) 1993-12-17 1999-01-19 Fowler; Timothy Cellulase enzymes and systems for their expressions
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) * 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
US8106260B2 (en) * 1996-04-12 2012-01-31 The Board Of Trustees Of The University Of Kentucky Chimeric isoprenoid synthases and uses thereof
US5824774A (en) * 1996-04-12 1998-10-20 Board Of Trustees Of The University Of Kentucky Chimeric isoprenoid synthases and uses thereof
USRE39350E1 (en) * 1997-01-17 2006-10-17 The Scripps Research Institute RNA binding protein and binding site useful for expression of recombinant molecules
EP2175025A1 (en) 1998-04-14 2010-04-14 Kyowa Hakko Bio Co., Ltd. Process for producing isoprenoid compounds by using microorganisms
US6176176B1 (en) 1998-04-30 2001-01-23 Board Of Trustees Operating Michigan State University Apparatus for treating cellulosic materials
AR022383A1 (es) 1998-09-18 2002-09-04 Univ Kentucky Res Found Sintasas
US6268328B1 (en) 1998-12-18 2001-07-31 Genencor International, Inc. Variant EGIII-like cellulase compositions
US6442536B1 (en) 2000-01-18 2002-08-27 Praxair Technology, Inc. Method for predicting flammability limits of complex mixtures
WO2001058839A1 (en) 2000-02-07 2001-08-16 Eastman Chemical Company Process to recover condensable gases from oxygen containing mixtures
KR20010084864A (ko) 2000-02-29 2001-09-06 김수언 개똥쑥의 아모파-4,11-디엔 합성효소, 이를 코딩하는유전자, 이 유전자를 포함하는 발현벡터 및, 이발현벡터로 형질전환된 대장균 및 식물체
US6270739B1 (en) * 2000-06-16 2001-08-07 Eastman Chemical Company Process for the removal of carbon dioxide from 3,4-epoxy-1-butene process recycle streams
WO2002010398A2 (en) * 2000-07-31 2002-02-07 Hahn Frederick M Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US6553689B2 (en) * 2000-09-24 2003-04-29 3M Innovative Properties Company Vapor collection method and apparatus
US6582914B1 (en) 2000-10-26 2003-06-24 Genencor International, Inc. Method for generating a library of oligonucleotides comprising a controlled distribution of mutations
IL158128A0 (en) * 2001-04-03 2004-03-28 Biocept Inc Methods and gel compositions for encapsulating living cells and organic molecules
WO2002081631A2 (en) * 2001-04-04 2002-10-17 Genencor International, Inc. Uncoupled productive and catabolic host cell pathways
RU2197461C2 (ru) 2001-04-05 2003-01-27 Общество с ограниченной ответственностью "Еврохим-СПб-Трейдинг" Способ получения изопрена
AU2002316966B2 (en) * 2001-06-06 2007-05-17 Dsm Ip Assets B.V. Improved isoprenoid production
US6998471B2 (en) * 2001-07-25 2006-02-14 E.I. Du Pont De Nemours And Company Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7192751B2 (en) * 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
KR20040104581A (ko) * 2002-04-22 2004-12-10 이 아이 듀폰 디 네모아 앤드 캄파니 유전공학용 프로모터 및 플라스미드 시스템
JPWO2003095651A1 (ja) * 2002-05-10 2005-09-15 協和醗酵工業株式会社 メバロン酸の製造方法
KR101148255B1 (ko) 2002-10-04 2012-08-08 다니스코 유에스 인크. 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법
US20040219629A1 (en) * 2002-12-19 2004-11-04 Qiong Cheng Increasing carotenoid production in bacteria via chromosomal integration
FR2850101B1 (fr) * 2003-01-22 2007-03-02 Michelin Soc Tech Procede d'obtention d'une coupe c5 "fcc" enrichie en isoprene et polymerisation selective de l'isoprene a partir de cette coupe
ATE524491T1 (de) 2003-05-29 2011-09-15 Genencor Int Neue trichoderma-gene
US7422884B2 (en) 2003-06-12 2008-09-09 Dsm Ip Assetts B.V. Feedback-resistant mevalonate kinases
PL202927B1 (pl) 2003-07-20 2009-08-31 Carr Daniel R Peptyd i kompozycja farmaceutyczna oraz ich zastosowania medyczne
CN102174490B (zh) 2003-11-21 2016-09-28 丹尼斯科美国公司 颗粒淀粉水解酶在木霉菌中的表达和从颗粒淀粉底物产生葡萄糖的方法
US20070281332A1 (en) 2004-02-13 2007-12-06 Allan Svendsen Protease Variants
ATE537269T1 (de) * 2004-05-21 2011-12-15 Univ California Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen
US7479565B2 (en) * 2004-06-18 2009-01-20 Shell Oil Company Process for the production of an olefin oxide, a 1,2-diol, a 1,2-diol ether, or an alkanolamine
US8338155B2 (en) 2004-12-14 2012-12-25 Dsm Ip Assets B.V. Modified mevalonate kinase with reduced feedback inhibition
JP4117350B2 (ja) 2005-03-03 2008-07-16 富山県 機能改変フェニルアラニン脱水素酵素、およびこの酵素を用いた生体試料中のアミノ酸の分析方法
JP4446482B2 (ja) 2005-08-10 2010-04-07 独立行政法人産業技術総合研究所 ユーカリ・モノテルペン合成酵素遺伝子
CN101384719B (zh) * 2006-02-14 2012-10-03 弗门尼舍有限公司 用于生成萜的方法和用于该方法的mep转化后的微生物
US8114645B2 (en) 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
WO2007140339A2 (en) 2006-05-26 2007-12-06 Amyris Biotechnologies, Inc. Production of isoprenoids
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
JP2008035831A (ja) 2006-08-09 2008-02-21 Nitta Ind Corp 有用部分の生産性が高められた植物及びその作製方法
JP2008182950A (ja) 2007-01-30 2008-08-14 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai 柑橘類酵素遺伝子調製方法
US8609385B2 (en) * 2007-05-01 2013-12-17 Zuvachem, Inc. Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
KR20100028031A (ko) 2007-06-06 2010-03-11 다니스코 유에스 인크. 단백질 특성의 개선 방법
AU2008299020A1 (en) 2007-09-11 2009-03-19 Sapphire Energy, Inc. Molecule production by photosynthetic organisms
WO2009064910A2 (en) 2007-11-13 2009-05-22 Synthetic Genomics, Inc. Dimethyloctane as an advanced biofuel
CN105368764B (zh) 2007-12-13 2019-03-12 丹尼斯科美国公司 用于生产异戊二烯的组合物和方法
US20110045563A1 (en) 2008-02-06 2011-02-24 The Regents Of The University Of California Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi
JP2009207402A (ja) 2008-03-04 2009-09-17 Shizuokaken Koritsu Daigaku Hojin 組換えサビネン合成酵素及びその利用
WO2009132220A2 (en) * 2008-04-23 2009-10-29 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
JP5624980B2 (ja) 2008-06-30 2014-11-12 ザ・グッドイヤー・タイヤ・アンド・ラバー・カンパニーThe Goodyeartire & Rubber Company 再生資源に由来するイソプレンの重合体
MX318543B (es) * 2008-07-02 2014-03-18 Danisco Us Inc Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
EP2340312A2 (en) 2008-09-15 2011-07-06 Danisco US Inc. Conversion of prenyl derivatives to isoprene
EP2344629B1 (en) * 2008-09-15 2018-01-24 Danisco US Inc. Systems using cell culture for production of isoprene
WO2010031062A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
CA2737082A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
CA2737223A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
MY161071A (en) * 2008-12-30 2017-04-14 Danisco Us Inc Methods of producing isoprene and a co-product
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
GB2459392B (en) 2009-05-29 2010-04-07 Softbox Systems Ltd Transport container
US9716308B2 (en) 2012-02-13 2017-07-25 The United States Of America, As Represented By The Secretary Of The Navy Wideband multi-function phased array antenna aperture
US9718908B2 (en) 2013-03-15 2017-08-01 Univation Technologies, Llc Polymer products and multi-stage polymerization processes for the production thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002550A2 (de) * 1996-07-15 1998-01-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrobielle erzeugung von isopren

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Sharkey TD et al, Plant Physiology, 2005, 137(2):700-712 *

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