ATE79901T1 - Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend. - Google Patents

Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.

Info

Publication number
ATE79901T1
ATE79901T1 AT86105365T AT86105365T ATE79901T1 AT E79901 T1 ATE79901 T1 AT E79901T1 AT 86105365 T AT86105365 T AT 86105365T AT 86105365 T AT86105365 T AT 86105365T AT E79901 T1 ATE79901 T1 AT E79901T1
Authority
AT
Austria
Prior art keywords
processes
compositions containing
intermediate products
mature human
human leukocyte
Prior art date
Application number
AT86105365T
Other languages
German (de)
English (en)
Inventor
David Van Norman Goeddel
Sidney Pestka
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE79901(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE79901T1 publication Critical patent/ATE79901T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT86105365T 1980-07-01 1981-06-30 Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend. ATE79901T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons
EP86105365A EP0211148B2 (en) 1980-07-01 1981-06-30 Mature human leukozyte interferons, process for their bacterial production, intermediates therefor and compositions containing them

Publications (1)

Publication Number Publication Date
ATE79901T1 true ATE79901T1 (de) 1992-09-15

Family

ID=27496622

Family Applications (3)

Application Number Title Priority Date Filing Date
AT86105365T ATE79901T1 (de) 1980-07-01 1981-06-30 Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.
AT0290981A AT380272B (de) 1980-07-01 1981-06-30 Verfahren zur herstellung von mikroorganismen
AT81105067T ATE29727T1 (de) 1980-07-01 1981-06-30 Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen.

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT0290981A AT380272B (de) 1980-07-01 1981-06-30 Verfahren zur herstellung von mikroorganismen
AT81105067T ATE29727T1 (de) 1980-07-01 1981-06-30 Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen.

Country Status (36)

Country Link
EP (2) EP0043980B1 (en, 2012)
AR (1) AR242833A1 (en, 2012)
AT (3) ATE79901T1 (en, 2012)
AU (1) AU552004B2 (en, 2012)
BG (1) BG42189A3 (en, 2012)
BR (1) BR8104189A (en, 2012)
CH (2) CH651308A5 (en, 2012)
CS (1) CS273152B2 (en, 2012)
DD (3) DD210304A5 (en, 2012)
DE (3) DE3125706C2 (en, 2012)
DK (1) DK173543B1 (en, 2012)
DZ (1) DZ312A1 (en, 2012)
ES (1) ES8207514A1 (en, 2012)
FI (1) FI82712C (en, 2012)
FR (1) FR2486098B1 (en, 2012)
GB (1) GB2079291B (en, 2012)
GE (1) GEP19960519B (en, 2012)
GR (1) GR75714B (en, 2012)
HK (1) HK49285A (en, 2012)
HU (1) HU196457B (en, 2012)
IE (1) IE49255B1 (en, 2012)
IT (1) IT1137272B (en, 2012)
KE (1) KE3534A (en, 2012)
LU (1) LU83461A1 (en, 2012)
MC (1) MC1396A1 (en, 2012)
MY (1) MY8700711A (en, 2012)
NL (1) NL8103151A (en, 2012)
NO (1) NO159392C (en, 2012)
NZ (1) NZ197572A (en, 2012)
PH (1) PH18036A (en, 2012)
PL (3) PL148261B1 (en, 2012)
PT (1) PT73289B (en, 2012)
RO (1) RO87590A (en, 2012)
SE (2) SE8104093L (en, 2012)
SU (1) SU1414319A3 (en, 2012)
YU (1) YU47700B (en, 2012)

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DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
EP0085693A1 (en) * 1981-08-14 1983-08-17 A/S Alfred Benzon Subjects relating to human inteferon-alpha subtype proteins and corresponding antibodies
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
ATE64618T1 (de) * 1982-03-15 1991-07-15 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
JPS60500574A (ja) * 1983-02-24 1985-04-25 インステイチユト　オルガニチエスコゴ　シンテザ　アカデミイ　ナウク　ラトビイスコイ　エスエスア−ル ヒト白血球インタ−フェロンｎ及び細菌細胞におけるその製造方法
WO1985002862A1 (en) * 1983-12-23 1985-07-04 Monash University PRODUCTION OF HUMAN INTERFERON-alpha
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
WO1995024212A1 (en) * 1994-03-07 1995-09-14 Imperial College Of Science, Technology & Medicine The use of interferon subtypes in the preparation of medicaments to treat viral infections
DK0679718T3 (da) * 1994-04-09 2001-10-22 Hoffmann La Roche Fremgangsmåde til fremstilling af alfa-interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
JP2001526033A (ja) 1997-12-08 2001-12-18 ジェネンテク・インコーポレイテッド ヒトインターフェロン−イプシロンというｉ型インターフェロン
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
CN1896231B (zh) 1998-08-06 2012-09-05 山景药品公司 分离四聚体尿酸氧化酶的方法
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
EP1355939A2 (en) * 2000-11-03 2003-10-29 Pestka Biomedical Laboratories, Inc. Interferons, uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
EP2947145A1 (en) 2005-04-11 2015-11-25 Crealta Pharmaceuticals LLC Variant forms of urate oxidase and use thereof
KR20100103595A (ko) * 2008-01-18 2010-09-27 에프. 호프만-라 로슈 아게 비-글라이코실화된 단백질의 정제
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
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IN150740B (en, 2012) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
DK170236B1 (da) * 1980-01-08 1995-07-10 Biogen Inc Rekombinante DNA-molekyler, fremgangsmåde til fremstilling af et polypeptid af IFN-alfa typen og fremgangsmåde til udvælgelse af DNA-sekvenser, der koder for polypeptider af IFN-alfa typen
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
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Also Published As

Publication number Publication date
NO159392C (no) 1988-12-21
AT380272B (de) 1986-05-12
CH651308A5 (de) 1985-09-13
IT8122682A0 (it) 1981-07-01
EP0211148B1 (en) 1992-08-26
DE3125706C2 (de) 1995-05-24
HK49285A (en) 1985-07-05
FR2486098B1 (fr) 1985-12-27
AR242833A1 (es) 1993-05-31
ES503528A0 (es) 1982-10-01
DD202307A5 (de) 1983-09-07
PH18036A (en) 1985-03-06
CS273152B2 (en) 1991-03-12
SE8104093L (sv) 1982-01-02
EP0211148B2 (en) 1999-11-24
AU552004B2 (en) 1986-05-22
DE3177288T3 (de) 2000-03-16
DE3176448D1 (en) 1987-10-22
PT73289B (en) 1983-05-11
IE811463L (en) 1982-01-01
CH657141A5 (de) 1986-08-15
EP0043980A2 (en) 1982-01-20
NZ197572A (en) 1985-07-31
PL148261B1 (en) 1989-09-30
MC1396A1 (fr) 1982-04-27
ES8207514A1 (es) 1982-10-01
SE465223C5 (sv) 1998-02-10
FI82712B (fi) 1990-12-31
NL8103151A (nl) 1982-02-01
ATE29727T1 (de) 1987-10-15
AU7246281A (en) 1982-01-07
LU83461A1 (de) 1983-04-06
HU196457B (en) 1988-11-28
DK173543B1 (da) 2001-02-05
RO87590A (ro) 1986-07-30
BR8104189A (pt) 1982-03-16
IE49255B1 (en) 1985-09-04
IT1137272B (it) 1986-09-03
GEP19960519B (en) 1996-07-02
PL148260B1 (en) 1989-09-30
DZ312A1 (fr) 2004-09-13
DE3125706A1 (de) 1982-04-15
NO159392B (no) 1988-09-12
KE3534A (en) 1985-06-07
FR2486098A1 (fr) 1982-01-08
YU47700B (sh) 1996-01-08
GB2079291A (en) 1982-01-20
YU162281A (en) 1984-02-29
GR75714B (en, 2012) 1984-08-02
DE3177288D1 (de) 1992-10-01
BG42189A3 (en) 1987-10-15
EP0043980B1 (en) 1987-09-16
EP0043980A3 (en) 1982-09-15
PL148276B1 (en) 1989-09-30
EP0211148A1 (en) 1987-02-25
FI812067L (fi) 1982-01-02
FI82712C (fi) 1991-04-10
MY8700711A (en) 1987-12-31
DE3177288T2 (de) 1992-12-10
GB2079291B (en) 1984-06-13
SE465223B (sv) 1991-08-12
DD210304A5 (de) 1984-06-06
PL231940A1 (en) 1983-07-18
SU1414319A3 (ru) 1988-07-30
ATA290981A (de) 1985-09-15
PT73289A (en) 1981-07-01
CS503781A2 (en) 1990-07-12
DD210305A5 (de) 1984-06-06
DK291081A (da) 1982-01-02
NO812247L (no) 1982-01-04

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