ATE378365T1 - Bioabbaubare niedermolekulare triblock-polyester- polyethylenglykol-copolymere mit umgekehrter thermischer gelierung - Google Patents

Bioabbaubare niedermolekulare triblock-polyester- polyethylenglykol-copolymere mit umgekehrter thermischer gelierung

Info

Publication number
ATE378365T1
ATE378365T1 AT99954698T AT99954698T ATE378365T1 AT E378365 T1 ATE378365 T1 AT E378365T1 AT 99954698 T AT99954698 T AT 99954698T AT 99954698 T AT99954698 T AT 99954698T AT E378365 T1 ATE378365 T1 AT E378365T1
Authority
AT
Austria
Prior art keywords
composition
tri
polymer
gel
drug
Prior art date
Application number
AT99954698T
Other languages
English (en)
Inventor
Ramesh Rathi
Gaylen Zentner
Byeongmoon Jeong
Original Assignee
Protherics Salt Lake City Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/164,865 external-priority patent/US6117949A/en
Application filed by Protherics Salt Lake City Inc filed Critical Protherics Salt Lake City Inc
Application granted granted Critical
Publication of ATE378365T1 publication Critical patent/ATE378365T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT99954698T 1998-10-01 1999-09-30 Bioabbaubare niedermolekulare triblock-polyester- polyethylenglykol-copolymere mit umgekehrter thermischer gelierung ATE378365T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/164,865 US6117949A (en) 1998-10-01 1998-10-01 Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US09/396,589 US6201072B1 (en) 1997-10-03 1999-09-15 Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties

Publications (1)

Publication Number Publication Date
ATE378365T1 true ATE378365T1 (de) 2007-11-15

Family

ID=26860925

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99954698T ATE378365T1 (de) 1998-10-01 1999-09-30 Bioabbaubare niedermolekulare triblock-polyester- polyethylenglykol-copolymere mit umgekehrter thermischer gelierung

Country Status (19)

Country Link
US (1) US6201072B1 (de)
EP (1) EP1141079B1 (de)
JP (1) JP4628545B2 (de)
KR (1) KR100558025B1 (de)
CN (1) CN1161396C (de)
AT (1) ATE378365T1 (de)
AU (1) AU758475B2 (de)
BR (1) BR9914258B1 (de)
CA (1) CA2345659C (de)
CY (1) CY1107888T1 (de)
DK (1) DK1141079T3 (de)
ES (1) ES2301250T3 (de)
IL (1) IL142313A0 (de)
NO (1) NO332941B1 (de)
NZ (1) NZ510832A (de)
PL (1) PL205127B1 (de)
RU (1) RU2232779C2 (de)
TR (1) TR200100900T2 (de)
WO (1) WO2000018821A1 (de)

Families Citing this family (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6841617B2 (en) * 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
EP1173151B1 (de) 1999-04-16 2003-07-09 Novo Nordisk A/S Trockene formbare arzneistoffformulierung
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US6998137B2 (en) * 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
CA2405557C (en) * 2000-04-12 2013-09-24 Human Genome Sciences, Inc. Albumin fusion proteins
US6723814B2 (en) * 2000-05-16 2004-04-20 Biocure, Inc. Amphiphilic copolymer planar membranes
US7767197B2 (en) 2000-06-22 2010-08-03 Endo Pharmaceuticals Colorado LLC Delivery vehicle composition and methods for delivering antigens and other drugs
EP1313425B1 (de) * 2000-07-14 2007-03-07 Novo Nordisk A/S Verfahren zum formen einer pharmazeutischen zusammensetzung in einem verpackungsmaterial
EP1328873A1 (de) * 2000-08-29 2003-07-23 Contivo, Inc. Virtuelle gruppen
US7666445B2 (en) 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
NZ525726A (en) * 2000-11-09 2004-10-29 Astrazeneca Ab Oral pharmaceutical composition containing a block copolymer
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
FR2822834B1 (fr) * 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
WO2002097038A2 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
KR100566911B1 (ko) * 2001-06-25 2006-04-03 주식회사 삼양사 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
DE60220796T2 (de) * 2001-07-14 2007-10-18 Samyang Corp. Positiv geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit negativ geladenem arzneistoff
US6592899B2 (en) 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
US7309498B2 (en) * 2001-10-10 2007-12-18 Belenkaya Bronislava G Biodegradable absorbents and methods of preparation
EP1443907A1 (de) * 2001-11-12 2004-08-11 Alkermes Controlled Therapeutics, Inc. Biokompatible polymer-mischungen und ihre verwendung
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
WO2003059934A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
ES2545090T3 (es) * 2001-12-21 2015-09-08 Human Genome Sciences, Inc. Proteínas de fusión de albúmina y GCSF
AU2003216424A1 (en) * 2002-02-25 2003-10-08 Guilford Pharmaceuticals, Inc. Phosphorus-containing compounds with polymeric chains, and methods of making and using the same
ITMI20020865A1 (it) * 2002-04-22 2003-10-22 Novamont Spa Poliesteri biodegradabili ottenuti mediante estrusione reattiva
US20030204180A1 (en) * 2002-04-30 2003-10-30 Kimberly-Clark Worldwide, Inc. Temperature responsive delivery systems
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20030228366A1 (en) * 2002-06-11 2003-12-11 Chung Shih Reconstitutable compositions of biodegradable block copolymers
CA2488497A1 (en) * 2002-06-11 2003-12-18 The Burnham Institute Neuroprotective synergy of erythropoietin and insulin-like growth factor
US20030232088A1 (en) * 2002-06-14 2003-12-18 Kimberly-Clark Worldwide, Inc. Materials with both bioadhesive and biodegradable components
US7037983B2 (en) 2002-06-14 2006-05-02 Kimberly-Clark Worldwide, Inc. Methods of making functional biodegradable polymers
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
DE60315472T2 (de) * 2002-09-24 2008-04-30 Asahi Kasei Chemicals Corp. Glycolsaüre copolymer und verfahren zu dessen herstellung
AU2003287488B8 (en) * 2002-11-12 2007-05-17 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions and dosage forms for buccal and sublingual delivery of tizanidine and methods of administering tizanidine sublingually or bucally
US6992543B2 (en) * 2002-11-22 2006-01-31 Raytheon Company Mems-tuned high power, high efficiency, wide bandwidth power amplifier
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
JP4735260B2 (ja) * 2003-07-07 2011-07-27 日油株式会社 三元ブロック共重合体、その製造法及び生体内適合材料
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862535B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US20080305140A1 (en) * 2004-01-12 2008-12-11 University Of Pennsylvania Long-Term Delivery Formulations and Methods of Use Thereof
US20090023644A1 (en) * 2004-01-13 2009-01-22 Southard Jeffery L Methods of using cgrp for cardiovascular and renal indications
US7976847B2 (en) * 2004-01-13 2011-07-12 Vasogenix Pharmaceuticals, Inc. Controlled release CGRP delivery composition for cardiovascular and renal indications
US20090023643A1 (en) * 2004-01-13 2009-01-22 Vasogenix Pharmaceuticals, Inc. Methods For Treating Acute Myocardial Infarction By Administering Calcitonin Gene Related Peptide And Compositions Containing The Same
WO2005074546A2 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human growth hormone polypeptides and their uses
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
KR101699142B1 (ko) * 2004-06-18 2017-01-23 암브룩스, 인코포레이티드 신규 항원-결합 폴리펩티드 및 이의 용도
US7638299B2 (en) * 2004-07-21 2009-12-29 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
US20060034889A1 (en) * 2004-08-16 2006-02-16 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
US20060153786A1 (en) 2004-12-10 2006-07-13 Talima Therapeutics, Inc. Compositions and methods for treating conditions of the nail unit
US20060275230A1 (en) 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
CN101087875B (zh) * 2004-12-22 2012-08-22 Ambrx公司 氨酰基-tRNA合成酶的组合物及其用途
NZ555206A (en) 2004-12-22 2010-09-30 Ambrx Inc Methods for expression and purification of recombinant human growth hormone
US7939496B2 (en) 2004-12-22 2011-05-10 Ambrx, Inc. Modified human growth horomone polypeptides and their uses
US7816320B2 (en) 2004-12-22 2010-10-19 Ambrx, Inc. Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
US8007775B2 (en) 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
EP1838305A1 (de) * 2005-01-21 2007-10-03 Richard H. Matthews Radiosensitizer-formulierungen mit nitrohistidinderivaten
MX2007009430A (es) * 2005-02-03 2007-08-17 Cinv Ag Materiales para suministro de farmacos producidos mediante la tecnologia de sol/gel.
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
CA2609205A1 (en) 2005-06-03 2006-12-14 Ambrx, Inc. Improved human interferon molecules and their uses
DE102005033101A1 (de) * 2005-07-15 2007-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Resorbierbare Polyetherester und ihre Verwendung zur Herstellung von medizinischen Implantaten
AU2006278328A1 (en) * 2005-08-04 2007-02-15 Angiotech International Ag Block copolymer compositions and uses thereof
NZ565294A (en) 2005-08-18 2010-06-25 Ambrx Inc Compositions of tRNA and uses thereof
CN1939534B (zh) * 2005-09-27 2010-12-01 长春金赛药业股份有限公司 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂
US7669732B2 (en) * 2005-10-25 2010-03-02 Imi Cornelius Inc. Cup lid dispenser
WO2007056448A2 (en) * 2005-11-08 2007-05-18 Ambrx, Inc. Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
US8124128B2 (en) * 2005-11-08 2012-02-28 Industrial Technology Research Institute Amphiphilic block copolymers and nano particles comprising the same
PT2339014E (pt) * 2005-11-16 2015-10-13 Ambrx Inc Métodos e composições compreendendo aminoácidos não-naturais
FR2893943B1 (fr) * 2005-11-28 2011-08-19 Centre Nat Rech Scient Procede de preparation de copolymeres par polymerisation anionique sans solvant
JP5485551B2 (ja) 2005-12-06 2014-05-07 コヴィディエン リミテッド パートナーシップ 生体吸収性化合物およびそれらを含む組成物
US20070142287A1 (en) * 2005-12-20 2007-06-21 Biomed Solutions, Llc Compositions And Methods For Treatment Of Cancer
US20070154546A1 (en) * 2005-12-30 2007-07-05 Zhang Jack Y Sustained release pharmaceutical compositions
KR100784485B1 (ko) 2006-01-18 2007-12-11 한국과학기술연구원 생분해성 온도 감응성 폴리포스파젠계 하이드로젤, 그의제조방법 및 그의 용도
ATE458773T1 (de) * 2006-03-09 2010-03-15 Coloplast As Abbaubare copolymere mit einem hydrophilen block mit verbesserter biokompatibilität für die weichgeweberegeneration
US20070224234A1 (en) * 2006-03-22 2007-09-27 Mark Steckel Medical devices having biodegradable polymeric regions
US7740877B2 (en) 2006-04-07 2010-06-22 University Of Utah Research Foundation Aliphatically modified biodegradable block copolymers as thermogelling polymers
CA2649915A1 (en) * 2006-04-20 2007-11-01 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
US8747870B2 (en) 2006-04-20 2014-06-10 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
US20100119529A1 (en) * 2006-05-12 2010-05-13 Furgeson Darin Y Elastin-like polymer delivery vehicles
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
DK2615108T3 (en) * 2006-09-08 2017-01-30 Ambrx Inc Modified human plasma polypeptide or fc scaffolds and their applications
NZ574960A (en) 2006-09-08 2012-02-24 Ambrx Inc Suppressor trna transcription in vertebrate cells
EP2061878B1 (de) * 2006-09-08 2014-01-08 Ambrx, Inc. Hybridunterdrücker-trna für wirbeltierzellen
JP2008069324A (ja) * 2006-09-15 2008-03-27 Mitsui Chemicals Inc 生分解性を有する水環境応答型ポリマーを含む水崩壊性組成物および水崩壊性成形体
CN1965802B (zh) * 2006-11-09 2010-04-14 复旦大学 一种聚乙二醇化药物的可注射性水凝胶制剂及其制备方法
MX2009004856A (es) * 2006-11-09 2009-06-05 Alcon Res Ltd Matriz polimerica insoluble en agua para suministro de farmaco.
US20080114076A1 (en) * 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
US8871242B2 (en) * 2006-11-17 2014-10-28 National Cerebral And Cardiovascular Center Blood anticoagulant material, coating material and indwelling device comprising the same, and treatment using blood anticoagulant material
US20080140106A1 (en) * 2006-12-12 2008-06-12 Kimberly-Clark Worldwide, Inc. Enhanced cuff sealing for endotracheal tubes
GB0701896D0 (en) 2007-02-01 2007-03-14 Regentec Ltd Composition
BRPI0809583B1 (pt) 2007-03-30 2022-02-22 Ambrx, Inc Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo
CN100445313C (zh) * 2007-04-24 2008-12-24 上海同杰良生物材料有限公司 一种聚乳酸/聚醚二元醇共聚物的制备方法
US8114630B2 (en) 2007-05-02 2012-02-14 Ambrx, Inc. Modified interferon beta polypeptides and their uses
FR2915683B1 (fr) * 2007-05-03 2009-08-07 Flamel Technologies Sa Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif
US20100099640A1 (en) * 2007-05-04 2010-04-22 Joannes Geuns Tissue degeneration protection
KR20080110473A (ko) 2007-06-14 2008-12-18 한국과학기술연구원 화학적 가교 결합을 가지는 포스파젠계 고분자 하이드로젤,그의 제조방법 및 그의 용도
KR100968591B1 (ko) * 2007-06-14 2010-07-08 한국과학기술연구원 약물전달용 폴리포스파젠계 하이드로젤, 그의 제조방법 및그의 용도
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
JP5171146B2 (ja) * 2007-07-27 2013-03-27 学校法人 関西大学 温度応答性を有する生分解性ポリマー及びその製造方法
EP2200613B1 (de) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazin-derivate und ihre verwendungen
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
NZ584825A (en) 2007-11-20 2013-03-28 Ambrx Inc Modified insulin polypeptides and their uses
WO2009091150A2 (en) * 2007-12-31 2009-07-23 Samyang Corporation Highly pure amphiphilic copolymer comprising hydrophobic block from alpha-hydroxy acid and process for the preparation thereof
US20090183503A1 (en) * 2008-01-18 2009-07-23 Alberto Verdesi Exhaust apparatus
EP3103880A1 (de) 2008-02-08 2016-12-14 Ambrx, Inc. Modifizierte leptinpolypeptide und deren verwendungen
WO2009100422A2 (en) * 2008-02-08 2009-08-13 Zimmer, Inc. Drug delivery system comprising microparticles and gelation system
UA90013C2 (ru) 2008-03-19 2010-03-25 Давид Анатолійович Нога Фармацевтическая композиция, содержащая инсулин, и способ его получения
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US8916188B2 (en) 2008-04-18 2014-12-23 Abbott Cardiovascular Systems Inc. Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
US20090285873A1 (en) * 2008-04-18 2009-11-19 Abbott Cardiovascular Systems Inc. Implantable medical devices and coatings therefor comprising block copolymers of poly(ethylene glycol) and a poly(lactide-glycolide)
US20090297584A1 (en) * 2008-04-18 2009-12-03 Florencia Lim Biosoluble coating with linear over time mass loss
KR20130097813A (ko) 2008-04-21 2013-09-03 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
AU2009246870B2 (en) 2008-05-14 2013-08-01 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of otic disorders
US8652506B2 (en) * 2008-06-05 2014-02-18 Boston Scientific Scimed, Inc. Bio-degradable block co-polymers for controlled release
WO2010005726A2 (en) 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
EA020753B1 (ru) 2008-06-16 2015-01-30 Бинд Терапьютикс, Инк. Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение
PL2774608T3 (pl) 2008-06-16 2020-05-18 Pfizer Inc. Polimerowe nanocząstki napełnione lekiem oraz sposoby ich wytwarzania i zastosowania
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
JP5421366B2 (ja) 2008-07-21 2014-02-19 オトノミ―，インク． 制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
CN102159230A (zh) 2008-07-23 2011-08-17 Ambrx公司 经修饰的牛g-csf多肽和其用途
JP5435534B2 (ja) * 2008-08-27 2014-03-05 多木化学株式会社 生体材料
PL2337846T3 (pl) 2008-09-26 2018-06-29 Ambrx, Inc. Mikroorganizmy i szczepionki z replikacją zależną od nie-naturalnych aminokwasów
CN102232085A (zh) 2008-09-26 2011-11-02 Ambrx公司 修饰的动物促红细胞生成素多肽和其用途
US20100081622A1 (en) * 2008-09-29 2010-04-01 Sanos Bioscience A/S Reduction of parathyroid hormone levels
WO2010053993A1 (en) 2008-11-04 2010-05-14 The Trustees Of Columbia University In The City Of New York Heterobifunctional polymers and methods for layer-by-layer construction of multilayer films
US8563041B2 (en) * 2008-12-12 2013-10-22 Bind Therapeutics, Inc. Therapeutic particles suitable for parenteral administration and methods of making and using same
ES2776126T3 (es) 2008-12-15 2020-07-29 Pfizer Nanopartículas de circulación prolongada para la liberación sostenida de agentes terapéuticos
TWI374903B (en) * 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
US9200112B2 (en) * 2009-08-10 2015-12-01 Ethicon, Inc. Semi-crystalline, fast absorbing polymer formulation
US9155722B2 (en) * 2009-09-18 2015-10-13 Protherics Salt Lake City, Inc. Reconstitutable reverse thermal gelling polymers
CA2774525C (en) * 2009-09-18 2018-04-24 Protherics Medicines Development Limited Reconstitutable reverse thermal gelling polymers
US8753621B2 (en) * 2009-09-18 2014-06-17 Protherics Salt Lake City, Inc. BAB triblock polymers having improved release characteristics
AU2010295314B2 (en) 2009-09-18 2014-08-28 Btg International Limited BAB triblock polymers having improved release characteristics
EP2490722A4 (de) 2009-10-21 2014-03-05 Otonomy Inc Modulation der geltemperatur poloxamerhaltiger formulierungen
US9044524B2 (en) 2009-10-30 2015-06-02 Ethicon, Inc. Absorbable polyethylene diglycolate copolymers to reduce microbial adhesion to medical devices and implants
CA2783535C (en) 2009-12-11 2017-11-28 Greg Troiano Stable formulations for lyophilizing therapeutic particles
US9295649B2 (en) 2009-12-15 2016-03-29 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
KR20120123365A (ko) 2009-12-21 2012-11-08 암브룩스, 인코포레이티드 변형된 돼지 소마토트로핀 폴리펩티드 및 이의 용도
CA2784793A1 (en) 2009-12-21 2011-07-21 Ambrx, Inc. Modified bovine somatotropin polypeptides and their uses
PT2521547T (pt) 2010-01-07 2017-11-17 Novartis Ag Métodos e composições para a aplicação de moxifloxacina no ouvido
EP2343046A1 (de) 2010-01-08 2011-07-13 Nirvana's Tree House B.V. Funktionalisierte Triblockcopolymere und Zusammensetzungen, die solche Polymere enthalten
US8551531B2 (en) 2010-04-12 2013-10-08 The Curators Of The University Of Missouri Pentablock polymers
EP2380920A1 (de) * 2010-04-22 2011-10-26 QGel SA Hydrogelvorstufenformulierung und Herstellungsverfahren dafür
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
FI3572091T3 (fi) 2010-08-17 2024-03-01 Ambrx Inc Muokattuja relaksiinipolypeptidejä ja niiden käyttötapoja
AR083006A1 (es) 2010-09-23 2013-01-23 Lilly Co Eli Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
EA201390600A1 (ru) * 2010-10-22 2013-09-30 Байнд Терапьютикс, Инк. Терапевтические наночастицы с сополимерами с большим молекулярным весом
US20120164100A1 (en) * 2010-11-02 2012-06-28 Ren-Ke Li Temperature sensitive hydrogel and block copolymers
US20140066439A1 (en) 2010-11-10 2014-03-06 Katholieke Universiteit Leuen, K.U.Leuven R&D Osteoclast activity
BR112013013676A2 (pt) * 2010-12-15 2016-09-06 3M Innovative Properties Co fibra degradáveis
US9006345B2 (en) 2011-03-25 2015-04-14 The Trustees Of Columbia University In The City Of New York Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
WO2012131104A2 (en) 2011-03-31 2012-10-04 Ingell Technologies Holding B.V. Biodegradable compositions suitable for controlled release
GB201105455D0 (en) * 2011-03-31 2011-05-18 British American Tobacco Co Blends of a polylactic acid and a water soluble polymer
CA2831471C (en) 2011-03-31 2020-02-25 Ingell Technologies Holding B.V. Biodegradable compositions suitable for controlled release
US8586020B2 (en) 2011-06-30 2013-11-19 Korea Institute Of Science And Technology Poly(organophosphazene) composition for biomaterials
EP2766407B1 (de) * 2011-10-12 2018-06-27 The Curators Of The University Of Missouri Pentablock-polymere
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
EP2791400B1 (de) * 2011-12-16 2021-02-17 NatureWorks LLC Polylactidfasern
US9422387B2 (en) * 2012-03-30 2016-08-23 Kimberly-Clark Worldwide, Inc. Dual responsive block copolymer compositions
CN103656679B (zh) * 2012-05-23 2016-02-10 上海交通大学 一种纳米颗粒的制备方法
CN102786675B (zh) * 2012-05-23 2014-04-30 上海交通大学 一种嵌段高分子及其合成方法和纳米颗粒的制备方法
BR112014030278A2 (pt) 2012-06-08 2017-06-27 Sutro Biopharma Inc anticorpo, e, composição.
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
EP3135690A1 (de) 2012-06-26 2017-03-01 Sutro Biopharma, Inc. Modifizierte fc-proteine mit stellenspezifischen nichtnatürlichen aminosäureresten, konjugate daraus, verfahren zu deren herstellung und verfahren zu deren verwendung
AU2013308494B2 (en) 2012-08-31 2018-03-01 Sutro Biopharma, Inc. Modified amino acids comprising an azido group
US9877923B2 (en) 2012-09-17 2018-01-30 Pfizer Inc. Process for preparing therapeutic nanoparticles
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN105377355A (zh) 2013-03-14 2016-03-02 拇趾公司 治疗甲单元的感染、疾病或病症的方法
EP2996683B1 (de) 2013-05-16 2018-04-18 The Curators of the University of Missouri Wirkstoffbeladene pentablockpolymere
WO2015006555A2 (en) 2013-07-10 2015-01-15 Sutro Biopharma, Inc. Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
US10682415B2 (en) * 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery
MX2016002408A (es) 2013-08-27 2016-10-28 Otonomy Inc Metodos para el tratamiento de trastornos oticos pediatricos.
WO2015054658A1 (en) 2013-10-11 2015-04-16 Sutro Biopharma, Inc. Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
US10364141B2 (en) * 2013-12-23 2019-07-30 Washington State University Block copolymer nanostructures formed by disturbed self-assembly and uses thereof
CN103819905B (zh) * 2014-03-07 2016-01-20 山东理工大学 一种用聚三亚甲基碳酸酯与聚乙烯吡咯烷酮对聚肽膜亲水性进行改进的方法
TWI693937B (zh) 2014-03-14 2020-05-21 美商輝瑞大藥廠 包含治療劑之治療性奈米顆粒及其製造及使用方法
MX2016014281A (es) 2014-05-22 2017-02-22 Therapeuticsmd Inc Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
KR20170021353A (ko) 2014-07-03 2017-02-27 오토노미, 인코포레이티드 시프로플록사신 조성물의 멸균
KR101570849B1 (ko) 2014-08-18 2015-11-20 성균관대학교산학협력단 온도감응형 이온성 복합체, 이의 제조 방법, 및 이를 포함하는 생분해성 조성물
WO2016065326A2 (en) 2014-10-24 2016-04-28 Bristol-Myers Squibb Company Modified fgf-21 polypeptides and uses thereof
AU2015362621B2 (en) 2014-12-15 2019-01-17 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of ocular disorders
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
CN104645356B (zh) * 2015-01-30 2018-11-13 复旦大学 一类x射线显影的热致水凝胶及其制备方法
US9375478B1 (en) 2015-01-30 2016-06-28 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR20180037994A (ko) 2015-07-28 2018-04-13 오토노미, 인코포레이티드 TrkB 또는 TrkC 아고니스트 조성물 및 귀 병태의 치료 방법
CN105062021B (zh) * 2015-08-18 2017-03-01 九江学院 一种非温敏可降解聚合物胶乳及其制备方法
CN108367079B (zh) 2015-11-12 2022-11-22 灰色视觉公司 用于治疗的聚集性微粒
US11246863B2 (en) 2015-12-11 2022-02-15 Alk-Abelló, Inc. Ciprofloxacin otic composition and kits and method for using same
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US11040004B2 (en) 2016-09-16 2021-06-22 Otonomy, Inc. Otic gel formulations for treating otitis externa
US9987369B2 (en) 2016-11-01 2018-06-05 International Business Machines Corporation Vitamin functionalized gel-forming block copolymers for biomedical applications
SG11201907209QA (en) 2017-02-08 2019-09-27 Bristol Myers Squibb Co Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
CA3056923A1 (en) 2017-03-23 2018-09-27 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
WO2018183624A1 (en) 2017-03-29 2018-10-04 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents
EP3600437A4 (de) * 2017-03-31 2021-01-06 Rowan University Optisch klare in-situ-ausbildung biologisch abbaubarer nanoträger für die augentherapie und denselben verwendendes verfahren
EP3621654A4 (de) 2017-05-10 2021-02-17 Graybug Vision, Inc. Mikropartikel mit verlängerter freisetzung und suspensionen davon zur medizinischen therapie
IL275780B2 (en) 2018-01-09 2024-07-01 Otonomy Inc Ear formulations of growth factor
WO2019154895A1 (en) 2018-02-08 2019-08-15 Strekin Ag Gel formulation for preventing or treating hearing loss
CN108250415B (zh) * 2018-02-09 2020-09-04 青岛科技大学 一种聚(γ-丁内酯)-b-聚乳酸嵌段共聚物及其制备方法
EP3849614B1 (de) 2018-09-11 2023-12-20 Ambrx, Inc. Interleukin-2-polypeptidkonjugate und deren verwendungen
EP3867265A1 (de) 2018-10-19 2021-08-25 Ambrx, Inc. Interleukin-10 -polypeptid-konjugate, dimere davon und ihre verwendungen
EP3679928A1 (de) * 2019-01-08 2020-07-15 Atlangram Pharmazeutische zusammenetzung vom typ gel zur behandlung/vorbeugung einer infektion
WO2020168017A1 (en) 2019-02-12 2020-08-20 Ambrx, Inc. Compositions containing, methods and uses of antibody-tlr agonist conjugates
WO2020210533A1 (en) * 2019-04-12 2020-10-15 The Regents Of The University Of Michigan Tri-block copolymers and nano-fibrous gelling microspheres including the same
WO2020254249A1 (en) 2019-06-21 2020-12-24 Proqr Therapeutics Ii B.V. Delivery of nucleic acids for the treatment of auditory disorders
CN114746080A (zh) 2019-09-30 2022-07-12 托尔玛国际有限公司 用于作为活性药物成分的肽的延长递送的液体聚合物组合物和系统
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
JP2023517595A (ja) 2020-03-11 2023-04-26 アンブルックス，インコーポレイテッド インターロイキン－２ポリペプチド結合物およびその使用方法
CA3190606A1 (en) 2020-08-20 2022-02-24 Ambrx, Inc. Antibody-tlr agonist conjugates, methods and uses thereof
IL307282A (en) 2021-04-03 2023-11-01 Ambrx Inc Antidote conjugates against HER2 and their applications
CN113354823B (zh) * 2021-06-18 2023-03-31 四川大学 一种用于全降解血管支架的嵌段聚合物及制备方法
CN115814146B (zh) * 2022-11-01 2023-12-22 山东大学 一种仿生凝血机制的止血粉制备方法
WO2024137849A1 (en) * 2022-12-20 2024-06-27 Northeast Ohio Medical University Gallium-loaded hydrogels for bone treatment

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092918B1 (de) 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Mittel mit verzögerter Freigabe
US4438253A (en) 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
DE3786309T2 (de) 1986-09-05 1994-02-10 American Cyanamid Co Alkylenoxydblöcke enthaltende Polyester und deren Verwendung als Arzneimittelabgabesysteme.
US4716203A (en) * 1986-09-05 1987-12-29 American Cyanamid Company Diblock and triblock copolymers
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
JPH064540B2 (ja) 1988-09-14 1994-01-19 多木化学株式会社 医用組成物
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5330768A (en) 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
GB9211268D0 (en) 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
FR2741628B1 (fr) * 1995-11-29 1998-02-06 Centre Nat Rech Scient Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
KR20010022708A (ko) * 1997-08-08 2001-03-26 프레드한 아룬디프 에스 약물 수송에 이용할 수 있는 생분해가능한 주사용 블록공중합체 겔
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
CA2305621C (en) * 1997-10-03 2009-01-20 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
KR20010010393A (ko) * 1999-07-20 2001-02-05 김윤 소수성 고분자와 친수성 고분자의 생분해성 블록 공중합체 및이를 포함하는 약물 전달체 조성물

Also Published As

Publication number Publication date
BR9914258B1 (pt) 2014-07-15
EP1141079A4 (de) 2004-03-24
WO2000018821A1 (en) 2000-04-06
KR100558025B1 (ko) 2006-03-07
RU2232779C2 (ru) 2004-07-20
NZ510832A (en) 2002-10-25
TR200100900T2 (tr) 2001-10-22
EP1141079B1 (de) 2007-11-14
EP1141079A1 (de) 2001-10-10
BR9914258A (pt) 2001-07-03
CA2345659C (en) 2010-09-21
PL205127B1 (pl) 2010-03-31
NO332941B1 (no) 2013-02-04
NO20011639D0 (no) 2001-03-30
PL346963A1 (en) 2002-03-11
JP2002525404A (ja) 2002-08-13
JP4628545B2 (ja) 2011-02-09
US6201072B1 (en) 2001-03-13
CN1161396C (zh) 2004-08-11
AU758475B2 (en) 2003-03-20
KR20010083880A (ko) 2001-09-03
AU1098300A (en) 2000-04-17
CY1107888T1 (el) 2013-06-19
IL142313A0 (en) 2002-03-10
CN1324374A (zh) 2001-11-28
NO20011639L (no) 2001-03-30
ES2301250T3 (es) 2008-06-16
DK1141079T3 (da) 2008-03-25
CA2345659A1 (en) 2000-04-06

Similar Documents

Publication Publication Date Title
ATE378365T1 (de) Bioabbaubare niedermolekulare triblock-polyester- polyethylenglykol-copolymere mit umgekehrter thermischer gelierung
AR022105A1 (es) COMPOSICIoN QUE COMPRENDE UN POLíMERO TRIBLOQUE TIPO ABA O TIPO BAB, QUE TIENE PROPIEDADES DE GELACIoN TÉRMICA REVERSIBLE; DICHO POLíMERO TRIBLOQUE; COMPOSICIoN POLIMÉRICA ACUOSA BIODEGRADABLE DE LIBERACIoN DE DROGA QUE LO COMPRENDE Y MÉTODO PARA AUMENTAR LA SOLUBILIDAD DE UNA DROGA MEZCLÁNDOLA EN D
AR015175A1 (es) COMPOSICIoN ACUOSA BIODEGRADABLE POLIMÉRICA PARA LA ENTREGA DE UN FÁRMACO.
Kang et al. Thermosensitive poly (organophosphazene) hydrogels for a controlled drug delivery
US4474753A (en) Topical drug delivery system utilizing thermosetting gels
KR950032370A (ko) 생분해성 하이드로겔 고분자
CA2407298A1 (en) Mixtures of triblock polyesterpolyethylene glycol copolymers
KR100933580B1 (ko) 약물 전달을 위한 생분해가능 블록 공중합성 조성물
ES2211028T3 (es) Nuevos copolimeros tensioactivos basados en malonato de metilideno.
EP1024790A1 (de) Injizierbare biologisch abbaubare blockcopolymergele zur verwendung in der arzneistoffverabreichung
CA2444529A1 (en) Micellar drug delivery systems for hydrophobic drugs
WO1997015287A1 (en) Thermosensitive biodegradable polymers based on poly(ether-ester) block copolymers
KR20070122521A (ko) Ｐｅｇ-폴리아세탈 및 ｐｅｇ-폴리아세탈-ｐｏｅ 그래프트공중합체 및 약학 조성물
KR101066763B1 (ko) 온도 반응성 전달계
Bashir et al. An in sight into novel drug delivery system: in situ gels
US20060235084A1 (en) PEG-polyacetal diblock and triblock copolymers and pharmaceutical compositions
CN105396137A (zh) 一种可注射温敏性物理水凝胶及其制备方法
JPH10501814A (ja) 生物的作用物質用のイン・シツゲル形成デリバリービヒクルおよびその使用方法
Jackson et al. The characterization of novel polymeric paste formulations for intratumoral delivery
MIYAZAKI et al. Effect of pluronic gels on the rectal absorption of indomethacin in rabbits
KR20070122522A (ko) Ｐｅｇ-폴리(오르토 에스테르) 그라프트 공중합체 및 약학조성물
JP4463337B2 (ja) 軟膏製剤
JPH01149717A (ja) 直腸内投与用医薬組成物

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1141079

Country of ref document: EP