KR950032370A - 생분해성 하이드로겔 고분자 - Google Patents

생분해성 하이드로겔 고분자 Download PDF

Info

Publication number
KR950032370A
KR950032370A KR1019940010696A KR19940010696A KR950032370A KR 950032370 A KR950032370 A KR 950032370A KR 1019940010696 A KR1019940010696 A KR 1019940010696A KR 19940010696 A KR19940010696 A KR 19940010696A KR 950032370 A KR950032370 A KR 950032370A
Authority
KR
South Korea
Prior art keywords
polymer
peo
integer
biodegradable
polyethylene oxide
Prior art date
Application number
KR1019940010696A
Other languages
English (en)
Other versions
KR0141431B1 (ko
Inventor
김호현
송수석
이일웅
Original Assignee
김상응
주식회사 삼양사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 김상응, 주식회사 삼양사 filed Critical 김상응
Priority to KR1019940010696A priority Critical patent/KR0141431B1/ko
Priority to US08/268,915 priority patent/US5514380A/en
Priority to JP6168187A priority patent/JPH07309938A/ja
Publication of KR950032370A publication Critical patent/KR950032370A/ko
Application granted granted Critical
Publication of KR0141431B1 publication Critical patent/KR0141431B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00—Compositions for preparing biodegradable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)

Abstract

폴리에틸렌옥사이드(PEO), 폴리락타이드(PLA), 폴리글라이 콜라이드(PGA), 폴리락타이드글리콜라이드(PLGA)등을 포함한 다중블럭 공중합체의 고분자로서, 친수성 고분자 블럭의 분자쇄내에 에스테르 결합이나 아미드 결합등을 포함하여, 체내에 사용시 단순 가수분해 또는 가수분해효소에 의해 작은 분자로 분해되어 신장을 통하여 체외로 배출되거나 체내의 대사과정에 의해 소멸될 수 있는 인체에 무해한 열가소성 생분해성 하이드로겔 합성에 관한 것이다.

Description

생분해성 하이드로겔 고분자
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기식(Ⅰ)a 내지 (Ⅰ)f로 표시되는 친수성 비분해성 고분자(A) 와 소수성생체분해성 고분자(B)를 결합시켜 합성한 생분해성 하이드로겔 고분자
    식(Ⅰ)a
    식(Ⅰ)b
    식(Ⅰ)c
    식(Ⅰ)d
    식(Ⅰ)e
    식(Ⅰ)f
    상기식에서 A(-)는 폴리에틸렌옥사이드(PEO)또는 폴리에틸렌옥사이드/폴리프로필렌옥사이드 공중합체와 같은 친수성 비분해성 고분자이고, B(…)는 폴리락타이드(PLA), 폴리글라이콜라이드(PGA), PLA/PGA공중합체, 폴리카프로락톤(PCL), 폴리오르소에스터, 폴리안하이드라이드와 같은 소수성 생체 분해성 고분자이며, X는 아미드 결합, 에스테르 결합, 카보네이트 결합과 같은 생체내에서 분해되는 화학결합이고, Y는 아미드 결합, 에스테르 결합, 카보네이트 결합과 같은 A와 B, 또는 B들을 공유결합에 의해 연결하는 화학결합이며, n은 0에서 10의 정수이며, q는 3에서 4의 정수이다.
  2. 제1항에 있어서, 2이상의 다양한 수의 소수성 고분자 사슬을 갖는 것을 특징으로 하는 생체 분해성 하이드로겔 고분자.
  3. 제1항에 있어서, 폴리에틸렌옥사이드(PEO), 폴리락타이드(PLA), 폴리글라이콜라이드(PGA) 및 폴리카프로락톤(PCL)등을 포함한 다중블럭 공중합체로 하기 구조식(Ⅰ) 또는 (Ⅰ´)을 갖는 생체 분해성 하이드로겔 고분자
    〔H-O(CH2)z-(OCHR1COOCHR2CO)m〕ℓ-Y-A-Y´-〔(COCHR1OC(=0)CHR2O)m-O(CH2)ℓ-H〕ℓ…(Ⅰ)
    〔H-O(CH2)z-(O(CH2)5CO)m〕ℓ-Y-A-Y´-〔(CO(CH2)5O)m-O(CH2)z-H〕ℓ…(Ⅰ´)
    상기식에서 A는 친수성과 소수성 고분자로 이루어진 다중블럭으로서, 〔(CH2CH2O)n-X-(OCH2CH2)n〕r이고, X는 -O(COCH2O)X-, -O〔COCH(CH3)O〕X-이며, Y는 -CHyNHCO-, Y´는 -CONHCHy-이고, R1및 R2는 수소원자이거나 메틸기이고, x는 1에서 10의 정수이고, z는 1에서 5의 정수이고, y는 0,1 또는 2이며, 이때 ℓ은 각각 3,2,1의 값을 가지며, m은 1에서 100의 정수이고, n은 20에서 500의 정수이고, k는 0에서 10의 정수이며, r은 0에서 10의 정수이다.
  4. 제3항에 있어서, 폴리에틸렌옥사이드(PEO)의 중량비가 5% 내지 95%의 범위를 갖는 것을 특징으로 하는 생체 분해성 하이드로겔 고분자
  5. 친수성 비분해성 고분자(A)로는 분자량 600 내지 30,000사이의 폴리에틸렌옥사이드(PEO) 또는 폴리에틸렌옥사이드/폴리프로필렌옥사이드 공중합체를 사용하고, 소수성 생체 분해성 고분자(B)블럭은 폴리락타이드(PLA), 폴리글라이콜라이드(PGA), 폴리카프로락톤(PCL) 또는 이들의 공중합체를 사용하여 친수성 고분자 블럭은 PEO 모노머를 음이온 중합기켜 합성하고, 연결부위(Y)에서 소수성 고분자 블럭과 결합시킨후, 친수성 고분자 블럭을 연속적으로 음이온 중합방법에 의해 합성시킴을 특징으로 하는 생체 분해성 하이드로겔 고분자의 제조방법.
  6. 제5항에 있어서, 친수성 비분해성 고분자(A)의 합성은 친수성 폴리에틸렌 글리콜 고분자를 이용하여 폴리에틸렌 글리콜 양말단기에 생분해가 가능한 락타이드, 글리콜라이드 및 카프로락톤등을 중합하고서 다시 에틸렌옥사이드모노머로 중합시킴을 특징으로 하는 생체 분해성 하이드로겔 고분자의 제조방법.
  7. 제5항 또는 제6항에 있어서, 폴리에틸렌옥사이(PEO)의 분자량은 2,000 내지 10,000임을 특징으로 하는 생체 분해성 하이드로겔 고분자의 제조방법.
  8. 제5항 내지 제6항에 있어서, 연결부위(Y)에서의 결합은 다중블럭 PEO를 제조한 후 여기에 트리스(히드록시알킬) 아미노메탄 또는 디히드록시알킬 아미노메탄을 결합시킴을 특징으로 하는 생체 분해성 하이드로겔 고분자의 제조방법.
  9. 제8항에 있어서, 알킬로는 탄소수가 1 내지 5인 지방족 화합물을 사용함을 특징으로 하는 생체 분해성 하이드로겔 고분자의 제조방법.
  10. 제8항에 있어서, 다중블럭 PEO제조 후 P-니트로페닐클로로포메이트(NPC)로 다중블럭 PEO 말단의 히드록실그룹을 보호시켜 결합시킴을 특징으로 하는 생체 분해서 하이드로겔 고분자의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940010696A 1994-05-17 1994-05-17 생분해성 하이드로겔 고분자 KR0141431B1 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019940010696A KR0141431B1 (ko) 1994-05-17 1994-05-17 생분해성 하이드로겔 고분자
US08/268,915 US5514380A (en) 1994-05-17 1994-06-30 Biodegradable hydrogel copolymer as drug delivery matrix
JP6168187A JPH07309938A (ja) 1994-05-17 1994-07-20 薬物送達マトリックス用の熱可塑性および生分解性ヒドロゲルマルチブロックコポリマー

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940010696A KR0141431B1 (ko) 1994-05-17 1994-05-17 생분해성 하이드로겔 고분자

Publications (2)

Publication Number Publication Date
KR950032370A true KR950032370A (ko) 1995-12-20
KR0141431B1 KR0141431B1 (ko) 1998-07-01

Family

ID=19383185

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940010696A KR0141431B1 (ko) 1994-05-17 1994-05-17 생분해성 하이드로겔 고분자

Country Status (3)

Country Link
US (1) US5514380A (ko)
JP (1) JPH07309938A (ko)
KR (1) KR0141431B1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100515035B1 (ko) * 2001-12-27 2005-09-15 한국과학기술원 약물전달시스템을 위한 생분해성 열감응성 스타형블록공중합체

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US6566406B1 (en) * 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
AU4648697A (en) 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US5912076A (en) 1996-12-31 1999-06-15 Kimberly-Clark Worldwide, Inc. Blends of polyethylene and peo having inverse phase morphology and method of making the blends
US5976694A (en) 1997-10-03 1999-11-02 Kimberly-Clark Worldwide, Inc. Water-sensitive compositions for improved processability
US6010971A (en) * 1997-11-21 2000-01-04 Kimberly-Clark Worldwide, Inc. Polyethylene oxide thermoplastic composition
US6110849A (en) * 1997-12-19 2000-08-29 Kimberly-Clark Worlwide, Inc. Thermoplastic composition including polyethylene oxide
US6096726A (en) 1998-03-11 2000-08-01 Surface Solutions Laboratories Incorporated Multicomponent complex for use with substrate
US5951597A (en) * 1998-04-14 1999-09-14 Cardiac Pacemakers, Inc. Coronary sinus lead having expandable matrix anchor
US6228920B1 (en) 1998-07-10 2001-05-08 Kimberly-Clark Woldwide, Inc. Compositions and process for making water soluble polyethylene oxide films with enhanced toughness and improved melt rheology and tear resistance
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
ES2187195T3 (es) * 1998-09-11 2003-05-16 Gerhard Dr Schmidmaier Implantes biologicamente activos.
US6579570B1 (en) 2000-05-04 2003-06-17 Kimberly-Clark Worldwide, Inc. Ion-sensitive, water-dispersible polymers, a method of making same and items using same
US6713414B1 (en) 2000-05-04 2004-03-30 Kimberly-Clark Worldwide, Inc. Ion-sensitive, water-dispersible polymers, a method of making same and items using same
US6423804B1 (en) 1998-12-31 2002-07-23 Kimberly-Clark Worldwide, Inc. Ion-sensitive hard water dispersible polymers and applications therefor
US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
ATE386075T1 (de) 1999-04-12 2008-03-15 Cornell Res Foundation Inc Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten
US6469132B1 (en) * 1999-05-05 2002-10-22 Mcgill University Diblock copolymer and use thereof in a micellar drug delivery system
US6444761B1 (en) 1999-12-28 2002-09-03 Kimberly-Clark Worldwide, Inc. Water-soluble adhesive compositions
KR100358027B1 (ko) * 2000-02-14 2002-10-25 한국과학기술연구원 의료용 생분해성 삼중블록 공중합체 및 그의 제조 방법
US6548592B1 (en) 2000-05-04 2003-04-15 Kimberly-Clark Worldwide, Inc. Ion-sensitive, water-dispersible polymers, a method of making same and items using same
US6599848B1 (en) 2000-05-04 2003-07-29 Kimberly-Clark Worldwide, Inc. Ion-sensitive, water-dispersible polymers, a method of making same and items using same
US6444214B1 (en) 2000-05-04 2002-09-03 Kimberly-Clark Worldwide, Inc. Ion-sensitive, water-dispersible polymers, a method of making same and items using same
US6429261B1 (en) 2000-05-04 2002-08-06 Kimberly-Clark Worldwide, Inc. Ion-sensitive, water-dispersible polymers, a method of making same and items using same
US6653406B1 (en) 2000-05-04 2003-11-25 Kimberly Clark Worldwide, Inc. Ion-sensitive, water-dispersible polymers, a method of making same and items using same
US6835678B2 (en) 2000-05-04 2004-12-28 Kimberly-Clark Worldwide, Inc. Ion sensitive, water-dispersible fabrics, a method of making same and items using same
US6683143B1 (en) 2000-05-04 2004-01-27 Kimberly Clark Worldwide, Inc. Ion-sensitive, water-dispersible polymers, a method of making same and items using same
US6815502B1 (en) 2000-05-04 2004-11-09 Kimberly-Clark Worldwide, Inc. Ion-sensitive, water-dispersable polymers, a method of making same and items using same
US6770721B1 (en) 2000-11-02 2004-08-03 Surface Logix, Inc. Polymer gel contact masks and methods and molds for making same
US6586529B2 (en) 2001-02-01 2003-07-01 Kimberly-Clark Worldwide, Inc. Water-dispersible polymers, a method of making same and items using same
US6828014B2 (en) 2001-03-22 2004-12-07 Kimberly-Clark Worldwide, Inc. Water-dispersible, cationic polymers, a method of making same and items using same
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
FR2822834B1 (fr) * 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
US7572288B2 (en) * 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US8715312B2 (en) 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
KR20030024103A (ko) * 2001-09-17 2003-03-26 육순홍 상전이 현상을 이용한 약물전달용 생분해성 고분자미소구의 제조방법
US6592899B2 (en) 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
KR100453130B1 (ko) * 2001-11-21 2004-10-15 한국과학기술연구원 구조적 배열이 일정한 생분해성 락타이드(글리콜라이드또는 락타이드/글리콜라이드)/ε-카프로락톤 멀티블록공중합체 및 이의 제조 방법
CN1331913C (zh) * 2002-02-05 2007-08-15 重庆永通信息工程实业有限公司 一种术后防粘连膜用新材料的合成和应用
US20030229333A1 (en) * 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
US7005143B2 (en) * 2002-04-12 2006-02-28 3M Innovative Properties Company Gel materials, medical articles, and methods
FR2838964B1 (fr) * 2002-04-26 2004-07-09 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs et leur mode de preparation
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
WO2004044012A1 (en) * 2002-11-12 2004-05-27 The Polymer Technology Group Incorporated Control of polymer surface molecular architecture via amphipathic endgroups
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
US8357391B2 (en) * 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
US7919112B2 (en) * 2004-08-26 2011-04-05 Pathak Holdings, Llc Implantable tissue compositions and method
US20060147689A1 (en) * 2004-12-30 2006-07-06 Raj Wallajapet Absorbent composites containing biodegradable reinforcing fibers
US20060147505A1 (en) * 2004-12-30 2006-07-06 Tanzer Richard W Water-dispersible wet wipe having mixed solvent wetting composition
US20060149363A1 (en) * 2005-01-06 2006-07-06 Scimed Life Systems, Inc. Optimally expanded, collagen sealed ePTFE graft with improved tissue ingrowth
CA2595633C (en) * 2005-02-09 2013-11-19 Ahmad R. Hadba Synthetic sealants
US8778376B2 (en) * 2006-06-09 2014-07-15 Advanced Cardiovascular Systems, Inc. Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
CA2704920C (en) 2007-06-25 2016-08-16 Microvention, Inc. Self-expanding prosthesis
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US20090285873A1 (en) * 2008-04-18 2009-11-19 Abbott Cardiovascular Systems Inc. Implantable medical devices and coatings therefor comprising block copolymers of poly(ethylene glycol) and a poly(lactide-glycolide)
TWI374903B (en) 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
EP2396070A4 (en) 2009-02-12 2012-09-19 Incept Llc ACTIVE COMPOSITION WITH HYDROGEL PLUGS
KR101224004B1 (ko) * 2009-12-29 2013-01-22 주식회사 삼양바이오팜 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법
US20140147431A1 (en) * 2010-09-20 2014-05-29 The Regents Of The University Of California Compositions and Methods for Modulating Desnutrin-Mediated Adipocyte Lipolysis
FR2967416B1 (fr) * 2010-11-15 2012-12-21 Ipsen Pharma Sas Procede de preparation de polymeres a architecture variee et amorcage amide
WO2012155093A1 (en) 2011-05-11 2012-11-15 Microvention, Inc. Device for occluding a lumen
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
KR101466893B1 (ko) * 2011-12-16 2014-12-05 주식회사 삼양바이오팜 안정성이 향상된 다중블록 공중합체의 수용액 조성물
EP2842583A1 (en) 2013-08-29 2015-03-04 Ella-CS, s.r.o. Biodegradable and bioerodible polyurethanes, method of preparation thereof and use thereof
US10822454B2 (en) 2016-12-02 2020-11-03 University Of Massachusetts Biodegradable amphiphilic shape memory polymers and compositions and methods thereof
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4716203A (en) * 1986-09-05 1987-12-29 American Cyanamid Company Diblock and triblock copolymers
US5041292A (en) * 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5330768A (en) * 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
US5352515A (en) * 1992-03-02 1994-10-04 American Cyanamid Company Coating for tissue drag reduction

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100515035B1 (ko) * 2001-12-27 2005-09-15 한국과학기술원 약물전달시스템을 위한 생분해성 열감응성 스타형블록공중합체

Also Published As

Publication number Publication date
JPH07309938A (ja) 1995-11-28
US5514380A (en) 1996-05-07
KR0141431B1 (ko) 1998-07-01

Similar Documents

Publication Publication Date Title
KR950032370A (ko) 생분해성 하이드로겔 고분자
KR950023661A (ko) 생체분해성 약물전달용 고분자
US4379138A (en) Biodegradable polymers of lactones
IL142313A0 (en) Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties
NZ302955A (en) Water soluble polymer prodrugs attached to macromolecular molecules, preparation and use thereof
CA2305621A1 (en) Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
ATE297954T1 (de) Polymere mit uniformem molekulargewicht
KR880003985A (ko) 블록 공중합체 및 시약운반시스템으로 이것의 사용
BR9007686A (pt) Polimerizacao de lactona catalisada por compostos de itrio e de terras raras
CA2481365A1 (en) Occlusive composition comprising a poly (2-cyanoacrylate) monomer
NO974678D0 (no) Heterotelechelisk blokk-kopolymer og en fremgangsmåte for fremstilling derav
KR890011918A (ko) 개선된 의료용 폴리(프로필렌 글리콜 푸마레이트)조성물
WO1999007343A1 (en) Injectable biodegradable block copolymer gels for use in drug delivery
DE3780218D1 (de) Tumor-nekrose-faktor-formulierung und ihre herstellung.
Andronova et al. Potential tissue implants from the networks based on 1, 5-dioxepan-2-one and ε-caprolactone
KR910006386A (ko) 수지 성형체의 정전 도장 방법
WO2005003214A1 (ja) 三元ブロック共重合体、その製造法及び生体内適合材料
Silvers et al. Strategies in aliphatic polyester synthesis for biomaterial and drug delivery applications
Lee et al. Synthesis and degradation behaviors of PEO/PL/PEO tri-block copolymers
Mohammadi‐Rovshandeh et al. Synthesis and characterization of novel ABA triblock copolymers from l‐lactide, glycolide, and PEG
JP3744800B2 (ja) 反応性置換基を有する生分解性重合体
Farnia et al. Synthesis and characterization of novel biodegradable triblock copolymers from L‐Lactide, glycolide, and PPG
KR100515035B1 (ko) 약물전달시스템을 위한 생분해성 열감응성 스타형블록공중합체
Benabdillah et al. Can the Glass Transition Temperature of P Polymers Be Increased?
JP3091208B2 (ja) ラクトン共重合体およびその製造方法

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20121130

Year of fee payment: 16

FPAY Annual fee payment

Payment date: 20131209

Year of fee payment: 17

EXPY Expiration of term