ATE321573T1 - Therapeutischer inhibitor von glatten muskelzellen - Google Patents
Therapeutischer inhibitor von glatten muskelzellenInfo
- Publication number
- ATE321573T1 ATE321573T1 AT04000646T AT04000646T ATE321573T1 AT E321573 T1 ATE321573 T1 AT E321573T1 AT 04000646 T AT04000646 T AT 04000646T AT 04000646 T AT04000646 T AT 04000646T AT E321573 T1 ATE321573 T1 AT E321573T1
- Authority
- AT
- Austria
- Prior art keywords
- iii
- coating
- smc
- intravascular stent
- smooth muscle
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 11
- 210000000329 smooth muscle myocyte Anatomy 0.000 title abstract 5
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000011248 coating agent Substances 0.000 abstract 4
- 238000000576 coating method Methods 0.000 abstract 4
- 239000011159 matrix material Substances 0.000 abstract 2
- 239000012730 sustained-release form Substances 0.000 abstract 2
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 208000031481 Pathologic Constriction Diseases 0.000 abstract 1
- 101001059240 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Site-specific recombinase Flp Proteins 0.000 abstract 1
- GBOGMAARMMDZGR-UHFFFAOYSA-N UNPD149280 Natural products N1C(=O)C23OC(=O)C=CC(O)CCCC(C)CC=CC3C(O)C(=C)C(C)C2C1CC1=CC=CC=C1 GBOGMAARMMDZGR-UHFFFAOYSA-N 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- GBOGMAARMMDZGR-JREHFAHYSA-N cytochalasin B Natural products C[C@H]1CCC[C@@H](O)C=CC(=O)O[C@@]23[C@H](C=CC1)[C@H](O)C(=C)[C@@H](C)[C@@H]2[C@H](Cc4ccccc4)NC3=O GBOGMAARMMDZGR-JREHFAHYSA-N 0.000 abstract 1
- GBOGMAARMMDZGR-TYHYBEHESA-N cytochalasin B Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@@H]3/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(=O)O[C@@]23C(=O)N1)=C)C)C1=CC=CC=C1 GBOGMAARMMDZGR-TYHYBEHESA-N 0.000 abstract 1
- 230000003436 cytoskeletal effect Effects 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 208000037804 stenosis Diseases 0.000 abstract 1
- 230000036262 stenosis Effects 0.000 abstract 1
- 210000002536 stromal cell Anatomy 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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US08/389,712 US6515009B1 (en) | 1991-09-27 | 1995-02-15 | Therapeutic inhibitor of vascular smooth muscle cells |
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AT96906490T ATE265233T1 (de) | 1995-02-15 | 1996-02-15 | Therapeutische inhibitoren der zellen der glatten gefässmuskulatur |
AT04000646T ATE321573T1 (de) | 1995-02-15 | 1996-02-15 | Therapeutischer inhibitor von glatten muskelzellen |
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AT96906490T ATE265233T1 (de) | 1995-02-15 | 1996-02-15 | Therapeutische inhibitoren der zellen der glatten gefässmuskulatur |
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1996
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US20120195951A1 (en) | 2012-08-02 |
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US8097642B2 (en) | 2012-01-17 |
EP0809515A1 (en) | 1997-12-03 |
EP1407786A1 (en) | 2004-04-14 |
CA2212537A1 (en) | 1996-08-22 |
US6515009B1 (en) | 2003-02-04 |
DE69632310D1 (de) | 2004-06-03 |
DE69635968D1 (de) | 2006-05-18 |
EP1669091A3 (en) | 2009-06-17 |
CA2212537C (en) | 2006-12-19 |
US6171609B1 (en) | 2001-01-09 |
DE69635968T2 (de) | 2007-01-25 |
US20070148207A1 (en) | 2007-06-28 |
ATE265233T1 (de) | 2004-05-15 |
EP1407786B1 (en) | 2006-03-29 |
US8158670B2 (en) | 2012-04-17 |
US20110300221A1 (en) | 2011-12-08 |
EP1669091A2 (en) | 2006-06-14 |
US6599928B2 (en) | 2003-07-29 |
EP0809515B1 (en) | 2004-04-28 |
JPH11500635A (ja) | 1999-01-19 |
AU4985196A (en) | 1996-09-04 |
JP2007075623A (ja) | 2007-03-29 |
WO1996025176A1 (en) | 1996-08-22 |
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