US5202352A - Intravascular embolizing agent containing angiogenesis-inhibiting substance - Google Patents
Intravascular embolizing agent containing angiogenesis-inhibiting substance Download PDFInfo
- Publication number
- US5202352A US5202352A US07/740,849 US74084991A US5202352A US 5202352 A US5202352 A US 5202352A US 74084991 A US74084991 A US 74084991A US 5202352 A US5202352 A US 5202352A
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- US
- United States
- Prior art keywords
- intravascular embolizing
- agent
- substance
- angiogenesis
- intravascular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
TABLE 1 ______________________________________ Treatment Number of (i.a.) animals V5/V0 (%) T/C (%) ______________________________________ Control 10 227 100 "Compound a" 3 175 77 PS 4 134 59 "Compound a" + PS 2 81 36 ______________________________________
TABLE 2 ______________________________________ Treatment Number of (i.a.) animals V7/V0 (%) T/C (%) ______________________________________ Control 10 358 100 Solution (i.a.) 3 247 69 msp-p (i.a.) 4 225 63 msp-1 (i.a.) 5 41 11 Solution (i.v.) 2 294 82 ______________________________________
TABLE 3 ______________________________________ Treatment Number of (i.a.) animals V7/V0 (%) T/C (%) ______________________________________ Control 10 358 100 msp-p 4 225 63 msp-2 2 31 9 ______________________________________
TABLE 4 ______________________________________ Treatment Number of (i.a.) animals 5th day 7th day 9th day ______________________________________ Control 10 227 358 468 DOX 4 162 324 377 msp-p + DOX 4 70 89 182 msp-1 + DOX 5 24 19 23 msp-3 + DOX 2 27 20 28 ______________________________________
TABLE 5 ______________________________________ Treatment Number of (i.a.) animals V7/V0 (%) T/C (%) ______________________________________ Control 16 350 100 msp-3 3 59 17 msp-BSA 3 50 14 ______________________________________
TABLE 6 ______________________________________ Treatment Number of (i.a.) animals V5/V0 (%) T/C (%) ______________________________________ Control 16 219 100 LPD + "Compound a" 4 86 39 LPD + "Compound c" 3 111 51 ______________________________________
Claims (19)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21062290 | 1990-08-08 | ||
JP632391 | 1991-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
US5202352A true US5202352A (en) | 1993-04-13 |
Family
ID=26340431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/740,849 Expired - Lifetime US5202352A (en) | 1990-08-08 | 1991-08-06 | Intravascular embolizing agent containing angiogenesis-inhibiting substance |
Country Status (6)
Country | Link |
---|---|
US (1) | US5202352A (en) |
EP (1) | EP0470569B1 (en) |
JP (1) | JP2001039869A (en) |
AT (1) | ATE130517T1 (en) |
CA (1) | CA2048544C (en) |
DE (1) | DE69114782T2 (en) |
Cited By (143)
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WO1998040052A1 (en) * | 1997-03-12 | 1998-09-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
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US11123453B2 (en) | 2018-02-21 | 2021-09-21 | Shinshu University | Liquid embolic agent composition |
Also Published As
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CA2048544C (en) | 2002-01-01 |
CA2048544A1 (en) | 1992-02-09 |
DE69114782T2 (en) | 1996-04-18 |
DE69114782D1 (en) | 1996-01-04 |
EP0470569B1 (en) | 1995-11-22 |
EP0470569A1 (en) | 1992-02-12 |
ATE130517T1 (en) | 1995-12-15 |
JP2001039869A (en) | 2001-02-13 |
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