ATE307114T1 - Kristalline polymorphe formen von lercanidipin hydrochlorid und verfahren zu deren herstellung - Google Patents
Kristalline polymorphe formen von lercanidipin hydrochlorid und verfahren zu deren herstellungInfo
- Publication number
- ATE307114T1 ATE307114T1 AT02762428T AT02762428T ATE307114T1 AT E307114 T1 ATE307114 T1 AT E307114T1 AT 02762428 T AT02762428 T AT 02762428T AT 02762428 T AT02762428 T AT 02762428T AT E307114 T1 ATE307114 T1 AT E307114T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- lercanidipine hydrochloride
- polymorphous forms
- crystalline polymorphous
- crystalline
- Prior art date
Links
- WMFYOYKPJLRMJI-UHFFFAOYSA-N Lercanidipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 WMFYOYKPJLRMJI-UHFFFAOYSA-N 0.000 title 1
- 229960002162 lercanidipine hydrochloride Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001726A ITMI20011726A1 (it) | 2001-08-06 | 2001-08-06 | Forme polimorfe della lercanidipina cloridrato |
| PCT/EP2002/008699 WO2003014084A1 (en) | 2001-08-06 | 2002-08-05 | Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE307114T1 true ATE307114T1 (de) | 2005-11-15 |
Family
ID=11448245
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02762428T ATE307114T1 (de) | 2001-08-06 | 2002-08-05 | Kristalline polymorphe formen von lercanidipin hydrochlorid und verfahren zu deren herstellung |
| AT05106264T ATE453624T1 (de) | 2001-08-06 | 2002-08-05 | Kristallform von lercanipidin-hydrochlorid zur verwendung als antihypertensives mittel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05106264T ATE453624T1 (de) | 2001-08-06 | 2002-08-05 | Kristallform von lercanipidin-hydrochlorid zur verwendung als antihypertensives mittel |
Country Status (35)
| Country | Link |
|---|---|
| EP (4) | EP1432683B9 (de) |
| JP (1) | JP2005504045A (de) |
| KR (3) | KR100667687B1 (de) |
| CN (2) | CN100448847C (de) |
| AP (1) | AP1766A (de) |
| AR (1) | AR037139A1 (de) |
| AT (2) | ATE307114T1 (de) |
| AU (1) | AU2002327924C1 (de) |
| BR (1) | BR0211739A (de) |
| CY (2) | CY1109711T1 (de) |
| DE (2) | DE60206787T2 (de) |
| DK (3) | DK1432683T3 (de) |
| EA (1) | EA005673B1 (de) |
| EC (1) | ECSP044973A (de) |
| ES (3) | ES2212759T3 (de) |
| HR (1) | HRP20040156B1 (de) |
| HU (1) | HU229563B1 (de) |
| IL (3) | IL153917A (de) |
| IT (1) | ITMI20011726A1 (de) |
| MA (1) | MA27133A1 (de) |
| ME (2) | ME01525B (de) |
| MX (1) | MXPA04001069A (de) |
| NO (2) | NO325541B1 (de) |
| NZ (2) | NZ541341A (de) |
| OA (1) | OA12648A (de) |
| PE (1) | PE20030328A1 (de) |
| PL (1) | PL216066B1 (de) |
| PT (2) | PT2157083E (de) |
| RS (1) | RS52161B (de) |
| SI (3) | SI1600441T1 (de) |
| TN (1) | TNSN04024A1 (de) |
| UA (1) | UA82988C2 (de) |
| UY (1) | UY27410A1 (de) |
| WO (1) | WO2003014084A1 (de) |
| ZA (1) | ZA200401806B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
| AR043395A1 (es) * | 2003-02-28 | 2005-07-27 | Recordati Ireland Ltd | Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii |
| US20070105912A1 (en) * | 2003-12-01 | 2007-05-10 | Per Holm | Pharmaceutical compositions comprising lercanidipine |
| AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
| RU2425033C2 (ru) * | 2005-09-16 | 2011-07-27 | Гленмарк Фармасьютикалз Лимитед | Полиморфная форма гидрохлорида лерканидипина и способ ее получения |
| KR100821165B1 (ko) * | 2006-03-10 | 2008-04-14 | 동우신테크 주식회사 | 레르카니디핀 염산염의 제조 방법 |
| WO2008082041A1 (en) * | 2006-12-29 | 2008-07-10 | Dongwoo Syntech Co., Ltd | Process for preparing lercanidipine hydrochloride |
| CN101868442A (zh) * | 2007-03-05 | 2010-10-20 | 阿克塔维什集团Ptc公司 | 盐酸乐卡地平多晶型物和1,1,n-三甲基-n-(3,3-二苯基丙基)-2-氨基乙酰醋酸乙酯的改进制法 |
| EP2585051B2 (de) | 2010-06-23 | 2020-04-08 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmazeutische orale dosierformen mit lercandipin und enalapril und ihren pharmazeutisch akzeptablen salzen |
| EP2444394A1 (de) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Verfahren zur Herstellung amorpher Formen von Lercanidipin HCl |
| EA023996B1 (ru) | 2010-12-24 | 2016-08-31 | КРКА, д.д., НОВО МЕСТО | Гомогенные фармацевтические пероральные лекарственные формы, содержащие лерканидипин и эналаприл или их фармацевтически приемлемые соли совместно с органической кислотой |
| US20140031557A1 (en) * | 2011-04-18 | 2014-01-30 | Hefeibeinie Medical Technology Company, Ltd. | Method for purification of calcium channel blockers of dihydorpyridine type and preparation of nanoparticles thereof |
| CN102558032B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 一种无定形盐酸乐卡地平及其制备方法 |
| CN102531999B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 无定形盐酸乐卡地平及其制备方法 |
| CN102584682A (zh) * | 2011-12-31 | 2012-07-18 | 苏州二叶制药有限公司 | 盐酸乐卡地平的制备方法 |
| CN103497075B (zh) * | 2013-09-25 | 2016-03-23 | 山西北化关铝化工有限公司 | 水悬浮延期药造型粉 |
| CN109232389B (zh) * | 2018-05-15 | 2021-10-08 | 迪嘉药业集团有限公司 | 一种小粒度硝苯地平的结晶制备方法 |
| CN115353485B (zh) * | 2022-07-26 | 2024-04-19 | 山西双雁药业有限公司 | 从硝苯地平母液中回收硝苯地平的方法及应用 |
| CN115671066B (zh) * | 2022-11-21 | 2024-07-02 | 安徽宏业药业有限公司 | 一种盐酸乐卡地平片及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US596139A (en) * | 1897-12-28 | Process of generating acetylene gas | ||
| GB8403866D0 (en) * | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
| IT1275532B (it) * | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
| IT1274480B (it) * | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
| US5767136A (en) | 1995-05-12 | 1998-06-16 | Recordati, S.A. Chemical And Pharmaceutical Company | 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls |
| US5696139A (en) * | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
| KR20030031886A (ko) | 2000-02-16 | 2003-04-23 | 뉴로젠 코포레이션 | 치환된 아릴피라진 |
| ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
| US20040198789A1 (en) | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
-
2001
- 2001-08-06 IT IT2001MI001726A patent/ITMI20011726A1/it unknown
-
2002
- 2002-05-08 UA UA2004031657A patent/UA82988C2/uk unknown
- 2002-08-02 AR ARP020102958A patent/AR037139A1/es unknown
- 2002-08-05 CN CNB028154134A patent/CN100448847C/zh not_active Expired - Lifetime
- 2002-08-05 DK DK02762428T patent/DK1432683T3/da active
- 2002-08-05 EP EP02762428A patent/EP1432683B9/de not_active Expired - Lifetime
- 2002-08-05 PT PT91746099T patent/PT2157083E/pt unknown
- 2002-08-05 BR BR0211739-8A patent/BR0211739A/pt not_active Application Discontinuation
- 2002-08-05 ME MEP-2008-29A patent/ME01525B/de unknown
- 2002-08-05 CN CN2008101812364A patent/CN101475524B/zh not_active Expired - Lifetime
- 2002-08-05 JP JP2003519034A patent/JP2005504045A/ja active Pending
- 2002-08-05 AT AT02762428T patent/ATE307114T1/de active
- 2002-08-05 EP EP08019093A patent/EP2036890A1/de not_active Withdrawn
- 2002-08-05 RS YU11304A patent/RS52161B/sr unknown
- 2002-08-05 HR HR20040156A patent/HRP20040156B1/xx not_active IP Right Cessation
- 2002-08-05 KR KR1020047001558A patent/KR100667687B1/ko not_active Expired - Fee Related
- 2002-08-05 SI SI200230871T patent/SI1600441T1/sl unknown
- 2002-08-05 EP EP09174609.9A patent/EP2157083B1/de not_active Expired - Lifetime
- 2002-08-05 AP APAP/P/2004/002989A patent/AP1766A/en active
- 2002-08-05 EA EA200400280A patent/EA005673B1/ru unknown
- 2002-08-05 AT AT05106264T patent/ATE453624T1/de active
- 2002-08-05 NZ NZ541341A patent/NZ541341A/en not_active IP Right Cessation
- 2002-08-05 DK DK05106264.4T patent/DK1600441T3/da active
- 2002-08-05 DK DK09174609.9T patent/DK2157083T3/en active
- 2002-08-05 NZ NZ531558A patent/NZ531558A/en not_active IP Right Cessation
- 2002-08-05 PL PL369522A patent/PL216066B1/pl unknown
- 2002-08-05 DE DE60206787T patent/DE60206787T2/de not_active Expired - Lifetime
- 2002-08-05 EP EP05106264A patent/EP1600441B1/de not_active Expired - Lifetime
- 2002-08-05 SI SI200230250T patent/SI1432683T1/sl unknown
- 2002-08-05 HU HU0401163A patent/HU229563B1/hu unknown
- 2002-08-05 OA OA1200400033A patent/OA12648A/en unknown
- 2002-08-05 ES ES02762428T patent/ES2212759T3/es not_active Expired - Lifetime
- 2002-08-05 WO PCT/EP2002/008699 patent/WO2003014084A1/en not_active Ceased
- 2002-08-05 ES ES09174609.9T patent/ES2555213T3/es not_active Expired - Lifetime
- 2002-08-05 KR KR1020057021508A patent/KR100626819B1/ko not_active Expired - Fee Related
- 2002-08-05 MX MXPA04001069A patent/MXPA04001069A/es active IP Right Grant
- 2002-08-05 DE DE60234961T patent/DE60234961D1/de not_active Expired - Lifetime
- 2002-08-05 SI SI200231065T patent/SI2157083T1/sl unknown
- 2002-08-05 ME MEP-29/08A patent/MEP2908A/xx unknown
- 2002-08-05 IL IL15391702A patent/IL153917A/xx active IP Right Grant
- 2002-08-05 PT PT05106264T patent/PT1600441E/pt unknown
- 2002-08-05 KR KR1020057006786A patent/KR20050043992A/ko not_active Ceased
- 2002-08-05 IL IL16464802A patent/IL164648A0/xx active IP Right Grant
- 2002-08-05 AU AU2002327924A patent/AU2002327924C1/en not_active Expired
- 2002-08-05 ES ES05106264T patent/ES2334678T3/es not_active Expired - Lifetime
- 2002-08-06 UY UY27410A patent/UY27410A1/es unknown
- 2002-08-06 PE PE2002000715A patent/PE20030328A1/es not_active Application Discontinuation
-
2004
- 2004-01-20 NO NO20040266A patent/NO325541B1/no not_active IP Right Cessation
- 2004-02-05 TN TNP2004000024A patent/TNSN04024A1/en unknown
- 2004-02-06 EC EC2004004973A patent/ECSP044973A/es unknown
- 2004-02-06 MA MA27517A patent/MA27133A1/fr unknown
- 2004-03-04 ZA ZA2004/01806A patent/ZA200401806B/en unknown
- 2004-10-17 IL IL164648A patent/IL164648A/en not_active IP Right Cessation
-
2008
- 2008-05-22 NO NO20082330A patent/NO335651B1/no not_active IP Right Cessation
-
2010
- 2010-01-05 CY CY20101100011T patent/CY1109711T1/el unknown
-
2015
- 2015-12-10 CY CY20151101129T patent/CY1117051T1/el unknown
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| UEP | Publication of translation of european patent specification |
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