MEP2908A - Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation - Google Patents

Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation

Info

Publication number
MEP2908A
MEP2908A MEP-29/08A MEP2908A MEP2908A ME P2908 A MEP2908 A ME P2908A ME P2908 A MEP2908 A ME P2908A ME P2908 A MEP2908 A ME P2908A
Authority
ME
Montenegro
Prior art keywords
preparation
polymorphic forms
novel crystalline
lercanidipine hydrochloride
crystalline polymorphic
Prior art date
Application number
MEP-29/08A
Other languages
Bosnian (bs)
Inventor
Fausto Bonifacio
Francesco Campana
Iasi Gianluca De
Amedeo Leonardi
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11448245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MEP2908(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Publication of MEP2908A publication Critical patent/MEP2908A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Ovaj pronalasak opisuje nove sirove oblike (A) i (B) lerkanidipina, nove kristalne oblike (I) i (II) lerkanidpin hidrohlorida, koji su dobijeni za pomenuti h sirovih oblika, farmaceutske anti hipertenzivne preparate koji kao akti vni agens sadrže najmanje jedan od kristalnih oblika (I) i /II) lerkanidipin hidrohlorida i postupak za njihovu upotrebu.The present invention describes novel crude forms (A) and (B) of lercanidipine, novel crystalline forms (I) and (II) of lercanidpine hydrochloride, obtained for said h crude forms, pharmaceutical anti-hypertensive preparations containing as active agent at least one of crystalline forms (I) and / II) of lercanidipine hydrochloride and a process for their use.

MEP-29/08A 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation MEP2908A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI001726A ITMI20011726A1 (en) 2001-08-06 2001-08-06 POLYMORPHIC FORMS OF LERCANIDIPINE HYDROCHLORIDE
PCT/EP2002/008699 WO2003014084A1 (en) 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation

Publications (1)

Publication Number Publication Date
MEP2908A true MEP2908A (en) 2010-10-10

Family

ID=11448245

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-2008-29A ME01525B (en) 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and processes for their preparation
MEP-29/08A MEP2908A (en) 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-2008-29A ME01525B (en) 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and processes for their preparation

Country Status (36)

Country Link
EP (4) EP2157083B1 (en)
JP (1) JP2005504045A (en)
KR (3) KR100667687B1 (en)
CN (2) CN101475524B (en)
AP (1) AP1766A (en)
AR (1) AR037139A1 (en)
AT (2) ATE453624T1 (en)
AU (1) AU2002327924C1 (en)
BR (1) BR0211739A (en)
CY (2) CY1109711T1 (en)
DE (2) DE60206787T2 (en)
DK (3) DK1600441T3 (en)
EA (1) EA005673B1 (en)
EC (1) ECSP044973A (en)
ES (3) ES2212759T3 (en)
HK (3) HK1067123A1 (en)
HR (1) HRP20040156B1 (en)
HU (1) HU229563B1 (en)
IL (3) IL153917A (en)
IT (1) ITMI20011726A1 (en)
MA (1) MA27133A1 (en)
ME (2) ME01525B (en)
MX (1) MXPA04001069A (en)
NO (2) NO325541B1 (en)
NZ (2) NZ541341A (en)
OA (1) OA12648A (en)
PE (1) PE20030328A1 (en)
PL (1) PL216066B1 (en)
PT (2) PT1600441E (en)
RS (1) RS52161B (en)
SI (3) SI1600441T1 (en)
TN (1) TNSN04024A1 (en)
UA (1) UA82988C2 (en)
UY (1) UY27410A1 (en)
WO (1) WO2003014084A1 (en)
ZA (1) ZA200401806B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (en) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma POLYMORPHIC FORMS OF LERCANIDIPINE HYDROCHLORIDE
AR043395A1 (en) * 2003-02-28 2005-07-27 Recordati Ireland Ltd COMBINATION THERAPY FOR HYPERTENSION USING LERCANIDIPINE AND A BLOCKER OF ANGIOTENSIN II RECEPTORS
EP1694305B1 (en) * 2003-12-01 2019-10-16 Recordati Ireland Limited Pharmaceutical compositions comprising lercanidipine
AR052918A1 (en) 2005-02-25 2007-04-11 Recordati Ireland Ltd LERCANIDIPINE AMORFO CHLORHYDRATE
WO2007031865A2 (en) 2005-09-16 2007-03-22 Glenmark Pharmaceuticals Limited Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof
KR100821165B1 (en) * 2006-03-10 2008-04-14 동우신테크 주식회사 Process for preparing lercanidipine hydrochloride
JP2010514753A (en) * 2006-12-29 2010-05-06 ドンウ シンテック カンパニー リミテッド Method for producing lercanidipine hydrochloride
CN101868442A (en) * 2007-03-05 2010-10-20 阿克塔维什集团Ptc公司 Lercanidipine hydrochloride polymorphs and 1,1, the improvement method for making of N-trimethylammonium-N-(3, the 3-diphenyl propyl)-2-glycyl vinyl acetic monomer
WO2011161223A2 (en) 2010-06-23 2011-12-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
EP2444394A1 (en) 2010-10-21 2012-04-25 Alembic Pharmaceuticals Limited Process for the preparation of amorphous form of lercanidipine HCI
EP2654729B1 (en) 2010-12-24 2016-05-04 KRKA, d.d., Novo mesto Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts together with an organic acid
WO2012142927A1 (en) * 2011-04-18 2012-10-26 合肥贝霓医药科技有限公司 Method for purification of calcium channel blockers of dihydropyridine type and preparation of nanoparticles thereof
CN102531999B (en) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 Amorphous lercanidipine hydrochloride and preparation method thereof
CN102558032B (en) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 Amorphous lercanidipine hydrochloride and preparation method thereof
CN102584682A (en) * 2011-12-31 2012-07-18 苏州二叶制药有限公司 Preparation method of lercanidipine hydrochloride
CN103497075B (en) * 2013-09-25 2016-03-23 山西北化关铝化工有限公司 Aqueous suspension delay powder modeling powder
CN109232389B (en) * 2018-05-15 2021-10-08 迪嘉药业集团有限公司 Method for preparing small-particle-size nifedipine crystals
CN115353485B (en) * 2022-07-26 2024-04-19 山西双雁药业有限公司 Method for recovering nifedipine from nifedipine mother solution and application thereof
CN115671066B (en) * 2022-11-21 2024-07-02 安徽宏业药业有限公司 Lercanidipine hydrochloride tablet and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US596139A (en) * 1897-12-28 Process of generating acetylene gas
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
IT1274480B (en) * 1995-05-12 1997-07-17 Recordati Chem Pharm IMPROVED PROCEDURE FOR THE PREPARATION OF LERCANIDIPINE HYDROCHLORIDE
IT1275532B (en) * 1995-07-14 1997-08-07 Recordati Chem Pharm USE OF 1,4-DIHYDROPYRIDINIC DERIVATIVES FOR THE PREVENTION AND THERAPY OF THE ATHEROSCLEROTIC DEGENERATION OF THE ARTERIAL WALL
US5767136A (en) * 1995-05-12 1998-06-16 Recordati, S.A. Chemical And Pharmaceutical Company 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls
US5696139A (en) 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
KR20080021603A (en) 2000-02-16 2008-03-07 뉴로젠 코포레이션 Substituted arylpyrazines
ITMI20011726A1 (en) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma POLYMORPHIC FORMS OF LERCANIDIPINE HYDROCHLORIDE
US20040198789A1 (en) 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations

Also Published As

Publication number Publication date
CY1109711T1 (en) 2014-08-13
ITMI20011726A1 (en) 2003-02-06
IL164648A0 (en) 2005-12-18
KR20050043992A (en) 2005-05-11
PL216066B1 (en) 2014-02-28
HK1067123A1 (en) 2005-04-01
NO20082330L (en) 2004-03-24
EP2036890A1 (en) 2009-03-18
PE20030328A1 (en) 2003-05-09
EP2157083A3 (en) 2010-03-24
UY27410A1 (en) 2003-03-31
HK1140487A1 (en) 2010-10-15
EP1432683B9 (en) 2006-01-18
EP1432683B1 (en) 2005-10-19
RS11304A (en) 2007-02-05
CN1538957A (en) 2004-10-20
SI1600441T1 (en) 2010-02-26
DE60234961D1 (en) 2010-02-11
EP2157083A2 (en) 2010-02-24
UA82988C2 (en) 2008-06-10
NO325541B1 (en) 2008-06-16
ES2334678T3 (en) 2010-03-15
HUP0401163A2 (en) 2004-09-28
KR20040030903A (en) 2004-04-09
ZA200401806B (en) 2005-06-29
SI1432683T1 (en) 2006-04-30
NZ541341A (en) 2007-02-23
CY1117051T1 (en) 2017-04-05
KR100667687B1 (en) 2007-01-12
BR0211739A (en) 2004-09-28
JP2005504045A (en) 2005-02-10
RS52161B (en) 2012-08-31
SI2157083T1 (en) 2016-01-29
AR037139A1 (en) 2004-10-27
ES2212759T1 (en) 2004-08-01
HRP20040156B1 (en) 2012-03-31
TNSN04024A1 (en) 2006-06-01
EP1600441A2 (en) 2005-11-30
HU229563B1 (en) 2014-02-28
PL369522A1 (en) 2005-05-02
NO335651B1 (en) 2015-01-19
PT2157083E (en) 2016-01-22
ECSP044973A (en) 2004-06-28
ITMI20011726A0 (en) 2001-08-06
HUP0401163A3 (en) 2009-04-28
DE60206787T2 (en) 2006-07-13
AP1766A (en) 2007-08-10
ES2212759T3 (en) 2006-04-16
ATE453624T1 (en) 2010-01-15
EA200400280A1 (en) 2004-08-26
CN100448847C (en) 2009-01-07
EP2157083B1 (en) 2015-09-30
HK1086263A1 (en) 2006-09-15
KR100626819B1 (en) 2006-09-20
DK1432683T3 (en) 2006-03-06
CN101475524B (en) 2012-08-29
EA005673B1 (en) 2005-04-28
ATE307114T1 (en) 2005-11-15
KR20050111799A (en) 2005-11-28
AU2002327924B2 (en) 2008-04-24
DK1600441T3 (en) 2010-02-08
IL153917A0 (en) 2003-07-31
MA27133A1 (en) 2005-01-03
MXPA04001069A (en) 2005-02-17
IL153917A (en) 2005-11-20
PT1600441E (en) 2010-01-20
EP1600441A3 (en) 2005-12-07
EP1600441B1 (en) 2009-12-30
NO20040266L (en) 2004-03-24
OA12648A (en) 2006-06-16
AP2004002989A0 (en) 2004-03-31
ME01525B (en) 2011-02-10
CN101475524A (en) 2009-07-08
DE60206787D1 (en) 2006-03-02
ES2555213T3 (en) 2015-12-29
HRP20040156A2 (en) 2004-08-31
IL164648A (en) 2007-02-11
AU2002327924C1 (en) 2009-12-10
WO2003014084A1 (en) 2003-02-20
EP1432683A1 (en) 2004-06-30
NZ531558A (en) 2005-12-23
DK2157083T3 (en) 2015-11-02

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