SI1600441T1 - Kristalna oblika lerkanidipin hidroklorida za uporabo kot sredstvo proti hipertenziji - Google Patents
Kristalna oblika lerkanidipin hidroklorida za uporabo kot sredstvo proti hipertenzijiInfo
- Publication number
- SI1600441T1 SI1600441T1 SI200230871T SI200230871T SI1600441T1 SI 1600441 T1 SI1600441 T1 SI 1600441T1 SI 200230871 T SI200230871 T SI 200230871T SI 200230871 T SI200230871 T SI 200230871T SI 1600441 T1 SI1600441 T1 SI 1600441T1
- Authority
- SI
- Slovenia
- Prior art keywords
- crystal form
- antihypertensive agent
- lercanidipine hydrochloride
- lercanidipine
- hydrochloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI001726A ITMI20011726A1 (it) | 2001-08-06 | 2001-08-06 | Forme polimorfe della lercanidipina cloridrato |
EP05106264A EP1600441B1 (en) | 2001-08-06 | 2002-08-05 | Crystal form of lercanidipine hydrochloride for use as an antihypertensive agent |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1600441T1 true SI1600441T1 (sl) | 2010-02-26 |
Family
ID=11448245
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200230250T SI1432683T1 (sl) | 2001-08-06 | 2002-08-05 | Nove kristalne polimorfne oblike lerkanidipina inpostopki za njihovo pripravo |
SI200231065T SI2157083T1 (sl) | 2001-08-06 | 2002-08-05 | Farmacevtske sestave, vsebujoče kristalno obliko (i) lerkanidipin hidroklorida |
SI200230871T SI1600441T1 (sl) | 2001-08-06 | 2002-08-05 | Kristalna oblika lerkanidipin hidroklorida za uporabo kot sredstvo proti hipertenziji |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200230250T SI1432683T1 (sl) | 2001-08-06 | 2002-08-05 | Nove kristalne polimorfne oblike lerkanidipina inpostopki za njihovo pripravo |
SI200231065T SI2157083T1 (sl) | 2001-08-06 | 2002-08-05 | Farmacevtske sestave, vsebujoče kristalno obliko (i) lerkanidipin hidroklorida |
Country Status (36)
Country | Link |
---|---|
EP (4) | EP2036890A1 (sl) |
JP (1) | JP2005504045A (sl) |
KR (3) | KR100626819B1 (sl) |
CN (2) | CN100448847C (sl) |
AP (1) | AP1766A (sl) |
AR (1) | AR037139A1 (sl) |
AT (2) | ATE307114T1 (sl) |
AU (1) | AU2002327924C1 (sl) |
BR (1) | BR0211739A (sl) |
CY (2) | CY1109711T1 (sl) |
DE (2) | DE60206787T2 (sl) |
DK (3) | DK1432683T3 (sl) |
EA (1) | EA005673B1 (sl) |
EC (1) | ECSP044973A (sl) |
ES (3) | ES2555213T3 (sl) |
HK (3) | HK1067123A1 (sl) |
HR (1) | HRP20040156B1 (sl) |
HU (1) | HU229563B1 (sl) |
IL (3) | IL153917A (sl) |
IT (1) | ITMI20011726A1 (sl) |
MA (1) | MA27133A1 (sl) |
ME (2) | ME01525B (sl) |
MX (1) | MXPA04001069A (sl) |
NO (2) | NO325541B1 (sl) |
NZ (2) | NZ531558A (sl) |
OA (1) | OA12648A (sl) |
PE (1) | PE20030328A1 (sl) |
PL (1) | PL216066B1 (sl) |
PT (2) | PT1600441E (sl) |
RS (1) | RS52161B (sl) |
SI (3) | SI1432683T1 (sl) |
TN (1) | TNSN04024A1 (sl) |
UA (1) | UA82988C2 (sl) |
UY (1) | UY27410A1 (sl) |
WO (1) | WO2003014084A1 (sl) |
ZA (1) | ZA200401806B (sl) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
AR043395A1 (es) * | 2003-02-28 | 2005-07-27 | Recordati Ireland Ltd | Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii |
MXPA06006118A (es) * | 2003-12-01 | 2006-08-11 | Lifecycle Pharma As | Composiciones farmaceuticas que comprenden lercanidipina. |
AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
WO2007031865A2 (en) | 2005-09-16 | 2007-03-22 | Glenmark Pharmaceuticals Limited | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof |
KR100821165B1 (ko) * | 2006-03-10 | 2008-04-14 | 동우신테크 주식회사 | 레르카니디핀 염산염의 제조 방법 |
WO2008082041A1 (en) * | 2006-12-29 | 2008-07-10 | Dongwoo Syntech Co., Ltd | Process for preparing lercanidipine hydrochloride |
EP2121575A2 (en) * | 2007-03-05 | 2009-11-25 | Actavis Group PTC EHF | Lercanidipine hydrochloride polymorphs and an improved process for preparation of 1,1,n-trimethyl-n-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate |
SI2585051T2 (sl) | 2010-06-23 | 2020-07-31 | Krka, D.D., Novo Mesto | Farmacevtske oralne odmerne oblike,ki obsegajo lerkanidipin in enalapril in njune farmacevtsko sprejemljive soli |
EP2444394A1 (en) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Process for the preparation of amorphous form of lercanidipine HCI |
SI2654729T1 (sl) | 2010-12-24 | 2016-08-31 | Krka, D.D., Novo Mesto | Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino |
EP2700632A4 (en) * | 2011-04-18 | 2014-09-03 | Hefei Beini Medical Technology Company Ltd | METHOD FOR CLEANING DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS AND PRODUCING NANOPARTICLES THEREFOR |
CN102531999B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 无定形盐酸乐卡地平及其制备方法 |
CN102558032B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 一种无定形盐酸乐卡地平及其制备方法 |
CN102584682A (zh) * | 2011-12-31 | 2012-07-18 | 苏州二叶制药有限公司 | 盐酸乐卡地平的制备方法 |
CN103497075B (zh) * | 2013-09-25 | 2016-03-23 | 山西北化关铝化工有限公司 | 水悬浮延期药造型粉 |
CN109232389B (zh) * | 2018-05-15 | 2021-10-08 | 迪嘉药业集团有限公司 | 一种小粒度硝苯地平的结晶制备方法 |
CN115353485B (zh) * | 2022-07-26 | 2024-04-19 | 山西双雁药业有限公司 | 从硝苯地平母液中回收硝苯地平的方法及应用 |
CN115671066B (zh) * | 2022-11-21 | 2024-07-02 | 安徽宏业药业有限公司 | 一种盐酸乐卡地平片及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US596139A (en) * | 1897-12-28 | Process of generating acetylene gas | ||
GB8403866D0 (en) | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
IT1275532B (it) * | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
IT1274480B (it) * | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
US5912351A (en) | 1995-05-12 | 1999-06-15 | Recordati, S.A. Chemical And Pharmaceutical Company | Anhydrous 1,4-Dihydropyridines and salts thereof |
US5696139A (en) | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
ES2247070T3 (es) | 2000-02-16 | 2006-03-01 | Neurogen Corporation | Arilpirazinas sustituidas. |
ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
US20040198789A1 (en) | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
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2001
- 2001-08-06 IT IT2001MI001726A patent/ITMI20011726A1/it unknown
-
2002
- 2002-05-08 UA UA2004031657A patent/UA82988C2/uk unknown
- 2002-08-02 AR ARP020102958A patent/AR037139A1/es unknown
- 2002-08-05 IL IL15391702A patent/IL153917A/xx active IP Right Grant
- 2002-08-05 CN CNB028154134A patent/CN100448847C/zh not_active Expired - Lifetime
- 2002-08-05 KR KR1020057021508A patent/KR100626819B1/ko not_active IP Right Cessation
- 2002-08-05 OA OA1200400033A patent/OA12648A/en unknown
- 2002-08-05 PT PT05106264T patent/PT1600441E/pt unknown
- 2002-08-05 DE DE60206787T patent/DE60206787T2/de not_active Expired - Lifetime
- 2002-08-05 ES ES09174609.9T patent/ES2555213T3/es not_active Expired - Lifetime
- 2002-08-05 EP EP08019093A patent/EP2036890A1/en not_active Withdrawn
- 2002-08-05 EP EP05106264A patent/EP1600441B1/en not_active Expired - Lifetime
- 2002-08-05 KR KR1020047001558A patent/KR100667687B1/ko not_active IP Right Cessation
- 2002-08-05 CN CN2008101812364A patent/CN101475524B/zh not_active Expired - Lifetime
- 2002-08-05 BR BR0211739-8A patent/BR0211739A/pt not_active Application Discontinuation
- 2002-08-05 SI SI200230250T patent/SI1432683T1/sl unknown
- 2002-08-05 IL IL16464802A patent/IL164648A0/xx active IP Right Grant
- 2002-08-05 DE DE60234961T patent/DE60234961D1/de not_active Expired - Lifetime
- 2002-08-05 ME MEP-2008-29A patent/ME01525B/me unknown
- 2002-08-05 ES ES02762428T patent/ES2212759T3/es not_active Expired - Lifetime
- 2002-08-05 AU AU2002327924A patent/AU2002327924C1/en not_active Expired
- 2002-08-05 MX MXPA04001069A patent/MXPA04001069A/es active IP Right Grant
- 2002-08-05 AP APAP/P/2004/002989A patent/AP1766A/en active
- 2002-08-05 HU HU0401163A patent/HU229563B1/hu unknown
- 2002-08-05 PL PL369522A patent/PL216066B1/pl unknown
- 2002-08-05 EP EP02762428A patent/EP1432683B9/en not_active Expired - Lifetime
- 2002-08-05 AT AT02762428T patent/ATE307114T1/de active
- 2002-08-05 ES ES05106264T patent/ES2334678T3/es not_active Expired - Lifetime
- 2002-08-05 SI SI200231065T patent/SI2157083T1/sl unknown
- 2002-08-05 DK DK02762428T patent/DK1432683T3/da active
- 2002-08-05 WO PCT/EP2002/008699 patent/WO2003014084A1/en active IP Right Grant
- 2002-08-05 EA EA200400280A patent/EA005673B1/ru unknown
- 2002-08-05 ME MEP-29/08A patent/MEP2908A/xx unknown
- 2002-08-05 DK DK09174609.9T patent/DK2157083T3/en active
- 2002-08-05 DK DK05106264.4T patent/DK1600441T3/da active
- 2002-08-05 EP EP09174609.9A patent/EP2157083B1/en not_active Expired - Lifetime
- 2002-08-05 SI SI200230871T patent/SI1600441T1/sl unknown
- 2002-08-05 NZ NZ531558A patent/NZ531558A/en not_active IP Right Cessation
- 2002-08-05 RS YU11304A patent/RS52161B/en unknown
- 2002-08-05 JP JP2003519034A patent/JP2005504045A/ja active Pending
- 2002-08-05 AT AT05106264T patent/ATE453624T1/de active
- 2002-08-05 NZ NZ541341A patent/NZ541341A/en not_active IP Right Cessation
- 2002-08-05 PT PT91746099T patent/PT2157083E/pt unknown
- 2002-08-05 KR KR1020057006786A patent/KR20050043992A/ko not_active Application Discontinuation
- 2002-08-06 UY UY27410A patent/UY27410A1/es unknown
- 2002-08-06 PE PE2002000715A patent/PE20030328A1/es not_active Application Discontinuation
-
2004
- 2004-01-20 NO NO20040266A patent/NO325541B1/no not_active IP Right Cessation
- 2004-02-05 TN TNP2004000024A patent/TNSN04024A1/en unknown
- 2004-02-06 MA MA27517A patent/MA27133A1/fr unknown
- 2004-02-06 EC EC2004004973A patent/ECSP044973A/es unknown
- 2004-02-18 HR HR20040156A patent/HRP20040156B1/xx not_active IP Right Cessation
- 2004-03-04 ZA ZA2004/01806A patent/ZA200401806B/en unknown
- 2004-10-17 IL IL164648A patent/IL164648A/en not_active IP Right Cessation
- 2004-12-23 HK HK04110181A patent/HK1067123A1/xx not_active IP Right Cessation
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2006
- 2006-05-29 HK HK10106911.1A patent/HK1140487A1/xx not_active IP Right Cessation
- 2006-05-29 HK HK06106196.3A patent/HK1086263A1/xx not_active IP Right Cessation
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2008
- 2008-05-22 NO NO20082330A patent/NO335651B1/no not_active IP Right Cessation
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2010
- 2010-01-05 CY CY20101100011T patent/CY1109711T1/el unknown
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2015
- 2015-12-10 CY CY20151101129T patent/CY1117051T1/el unknown
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