AR037139A1 - Formas crudas a y b de 1,1-trimetil-n-(3,3-difenil-propil)2-aminoetil-1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5 dicarboxilato, formas cristalinas (i) y (ii) obtenidas a partir de dichas formas crudas y composiciones farmaceuticas antihipertensivas que contienen por lo menos una de dichas f - Google Patents
Formas crudas a y b de 1,1-trimetil-n-(3,3-difenil-propil)2-aminoetil-1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5 dicarboxilato, formas cristalinas (i) y (ii) obtenidas a partir de dichas formas crudas y composiciones farmaceuticas antihipertensivas que contienen por lo menos una de dichas fInfo
- Publication number
- AR037139A1 AR037139A1 ARP020102958A ARP020102958A AR037139A1 AR 037139 A1 AR037139 A1 AR 037139A1 AR P020102958 A ARP020102958 A AR P020102958A AR P020102958 A ARP020102958 A AR P020102958A AR 037139 A1 AR037139 A1 AR 037139A1
- Authority
- AR
- Argentina
- Prior art keywords
- forms
- crude
- dicarboxylate
- nitrophenyl
- trimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
La presente describe formas crudas de clorhidrato de metil 1,1 N-trimetil-N-(3,3-difenil-propil)-2-aminoetil 1,4 dihidro-2,6-dimetil-4-(3-nitrofenil) piridin-3,5 dicarboxilato lercanidipina (A) y (B) preparadas con un método que comprende formas cristalinas de clorhidrato de lercanidipina (I) y (II) que se obtiene a partir de dichas formas crudas, composiciones farmacéuticas antihipertensivas que contienen como agente activo por lo menos una de las formas cristalinas de clorhidrato de lercanidipina (I) y (II) y los métodos de uso de las mismas, en particular para tratar y prevenir lesiones arteroescleróticas en las arterias de un individuo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI001726A ITMI20011726A1 (it) | 2001-08-06 | 2001-08-06 | Forme polimorfe della lercanidipina cloridrato |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037139A1 true AR037139A1 (es) | 2004-10-27 |
Family
ID=11448245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102958A AR037139A1 (es) | 2001-08-06 | 2002-08-02 | Formas crudas a y b de 1,1-trimetil-n-(3,3-difenil-propil)2-aminoetil-1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5 dicarboxilato, formas cristalinas (i) y (ii) obtenidas a partir de dichas formas crudas y composiciones farmaceuticas antihipertensivas que contienen por lo menos una de dichas f |
Country Status (36)
Country | Link |
---|---|
EP (4) | EP2157083B1 (es) |
JP (1) | JP2005504045A (es) |
KR (3) | KR100667687B1 (es) |
CN (2) | CN101475524B (es) |
AP (1) | AP1766A (es) |
AR (1) | AR037139A1 (es) |
AT (2) | ATE453624T1 (es) |
AU (1) | AU2002327924C1 (es) |
BR (1) | BR0211739A (es) |
CY (2) | CY1109711T1 (es) |
DE (2) | DE60206787T2 (es) |
DK (3) | DK1600441T3 (es) |
EA (1) | EA005673B1 (es) |
EC (1) | ECSP044973A (es) |
ES (3) | ES2212759T3 (es) |
HK (3) | HK1067123A1 (es) |
HR (1) | HRP20040156B1 (es) |
HU (1) | HU229563B1 (es) |
IL (3) | IL153917A (es) |
IT (1) | ITMI20011726A1 (es) |
MA (1) | MA27133A1 (es) |
ME (2) | ME01525B (es) |
MX (1) | MXPA04001069A (es) |
NO (2) | NO325541B1 (es) |
NZ (2) | NZ541341A (es) |
OA (1) | OA12648A (es) |
PE (1) | PE20030328A1 (es) |
PL (1) | PL216066B1 (es) |
PT (2) | PT1600441E (es) |
RS (1) | RS52161B (es) |
SI (3) | SI1600441T1 (es) |
TN (1) | TNSN04024A1 (es) |
UA (1) | UA82988C2 (es) |
UY (1) | UY27410A1 (es) |
WO (1) | WO2003014084A1 (es) |
ZA (1) | ZA200401806B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
AR043395A1 (es) * | 2003-02-28 | 2005-07-27 | Recordati Ireland Ltd | Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii |
EP1694305B1 (en) * | 2003-12-01 | 2019-10-16 | Recordati Ireland Limited | Pharmaceutical compositions comprising lercanidipine |
AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
WO2007031865A2 (en) | 2005-09-16 | 2007-03-22 | Glenmark Pharmaceuticals Limited | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof |
KR100821165B1 (ko) * | 2006-03-10 | 2008-04-14 | 동우신테크 주식회사 | 레르카니디핀 염산염의 제조 방법 |
JP2010514753A (ja) * | 2006-12-29 | 2010-05-06 | ドンウ シンテック カンパニー リミテッド | レルカニジピン塩酸塩の製造方法 |
CN101868442A (zh) * | 2007-03-05 | 2010-10-20 | 阿克塔维什集团Ptc公司 | 盐酸乐卡地平多晶型物和1,1,n-三甲基-n-(3,3-二苯基丙基)-2-氨基乙酰醋酸乙酯的改进制法 |
WO2011161223A2 (en) | 2010-06-23 | 2011-12-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts |
EP2444394A1 (en) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Process for the preparation of amorphous form of lercanidipine HCI |
EP2654729B1 (en) | 2010-12-24 | 2016-05-04 | KRKA, d.d., Novo mesto | Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts together with an organic acid |
WO2012142927A1 (zh) * | 2011-04-18 | 2012-10-26 | 合肥贝霓医药科技有限公司 | 一种纯化二氢吡啶类钙通道阻滞剂并制备其纳米的方法 |
CN102531999B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 无定形盐酸乐卡地平及其制备方法 |
CN102558032B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 一种无定形盐酸乐卡地平及其制备方法 |
CN102584682A (zh) * | 2011-12-31 | 2012-07-18 | 苏州二叶制药有限公司 | 盐酸乐卡地平的制备方法 |
CN103497075B (zh) * | 2013-09-25 | 2016-03-23 | 山西北化关铝化工有限公司 | 水悬浮延期药造型粉 |
CN109232389B (zh) * | 2018-05-15 | 2021-10-08 | 迪嘉药业集团有限公司 | 一种小粒度硝苯地平的结晶制备方法 |
CN115353485B (zh) * | 2022-07-26 | 2024-04-19 | 山西双雁药业有限公司 | 从硝苯地平母液中回收硝苯地平的方法及应用 |
CN115671066B (zh) * | 2022-11-21 | 2024-07-02 | 安徽宏业药业有限公司 | 一种盐酸乐卡地平片及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US596139A (en) * | 1897-12-28 | Process of generating acetylene gas | ||
GB8403866D0 (en) * | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
IT1274480B (it) * | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
IT1275532B (it) * | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
US5767136A (en) * | 1995-05-12 | 1998-06-16 | Recordati, S.A. Chemical And Pharmaceutical Company | 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls |
US5696139A (en) | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
KR20080021603A (ko) | 2000-02-16 | 2008-03-07 | 뉴로젠 코포레이션 | 치환된 아릴피라진 |
ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
US20040198789A1 (en) | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
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2001
- 2001-08-06 IT IT2001MI001726A patent/ITMI20011726A1/it unknown
-
2002
- 2002-05-08 UA UA2004031657A patent/UA82988C2/uk unknown
- 2002-08-02 AR ARP020102958A patent/AR037139A1/es unknown
- 2002-08-05 PT PT05106264T patent/PT1600441E/pt unknown
- 2002-08-05 KR KR1020047001558A patent/KR100667687B1/ko not_active IP Right Cessation
- 2002-08-05 EP EP09174609.9A patent/EP2157083B1/en not_active Expired - Lifetime
- 2002-08-05 EP EP02762428A patent/EP1432683B9/en not_active Expired - Lifetime
- 2002-08-05 DK DK05106264.4T patent/DK1600441T3/da active
- 2002-08-05 EP EP05106264A patent/EP1600441B1/en not_active Expired - Lifetime
- 2002-08-05 ES ES02762428T patent/ES2212759T3/es not_active Expired - Lifetime
- 2002-08-05 DE DE60206787T patent/DE60206787T2/de not_active Expired - Lifetime
- 2002-08-05 EP EP08019093A patent/EP2036890A1/en not_active Withdrawn
- 2002-08-05 RS YU11304A patent/RS52161B/en unknown
- 2002-08-05 OA OA1200400033A patent/OA12648A/en unknown
- 2002-08-05 DK DK09174609.9T patent/DK2157083T3/en active
- 2002-08-05 BR BR0211739-8A patent/BR0211739A/pt not_active Application Discontinuation
- 2002-08-05 ES ES05106264T patent/ES2334678T3/es not_active Expired - Lifetime
- 2002-08-05 CN CN2008101812364A patent/CN101475524B/zh not_active Expired - Lifetime
- 2002-08-05 JP JP2003519034A patent/JP2005504045A/ja active Pending
- 2002-08-05 SI SI200230871T patent/SI1600441T1/sl unknown
- 2002-08-05 AP APAP/P/2004/002989A patent/AP1766A/en active
- 2002-08-05 ES ES09174609.9T patent/ES2555213T3/es not_active Expired - Lifetime
- 2002-08-05 SI SI200231065T patent/SI2157083T1/sl unknown
- 2002-08-05 NZ NZ541341A patent/NZ541341A/en not_active IP Right Cessation
- 2002-08-05 PT PT91746099T patent/PT2157083E/pt unknown
- 2002-08-05 KR KR1020057006786A patent/KR20050043992A/ko not_active Application Discontinuation
- 2002-08-05 AT AT05106264T patent/ATE453624T1/de active
- 2002-08-05 ME MEP-2008-29A patent/ME01525B/me unknown
- 2002-08-05 DE DE60234961T patent/DE60234961D1/de not_active Expired - Lifetime
- 2002-08-05 ME MEP-29/08A patent/MEP2908A/xx unknown
- 2002-08-05 WO PCT/EP2002/008699 patent/WO2003014084A1/en active IP Right Grant
- 2002-08-05 DK DK02762428T patent/DK1432683T3/da active
- 2002-08-05 MX MXPA04001069A patent/MXPA04001069A/es active IP Right Grant
- 2002-08-05 SI SI200230250T patent/SI1432683T1/sl unknown
- 2002-08-05 IL IL15391702A patent/IL153917A/xx active IP Right Grant
- 2002-08-05 AT AT02762428T patent/ATE307114T1/de active
- 2002-08-05 AU AU2002327924A patent/AU2002327924C1/en not_active Expired
- 2002-08-05 KR KR1020057021508A patent/KR100626819B1/ko not_active IP Right Cessation
- 2002-08-05 CN CNB028154134A patent/CN100448847C/zh not_active Expired - Lifetime
- 2002-08-05 EA EA200400280A patent/EA005673B1/ru unknown
- 2002-08-05 IL IL16464802A patent/IL164648A0/xx active IP Right Grant
- 2002-08-05 NZ NZ531558A patent/NZ531558A/en not_active IP Right Cessation
- 2002-08-05 PL PL369522A patent/PL216066B1/pl unknown
- 2002-08-05 HU HU0401163A patent/HU229563B1/hu unknown
- 2002-08-06 UY UY27410A patent/UY27410A1/es unknown
- 2002-08-06 PE PE2002000715A patent/PE20030328A1/es not_active Application Discontinuation
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2004
- 2004-01-20 NO NO20040266A patent/NO325541B1/no not_active IP Right Cessation
- 2004-02-05 TN TNP2004000024A patent/TNSN04024A1/en unknown
- 2004-02-06 EC EC2004004973A patent/ECSP044973A/es unknown
- 2004-02-06 MA MA27517A patent/MA27133A1/fr unknown
- 2004-02-18 HR HR20040156A patent/HRP20040156B1/xx not_active IP Right Cessation
- 2004-03-04 ZA ZA2004/01806A patent/ZA200401806B/en unknown
- 2004-10-17 IL IL164648A patent/IL164648A/en not_active IP Right Cessation
- 2004-12-23 HK HK04110181A patent/HK1067123A1/xx not_active IP Right Cessation
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2006
- 2006-05-29 HK HK06106196.3A patent/HK1086263A1/xx not_active IP Right Cessation
- 2006-05-29 HK HK10106911.1A patent/HK1140487A1/xx not_active IP Right Cessation
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2008
- 2008-05-22 NO NO20082330A patent/NO335651B1/no not_active IP Right Cessation
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2010
- 2010-01-05 CY CY20101100011T patent/CY1109711T1/el unknown
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2015
- 2015-12-10 CY CY20151101129T patent/CY1117051T1/el unknown
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