AR037230A1 - Solvatos de clorhidrato de metil 1,1-n-trimetil-n-(3,3-difenil-propil)-2-aminoetil 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5-dicarboxilato (lercanidipina) con cloruro de metileno, acetona, anisol, tetrahidrofuran, metil-terbutil-ester, isopropanol, 2-butanol, heptano, metil-etil-cetona y a - Google Patents

Solvatos de clorhidrato de metil 1,1-n-trimetil-n-(3,3-difenil-propil)-2-aminoetil 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5-dicarboxilato (lercanidipina) con cloruro de metileno, acetona, anisol, tetrahidrofuran, metil-terbutil-ester, isopropanol, 2-butanol, heptano, metil-etil-cetona y a

Info

Publication number
AR037230A1
AR037230A1 ARP020102957A ARP020102957A AR037230A1 AR 037230 A1 AR037230 A1 AR 037230A1 AR P020102957 A ARP020102957 A AR P020102957A AR P020102957 A ARP020102957 A AR P020102957A AR 037230 A1 AR037230 A1 AR 037230A1
Authority
AR
Argentina
Prior art keywords
methyl
lercanidipine
solvates
nitrophenyl
trimethyl
Prior art date
Application number
ARP020102957A
Other languages
English (en)
Inventor
Amedeo Leonardi
Iasi Gianluca De
Fausto Bonifacio
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Publication of AR037230A1 publication Critical patent/AR037230A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente describe solvatos de clorhidrato de metil 1,1 N-trimetil-N-(3,3-difenil-propil)-2-aminoetil 1,4 dihidro-2,6-dimetil-4(3-nitrofenil)piridin-3,5 dicarboxilato (lercanidipina) con solventes orgánicos, nuevas formas cristalinas (III) y (IV) de clorhidrato de lercanidipina que se obtienen a partir de dichos solvatos mediante la eliminación de los solventes de solvatación y describe, también, composiciones farmacéuticas antihipertensivas que contienen por lo menos una de dichas formas cristalinas (III) y (IV) de clorhidrato de lercanidipina, como agente activo.
ARP020102957A 2001-08-06 2002-08-02 Solvatos de clorhidrato de metil 1,1-n-trimetil-n-(3,3-difenil-propil)-2-aminoetil 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5-dicarboxilato (lercanidipina) con cloruro de metileno, acetona, anisol, tetrahidrofuran, metil-terbutil-ester, isopropanol, 2-butanol, heptano, metil-etil-cetona y a AR037230A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001MI001727A ITMI20011727A1 (it) 2001-08-06 2001-08-06 Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi

Publications (1)

Publication Number Publication Date
AR037230A1 true AR037230A1 (es) 2004-11-03

Family

ID=11448246

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020102957A AR037230A1 (es) 2001-08-06 2002-08-02 Solvatos de clorhidrato de metil 1,1-n-trimetil-n-(3,3-difenil-propil)-2-aminoetil 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5-dicarboxilato (lercanidipina) con cloruro de metileno, acetona, anisol, tetrahidrofuran, metil-terbutil-ester, isopropanol, 2-butanol, heptano, metil-etil-cetona y a

Country Status (21)

Country Link
EP (1) EP1423367B1 (es)
JP (1) JP2005502648A (es)
KR (1) KR100912664B1 (es)
CN (1) CN100494175C (es)
AR (1) AR037230A1 (es)
AT (1) ATE294162T1 (es)
AU (1) AU2002331390B2 (es)
BR (1) BR0211738A (es)
DE (1) DE60203919D1 (es)
EA (1) EA200400279A1 (es)
ES (1) ES2209684T1 (es)
HR (1) HRP20040157A2 (es)
HU (1) HUP0401161A3 (es)
IL (2) IL153916A0 (es)
IT (1) ITMI20011727A1 (es)
MX (1) MXPA04001073A (es)
NO (1) NO20040479L (es)
PE (1) PE20030350A1 (es)
PL (1) PL369449A1 (es)
UY (1) UY27409A1 (es)
WO (1) WO2003014085A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100651212B1 (ko) 2004-10-27 2006-12-01 제일약품주식회사 무정형 레르카니디핀의 제조방법
AR052918A1 (es) 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
BRPI0616169B8 (pt) 2005-09-16 2021-05-25 Glenmark Pharmaceuticals Ltd cloridrato de lercanidipina na forma polimorfa v, composição farmacêutica compreendendo dito composto e processos para preparação de cloridrato de lercanidipina
US20100104649A1 (en) * 2007-03-05 2010-04-29 Actavis Group Ptc Ehf Lercanidipine Hydrochloride Polymorphs and an Improved Process for Preparation of 1,1,N-Trimethyl-N-(3,3-Diphenylpropyl)-2-Aminoethyl Acetoacetate
WO2008136393A1 (ja) * 2007-04-27 2008-11-13 Ajinomoto Co., Inc. ラクタム化合物の結晶形およびその製造方法
EP2585051B2 (en) 2010-06-23 2020-04-08 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
EP2654729B1 (en) 2010-12-24 2016-05-04 KRKA, d.d., Novo mesto Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts together with an organic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
US5912351A (en) * 1995-05-12 1999-06-15 Recordati, S.A. Chemical And Pharmaceutical Company Anhydrous 1,4-Dihydropyridines and salts thereof

Also Published As

Publication number Publication date
PE20030350A1 (es) 2003-06-06
ITMI20011727A0 (it) 2001-08-06
EP1423367A1 (en) 2004-06-02
WO2003014085A1 (en) 2003-02-20
ATE294162T1 (de) 2005-05-15
UY27409A1 (es) 2003-03-31
CN1538958A (zh) 2004-10-20
ES2209684T1 (es) 2004-07-01
EP1423367B1 (en) 2005-04-27
ITMI20011727A1 (it) 2003-02-06
PL369449A1 (en) 2005-04-18
EA200400279A1 (ru) 2004-06-24
AU2002331390B2 (en) 2008-06-05
DE60203919D1 (de) 2005-06-02
HUP0401161A3 (en) 2009-04-28
IL153916A0 (en) 2003-07-31
KR20040030932A (ko) 2004-04-09
IL153916A (en) 2008-07-08
HRP20040157A2 (en) 2004-08-31
HUP0401161A2 (hu) 2004-09-28
KR100912664B1 (ko) 2009-08-17
NO20040479L (no) 2004-02-03
JP2005502648A (ja) 2005-01-27
BR0211738A (pt) 2004-09-28
CN100494175C (zh) 2009-06-03
MXPA04001073A (es) 2005-02-17

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