NO20031701L - Fremgangsmåte og mellomprodukter i fremstilling av 7- substituerte antiöstrogener - Google Patents
Fremgangsmåte og mellomprodukter i fremstilling av 7- substituerte antiöstrogenerInfo
- Publication number
- NO20031701L NO20031701L NO20031701A NO20031701A NO20031701L NO 20031701 L NO20031701 L NO 20031701L NO 20031701 A NO20031701 A NO 20031701A NO 20031701 A NO20031701 A NO 20031701A NO 20031701 L NO20031701 L NO 20031701L
- Authority
- NO
- Norway
- Prior art keywords
- group
- preparation
- intermediates
- formula
- antiestrogens
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 229940046836 anti-estrogen Drugs 0.000 title 1
- 230000001833 anti-estrogenic effect Effects 0.000 title 1
- 239000000328 estrogen antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002243 precursor Substances 0.000 abstract 2
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229960002258 fulvestrant Drugs 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Fremgangsmåte for fremstilling av en mellomprodukt-forbindelse med formel (II): hvor X er som definert i beskrivelsen, Rer halogenalkyl, alkyl, alkenyl, cykloalkyl, karboksyalkyl, alkoksykarbonylalkyl, aryl eller arylalkyl; R, R, Rog Rer organiske grupper som definert i beskrivelsen, hvilken fremgangsmåte omfatter aromatisering av en forbindelse med formel (EI): hvor R1, R2, R3, n, X og R5 er som definert i forbindelse med formel (II) og R4 er en gruppe Reller en forløpergruppe derav, og deretter, hvis nødvendig eller ønsket, utførelse av ett eller flere av de følgende trinn: (i) fjerning av hvilke som helst hydroksybeskyttelsesgrupper R; (ii) omdannelse av en forløper gruppe R4 til en gruppe R, eller hvor Rer en gruppe R, omdannelse av den til en annen slik gruppe. Forbindelser som blir oppnådd er anvendelige mellomprodukter for eksempel ved fremstilling av fulvestrant. Nye mellomprodukter er også krevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0025221.3A GB0025221D0 (en) | 2000-10-14 | 2000-10-14 | New process |
PCT/GB2001/004485 WO2002032922A1 (en) | 2000-10-14 | 2001-10-09 | Process and intermediates for the production of 7-substituted antiestrogens |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20031701D0 NO20031701D0 (no) | 2003-04-11 |
NO20031701L true NO20031701L (no) | 2003-05-23 |
NO326020B1 NO326020B1 (no) | 2008-09-01 |
Family
ID=9901292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20031701A NO326020B1 (no) | 2000-10-14 | 2003-04-11 | Fremgangsmate for fremstilling av 7-substituerte antiostrogener |
Country Status (26)
Country | Link |
---|---|
US (1) | US7947667B2 (no) |
EP (2) | EP1328538B1 (no) |
JP (2) | JP4363846B2 (no) |
KR (2) | KR100864266B1 (no) |
CN (1) | CN1255425C (no) |
AR (2) | AR034561A1 (no) |
AT (1) | ATE403667T1 (no) |
AU (3) | AU2001292132B2 (no) |
BR (1) | BR0114649A (no) |
CA (1) | CA2425572C (no) |
CY (1) | CY1108398T1 (no) |
DE (1) | DE60135240D1 (no) |
DK (1) | DK1328538T3 (no) |
EG (1) | EG23373A (no) |
ES (2) | ES2309094T3 (no) |
GB (1) | GB0025221D0 (no) |
IL (2) | IL155172A0 (no) |
MX (1) | MXPA03003302A (no) |
MY (2) | MY145819A (no) |
NO (1) | NO326020B1 (no) |
NZ (1) | NZ525096A (no) |
PT (1) | PT1328538E (no) |
SA (1) | SA01220570B1 (no) |
SI (1) | SI1328538T1 (no) |
WO (1) | WO2002032922A1 (no) |
ZA (1) | ZA200302526B (no) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0025221D0 (en) | 2000-10-14 | 2000-11-29 | Astrazeneca Ab | New process |
GB0123961D0 (en) | 2001-10-05 | 2001-11-28 | Astrazeneca Ab | Process and intermediates |
DE602005023877D1 (de) | 2004-07-27 | 2010-11-11 | Sicor Inc | Verfahren zur herstellung von 7-alpha-alkylierte 19-norsteroide |
US20100174101A1 (en) * | 2007-09-24 | 2010-07-08 | Xi'an Liband Pharmaceutical Co., Ltd. | Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol |
EP2070942A1 (de) | 2007-12-13 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen |
CN101525364B (zh) * | 2008-03-07 | 2012-12-12 | 杭州九源基因工程有限公司 | 一种氟维司群的晶型及其制备方法 |
US8063249B1 (en) | 2008-04-25 | 2011-11-22 | Olema Pharmaceuticals, Inc. | Substituted triphenyl butenes |
CN102391341B (zh) * | 2011-08-09 | 2013-05-22 | 福建省微生物研究所 | 制备6,7-脱氢-17β-烃酰氧基诺龙的方法 |
CN102600064A (zh) * | 2012-03-31 | 2012-07-25 | 西安力邦制药有限公司 | 氟维司群或其衍生物缓释制剂及其制备方法 |
EP2909224B1 (en) | 2012-10-22 | 2020-03-18 | Intas Pharmaceuticals Limited | An improved process for the preparation of fulvestrant |
CN103788164A (zh) * | 2012-10-31 | 2014-05-14 | 正大天晴药业集团股份有限公司 | 一种氟维司群的制备方法 |
CN103965280B (zh) * | 2014-05-21 | 2016-04-20 | 天津孚音生物科技发展有限公司 | 一种氟维司群中间体的制备方法 |
WO2015181116A1 (en) | 2014-05-26 | 2015-12-03 | Crystal Pharma, S.A.U. | Process and intermediades for the preparation of 7-alkylated steroids |
CN104387435B (zh) * | 2014-12-10 | 2017-05-10 | 天津孚音生物科技发展有限公司 | 一种化合物及其制备方法与应用 |
KR101640747B1 (ko) | 2015-05-20 | 2016-07-19 | 이금운 | 확장 가능형 끼움식 엘이디 조명 등기구 |
CN107488205A (zh) * | 2016-06-13 | 2017-12-19 | 重庆圣华曦药业股份有限公司 | 一种氟维司群有关物质的制备方法及其在制剂中的检测方法 |
CN110818764A (zh) * | 2018-08-07 | 2020-02-21 | 重庆圣华曦药业股份有限公司 | 一种应用加料监测系统制备氟维斯群中间体的方法 |
CN111018936B (zh) * | 2019-11-12 | 2021-10-29 | 广州曼翔医药有限公司 | 一种氟维司群有关物质e的合成方法 |
CN116535454A (zh) * | 2023-04-28 | 2023-08-04 | 香港中文大学(深圳) | 氟维司群类化合物及其制备方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7305171A (no) * | 1973-04-13 | 1974-10-15 | ||
GB8327256D0 (en) * | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
US5595985A (en) * | 1989-03-10 | 1997-01-21 | Endorecherche Inc. | Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia |
DE4132182A1 (de) * | 1991-09-24 | 1993-03-25 | Schering Ag | 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln |
US5211831A (en) * | 1991-11-27 | 1993-05-18 | Mcgean-Rohco, Inc. | Process for extending the life of a displacement plating bath |
DE19622457A1 (de) * | 1996-05-24 | 1997-11-27 | Schering Ag | 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
US5952319A (en) * | 1997-11-26 | 1999-09-14 | Research Triangle Institute | Androgenic steroid compounds and a method of making and using the same |
CA2402524C (en) * | 2000-03-31 | 2009-11-17 | Richard P. Blye | Methods of making and using 7.alpha.,11.beta.-dimethyl-17.beta.-hydroxy-4-estren-3-one 17.beta.-trans-4-n-butylcyclohexane carboxylate and 7.alpha.,11.beta.-dimethyl-17.beta.-hydroxyestr-4-en-3-one 17-undecanoate |
GB0025221D0 (en) | 2000-10-14 | 2000-11-29 | Astrazeneca Ab | New process |
GB0123961D0 (en) * | 2001-10-05 | 2001-11-28 | Astrazeneca Ab | Process and intermediates |
-
2000
- 2000-10-14 GB GBGB0025221.3A patent/GB0025221D0/en not_active Ceased
-
2001
- 2001-10-09 KR KR1020037005110A patent/KR100864266B1/ko active IP Right Grant
- 2001-10-09 DE DE60135240T patent/DE60135240D1/de not_active Expired - Lifetime
- 2001-10-09 DK DK01972358T patent/DK1328538T3/da active
- 2001-10-09 US US10/398,924 patent/US7947667B2/en not_active Expired - Fee Related
- 2001-10-09 NZ NZ525096A patent/NZ525096A/en not_active IP Right Cessation
- 2001-10-09 SI SI200130863T patent/SI1328538T1/sl unknown
- 2001-10-09 IL IL15517201A patent/IL155172A0/xx unknown
- 2001-10-09 EP EP01972358A patent/EP1328538B1/en not_active Expired - Lifetime
- 2001-10-09 WO PCT/GB2001/004485 patent/WO2002032922A1/en active Application Filing
- 2001-10-09 MX MXPA03003302A patent/MXPA03003302A/es active IP Right Grant
- 2001-10-09 PT PT01972358T patent/PT1328538E/pt unknown
- 2001-10-09 BR BR0114649-1A patent/BR0114649A/pt not_active Application Discontinuation
- 2001-10-09 KR KR1020087013092A patent/KR20080056029A/ko not_active Application Discontinuation
- 2001-10-09 AT AT01972358T patent/ATE403667T1/de active
- 2001-10-09 CA CA002425572A patent/CA2425572C/en not_active Expired - Lifetime
- 2001-10-09 AU AU2001292132A patent/AU2001292132B2/en not_active Expired
- 2001-10-09 AU AU9213201A patent/AU9213201A/xx active Pending
- 2001-10-09 CN CNB018202705A patent/CN1255425C/zh not_active Expired - Lifetime
- 2001-10-09 EP EP08150796.4A patent/EP1918295B1/en not_active Expired - Lifetime
- 2001-10-09 ES ES01972358T patent/ES2309094T3/es not_active Expired - Lifetime
- 2001-10-09 ES ES08150796.4T patent/ES2581379T3/es not_active Expired - Lifetime
- 2001-10-09 JP JP2002536303A patent/JP4363846B2/ja not_active Expired - Lifetime
- 2001-10-10 EG EG20011065A patent/EG23373A/xx active
- 2001-10-12 AR ARP010104814A patent/AR034561A1/es active IP Right Grant
- 2001-10-12 MY MYPI20014756A patent/MY145819A/en unknown
- 2001-10-12 MY MYPI2010001633A patent/MY149146A/en unknown
- 2001-12-04 SA SA01220570A patent/SA01220570B1/ar unknown
-
2003
- 2003-03-31 ZA ZA200302526A patent/ZA200302526B/en unknown
- 2003-03-31 IL IL155172A patent/IL155172A/en active IP Right Grant
- 2003-04-11 NO NO20031701A patent/NO326020B1/no not_active IP Right Cessation
-
2007
- 2007-04-19 AU AU2007201740A patent/AU2007201740B2/en not_active Expired
-
2008
- 2008-10-07 CY CY20081101106T patent/CY1108398T1/el unknown
-
2009
- 2009-05-08 JP JP2009113404A patent/JP5133937B2/ja not_active Expired - Lifetime
-
2011
- 2011-07-28 AR ARP110102734A patent/AR082409A2/es active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20031701L (no) | Fremgangsmåte og mellomprodukter i fremstilling av 7- substituerte antiöstrogener | |
CY1107575T1 (el) | Μεθοδος παρασκευης αρυλοκτανοϋλικων αμιδiων | |
ES2159462A1 (es) | Preparacion de eteres aminicos estericamente impedidos. | |
DE60306667D1 (de) | Cefdinir salze als zwischenprodukte | |
DK1601653T3 (da) | Fremgangsmåde til fremstilling af substituerede nikotinsyreestre | |
PT1172371E (pt) | Preparacao de derivados esteroides | |
NO20063111L (no) | Fremgangsmate for fremstilling av tiazolpyrimidiner | |
TW200619201A (en) | Process for the preparation of pyrazoles | |
KR970010731A (ko) | 광학 활성 2-할로-1-(치환된 페닐) 에탄올 및 치환된 스티렌 옥사이드의 제조방법 | |
DK1741716T3 (da) | Fremgangsmåde til fremstilling af pentacyklisk taxan | |
NO970766D0 (no) | Fremgangsmåte for fremstilling av taxol og derivater derav | |
EA200101209A1 (ru) | Новые производные бензола, способ их получения и фармацевтические композиции, содержащие их | |
WO2002057251A3 (en) | Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues | |
EA200300458A1 (ru) | Новые соединения аминотриазолона, способ их получения и фармацевтические композиции, содержащие их | |
WO2004013082A3 (de) | Verfahren zur herstellung von aminoalkoxybenzylaminen und aminoalkoxybenzonitrilen als zwischenprodukte | |
EE200300090A (et) | Asendatud imidasopüridiinühendite valmistamise meetod | |
BR0210512A (pt) | Processo de decomposição papa o ácido (r)-(-)-2-hidroxi-2-(2-clorofenil) acético | |
NO20023513L (no) | Anvendelse av et ekstraheringsmiddel som et antiskummiddel ved fremstilling av vannfri maursyre | |
NO20070610L (no) | Fremgangsmate for fremstilling av synteseintermediater anvendelige ved fremstilling av pyrazolforbindelser. | |
FI20030026A (fi) | Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita | |
PT1117636E (pt) | Processo para a preparacao de derivados de triona-bis(oxima-eter) assim como derivados de triona-mono(oxima-eter) e de triona-bis(oxima-eter) obtidos com o mesmo | |
NO994108L (no) | Fremgangsmaate ved fremstilling av 4H-4-okso-kinolizin-3-karboksylsyrederivater | |
TW200800955A (en) | Improved process for preparing insecticidal (disubstitutedpropenyl) phenylalkyl substituted heterocycles | |
WO2005046854A3 (en) | A process for the preparation of diphenylmethylsulfinyl derivatives | |
WO2007005455A3 (en) | Improved process for preparing (disubstitutedpropenyl) phenylalkyl substituted heterocycles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |