BR0114649A - Processos para prepapar um composto e fulvestrant, e, composto - Google Patents

Processos para prepapar um composto e fulvestrant, e, composto

Info

Publication number
BR0114649A
BR0114649A BR0114649-1A BR0114649A BR0114649A BR 0114649 A BR0114649 A BR 0114649A BR 0114649 A BR0114649 A BR 0114649A BR 0114649 A BR0114649 A BR 0114649A
Authority
BR
Brazil
Prior art keywords
compound
group
fulvestrant
formula
processes
Prior art date
Application number
BR0114649-1A
Other languages
English (en)
Inventor
Robert Stevenson
Fraser Witton Kerr
Anthony Raymond Lane
Eve Joanne Brazier
Philip John Hogan
David Dermot Patrick Laffan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9901292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0114649(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0114649A publication Critical patent/BR0114649A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

"PROCESSOS PARA PREPARAR UM COMPOSTO E FULVESTRANT, E, COMPOSTO". Um processo para a preparação de um composto intermediário de fórmula (II): onde X é como definido no relatório descritivo, R1 é haloalquila, alquila, alquenila, cicloalquila, carboxialquila, alcoxicarbonilalquila, arila, ou arilalquila; R^ 2^, R^ 3^, R^ 4^ e R^ 5^ são grupos orgânicos como definido no relatório descritivo, cujo processo compreende a aromatização de um composto de fórmula (III): onde R^ 1^, R^ 2^, R^ 3^ n,X e R^ 5^ são com definidos na relação para a fórmula (II) e R^ 4^ é um grupo ou um grupo precursor deste, e portanto se necessário ou desejado, realizar uma ou mais das seguintes etapas: (i) remover quaisquer grupos de proteção de hidróxi R; (ii) converter um grupo precursor R^ 4,^ em um grupo R^ 4^, ou onde R^ 4,^ for um grupo R^ 4^, convertê-lo em um tal grupo diferente. Os compostos obtidos são intermediários úteis, por exemplo, na preparação de fulvestrant. Novos intermediários são igualmente reivindicados.
BR0114649-1A 2000-10-14 2001-10-09 Processos para prepapar um composto e fulvestrant, e, composto BR0114649A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0025221.3A GB0025221D0 (en) 2000-10-14 2000-10-14 New process
PCT/GB2001/004485 WO2002032922A1 (en) 2000-10-14 2001-10-09 Process and intermediates for the production of 7-substituted antiestrogens

Publications (1)

Publication Number Publication Date
BR0114649A true BR0114649A (pt) 2004-02-10

Family

ID=9901292

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114649-1A BR0114649A (pt) 2000-10-14 2001-10-09 Processos para prepapar um composto e fulvestrant, e, composto

Country Status (26)

Country Link
US (1) US7947667B2 (pt)
EP (2) EP1918295B1 (pt)
JP (2) JP4363846B2 (pt)
KR (2) KR100864266B1 (pt)
CN (1) CN1255425C (pt)
AR (2) AR034561A1 (pt)
AT (1) ATE403667T1 (pt)
AU (3) AU2001292132B2 (pt)
BR (1) BR0114649A (pt)
CA (1) CA2425572C (pt)
CY (1) CY1108398T1 (pt)
DE (1) DE60135240D1 (pt)
DK (1) DK1328538T3 (pt)
EG (1) EG23373A (pt)
ES (2) ES2309094T3 (pt)
GB (1) GB0025221D0 (pt)
IL (2) IL155172A0 (pt)
MX (1) MXPA03003302A (pt)
MY (2) MY145819A (pt)
NO (1) NO326020B1 (pt)
NZ (1) NZ525096A (pt)
PT (1) PT1328538E (pt)
SA (1) SA01220570B1 (pt)
SI (1) SI1328538T1 (pt)
WO (1) WO2002032922A1 (pt)
ZA (1) ZA200302526B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process
GB0123961D0 (en) 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates
US7790910B2 (en) 2004-07-27 2010-09-07 Sicor Inc. Process for the preparation of 7α-alkylated 19-norsteroids
US20100174101A1 (en) * 2007-09-24 2010-07-08 Xi'an Liband Pharmaceutical Co., Ltd. Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol
EP2070942A1 (de) * 2007-12-13 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen
CN101525364B (zh) * 2008-03-07 2012-12-12 杭州九源基因工程有限公司 一种氟维司群的晶型及其制备方法
US8063249B1 (en) 2008-04-25 2011-11-22 Olema Pharmaceuticals, Inc. Substituted triphenyl butenes
CN102391341B (zh) * 2011-08-09 2013-05-22 福建省微生物研究所 制备6,7-脱氢-17β-烃酰氧基诺龙的方法
CN102600064A (zh) * 2012-03-31 2012-07-25 西安力邦制药有限公司 氟维司群或其衍生物缓释制剂及其制备方法
US9315540B2 (en) 2012-10-22 2016-04-19 Intas Pharmaceuticals Ltd. Process for the preparation of fulvestrant
CN103788164A (zh) * 2012-10-31 2014-05-14 正大天晴药业集团股份有限公司 一种氟维司群的制备方法
CN103965280B (zh) * 2014-05-21 2016-04-20 天津孚音生物科技发展有限公司 一种氟维司群中间体的制备方法
WO2015181116A1 (en) 2014-05-26 2015-12-03 Crystal Pharma, S.A.U. Process and intermediades for the preparation of 7-alkylated steroids
CN104387435B (zh) * 2014-12-10 2017-05-10 天津孚音生物科技发展有限公司 一种化合物及其制备方法与应用
KR101640747B1 (ko) 2015-05-20 2016-07-19 이금운 확장 가능형 끼움식 엘이디 조명 등기구
CN107488205A (zh) * 2016-06-13 2017-12-19 重庆圣华曦药业股份有限公司 一种氟维司群有关物质的制备方法及其在制剂中的检测方法
CN110818764A (zh) * 2018-08-07 2020-02-21 重庆圣华曦药业股份有限公司 一种应用加料监测系统制备氟维斯群中间体的方法
CN111018936B (zh) * 2019-11-12 2021-10-29 广州曼翔医药有限公司 一种氟维司群有关物质e的合成方法
CN116535454A (zh) * 2023-04-28 2023-08-04 香港中文大学（深圳） 氟维司群类化合物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7305171A (pt) * 1973-04-13 1974-10-15
GB8327256D0 (en) * 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
US5595985A (en) * 1989-03-10 1997-01-21 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
DE4132182A1 (de) 1991-09-24 1993-03-25 Schering Ag 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
US5211831A (en) * 1991-11-27 1993-05-18 Mcgean-Rohco, Inc. Process for extending the life of a displacement plating bath
DE19622457A1 (de) * 1996-05-24 1997-11-27 Schering Ag 7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
US5952319A (en) * 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
AU4966101A (en) * 2000-03-31 2001-10-15 Us Gov Health & Human Serv Methods of making and using 7alpha,11beta-dimethyl-17beta-hydroxy-4-estren-3-one17beta-trans-4-m-butylcyclohexane carboxylate and 7alpha,11beta-dimethyl-17beta -hydroxyestr-4-en-3-one 17-undecanoate
GB0025221D0 (en) 2000-10-14 2000-11-29 Astrazeneca Ab New process
GB0123961D0 (en) 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates

Also Published As

Publication number Publication date
EP1328538A1 (en) 2003-07-23
AU9213201A (en) 2002-04-29
KR100864266B1 (ko) 2008-10-20
DE60135240D1 (de) 2008-09-18
CN1479746A (zh) 2004-03-03
ATE403667T1 (de) 2008-08-15
CY1108398T1 (el) 2014-02-12
NO20031701L (no) 2003-05-23
GB0025221D0 (en) 2000-11-29
KR20030081319A (ko) 2003-10-17
CN1255425C (zh) 2006-05-10
IL155172A (en) 2012-04-30
MY149146A (en) 2013-07-15
AR034561A1 (es) 2004-03-03
NO20031701D0 (no) 2003-04-11
SA01220570B1 (ar) 2007-03-18
AU2007201740B2 (en) 2010-04-08
CA2425572C (en) 2010-03-09
SI1328538T1 (sl) 2008-12-31
AR082409A2 (es) 2012-12-05
EP1328538B1 (en) 2008-08-06
JP2004511567A (ja) 2004-04-15
US20050101583A1 (en) 2005-05-12
MXPA03003302A (es) 2003-08-07
DK1328538T3 (da) 2008-11-03
WO2002032922A1 (en) 2002-04-25
JP5133937B2 (ja) 2013-01-30
ES2581379T3 (es) 2016-09-05
PT1328538E (pt) 2008-09-30
EP1918295A2 (en) 2008-05-07
NZ525096A (en) 2004-10-29
AU2001292132B2 (en) 2007-01-25
ES2309094T3 (es) 2008-12-16
KR20080056029A (ko) 2008-06-19
US7947667B2 (en) 2011-05-24
JP2009215303A (ja) 2009-09-24
AU2007201740A1 (en) 2007-05-10
NO326020B1 (no) 2008-09-01
EP1918295A3 (en) 2012-10-17
IL155172A0 (en) 2003-10-31
ZA200302526B (en) 2004-02-16
EP1918295B1 (en) 2016-04-06
EG23373A (en) 2005-02-28
JP4363846B2 (ja) 2009-11-11
CA2425572A1 (en) 2002-04-25
MY145819A (en) 2012-04-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements