NO20060631L - Fast dispersjon av takrolimus - Google Patents

Fast dispersjon av takrolimus

Info

Publication number
NO20060631L
NO20060631L NO20060631A NO20060631A NO20060631L NO 20060631 L NO20060631 L NO 20060631L NO 20060631 A NO20060631 A NO 20060631A NO 20060631 A NO20060631 A NO 20060631A NO 20060631 L NO20060631 L NO 20060631L
Authority
NO
Norway
Prior art keywords
tacrolimus
solid dispersion
carrier
solid
bioavailability
Prior art date
Application number
NO20060631A
Other languages
English (en)
Inventor
Hee-Jong Shin
Jong-Lae Lim
Min-Hyo Kl
Ji-Hun Yun
Original Assignee
Chong Kun Dang Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Pharm Corp filed Critical Chong Kun Dang Pharm Corp
Publication of NO20060631L publication Critical patent/NO20060631L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

Oppfinnelsen angår en bærer for en fast dispersjon av takrolimus, som fremstilles ved anvendelse av en fast surfaktant med en HLB-verdi høyere enn eller lik ca. 7. Surfaktantene har funksjon som bærer og funksjon som oppløsningsfremmer samtidig. Som et resultat forbedres oppløsningshastigheten til takrolimus og den orale absorpsjonsevnen og biotilgjengeligheten kan økes basert på den raske medikamentfrigivelsen.
NO20060631A 2003-07-09 2006-02-09 Fast dispersjon av takrolimus NO20060631L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20030046550 2003-07-09
PCT/KR2004/001684 WO2005004848A1 (en) 2003-07-09 2004-07-09 The solid dispersion of tacrolimus

Publications (1)

Publication Number Publication Date
NO20060631L true NO20060631L (no) 2006-04-05

Family

ID=36587202

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060631A NO20060631L (no) 2003-07-09 2006-02-09 Fast dispersjon av takrolimus

Country Status (9)

Country Link
US (1) US20060177500A1 (no)
EP (1) EP1641437A4 (no)
JP (1) JP2007527383A (no)
KR (1) KR100486016B1 (no)
CN (1) CN1819817A (no)
BR (1) BRPI0412329A (no)
MX (1) MXPA06000370A (no)
NO (1) NO20060631L (no)
WO (1) WO2005004848A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004267910B2 (en) 2003-08-29 2011-01-06 Veloxis Pharmaceuticals, Inc. Solid dispersions comprising tacrolimus
JP4903568B2 (ja) * 2003-08-29 2012-03-28 ベロクシス ファーマシューティカルズ エー／エス タクロリムスを含む固体分散体
KR100539706B1 (ko) * 2005-01-25 2005-12-28 지엘팜텍 주식회사 타크로리무스 및 장용성 고분자를 함유하는 고체분산체
KR100678824B1 (ko) * 2005-02-04 2007-02-05 한미약품 주식회사 용해성이 증가된 무정형 타크로리무스 고체분산체 및 이를포함하는 약제학적 조성물
KR100711220B1 (ko) * 2005-06-14 2007-04-24 삼천당제약주식회사 타크로리무스를 함유하는 경구용 조성물 및 그의 제조방법
KR100693461B1 (ko) * 2005-07-29 2007-03-12 동국제약 주식회사 마크로라이드계 항생물질을 유효성분으로 함유하는약제학적 조성물 및 이의 제조방법과, 상기 약제학적조성물을 함유하는 서방성 제제
MXPA05010457A (es) * 2005-09-28 2007-03-27 Fernando Ahumada Ayala Preparacion para el tratamiento de enfermedades inflamatorias de la piel, que contiene tacrolimus.
DE102005047561A1 (de) * 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
CA2664315C (en) 2006-09-15 2016-01-19 Echo Pharmaceuticals B.V. Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances
US20100034888A1 (en) * 2006-09-15 2010-02-11 Hubert Clemens Pellikaan Granulate containing a pharmaceutically active substance and method for its manufacture
JPWO2008041553A1 (ja) * 2006-09-26 2010-02-04 アステラス製薬株式会社 タクロリムス徐放性製剤
WO2008127746A1 (en) 2007-01-10 2008-10-23 Board Of Regents The University Of Texas System Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery
LT2167033T (lt) 2007-05-30 2017-08-10 Veloxis Pharmaceuticals A/S Kartą per dieną vartojama geriamoji vaisto forma, apimanti takrolimą
DK2400950T3 (da) 2009-02-26 2019-07-29 Glaxo Group Ltd Farmaceutiske formuleringer omfattende 4-{(1 r)-2-[(6-{2-[(2,6-dichlorbenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
PT2575769T (pt) 2010-02-17 2016-09-22 Veloxis Pharmaceuticals As Composição de tacrolímus estabilizada
KR20130028824A (ko) * 2011-09-09 2013-03-20 주식회사 삼양바이오팜 타크로리무스를 포함하는 고체 분산체 및 이의 제조방법
WO2013169101A1 (en) 2012-05-07 2013-11-14 Echo Pharmaceuticals B.V. Granulate containing cannabinoid, method for its manufacture and oral dosage unit comprising such granulate
CN104415054A (zh) * 2013-08-20 2015-03-18 哈药集团三精制药股份有限公司 一种速释复方氨酚烷胺片的制备方法
CN110639020B (zh) * 2019-08-15 2022-07-08 浙江工业大学 一种固体分散体基质及其制备方法和应用
CN113577032A (zh) * 2021-08-27 2021-11-02 国药集团川抗制药有限公司 他克莫司固体分散体的制备方法、速释药物组合物和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
GB8608080D0 (en) * 1986-04-02 1986-05-08 Fujisawa Pharmaceutical Co Solid dispersion composition
BE1009856A5 (fr) * 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
CZ267796A3 (cs) * 1996-09-12 1998-04-15 Galena A.S. Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů
TW426516B (en) * 1996-12-06 2001-03-21 Fujisawa Pharmaceutical Co An oral pharmaceutical composition in solid dispersion containing water-insoluble tricyclic compounds
EP0978288A4 (en) * 1997-04-11 2006-07-12 Astellas Pharma Inc DRUG COMPOSITION
TR200002771T2 (tr) * 1998-03-26 2001-02-21 Fujisawa Pharmaceutical Co.,Ltd. Devamlı salımı olan preparatlar
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
AU2004267910B2 (en) * 2003-08-29 2011-01-06 Veloxis Pharmaceuticals, Inc. Solid dispersions comprising tacrolimus

Also Published As

Publication number Publication date
BRPI0412329A (pt) 2006-09-05
MXPA06000370A (es) 2006-03-28
WO2005004848A1 (en) 2005-01-20
CN1819817A (zh) 2006-08-16
KR20050007173A (ko) 2005-01-17
EP1641437A4 (en) 2009-06-03
EP1641437A1 (en) 2006-04-05
JP2007527383A (ja) 2007-09-27
US20060177500A1 (en) 2006-08-10
KR100486016B1 (ko) 2005-04-29

Similar Documents

Publication Publication Date Title
NO20060631L (no) Fast dispersjon av takrolimus
ATE434639T1 (de) Wässrige dispersionen von silikon-polyether- blockcopolymeren
WO2005011592A3 (en) Substituted indazole-o-glucosides
WO2005012243A3 (en) Substituted indole-o-glucosides
WO2003093290A3 (en) Nucleoside derivatives for treating hepatitis c virus infection
WO2004028481A3 (en) Nucleoside derivatives for treating hepatitis c virus infection
WO2006039668A3 (en) 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
EA200901186A1 (ru) S-ТРИАЗОЛИЛ-α-МЕРКАПТОАЦЕТАНИЛИДЫ КАК ИНГИБИТОРЫ ОБРАТНОЙ ТРАНСКРИПТАЗЫ ВИЧ
EP1924593B8 (en) Hcv ns3 protease inhibitors
DK1670433T3 (da) Transdermal farmaceutisk formulering til mindskelse af hudrester
WO2004011478A3 (en) Anti-viral 7-deaza d-nucleosides and uses thereof
DK1792927T3 (da) Ny blokcopolymer, micelletilberedning og anticancermiddel indeholdende samme som aktiv ingrediens
NO20070751L (no) Inhibitorer av HCV-replifikasjon
NO20092053L (no) HCV NS3-proteaseinhibitorer
TW200642689A (en) Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient
WO2007092645A3 (en) Novel hcv inhibitor combinations and methods
WO2005123093A3 (en) Ophthalmic formulations including selective alpha 1 antagonists
WO2003097794A3 (en) Universal-tagged oligonucleotide primers and methods of use
WO2006138418A3 (en) Improvement of cognitive performance with sirtuin activators
WO2004014926A8 (fr) Alcoxyamines issues de nitroxydes βετα-phosphores, leur utilisation en polymerisation radicalaire
NO20054776L (no) Kontrollert frigivelsessystem som inneholder sakkaroseacctatisobutyrat
NO20050801L (no) Prodrug av protonpumpe inhibitorer
WO2004002940A8 (en) Inhibitors of hcv ns5b polymerase
NO20024891L (no) Farmasöytiske sammensetninger
NO20050346L (no) Nitro-oksyderivater av syklooksygenase-2-inhibitorer

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application