NO325541B1 - Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmate for fremstilling derav - Google Patents
Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmate for fremstilling derav Download PDFInfo
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- NO325541B1 NO325541B1 NO20040266A NO20040266A NO325541B1 NO 325541 B1 NO325541 B1 NO 325541B1 NO 20040266 A NO20040266 A NO 20040266A NO 20040266 A NO20040266 A NO 20040266A NO 325541 B1 NO325541 B1 NO 325541B1
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- Norway
- Prior art keywords
- lercanidipine hydrochloride
- lercanidipine
- solid
- solvent
- mixture
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI001726A ITMI20011726A1 (it) | 2001-08-06 | 2001-08-06 | Forme polimorfe della lercanidipina cloridrato |
PCT/EP2002/008699 WO2003014084A1 (en) | 2001-08-06 | 2002-08-05 | Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20040266L NO20040266L (no) | 2004-03-24 |
NO325541B1 true NO325541B1 (no) | 2008-06-16 |
Family
ID=11448245
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20040266A NO325541B1 (no) | 2001-08-06 | 2004-01-20 | Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmate for fremstilling derav |
NO20082330A NO335651B1 (no) | 2001-08-06 | 2008-05-22 | Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmåte for fremstilling derav |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20082330A NO335651B1 (no) | 2001-08-06 | 2008-05-22 | Nye krystallinske polymorfe former av lerkanidipinhydroklorid og fremgangsmåte for fremstilling derav |
Country Status (36)
Country | Link |
---|---|
EP (4) | EP2157083B1 (de) |
JP (1) | JP2005504045A (de) |
KR (3) | KR100667687B1 (de) |
CN (2) | CN101475524B (de) |
AP (1) | AP1766A (de) |
AR (1) | AR037139A1 (de) |
AT (2) | ATE453624T1 (de) |
AU (1) | AU2002327924C1 (de) |
BR (1) | BR0211739A (de) |
CY (2) | CY1109711T1 (de) |
DE (2) | DE60206787T2 (de) |
DK (3) | DK1600441T3 (de) |
EA (1) | EA005673B1 (de) |
EC (1) | ECSP044973A (de) |
ES (3) | ES2212759T3 (de) |
HK (3) | HK1067123A1 (de) |
HR (1) | HRP20040156B1 (de) |
HU (1) | HU229563B1 (de) |
IL (3) | IL153917A (de) |
IT (1) | ITMI20011726A1 (de) |
MA (1) | MA27133A1 (de) |
ME (2) | ME01525B (de) |
MX (1) | MXPA04001069A (de) |
NO (2) | NO325541B1 (de) |
NZ (2) | NZ541341A (de) |
OA (1) | OA12648A (de) |
PE (1) | PE20030328A1 (de) |
PL (1) | PL216066B1 (de) |
PT (2) | PT1600441E (de) |
RS (1) | RS52161B (de) |
SI (3) | SI1600441T1 (de) |
TN (1) | TNSN04024A1 (de) |
UA (1) | UA82988C2 (de) |
UY (1) | UY27410A1 (de) |
WO (1) | WO2003014084A1 (de) |
ZA (1) | ZA200401806B (de) |
Families Citing this family (19)
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ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
AR043395A1 (es) * | 2003-02-28 | 2005-07-27 | Recordati Ireland Ltd | Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii |
EP1694305B1 (de) * | 2003-12-01 | 2019-10-16 | Recordati Ireland Limited | Pharmazeutische zusammensetzungen mit lercanidipin |
AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
WO2007031865A2 (en) | 2005-09-16 | 2007-03-22 | Glenmark Pharmaceuticals Limited | Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof |
KR100821165B1 (ko) * | 2006-03-10 | 2008-04-14 | 동우신테크 주식회사 | 레르카니디핀 염산염의 제조 방법 |
JP2010514753A (ja) * | 2006-12-29 | 2010-05-06 | ドンウ シンテック カンパニー リミテッド | レルカニジピン塩酸塩の製造方法 |
CN101868442A (zh) * | 2007-03-05 | 2010-10-20 | 阿克塔维什集团Ptc公司 | 盐酸乐卡地平多晶型物和1,1,n-三甲基-n-(3,3-二苯基丙基)-2-氨基乙酰醋酸乙酯的改进制法 |
WO2011161223A2 (en) | 2010-06-23 | 2011-12-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts |
EP2444394A1 (de) | 2010-10-21 | 2012-04-25 | Alembic Pharmaceuticals Limited | Verfahren zur Herstellung amorpher Formen von Lercanidipin HCl |
EP2654729B1 (de) | 2010-12-24 | 2016-05-04 | KRKA, d.d., Novo mesto | Orale homogene pharmazeutische zubereitung enthaltend lercanidipine und enalapril oder ihre pharmazeutische salze zusammen mit einer organischen säure |
WO2012142927A1 (zh) * | 2011-04-18 | 2012-10-26 | 合肥贝霓医药科技有限公司 | 一种纯化二氢吡啶类钙通道阻滞剂并制备其纳米的方法 |
CN102531999B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 无定形盐酸乐卡地平及其制备方法 |
CN102558032B (zh) * | 2011-12-16 | 2014-02-26 | 华润赛科药业有限责任公司 | 一种无定形盐酸乐卡地平及其制备方法 |
CN102584682A (zh) * | 2011-12-31 | 2012-07-18 | 苏州二叶制药有限公司 | 盐酸乐卡地平的制备方法 |
CN103497075B (zh) * | 2013-09-25 | 2016-03-23 | 山西北化关铝化工有限公司 | 水悬浮延期药造型粉 |
CN109232389B (zh) * | 2018-05-15 | 2021-10-08 | 迪嘉药业集团有限公司 | 一种小粒度硝苯地平的结晶制备方法 |
CN115353485B (zh) * | 2022-07-26 | 2024-04-19 | 山西双雁药业有限公司 | 从硝苯地平母液中回收硝苯地平的方法及应用 |
CN115671066B (zh) * | 2022-11-21 | 2024-07-02 | 安徽宏业药业有限公司 | 一种盐酸乐卡地平片及其制备方法 |
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US596139A (en) * | 1897-12-28 | Process of generating acetylene gas | ||
GB8403866D0 (en) * | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
IT1274480B (it) * | 1995-05-12 | 1997-07-17 | Recordati Chem Pharm | Procedimento migliorato per la preparazione della lercanidipina cloridrato |
IT1275532B (it) * | 1995-07-14 | 1997-08-07 | Recordati Chem Pharm | Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa |
US5767136A (en) * | 1995-05-12 | 1998-06-16 | Recordati, S.A. Chemical And Pharmaceutical Company | 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls |
US5696139A (en) | 1995-05-12 | 1997-12-09 | Recordati S.A., Chemical And Pharmaceutical Company | Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure |
KR20080021603A (ko) | 2000-02-16 | 2008-03-07 | 뉴로젠 코포레이션 | 치환된 아릴피라진 |
ITMI20011726A1 (it) | 2001-08-06 | 2003-02-06 | Recordati Ind Chimica E Farma | Forme polimorfe della lercanidipina cloridrato |
US20040198789A1 (en) | 2003-02-28 | 2004-10-07 | Recordati Ireland Limited | Lercanidipine/ARB/diuretic therapeutic combinations |
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