AR041198A1 - Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen - Google Patents

Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen

Info

Publication number
AR041198A1
AR041198A1 ARP030103673A ARP030103673A AR041198A1 AR 041198 A1 AR041198 A1 AR 041198A1 AR P030103673 A ARP030103673 A AR P030103673A AR P030103673 A ARP030103673 A AR P030103673A AR 041198 A1 AR041198 A1 AR 041198A1
Authority
AR
Argentina
Prior art keywords
group
substituted
halogen
phenyl
unsubstituted
Prior art date
Application number
ARP030103673A
Other languages
English (en)
Spanish (es)
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR041198A1 publication Critical patent/AR041198A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ARP030103673A 2002-10-11 2003-10-09 Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen AR041198A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002298259 2002-10-11

Publications (1)

Publication Number Publication Date
AR041198A1 true AR041198A1 (es) 2005-05-04

Family

ID=32089299

Family Applications (4)

Application Number Title Priority Date Filing Date
ARP030103673A AR041198A1 (es) 2002-10-11 2003-10-09 Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
ARP120101394A AR086485A2 (es) 2002-10-11 2012-04-23 Compuesto 2,3-dihidro-6-nitroimidazol[2,1-b]oxazol que posee actividad bactericida contra la mycobacterium tuberculosis resistente a multiples drogas
ARP130100408A AR089950A2 (es) 2002-10-11 2013-02-08 Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b]oxazol
ARP130102514 AR091771A2 (es) 2002-10-11 2013-07-15 Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b]oxazol

Family Applications After (3)

Application Number Title Priority Date Filing Date
ARP120101394A AR086485A2 (es) 2002-10-11 2012-04-23 Compuesto 2,3-dihidro-6-nitroimidazol[2,1-b]oxazol que posee actividad bactericida contra la mycobacterium tuberculosis resistente a multiples drogas
ARP130100408A AR089950A2 (es) 2002-10-11 2013-02-08 Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b]oxazol
ARP130102514 AR091771A2 (es) 2002-10-11 2013-07-15 Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b]oxazol

Country Status (26)

Country Link
US (1) US7262212B2 (enExample)
EP (2) EP1555267B1 (enExample)
JP (1) JP4186065B2 (enExample)
KR (1) KR100723847B1 (enExample)
CN (4) CN102532162B (enExample)
AR (4) AR041198A1 (enExample)
AU (1) AU2003272979B2 (enExample)
BE (1) BE2014C053I2 (enExample)
BR (1) BRPI0314344B8 (enExample)
CA (1) CA2497569C (enExample)
CY (2) CY1113578T1 (enExample)
DK (1) DK1555267T3 (enExample)
ES (1) ES2400179T3 (enExample)
FR (1) FR14C0066I2 (enExample)
HU (1) HUS1400046I1 (enExample)
LU (1) LU92517I2 (enExample)
MX (1) MXPA05003674A (enExample)
MY (1) MY139244A (enExample)
PL (3) PL409525A1 (enExample)
PT (1) PT1555267E (enExample)
RU (1) RU2326121C3 (enExample)
SI (1) SI1555267T1 (enExample)
TW (1) TWI347946B (enExample)
UA (1) UA83200C2 (enExample)
WO (1) WO2004033463A1 (enExample)
ZA (1) ZA200501033B (enExample)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4564713B2 (ja) 2000-11-01 2010-10-20 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法
CA2494710C (en) 2002-10-15 2011-05-03 Otsuka Pharmaceutical Co., Ltd. 1-substituted-4-nitroimidazole compound and method for preparing the same
PT1678185E (pt) 2003-10-31 2009-01-13 Otsuka Pharma Co Ltd Compostos 2,3-di-hidro-6-nitroimidazo[2,1-b]oxazole para o tratamento da tuberculose
JP4761756B2 (ja) * 2003-10-31 2011-08-31 大塚製薬株式会社 ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物
TWI300409B (en) 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound
AU2005228289B2 (en) 2004-03-31 2008-01-10 Nippon Soda Co., Ltd. Cyclic amine compound and pest control agent
JP4789966B2 (ja) * 2004-04-09 2011-10-12 大塚製薬株式会社 医薬組成物
JP4787529B2 (ja) * 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
ATE450525T1 (de) * 2005-06-20 2009-12-15 Schering Corp Kohlenstoffgebundene substituierte piperidine und derivate daraus als histamin-h3-antagonisten
PT1906926E (pt) * 2005-07-28 2011-01-26 Otsuka Pharma Co Ltd Composição farmacêutica que contém derivados de 2,3-di-hidro-6-nitroimidazo[2,1-b]oxazole
TWI368509B (en) * 2005-10-05 2012-07-21 Otsuka Pharma Co Ltd Antituberculous therapeutic drugs and kit containing the same
JP5105818B2 (ja) * 2005-10-05 2012-12-26 大塚製薬株式会社 医薬組成物
MY141762A (en) 2005-10-06 2010-06-30 Nippon Soda Co Cross-linked cyclic amine compounds and agents for pest control
TW200800268A (en) * 2005-11-04 2008-01-01 Otsuka Pharma Co Ltd Medicinal composition showing improved drug absorbability
CA2636929A1 (en) * 2005-12-21 2007-07-12 Decode Genetics, Ehf Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
WO2007093557A1 (en) * 2006-02-13 2007-08-23 Laboratoires Serono S.A. Sulfonamide derivatives for the treatment of bacterial infections
JP2007297305A (ja) * 2006-04-28 2007-11-15 Daiso Co Ltd Ｎ−（２，３−エポキシ−２−メチルプロピル）フタルイミドの製造法
CA2678577A1 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
AR070301A1 (es) 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
JP5470557B2 (ja) * 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
PE20090595A1 (es) * 2007-08-15 2009-06-06 Glaxo Group Ltd Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1
EP2205585A1 (en) * 2007-10-16 2010-07-14 Glaxo Group Limited Quinoline derivatives used to treat inflammatory and allergic diseases
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2009117109A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
JP5613656B2 (ja) * 2008-03-26 2014-10-29 グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール
RU2531272C2 (ru) 2008-05-01 2014-10-20 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
US8242111B2 (en) * 2008-05-01 2012-08-14 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
EP2291370B1 (en) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US20120040974A1 (en) * 2008-08-18 2012-02-16 Yale University Mif modulators
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
WO2010143007A1 (en) * 2009-06-10 2010-12-16 Dynamit Nobel Gmbh Explosivstoff-Und Systemtechnik Method for the production of 2-halogeno-4-nitroimidazole
EP2323990B1 (en) * 2008-08-21 2014-06-18 Dynamit Nobel GmbH Explosivstoff- und Systemtechnik Methods for the production of 2-halo-4-nitroimidazole and intermediates thereof
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
GEP20156309B (en) * 2009-04-30 2015-07-10 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
BR112012002214B1 (pt) 2009-07-31 2022-01-25 Global Alliance For Tb Drug Development Análogos de nitroimidazooxazina e nitroimidazooxazol, seus usos e composição farmacêutica
US9198913B2 (en) 2009-07-31 2015-12-01 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
CA2769359C (en) * 2009-07-31 2017-03-07 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
JP5770096B2 (ja) 2009-10-26 2015-08-26 富士フイルムＲｉファーマ株式会社 感染症診断薬
TW201200523A (en) 2010-01-29 2012-01-01 Otsuka Pharma Co Ltd Synthetic intermediate of oxazole compound and method for producing the same
GB201012209D0 (en) * 2010-05-31 2010-09-08 Ge Healthcare Ltd In vivo imaging agent
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
WO2011161128A1 (en) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
WO2012059416A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
US9051333B2 (en) 2011-04-15 2015-06-09 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
JP2015006994A (ja) * 2011-10-28 2015-01-15 大正製薬株式会社 ジヒドロイミダゾオキサゾール誘導体
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases
FR3000064A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes
IN2013DE02954A (enExample) 2013-10-04 2015-04-10 Council Scient Ind Res
CN103524492A (zh) * 2013-10-23 2014-01-22 中国药科大学 侧链含硝基咪唑基团取代的喹诺酮类化合物、其制备及用途
TWI687409B (zh) 2014-08-28 2020-03-11 日商大塚製藥股份有限公司 稠合雜環化合物
EP3209669B1 (en) * 2014-10-21 2018-11-07 Council of Scientific and Industrial Research Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof
CN105732659B (zh) * 2014-12-12 2019-07-16 上海阳帆医药科技有限公司 硝基咪唑类化合物及其制备方法和在制药中的用途
WO2016119706A1 (zh) * 2015-01-29 2016-08-04 南京明德新药研发股份有限公司 抗肺结核病的硝基咪唑衍生物
EA201792154A1 (ru) * 2015-03-27 2018-02-28 Оцука Фармасьютикал Ко., Лтд. Способ получения 1-(4-гидроксифенил)-4-(4- трифторметоксифенокси)пиперидина или его соли
CN106317072B (zh) * 2015-06-17 2020-03-17 盟科医药技术(上海)有限公司 用于分枝杆菌感染治疗的杂环化合物及其应用
EP3421454B9 (en) 2016-02-26 2023-08-09 Otsuka Pharmaceutical Co., Ltd. Piperidine derivative
CN105859628B (zh) * 2016-04-19 2018-08-07 清远职业技术学院 一种抗菌化合物对n咪唑苯甲醛缩邻甲苯胺希夫碱及其制备方法和应用
US20190276475A1 (en) * 2016-07-22 2019-09-12 Medshine Discovery Inc. Crystal and salt of nitroimidazole, and manufacturing method thereof
PT3668879T (pt) * 2017-08-16 2021-12-02 BioVersys AG Novos compostos
US20210251902A1 (en) 2018-06-11 2021-08-19 Otsuka Pharmaceutical Co., Ltd. Delamanid-containing composition
CN109705022A (zh) * 2018-12-28 2019-05-03 上海彩迩文生化科技有限公司 一种芳香胺中间体的制备方法
CN112300192B (zh) * 2019-08-02 2023-08-11 南京长澳医药科技有限公司 硝基咪唑类化合物及其制备方法和用途
CN110483549B (zh) * 2019-08-30 2021-03-05 沈阳药科大学 一种硝基咪唑吡喃类抗结核药物的制备方法
CN110615800A (zh) * 2019-10-16 2019-12-27 李丽丽 硝基咪唑类化合物及其制备方法和用途
CN112156088B (zh) * 2020-10-30 2021-08-31 健民药业集团股份有限公司 一种化合物在制备结核分枝杆菌抑制剂中的用途
CN113603706A (zh) * 2021-08-04 2021-11-05 深圳市泰力生物医药有限公司 德拉马尼的晶型、含有该晶型的活性药物和药物组合物
EP4563147A1 (en) 2022-07-29 2025-06-04 Otsuka Pharmaceutical Co., Ltd. Delamanid-containing solid dispersion
CN115368252B (zh) * 2022-09-19 2024-01-12 西北农林科技大学 一种4-胺基酚类衍生物及应用
CN116640106B (zh) * 2023-05-11 2024-03-08 郑州大学 一种苯基哌嗪类化合物及其制备方法、应用
CN119059990B (zh) * 2024-11-01 2025-02-07 安徽昊帆生物有限公司 1-氨基甲酸叔丁酯哌嗪的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof

Also Published As

Publication number Publication date
TWI347946B (en) 2011-09-01
SI1555267T1 (sl) 2013-05-31
BRPI0314344B8 (pt) 2021-05-25
EP2570418A2 (en) 2013-03-20
PL217919B1 (pl) 2014-09-30
DK1555267T3 (da) 2013-02-11
KR100723847B1 (ko) 2007-05-31
HK1085463A1 (zh) 2006-08-25
PT1555267E (pt) 2013-01-29
BR0314344A (pt) 2005-07-12
PL404913A1 (pl) 2013-09-30
RU2326121C2 (ru) 2008-06-10
HUS1400046I1 (hu) 2017-04-28
CA2497569C (en) 2011-05-24
MXPA05003674A (es) 2005-06-08
AU2003272979B2 (en) 2009-07-23
CY1113578T1 (el) 2016-06-22
AR091771A2 (es) 2015-02-25
CN102532162A (zh) 2012-07-04
AR089950A2 (es) 2014-10-01
TW200420568A (en) 2004-10-16
EP1555267A1 (en) 2005-07-20
LU92517I2 (fr) 2014-10-13
EP1555267B1 (en) 2013-01-16
HK1171018A1 (en) 2013-03-15
CA2497569A1 (en) 2004-04-22
BE2014C053I2 (enExample) 2022-08-30
AR086485A2 (es) 2013-12-18
EP2570418A3 (en) 2013-07-03
PL376157A1 (en) 2005-12-27
RU2005114017A (ru) 2006-01-20
CN101255170A (zh) 2008-09-03
AU2003272979A1 (en) 2004-05-04
CN100366624C (zh) 2008-02-06
ES2400179T3 (es) 2013-04-08
WO2004033463A1 (ja) 2004-04-22
US20060094767A1 (en) 2006-05-04
EP1555267A4 (en) 2010-08-18
JP2004149527A (ja) 2004-05-27
UA83200C2 (en) 2008-06-25
KR20050061473A (ko) 2005-06-22
RU2326121C3 (ru) 2021-09-17
BRPI0314344B1 (pt) 2019-11-26
CY2014041I1 (el) 2016-07-27
FR14C0066I1 (enExample) 2014-10-17
CN101172981A (zh) 2008-05-07
PL409525A1 (pl) 2014-11-10
MY139244A (en) 2009-09-30
ZA200501033B (en) 2006-06-28
FR14C0066I2 (fr) 2015-05-22
CN1705670A (zh) 2005-12-07
US7262212B2 (en) 2007-08-28
CN102532162B (zh) 2015-05-27
JP4186065B2 (ja) 2008-11-26
CY2014041I2 (el) 2016-07-27

Similar Documents

Publication Publication Date Title
AR041198A1 (es) Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
Eicher et al. The chemistry of heterocycles: structures, reactions, synthesis, and applications
AU2008333320B2 (en) Isoxazolo-pyrazine derivatives
AR054809A1 (es) Compuestos de amino -5-heteroarilo (5 miembros) imidazolona y su uso para la modulacion de la b- secretasa
BR112020021921A2 (pt) compostos bicíclicos fundidos úteis como inibidores de peptidase 30 específica de ubiquitina
UA82888C2 (en) Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators
NO20081214L (no) Azol og tiazolderivater og deres anvendelse
KR102511898B1 (ko) 항미생물 요법을 위한 치환된 페닐옥사졸리디논
AR063028A1 (es) Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.
MY145746A (en) Heterocyclic substituted pyridine derivatives and antifungal agent containing same
AU2010277384B2 (en) Spirocyclic amide derivatives
WO2002051983A2 (en) Novel compounds and compositions as cathepsin inhibitors
ECSP056257A (es) Antibióticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos
TW202041217A (zh) 一種多環類衍生物調節劑、其製備方法和應用
ECSP066415A (es) 2-carbonilamino-6-piperidinaminopiridinas sustituidas y 1-carbonilamino-3-piperidinaminobenzenos sustituidos como 5-ht1f agonistas
PE20050582A1 (es) Derivados de quinolona como agentes antibacterianos
WO2008022786A1 (de) Aminoacyl-prodrug derivate und arzneimittel zur behandlung von thromboembolischen erkrankungen
AR074915A1 (es) Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de trastornos del aparato cardiovascular, glaucoma y otras patologias.
US4247449A (en) Urea derivatives, process for their manufacture and their use as light protecting agents for polymers
EP2167500A1 (de) Aminoacyl-prodrugs als arzneimittelwirkstoff für thromboembolische erkrankungen
DE102007032347A1 (de) Aminoacyl-Prodrugs
WO2010136128A1 (de) Substituierte piperidine
WO2023247666A1 (en) Fluorescent probes for magl
AR125299A1 (es) Nuevos (homo)piperidinil heterociclos como ligandos sigma
ES2568470T3 (es) Derivados aromáticos bicíclicos de sulfinil

Legal Events

Date Code Title Description
FG Grant, registration