AR051051A1 - Antibioticos de piperidina - Google Patents

Antibioticos de piperidina

Info

Publication number
AR051051A1
AR051051A1 ARP050104194A ARP050104194A AR051051A1 AR 051051 A1 AR051051 A1 AR 051051A1 AR P050104194 A ARP050104194 A AR P050104194A AR P050104194 A ARP050104194 A AR P050104194A AR 051051 A1 AR051051 A1 AR 051051A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
alkoxy
aryl
halogen
Prior art date
Application number
ARP050104194A
Other languages
English (en)
Original Assignee
Actelion Percurex Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35453391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR051051(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Percurex Ag filed Critical Actelion Percurex Ag
Publication of AR051051A1 publication Critical patent/AR051051A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Reivindicación 1: Un compuesto seleccionado desde el grupo consistente de un compuesto de la fórmula (1) donde uno de U y V representa N, el oro representa N o CH; M representa CH₂CH₂, CH=CH, CH(OH)CH(OH), CH(OH)CH₂, CH(NH₂)CH₂, COCH₂ o OCH₂; R¹ representa alquil, haloalquil, alcoxi, haloalcoxi, halógeno o ciano; R² representa H o halógeno; R³ representa carboxi, carboxamido, alquilaminocarbonil, hidroxi, aminocarboniloxi, 2-tetrazolil o 3-metil-1,2,4-oxadiazol-5-il; R⁴ representa alquil, alcoxi C₁₋₄-alquil C₁₋₄, haloalquil, alquenil, arilalquil, aril-S(O)ₘ-alquil, heteroarilalquil, heteroarilaminocarbonilalquil, heteroaril-S(O)ₘ-alquil, CH₂-CH=CH-aril o cicloalquil-S(O)ₘ-alquil; n es un entero desde 0 a 3; y m es 0 ó 2; y una prodroga, un tautómero, un enantiómero ópticamente puro, mezclas de enantiómeros, un racemato, un distereoisómero ópticamente puro, mezclas de diatereoisómeros, un racemato diastereoisomérico, mezcla de racematos diatereoisoméricos, una forma meso, una forma morfológica, una sal o un complejo solvente de tales compuestos.
ARP050104194A 2004-10-05 2005-10-04 Antibioticos de piperidina AR051051A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2004011087 2004-10-05

Publications (1)

Publication Number Publication Date
AR051051A1 true AR051051A1 (es) 2006-12-13

Family

ID=35453391

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104194A AR051051A1 (es) 2004-10-05 2005-10-04 Antibioticos de piperidina

Country Status (10)

Country Link
US (1) US20070173532A1 (es)
JP (1) JP2008515796A (es)
CN (1) CN101039935B (es)
AR (1) AR051051A1 (es)
AT (1) ATE466857T1 (es)
CA (1) CA2581057A1 (es)
DE (1) DE602005021133D1 (es)
ES (1) ES2343127T3 (es)
TW (1) TW200616959A (es)
WO (1) WO2006038172A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101180298B (zh) * 2005-05-25 2011-04-27 埃科特莱茵药品有限公司 抗生素衍生物
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
KR20080064953A (ko) * 2005-10-13 2008-07-10 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 항균 활성을 갖는 5-퀴놀린 유도체
US7709483B2 (en) 2006-04-06 2010-05-04 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
TW200819457A (en) * 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
KR101567096B1 (ko) * 2007-04-20 2015-11-06 글락소 그룹 리미티드 항균제로서의 트리시클릭 질소 함유 화합물
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
ES2561631T3 (es) 2009-01-15 2016-02-29 Glaxo Group Limited Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos
EP2566863B1 (en) * 2010-05-06 2014-05-14 Council of Scientific and Industrial Research Quinolylpiperazino substituted thiolactone compounds and process for the preparation thereof
EA031589B1 (ru) 2014-08-22 2019-01-31 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Трициклические азотсодержащие соединения для лечения инфекции, вызываемой neisseria gonorrhoeae
UY36851A (es) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
MX2018014032A (es) 2017-03-20 2019-08-21 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de piruvato cinasa (pkr).
EP3853206B1 (en) 2018-09-19 2024-04-10 Novo Nordisk Health Care AG Treating sickle cell disease with a pyruvate kinase r activating compound
CN113226356A (zh) 2018-09-19 2021-08-06 福马治疗股份有限公司 活化丙酮酸激酶r

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
AU2437900A (en) * 1999-01-20 2000-08-07 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors
FR2798656B1 (fr) * 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
DE50312598D1 (de) * 2002-10-10 2010-05-20 Morphochem Ag Komb Chemie Neue verbindungen mit antibakterieller aktivität
DE10247233A1 (de) * 2002-10-10 2004-06-17 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Topoisomerase IV inhibieren
US6982334B2 (en) * 2002-12-20 2006-01-03 Aventis Pharma S.A. Crystalline form of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperindine-3-carboxylic acid
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität

Also Published As

Publication number Publication date
CN101039935B (zh) 2011-04-20
CN101039935A (zh) 2007-09-19
ATE466857T1 (de) 2010-05-15
TW200616959A (en) 2006-06-01
WO2006038172A1 (en) 2006-04-13
ES2343127T3 (es) 2010-07-23
DE602005021133D1 (de) 2010-06-17
JP2008515796A (ja) 2008-05-15
US20070173532A1 (en) 2007-07-26
CA2581057A1 (en) 2006-04-13

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