TW200616959A - New piperidine antibiotics - Google Patents

New piperidine antibiotics

Info

Publication number
TW200616959A
TW200616959A TW094134680A TW94134680A TW200616959A TW 200616959 A TW200616959 A TW 200616959A TW 094134680 A TW094134680 A TW 094134680A TW 94134680 A TW94134680 A TW 94134680A TW 200616959 A TW200616959 A TW 200616959A
Authority
TW
Taiwan
Prior art keywords
alkyl
antibiotics
haloalkyl
alkoxy
halogen
Prior art date
Application number
TW094134680A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Original Assignee
Actelion Percurex Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35453391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200616959(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Percurex Ag filed Critical Actelion Percurex Ag
Publication of TW200616959A publication Critical patent/TW200616959A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
TW094134680A 2004-10-05 2005-10-04 New piperidine antibiotics TW200616959A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2004011087 2004-10-05

Publications (1)

Publication Number Publication Date
TW200616959A true TW200616959A (en) 2006-06-01

Family

ID=35453391

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094134680A TW200616959A (en) 2004-10-05 2005-10-04 New piperidine antibiotics

Country Status (10)

Country Link
US (1) US20070173532A1 (zh)
JP (1) JP2008515796A (zh)
CN (1) CN101039935B (zh)
AR (1) AR051051A1 (zh)
AT (1) ATE466857T1 (zh)
CA (1) CA2581057A1 (zh)
DE (1) DE602005021133D1 (zh)
ES (1) ES2343127T3 (zh)
TW (1) TW200616959A (zh)
WO (1) WO2006038172A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101180298B (zh) * 2005-05-25 2011-04-27 埃科特莱茵药品有限公司 抗生素衍生物
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
BRPI0617376A2 (pt) * 2005-10-13 2011-07-26 Morphochem Ag derivados de 5-quinolina tendo uma atividade antibacteriana
JP2009532423A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌剤としてのピロロ−キノキサリノン誘導体
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
TW200819457A (en) * 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
BRPI0810064B8 (pt) * 2007-04-20 2021-05-25 Glaxo Group Ltd compostos contendo nitrogênio tricíclico como agentes antibacterianos, composições farmacêuticas que compreendem os ditos compostos e uso dos mesmos para o tratamento de infecções bacterianas em mamíferos
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
ES2561631T3 (es) 2009-01-15 2016-02-29 Glaxo Group Limited Compuestos de naftiridin-2(1H)-ona útiles como agentes antibacterianos
EP2566863B1 (en) * 2010-05-06 2014-05-14 Council of Scientific and Industrial Research Quinolylpiperazino substituted thiolactone compounds and process for the preparation thereof
EP3182973B1 (en) 2014-08-22 2019-09-18 GlaxoSmithKline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
RS60209B1 (sr) 2017-03-20 2020-06-30 Forma Therapeutics Inc Kompozicije pirolopirola kao aktivatori piruvat kinaze (pkr)
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20220031671A1 (en) 2018-09-19 2022-02-03 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
WO2000043383A1 (en) * 1999-01-20 2000-07-27 Smithkline Beecham P.L.C. Piperidinylquinolines as protein tyrosine kinase inhibitors
FR2798656B1 (fr) * 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
TW200406413A (en) * 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
DE10247233A1 (de) * 2002-10-10 2004-06-17 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Topoisomerase IV inhibieren
CA2500320A1 (en) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Novel compounds with antibacterial activity
US6982334B2 (en) * 2002-12-20 2006-01-03 Aventis Pharma S.A. Crystalline form of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperindine-3-carboxylic acid
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität

Also Published As

Publication number Publication date
ES2343127T3 (es) 2010-07-23
AR051051A1 (es) 2006-12-13
WO2006038172A1 (en) 2006-04-13
DE602005021133D1 (de) 2010-06-17
CA2581057A1 (en) 2006-04-13
CN101039935A (zh) 2007-09-19
CN101039935B (zh) 2011-04-20
US20070173532A1 (en) 2007-07-26
ATE466857T1 (de) 2010-05-15
JP2008515796A (ja) 2008-05-15

Similar Documents

Publication Publication Date Title
TW200616959A (en) New piperidine antibiotics
HK1101824A1 (en) Aromatic compounds
MX2010006202A (es) Derivados de oxindol substituidos por amidometil y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina.
NZ594537A (en) Compounds, compositions, and methods for preventing metastasis of cancer cells
NZ515458A (en) Metalloprotease inhibitors
BG106038A (en) Aminopyridines as sorbitol dehydrogenase inhibitors
TW200420568A (en) 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
MY126176A (en) Nicotin-or isonicotin benzothiazole derivatives.
DE60330150D1 (en) Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren
WO2008126831A1 (ja) ピロール誘導体のアトロプ異性体
BRPI0609322A (pt) composições abosorvìveis de alfa-cianoacrilato
NZ524559A (en) 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors
MX2009002919A (es) Derivados de azetidina y azetidona utiles en el tratamiento del dolor y trastornos del metabolismo de los lipidos.
MXPA05010638A (es) Aditivo para cemento.
TW200637599A (en) Cosmetic
EA200700758A1 (ru) Новые производные бис-азаиндолов, их получение и фармацевтическое применение в качестве ингибиторов киназ
TR200705187T1 (tr) 2-Kromen hazırlanması için yeni yöntemler
PH12015501098A1 (en) Antituberculous composition comprising oxazole compounds
EP1778619A4 (en) CALCIUM CHANNEL INHIBITORS TYPE T
MX2008016558A (es) Preparacion y aplicacion terapéutica de derivados de 2-benzoil-imidazopiridinas.
MY147504A (en) Electrode for energy storage device and method for making same
WO2007082262A3 (en) Novel compounds
WO2005097100A3 (en) Antibacterial agents
WO2003099206A3 (en) Indole compounds useful as impdh inhibitors
TW200619201A (en) Process for the preparation of pyrazoles