AR034320A1 - Forma de dosificacion farmaceutica del mesilato de nelfinavir amorfo - Google Patents
Forma de dosificacion farmaceutica del mesilato de nelfinavir amorfoInfo
- Publication number
- AR034320A1 AR034320A1 ARP020101580A ARP020101580A AR034320A1 AR 034320 A1 AR034320 A1 AR 034320A1 AR P020101580 A ARP020101580 A AR P020101580A AR P020101580 A ARP020101580 A AR P020101580A AR 034320 A1 AR034320 A1 AR 034320A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical dosage
- dosage form
- amorfo
- mesilate
- nelfinavir
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 title 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 title 1
- 229950002475 mesilate Drugs 0.000 title 1
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 title 1
- 229960000884 nelfinavir Drugs 0.000 title 1
- 239000002552 dosage form Substances 0.000 abstract 2
- 229960005230 nelfinavir mesylate Drugs 0.000 abstract 2
- NQHXCOAXSHGTIA-SKXNDZRYSA-N nelfinavir mesylate Chemical compound CS(O)(=O)=O.CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 NQHXCOAXSHGTIA-SKXNDZRYSA-N 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012943 hotmelt Substances 0.000 abstract 1
- 229920000831 ionic polymer Polymers 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000007909 melt granulation Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000006186 oral dosage form Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una forma de dosificación farmacéutica oral unitaria sólida de mesilato de nelfinavir amorfo que comprende mesilato de nelfinavir amorfo, y un polímero sintético, no iónico, de bloqueo de óxido de etileno y óxido de propileno, soluble en agua, farmacéuticamente aceptable, teniendo dicho copolímero un punto de fusión de al menos 40°C. Se proporciona un proceso de granulación de fusión caliente para la elaboración de una forma de dosificación. Forma de dosificación oral unitaria sólida para uso en terapia, particularmente para el tratamiento de enfermedades mediadas por HIV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28841001P | 2001-05-03 | 2001-05-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR034320A1 true AR034320A1 (es) | 2004-02-18 |
Family
ID=23106974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020101580A AR034320A1 (es) | 2001-05-03 | 2002-04-30 | Forma de dosificacion farmaceutica del mesilato de nelfinavir amorfo |
Country Status (37)
Country | Link |
---|---|
US (1) | US7014866B2 (es) |
EP (1) | EP1390063B1 (es) |
JP (1) | JP4101661B2 (es) |
KR (1) | KR100554816B1 (es) |
CN (1) | CN1255185C (es) |
AR (1) | AR034320A1 (es) |
AT (1) | ATE282428T1 (es) |
BG (1) | BG108311A (es) |
BR (1) | BR0209325A (es) |
CA (1) | CA2444116C (es) |
CZ (1) | CZ20033211A3 (es) |
DE (1) | DE60201988T2 (es) |
EA (1) | EA006627B1 (es) |
EC (1) | ECSP034827A (es) |
ES (1) | ES2231717T3 (es) |
GE (1) | GEP20053466B (es) |
GT (1) | GT200200079A (es) |
HK (1) | HK1070285A1 (es) |
HR (1) | HRP20030873B1 (es) |
HU (1) | HU229938B1 (es) |
IL (2) | IL158306A0 (es) |
IS (1) | IS7010A (es) |
JO (1) | JO2401B1 (es) |
MA (1) | MA27018A1 (es) |
MX (1) | MXPA03009971A (es) |
MY (1) | MY128509A (es) |
NO (1) | NO20034689L (es) |
NZ (1) | NZ528689A (es) |
PA (1) | PA8544501A1 (es) |
PE (1) | PE20021159A1 (es) |
PL (1) | PL366998A1 (es) |
PT (1) | PT1390063E (es) |
RS (1) | RS83503A (es) |
SK (1) | SK14572003A3 (es) |
TW (1) | TWI234461B (es) |
UA (1) | UA76463C2 (es) |
WO (1) | WO2002089835A2 (es) |
Families Citing this family (111)
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US5281420A (en) | 1992-05-19 | 1994-01-25 | The Procter & Gamble Company | Solid dispersion compositions of tebufelone |
IE80467B1 (en) * | 1995-07-03 | 1998-07-29 | Elan Corp Plc | Controlled release formulations for poorly soluble drugs |
US5834472A (en) | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
US6232333B1 (en) * | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
US6045829A (en) * | 1997-02-13 | 2000-04-04 | Elan Pharma International Limited | Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers |
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AU8145198A (en) * | 1997-06-16 | 1999-01-04 | Vertex Pharmaceuticals Incorporated | Methods of increasing the bioavailability of stable crystal polymorphs of a compound |
JP2002522354A (ja) * | 1997-09-19 | 2002-07-23 | シャイア ラボラトリーズ,インコーポレイテッド | 固溶体ビードレット |
DE60017444T2 (de) * | 1999-11-12 | 2006-02-09 | Abbott Laboratories, Abbott Park | Pharmazeutische formulierungen auf basis fester dispersionen |
US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
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