BRPI1009199A2 - compostos de pirazinoisoquinolina - Google Patents
compostos de pirazinoisoquinolinaInfo
- Publication number
- BRPI1009199A2 BRPI1009199A2 BRPI1009199A BRPI1009199A BRPI1009199A2 BR PI1009199 A2 BRPI1009199 A2 BR PI1009199A2 BR PI1009199 A BRPI1009199 A BR PI1009199A BR PI1009199 A BRPI1009199 A BR PI1009199A BR PI1009199 A2 BRPI1009199 A2 BR PI1009199A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrazinoisoquinoline
- compounds
- pyrazinoisoquinoline compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21027909P | 2009-03-17 | 2009-03-17 | |
| PCT/US2010/027476 WO2010107791A2 (en) | 2009-03-17 | 2010-03-16 | Pyrazinoisoquinoline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1009199A2 true BRPI1009199A2 (pt) | 2016-03-08 |
Family
ID=42670542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1009199A BRPI1009199A2 (pt) | 2009-03-17 | 2010-03-16 | compostos de pirazinoisoquinolina |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8563554B2 (pt) |
| EP (1) | EP2408771B1 (pt) |
| AP (1) | AP2909A (pt) |
| BR (1) | BRPI1009199A2 (pt) |
| WO (1) | WO2010107791A2 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563554B2 (en) | 2009-03-17 | 2013-10-22 | Concert Pharmaceuticals, Inc. | Deuterated pyrazinoisoquinoline compounds |
| US8889687B2 (en) | 2011-03-04 | 2014-11-18 | Concert Pharmaceuticals, Inc. | Deuterated pyrazinoisoquinoline compounds |
| CN102520149A (zh) * | 2011-12-26 | 2012-06-27 | 江苏省血吸虫病防治研究所 | 一种体外检测日本血吸虫尾蚴对吡喹酮抗药性的方法 |
| WO2018111893A1 (en) | 2016-12-13 | 2018-06-21 | Princeton Drug Discovery Inc | Protein kinase inhibitors |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1411A (en) * | 1839-11-16 | Improvement in the machine for turning the heads of wood screws and rivets | ||
| DE2362539C2 (de) | 1973-12-17 | 1986-05-07 | Merck Patent Gmbh, 6100 Darmstadt | 2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE2457971A1 (de) | 1974-12-07 | 1976-06-10 | Merck Patent Gmbh | Verfahren zur herstellung von 2-acyl4-oxo-pyrazino-isochinolin-derivaten |
| DE2504250A1 (de) | 1975-02-01 | 1976-08-05 | Merck Patent Gmbh | Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung |
| US4303659A (en) | 1979-08-22 | 1981-12-01 | Pfizer Inc. | Schistosomicidal compositions |
| JPS57139012A (en) | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
| US4447414A (en) | 1982-12-21 | 1984-05-08 | Cutter Laboratories, Inc. | Carnivore anthelmintics |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| BG61064B1 (bg) | 1993-08-12 | 1996-10-31 | Илия Илиев | Лекарствено средство за обезпаразитяване на животни |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| KR20040068613A (ko) | 1994-03-25 | 2004-07-31 | 이소테크니카 인코포레이티드 | 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물 |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6051604A (en) | 1995-12-07 | 2000-04-18 | The Proctor & Gamble Company | Methods and compositions for the prevention and treatment of gastrointestinal disorders |
| US6165987A (en) | 1996-07-30 | 2000-12-26 | Harvey; Colin Manson | Anthelmintic formulations |
| US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| US6429211B1 (en) | 2000-05-23 | 2002-08-06 | Bayer Corporation | Praziquantel compounds for treating diseases due to Sarcocystis Neospora Toxoplasma and Isospora |
| US6689756B2 (en) | 2001-03-02 | 2004-02-10 | Integra Lifesciences Corporation | Treatment of neurological disease |
| GB0108485D0 (en) | 2001-04-04 | 2001-05-23 | Pfizer Ltd | Combination therapy |
| JP4101661B2 (ja) | 2001-05-03 | 2008-06-18 | エフ．ホフマン−ラ ロシュ アーゲー | 非晶質メシル酸ネルフィナビルの製薬剤形 |
| JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
| AU2003249244A1 (en) | 2002-07-15 | 2004-02-02 | Combinatorx, Incorporated | Methods for the treatment of neoplasms |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| WO2004047842A1 (en) | 2002-11-28 | 2004-06-10 | Moore, Bronwyn | Treatment of immune system dysfunction |
| DE10358525A1 (de) | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
| CA2581169A1 (en) | 2004-09-29 | 2006-04-13 | Cordis Corporation | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
| EP1824474A1 (en) | 2004-12-10 | 2007-08-29 | Bayer HealthCare AG | Anthelmintic composition |
| CN100503582C (zh) | 2005-03-01 | 2009-06-24 | 江苏工业学院 | 吡喹酮合成工艺 |
| WO2006120495A1 (fr) | 2005-05-13 | 2006-11-16 | Advanced Scientific Developements | Composition pharmaceutique comprenant un antiviral, an antitumoral ou un antiparasitaire, et un actif choisi parmi le carveol, le thymol, l’eugenol, le borneol et le carvacrol |
| BRPI0614169A2 (pt) | 2005-07-26 | 2016-11-22 | Merck Frosst Canada Ltd | método para tratar uma doença parasítica, e, composição farmacêutica |
| CA2624179A1 (en) | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| JP2010502702A (ja) | 2006-09-05 | 2010-01-28 | シェーリング コーポレイション | 脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物 |
| US8563554B2 (en) | 2009-03-17 | 2013-10-22 | Concert Pharmaceuticals, Inc. | Deuterated pyrazinoisoquinoline compounds |
| US8889687B2 (en) | 2011-03-04 | 2014-11-18 | Concert Pharmaceuticals, Inc. | Deuterated pyrazinoisoquinoline compounds |
-
2010
- 2010-03-16 US US13/256,787 patent/US8563554B2/en not_active Expired - Fee Related
- 2010-03-16 BR BRPI1009199A patent/BRPI1009199A2/pt not_active IP Right Cessation
- 2010-03-16 WO PCT/US2010/027476 patent/WO2010107791A2/en active Application Filing
- 2010-03-16 AP AP2011005932A patent/AP2909A/xx active
- 2010-03-16 EP EP10709147.2A patent/EP2408771B1/en not_active Not-in-force
-
2013
- 2013-09-18 US US14/030,617 patent/US9199986B2/en active Active
-
2015
- 2015-11-04 US US14/932,321 patent/US20160060263A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US8563554B2 (en) | 2013-10-22 |
| US20160060263A1 (en) | 2016-03-03 |
| WO2010107791A2 (en) | 2010-09-23 |
| AP2011005932A0 (en) | 2011-10-31 |
| EP2408771A2 (en) | 2012-01-25 |
| WO2010107791A3 (en) | 2010-11-18 |
| US20120149709A1 (en) | 2012-06-14 |
| US9199986B2 (en) | 2015-12-01 |
| WO2010107791A4 (en) | 2011-01-13 |
| EP2408771B1 (en) | 2016-11-16 |
| US20140107127A1 (en) | 2014-04-17 |
| AP2909A (en) | 2014-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |