AP3076A - Carba-nucleoside analogs for antiviral treatment - Google Patents
Carba-nucleoside analogs for antiviral treatmentInfo
- Publication number
- AP3076A AP3076A AP2010005439A AP2010005439A AP3076A AP 3076 A AP3076 A AP 3076A AP 2010005439 A AP2010005439 A AP 2010005439A AP 2010005439 A AP2010005439 A AP 2010005439A AP 3076 A AP3076 A AP 3076A
- Authority
- AP
- ARIPO
- Prior art keywords
- carba
- nucleoside analogs
- antiviral treatment
- antiviral
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4726308P | 2008-04-23 | 2008-04-23 | |
US13944908P | 2008-12-19 | 2008-12-19 | |
PCT/US2009/041432 WO2009132123A1 (fr) | 2008-04-23 | 2009-04-22 | Analogues de carba-nucléoside pour un traitement antiviral |
Publications (2)
Publication Number | Publication Date |
---|---|
AP2010005439A0 AP2010005439A0 (en) | 2010-10-31 |
AP3076A true AP3076A (en) | 2014-12-31 |
Family
ID=40887058
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2010005414A AP3237A (en) | 2008-04-23 | 2009-04-22 | 1'-Substituted carba-nucleoside analogs for antiviral treatment |
AP2010005439A AP3076A (en) | 2008-04-23 | 2009-04-22 | Carba-nucleoside analogs for antiviral treatment |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2010005414A AP3237A (en) | 2008-04-23 | 2009-04-22 | 1'-Substituted carba-nucleoside analogs for antiviral treatment |
Country Status (32)
Country | Link |
---|---|
US (5) | US8008264B2 (fr) |
EP (3) | EP2937350B9 (fr) |
JP (4) | JP5425186B2 (fr) |
KR (3) | KR101645742B1 (fr) |
CN (3) | CN104262345B (fr) |
AP (2) | AP3237A (fr) |
AR (1) | AR071395A1 (fr) |
AU (2) | AU2009240642B2 (fr) |
BR (2) | BRPI0911410A2 (fr) |
CA (2) | CA2722084C (fr) |
CO (2) | CO6321235A2 (fr) |
CY (4) | CY1113647T1 (fr) |
DK (3) | DK2937350T3 (fr) |
EA (2) | EA020659B1 (fr) |
EC (2) | ECSP10010609A (fr) |
ES (3) | ES2665272T3 (fr) |
HK (3) | HK1152709A1 (fr) |
HR (3) | HRP20130048T1 (fr) |
HU (3) | HUE025528T2 (fr) |
IL (2) | IL208515A (fr) |
LT (2) | LT2937350T (fr) |
ME (1) | ME03089B (fr) |
MX (2) | MX2010011661A (fr) |
NO (1) | NO2937350T3 (fr) |
NZ (2) | NZ588670A (fr) |
PL (3) | PL2280973T3 (fr) |
PT (3) | PT2280973E (fr) |
RS (2) | RS54008B1 (fr) |
SI (3) | SI2268642T1 (fr) |
TW (2) | TW201334784A (fr) |
WO (2) | WO2009132123A1 (fr) |
ZA (2) | ZA201007713B (fr) |
Families Citing this family (159)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
AU2001272923A1 (en) | 2000-05-26 | 2001-12-11 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
JP2006519753A (ja) | 2002-11-15 | 2006-08-31 | イデニクス(ケイマン)リミテツド | 2’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異 |
KR101645742B1 (ko) | 2008-04-23 | 2016-08-04 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료를 위한 카바-뉴클레오사이드 유사체 |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
WO2010002877A2 (fr) | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Nucléosides bicycliques et nucléotides convenant comme agents thérapeutiques |
ES2623794T3 (es) | 2008-12-09 | 2017-07-12 | Gilead Sciences, Inc. | Intermedios para la preparación de moduladores de receptores tipo toll |
MX2011006891A (es) | 2008-12-23 | 2011-10-06 | Pharmasset Inc | Fosforamidatos de nucleosidos. |
WO2010075517A2 (fr) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Analogues de nucléoside |
EA019295B1 (ru) | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Соединения пуриновых нуклеозидов и способ их получения |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
ME02656B (fr) * | 2009-09-21 | 2017-06-20 | Gilead Sciences Inc | Analogues de carbanucléoside 2'-fluoro-substitués pour traitement antiviral |
SI2480559T1 (sl) * | 2009-09-21 | 2013-10-30 | Gilead Sciences, Inc. | Postopki in intermediati za pripravo 1'-ciano-karbanukleozidnih analogov |
US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
US7973013B2 (en) | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
MX2012004990A (es) | 2009-10-30 | 2012-06-12 | Janssen Pharmaceutica Nv | Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10. |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
HUE034239T2 (en) * | 2010-03-31 | 2018-02-28 | Gilead Pharmasset Llc | Method for Crystallization of (S) -isopropyl 2 - (((S) (perfluorophenoxy) (phenoxy) phosphoryl) amino) propanoate \ t |
TW201201815A (en) | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
ES2524398T3 (es) | 2010-07-19 | 2014-12-09 | Gilead Sciences, Inc. | Métodos para la preparación de profármacos de fosforoamidato diastereoméricamente puros |
WO2012012776A1 (fr) * | 2010-07-22 | 2012-01-26 | Gilead Sciences, Inc. | Procédés et composés pour traiter des infections à virus paramyxoviridae |
TW201305185A (zh) * | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之2’-氟取代之碳-核苷類似物 |
AP3699A (en) * | 2010-09-20 | 2016-05-31 | Gilead Sciences Inc | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
EP2619215B1 (fr) | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucléosides et analogues nucléotidiques |
EP2646453A1 (fr) | 2010-11-30 | 2013-10-09 | Gilead Pharmasset LLC | Composés |
JP5891241B2 (ja) * | 2010-12-20 | 2016-03-22 | ギリアード サイエンシーズ, インコーポレイテッド | Hcvを処置するための組合せ |
CA2843324A1 (fr) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Composes et compositions pharmaceutiques pour le traitement d'infections virales |
US8877744B2 (en) * | 2011-04-04 | 2014-11-04 | Hoffmann-La Roche Inc. | 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors |
US9156872B2 (en) | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
EP2696681B1 (fr) | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | Dérivés de nucléoside 2'-substitués et procédés d'utilisation de ceux-ci pour le traitement de maladies virales |
US9150603B2 (en) | 2011-04-13 | 2015-10-06 | Merck Sharp & Dohme Corp. | 2′-cyano substituted nucleoside derivatives and methods of use thereof useful for the treatment of viral diseases |
JP6115962B2 (ja) | 2011-06-27 | 2017-04-19 | ヤンセン ファーマシューティカ エヌ.ベー. | 1−アリール−4−メチル−[1,2,4]トリアゾロ[4,3−a]キノキサリン誘導体 |
EP2731434A4 (fr) | 2011-07-13 | 2014-12-31 | Merck Sharp & Dohme | Dérivés de nucléosides 5'-substitués et leurs procédés d'utilisation pour le traitement de maladies virales |
US9408863B2 (en) | 2011-07-13 | 2016-08-09 | Merck Sharp & Dohme Corp. | 5′-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases |
WO2013030750A1 (fr) | 2011-09-01 | 2013-03-07 | Lupin Limited | Composés antiviraux |
TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
DE202012013074U1 (de) | 2011-09-16 | 2014-10-29 | Gilead Pharmasset Lcc | Zusammensetzungen zur Behandlung von HCV |
US20140227321A1 (en) * | 2011-09-30 | 2014-08-14 | Kineta, Inc. | Anti-viral compounds |
US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
CN104436197A (zh) * | 2011-10-21 | 2015-03-25 | 艾伯维公司 | 至少两种直接作用抗病毒剂的组合产品 |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
SG11201404475TA (en) | 2012-02-10 | 2014-08-28 | Lupin Ltd | Antiviral compounds with a dibenzooxaheterocycle moiety |
NZ629996A (en) * | 2012-03-13 | 2016-10-28 | Gilead Sciences Inc | 2’- substituted carba-nucleoside analogs for antiviral treatment |
JP6165848B2 (ja) | 2012-05-22 | 2017-07-19 | イデニク ファーマシューティカルズ エルエルシー | 肝疾患のためのd−アミノ酸化合物 |
US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
EP2852605B1 (fr) | 2012-05-22 | 2018-01-31 | Idenix Pharmaceuticals LLC | Promédicaments de 3',5'-phosphate cyclique pour traiter une infection par le virus de l'hépatite c |
SG11201407336PA (en) | 2012-05-25 | 2015-03-30 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
CA2872216C (fr) | 2012-06-26 | 2021-07-20 | Janssen Pharmaceutica Nv | Combinaisons comprenant des inhibiteurs de la pde 2 tels que des composes 1-aryl-4-methyl-[1,2,4]triazolo [4,3-a]-quinoxaline et des inhibiteurs de la pde 10 pour utilisation dans le traitement de troublesneurologiques ou metaboliques |
BR112015000459B1 (pt) | 2012-07-09 | 2022-02-08 | Janssen Pharmaceutica N.V. | Inibidores da enzima fosfodiesterase 10, seu uso, composição farmacêutica que os compreende, seus processo de preparação e produto |
WO2014035140A2 (fr) * | 2012-08-30 | 2014-03-06 | Kainos Medicine, Inc. | Composés et compositions pour la modulation de l'activité histone méthyltransférase |
WO2014042433A2 (fr) * | 2012-09-14 | 2014-03-20 | Kainos Medicine, Inc. | Composés et compositions de modulation de l'activité du récepteur adénosine a3 |
WO2014052638A1 (fr) * | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters et malonates de promédicaments à base de s-acyl-2-thioéthyle (sate) |
AP2015008384A0 (en) | 2012-10-08 | 2015-04-30 | Univ Montpellier Ct Nat De La Rech Scient | 2'-Chloro nucleoside analogs for hcv infection |
WO2014059901A1 (fr) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Dérivés nucléosides à substitution 2'-cyano et leurs méthodes d'utilisation pour le traitement de maladies virales |
WO2014059902A1 (fr) * | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Dérivés nucléosides substitués 2'-disubstitués et leurs procédés d'utilisation pour le traitement de maladies virales |
AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
EP2909222B1 (fr) | 2012-10-22 | 2021-05-26 | Idenix Pharmaceuticals LLC | Nucléosides 2', 4'-pontés pour l'infection par le vhc |
KR20150086325A (ko) | 2012-11-19 | 2015-07-27 | 머크 샤프 앤드 돔 코포레이션 | 바이러스성 질환을 치료하기 위한 2''-알키닐 치환된 뉴클레오시드 유도체 |
WO2014099941A1 (fr) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro-nucléosides pour le traitement du vhc |
SG10201706949VA (en) | 2013-01-31 | 2017-09-28 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
US10034893B2 (en) | 2013-02-01 | 2018-07-31 | Enanta Pharmaceuticals, Inc. | 5, 6-D2 uridine nucleoside/tide derivatives |
US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
EP2981542B1 (fr) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoronucléosides pour le traitement du vhc |
EP3004130B1 (fr) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucléosides pour le traitement du virus de l'hépatite c (vhc) |
WO2014204831A1 (fr) | 2013-06-18 | 2014-12-24 | Merck Sharp & Dohme Corp. | Dérivés de nucléosides cycliques à substitution phosphonate et leurs méthodes d'utilisation pour le traitement de maladies virales |
US20150037282A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
US20170198005A1 (en) * | 2013-11-27 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
WO2015143712A1 (fr) | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | Inhibiteurs nucléosidiques substitués en 4' de la transcriptase inverse |
EP3131914B1 (fr) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | Nucléosides méthyle ou alcynyle substitués en position 3 pour le traitement du virus de l'hépatite c |
WO2015166370A1 (fr) | 2014-04-28 | 2015-11-05 | Pfizer Inc. | Composés hétéroaromatiques et leur utilisation en tant que ligands de la dopamine d1 |
US11116774B2 (en) | 2014-07-11 | 2021-09-14 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of HIV |
TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並[3,2-d]嘧啶、呋喃並[3,2-d]嘧啶及吡咯並[3,2-d]嘧啶化合物類 |
WO2016023522A2 (fr) | 2014-08-15 | 2016-02-18 | Merck Sharp & Dohme Corp. | Composés de phosphoramidates substitués et leurs usages |
TWI673283B (zh) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | 2’-氯胺基嘧啶酮及嘧啶二酮核苷類 |
WO2016033164A1 (fr) | 2014-08-26 | 2016-03-03 | Enanta Pharmaceuticals, Inc. | Dérivés de nucléosides et de nucléotides |
US9738646B2 (en) | 2014-09-16 | 2017-08-22 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
EP3212658A4 (fr) * | 2014-10-31 | 2018-07-25 | Cocrystal Pharma, Inc. | Analogues de 2',2'-dihalo-nucléosides utilisables en vue du traitement d'infections par des virus de la famille des flaviviridae et du cancer |
US9718851B2 (en) | 2014-11-06 | 2017-08-01 | Enanta Pharmaceuticals, Inc. | Deuterated nucleoside/tide derivatives |
US9732110B2 (en) | 2014-12-05 | 2017-08-15 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
JP6735751B2 (ja) | 2014-12-15 | 2020-08-05 | エモリー ユニバーシティー | B型肝炎ウイルスの治療のためのホスホルアミデート |
HUE056470T2 (hu) | 2014-12-26 | 2022-02-28 | Univ Emory | Vírusellenes N4-Hidroxicitidin származékok |
EA039561B1 (ru) * | 2015-01-20 | 2022-02-10 | Джилид Сайэнс, Инк. | Соединения для лечения вирусных инфекций filoviridae |
AU2016229966B2 (en) | 2015-03-06 | 2018-09-27 | Atea Pharmaceuticals, Inc. | Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
US10618926B2 (en) | 2015-04-02 | 2020-04-14 | Merck Sharp & Dohme | Process for making phosphoramidate protected nucleoside compounds |
US10011629B2 (en) | 2015-05-01 | 2018-07-03 | Cocrystal Pharma, Inc. | Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
CN107592864B (zh) * | 2015-05-12 | 2021-04-16 | 豪夫迈·罗氏有限公司 | 用于治疗和预防病毒感染的新的取代的氨基噻唑并嘧啶二酮 |
CN108137639B (zh) | 2015-08-05 | 2021-10-08 | 麦德龙国际生物科技有限责任公司 | 烟酰胺单核苷酸衍生物及其用途 |
CN114366745A (zh) | 2015-09-16 | 2022-04-19 | 吉利德科学公司 | 治疗沙粒病毒科和冠状病毒科病毒感染的方法 |
KR102185996B1 (ko) | 2015-09-23 | 2020-12-02 | 머크 샤프 앤드 돔 코포레이션 | 4'-치환된 뉴클레오시드 리버스 트랜스크립타제 억제제 및 그의 제조법 |
CN109071467B (zh) | 2016-03-09 | 2023-04-04 | 艾丽奥斯生物制药有限公司 | 无环抗病毒药 |
JP7034084B2 (ja) | 2016-03-28 | 2022-03-11 | インサイト・コーポレイション | Tam阻害剤としてのピロロトリアジン化合物 |
WO2017184668A1 (fr) * | 2016-04-20 | 2017-10-26 | Gilead Sciences, Inc. | Méthodes de traitement d'infections virales à flaviviridae |
WO2017184670A2 (fr) | 2016-04-22 | 2017-10-26 | Gilead Sciences, Inc. | Méthodes de traitement d'infections à virus zika |
JP2019525905A (ja) | 2016-06-24 | 2019-09-12 | エモリー ユニバーシティー | B型肝炎ウイルスの治療のためのホスホロアミデート |
US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
WO2018013937A1 (fr) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Nucléotides de purine beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substitué-4'-fluoro-n6-substitué-6-amino-2-substitué pour le traitement de l'infection par le virus de l'hépatite c |
EP3497111A2 (fr) * | 2016-08-12 | 2019-06-19 | Janssen BioPharma, Inc. | Nucléosides et nucléotides substitués et leurs analogues |
KR102456417B1 (ko) | 2016-09-07 | 2022-10-19 | 아테아 파마슈티컬즈, 인크. | Rna 바이러스 치료를 위한 2'-치환된-n6-치환된 퓨린 뉴클레오티드 |
WO2018129039A1 (fr) | 2017-01-04 | 2018-07-12 | President And Fellows Of Harvard College | Modulation du domaine d'homologie nudix (nhd) au moyen d'analogues de mononucléotide de nicotinamide et leurs dérivés |
CN110248951B (zh) | 2017-02-01 | 2022-10-28 | 阿堤亚制药公司 | 用于治疗丙型肝炎病毒的核苷酸半硫酸盐 |
KR102460968B1 (ko) | 2017-03-14 | 2022-11-01 | 길리애드 사이언시즈, 인코포레이티드 | 고양이 코로나바이러스 감염의 치료 방법 |
ES2938859T3 (es) | 2017-05-01 | 2023-04-17 | Gilead Sciences Inc | Una forma cristalina de (S)-2-etilbutilo 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopirrolo[2,1-f][1,2,4]triazin-7-il)-5-ciano-3,4-dihidroxitetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato |
TW201919648A (zh) | 2017-07-11 | 2019-06-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之含rna聚合酶抑制劑與環糊精的組合物 |
TWI624264B (zh) * | 2017-08-11 | 2018-05-21 | 景鑫生物科技股份有限公司 | 南洋山蘇水萃物的用途 |
US11149049B2 (en) * | 2017-09-18 | 2021-10-19 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
GB2590198B (en) | 2017-12-07 | 2022-02-23 | Univ Emory | N4-hydroxycytidine derivatives and anti-viral uses related thereto |
US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
WO2019133712A1 (fr) * | 2017-12-27 | 2019-07-04 | Schinazi Raymond F | Modalités combinées pour des nucléosides et/ou des inhibiteurs de la nadph oxydase (nox) en tant qu'agents antiviraux spécifiques de cellules myéloïdes |
KR20200140865A (ko) | 2018-04-10 | 2020-12-16 | 아테아 파마슈티컬즈, 인크. | 간경변증을 갖는 hcv 감염 환자의 치료 |
EP3966222A4 (fr) | 2019-05-09 | 2023-10-04 | Aligos Therapeutics, Inc. | Composés di-nucléosidiques cycliques modifiés servant de modulateurs sting |
CN110724174B (zh) * | 2019-09-10 | 2021-02-05 | 广州六顺生物科技股份有限公司 | 吡咯并三嗪类化合物、组合物及其应用 |
TW202313067A (zh) | 2020-01-27 | 2023-04-01 | 美商基利科學股份有限公司 | 治療sars cov-2感染之方法 |
CN113214334A (zh) * | 2020-02-05 | 2021-08-06 | 华创合成制药股份有限公司 | 用于治疗病毒感染的化合物及其制备方法和用途 |
CN113214262B (zh) * | 2020-02-05 | 2023-07-07 | 华创合成制药股份有限公司 | 一种含有胍基的化合物及其制备方法和用途 |
JP7429799B2 (ja) | 2020-02-18 | 2024-02-08 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス化合物 |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
TWI791193B (zh) | 2020-02-18 | 2023-02-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
CN113292565B (zh) * | 2020-02-24 | 2023-01-31 | 浙江森科建设有限公司 | 核苷类化合物及其制备方法和应用 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
CN111269248A (zh) * | 2020-03-05 | 2020-06-12 | 江苏福瑞康泰药业有限公司 | 一种核苷氨基磷酸酯类药物母液回收的新方法 |
JP2023516087A (ja) | 2020-03-12 | 2023-04-17 | ギリアード サイエンシーズ, インコーポレイテッド | 1’-シアノヌクレオシドを調製する方法 |
AU2021237718B2 (en) | 2020-03-20 | 2023-09-21 | Gilead Sciences, Inc. | Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
TW202143949A (zh) * | 2020-03-22 | 2021-12-01 | 盈擘醫藥股份有限公司 | 用於預防或暴露後治療感染或呼吸疾病的抗病毒組成物 |
WO2021202669A2 (fr) | 2020-04-01 | 2021-10-07 | Reyoung Corporation | Composés conjugués de nucléoside et de nucléotide et leurs utilisations |
CN115362004A (zh) | 2020-04-06 | 2022-11-18 | 吉利德科学公司 | 1’-氰基取代的碳核苷类似物的吸入制剂 |
CN112778310A (zh) * | 2020-04-20 | 2021-05-11 | 中国科学院上海药物研究所 | 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用 |
JP2023528810A (ja) | 2020-05-29 | 2023-07-06 | ギリアード サイエンシーズ, インコーポレイテッド | レムデシビル治療方法 |
KR20230028486A (ko) | 2020-06-24 | 2023-02-28 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 뉴클레오시드 유사체 및 이의 용도 |
EP4192839A1 (fr) | 2020-08-06 | 2023-06-14 | Richter Gedeon Nyrt. | Intermédiaires de remdésivir |
CN111956630A (zh) * | 2020-08-20 | 2020-11-20 | 大连理工大学 | 一种瑞德西韦供雾化器用的液体制剂、制备方法及其应用 |
TW202228722A (zh) | 2020-08-27 | 2022-08-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之化合物及方法 |
TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
WO2022098371A1 (fr) * | 2020-11-09 | 2022-05-12 | Yan Matthew | Promédicaments d'analogues de carba-nucléoside 1'-substitués pour un traitement antiviral |
US20220144923A1 (en) | 2020-11-11 | 2022-05-12 | Gilead Sciences, Inc. | METHODS OF IDENTIFYING HIV PATIENTS SENSITIVE TO THERAPY WITH gp120 CD4 BINDING SITE-DIRECTED ANTIBODIES |
CN112494500B (zh) * | 2020-11-26 | 2022-01-11 | 北京箭牧科技有限公司 | 瑞德西韦在制备治疗抗肿瘤药物心脏毒性药物中的应用 |
CN114621229A (zh) * | 2020-12-11 | 2022-06-14 | 嘉兴金派特生物科技有限公司 | 治疗或预防猫传染性腹膜炎的化合物或组合物 |
CN112592348B (zh) * | 2020-12-21 | 2022-03-08 | 南京法恩化学有限公司 | 一种4-氨基吡咯并[2,1-f][1,2,4]三嗪的制备方法 |
CA3203874A1 (fr) * | 2020-12-30 | 2022-07-07 | Xumu Zhang | Methodes et nucleosides modifies pour le traitement d'infections a coronavirus |
AU2022256476A1 (en) | 2021-04-16 | 2023-10-12 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
KR20230001208A (ko) | 2021-06-28 | 2023-01-04 | 동아대학교 산학협력단 | 오각고리 염기를 포함하는 비고리형 핵산 모방체 |
CN115703796A (zh) * | 2021-08-09 | 2023-02-17 | 苏州恩泰新材料科技有限公司 | 一种瑞德西韦重要中间体制备方法 |
TW202342447A (zh) | 2021-12-03 | 2023-11-01 | 美商基利科學股份有限公司 | 用於hiv病毒感染之治療性化合物 |
CA3235937A1 (fr) | 2021-12-03 | 2023-06-08 | Gilead Sciences, Inc. | Composes therapeutiques contre l'infection par le virus du vih |
TW202342448A (zh) | 2021-12-03 | 2023-11-01 | 美商基利科學股份有限公司 | 用於hiv病毒感染之治療性化合物 |
WO2023167944A1 (fr) | 2022-03-02 | 2023-09-07 | Gilead Sciences, Inc. | Composés et méthodes pour traiter des infections virales |
TW202400172A (zh) | 2022-04-06 | 2024-01-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
CN114437159B (zh) * | 2022-04-11 | 2022-06-28 | 佛山市晨康生物科技有限公司 | 一种环状碳酸酯核苷类化合物及其应用 |
WO2023207942A1 (fr) * | 2022-04-25 | 2023-11-02 | 北京沐华生物科技有限责任公司 | Médicament nucléosidique pour le traitement ou la prévention d'une infection à coronavirus, et son utilisation |
WO2024006461A1 (fr) * | 2022-06-30 | 2024-01-04 | Gilead Sciences, Inc. | Formes solides d'un analogue nucléosidique et leurs utilisations |
US20240034724A1 (en) | 2022-07-01 | 2024-02-01 | Gilead Sciences, Inc. | Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection |
US20240083984A1 (en) | 2022-08-26 | 2024-03-14 | Gilead Sciences, Inc. | Dosing and scheduling regimen for broadly neutralizing antibodies |
WO2024076915A1 (fr) | 2022-10-04 | 2024-04-11 | Gilead Sciences, Inc. | Analogues de 4'-thionucléosides et leur utilisation pharmaceutique |
CN115819423A (zh) * | 2022-11-29 | 2023-03-21 | 武汉大学 | 一种瑞德西韦或其中间体的protac化合物及其制备方法与抗ev71的应用 |
CN116217621B (zh) * | 2023-04-26 | 2023-08-11 | 北京沐华生物科技有限责任公司 | 一种核苷类双前药、合成方法及应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000056734A1 (fr) * | 1999-03-20 | 2000-09-28 | Aventis Cropscience Gmbh | Heterocycles bicycliques, leur procede de production et leur utilisation comme herbicides et produits pharmaceutiques |
WO2002057287A2 (fr) * | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Derives de nucleoside servant d'inhibiteurs de l'arn polymerase virale arn dependante |
WO2008005542A2 (fr) * | 2006-07-07 | 2008-01-10 | Gilead Sciences, Inc., | Composés antiviraux à base de phosphinate |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
JPS59141856A (ja) | 1983-02-02 | 1984-08-14 | Fuji Electric Co Ltd | Fs変復調方式 |
US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
DK0533833T3 (da) | 1990-06-13 | 1996-04-22 | Arnold Glazier | Phosphorprolægemidler |
DE69129650T2 (de) | 1990-09-14 | 1999-03-25 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
US6887707B2 (en) | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
ES2291043T3 (es) | 1998-10-16 | 2008-02-16 | MERCK SHARP & DOHME LIMITED | Derivados de pirazolotriazina como ligandos para receptores de gaba. |
AU7490600A (en) | 1999-09-15 | 2001-04-17 | Biocryst Pharmaceuticals, Inc. | Inhibiting t-cell proliferation |
WO2001032153A2 (fr) | 1999-11-04 | 2001-05-10 | Shire Biochem Inc. | Procede de traitement ou de prevention de l'infection virale par flaviviridae faisant appel a des analogues des nucleosides |
EP1296690A2 (fr) | 2000-02-18 | 2003-04-02 | Shire Biochem Inc. | METHODE DE TRAITEMENT OU DE PREVENTION D'INFECTIONS A i FLAVIVIRUS /i A L'AIDE D'ANALOGUES NUCLEOSIDIQUES |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
AU2001272923A1 (en) | 2000-05-26 | 2001-12-11 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
CN101862345B (zh) | 2000-10-18 | 2014-06-04 | 吉利德制药有限责任公司 | 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物 |
EP1438054A4 (fr) | 2001-09-28 | 2006-07-26 | Idenix Cayman Ltd | Procedes et compositions pour traiter des flavivirus et des pestivirus au moyen d'un nucleoside modifie en position 4' |
AT410792B (de) | 2001-12-28 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
AU2003213628A1 (en) | 2002-02-28 | 2003-09-16 | Biota, Inc. | Nucleoside 5'-monophosphate mimics and their prodrugs |
EP1485395A4 (fr) | 2002-02-28 | 2011-04-13 | Biota Scient Management | Mimetiques nucleotidiques et leurs promedicaments |
US20040138170A1 (en) | 2002-03-06 | 2004-07-15 | Montgomery John A. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
GB0210124D0 (en) | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
GB0210127D0 (en) | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
MXPA04010983A (es) * | 2002-05-06 | 2005-02-14 | Genelabs Tech Inc | Derivados de nucleosidos para tratar infecciones por el virus de la hepatitis c. |
US20050250728A1 (en) | 2002-05-23 | 2005-11-10 | Shanta Bantia | Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof |
JP2006519753A (ja) | 2002-11-15 | 2006-08-31 | イデニクス(ケイマン)リミテツド | 2’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異 |
PT1628685E (pt) | 2003-04-25 | 2011-03-16 | Gilead Sciences Inc | Análogos de fosfonatos antivirais |
WO2005020885A2 (fr) * | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions et methodes pour le traitement du syndrome respiratoire aigu severe (sras) |
RU2006105640A (ru) * | 2003-07-25 | 2007-09-10 | Айденикс (Кайман) Лимитед (Ky) | Аналоги пуриновых нуклеозидов для лечения flaviviridae, включая гепатит с |
EP1660511B1 (fr) | 2003-08-27 | 2010-11-03 | Biota Scientific Management Pty. Ltd. | Nouveau nucleosides ou nucleotides tricycliques utillises comme agents therapeutiques |
US7534767B2 (en) | 2004-06-15 | 2009-05-19 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase |
WO2006002231A1 (fr) | 2004-06-22 | 2006-01-05 | Biocryst Pharmaceuticals, Inc. | Azanucleosides, leur preparation et leur utilisation comme inhibiteur des arn polymerases virales |
PT3109244T (pt) | 2004-09-14 | 2019-06-04 | Gilead Pharmasset Llc | ¿preparação de ribofuranosil pirimidinas e purinas 2¿-fluoro-2¿-alquil substituídas ou outras opcionalmente substituídas e os seus derivados |
CN101043893A (zh) | 2004-10-21 | 2007-09-26 | 默克公司 | 治疗RNA-依赖性RNA病毒感染的氟化吡咯并[2,3-d]嘧啶核苷 |
US20080280842A1 (en) | 2004-10-21 | 2008-11-13 | Merck & Co., Inc. | Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection |
EP1814561A4 (fr) | 2004-10-29 | 2012-12-19 | Biocryst Pharm Inc | Furopyrimidines et thienopyrimidines therapeutiques |
US8802840B2 (en) | 2005-03-08 | 2014-08-12 | Biota Scientific Management Pty Ltd. | Bicyclic nucleosides and nucleotides as therapeutic agents |
WO2006104945A2 (fr) | 2005-03-29 | 2006-10-05 | Biocryst Pharmaceuticals, Inc. | Therapies contre l'hepatite c |
WO2006121820A1 (fr) | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Promedicaments de phosphoramidate pour traitement d'infections virales |
WO2007027248A2 (fr) | 2005-05-16 | 2007-03-08 | Valeant Research & Development | Analogues de nucleoside cyclique 3', 5' pour le traitement du virus de l'hepatite c (vhc) |
WO2007038860A2 (fr) | 2005-10-03 | 2007-04-12 | University Health Network | Inhibiteurs d'odcase en tant qu'antiviraux et antibiotiques |
US8431695B2 (en) | 2005-11-02 | 2013-04-30 | Bayer Intellectual Property Gmbh | Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
AU2006320440B2 (en) | 2005-12-02 | 2012-04-05 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
PE20070855A1 (es) | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
WO2007097991A2 (fr) | 2006-02-16 | 2007-08-30 | Pharmasset, Inc. | Méthodes et trousses pour administrer des agents antiviraux |
AR061024A1 (es) | 2006-05-22 | 2008-07-30 | Novartis Ag | Maleato de 5-amino-3- (2'3'-di-o-acetil-beta-d-ribofuranosil)-3h-tiazolo[4,5-d] pirimidin-2-ona. |
WO2008033466A2 (fr) | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions et procédés pour le traitement de maladies virales |
ITBO20060683A1 (it) | 2006-10-03 | 2008-04-04 | Sympak Corazza S P A | Dispositivo per il raggruppamento di confezioni. |
US8148349B2 (en) | 2006-12-20 | 2012-04-03 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection |
US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
AU2007342367B2 (en) | 2007-01-05 | 2012-12-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
US8440813B2 (en) * | 2007-01-12 | 2013-05-14 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
US8188272B2 (en) | 2007-03-21 | 2012-05-29 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
WO2008141079A1 (fr) | 2007-05-10 | 2008-11-20 | Biocryst Pharmaceuticals, Inc. | Composés de tétrahydrofuro [3,4-d] dioxolane pour utilisation dans le traitement d'infections virales et de cancer |
CN100532388C (zh) | 2007-07-16 | 2009-08-26 | 郑州大学 | 2’-氟-4’-取代-核苷类似物、其制备方法及应用 |
TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
KR101645742B1 (ko) | 2008-04-23 | 2016-08-04 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료를 위한 카바-뉴클레오사이드 유사체 |
US7863291B2 (en) | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
WO2010036407A2 (fr) | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Analogues nucléosidiques antiviraux |
WO2010002877A2 (fr) | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Nucléosides bicycliques et nucléotides convenant comme agents thérapeutiques |
NZ594370A (en) | 2009-02-10 | 2014-01-31 | Gilead Sciences Inc | Carba-nucleoside analogs for antiviral treatment |
PL2411394T3 (pl) | 2009-03-24 | 2015-01-30 | Biocryst Pharm Inc | Użyteczne sole farmaceutyczne 7-[(3r, 4r)-3-hydroksy-4-hydroksymetylopirolidyn-1-ylometylo]-3,5-dihydropirolo[3,2-d]pirymidyno-4-nu |
TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US7973013B2 (en) | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
ME02656B (fr) | 2009-09-21 | 2017-06-20 | Gilead Sciences Inc | Analogues de carbanucléoside 2'-fluoro-substitués pour traitement antiviral |
SI2480559T1 (sl) | 2009-09-21 | 2013-10-30 | Gilead Sciences, Inc. | Postopki in intermediati za pripravo 1'-ciano-karbanukleozidnih analogov |
EP3290428B1 (fr) | 2010-03-31 | 2021-10-13 | Gilead Pharmasset LLC | Comprimé contenant cristallin (s)-isopropyl 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1 (2h)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate |
TW201201815A (en) | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
ES2524398T3 (es) | 2010-07-19 | 2014-12-09 | Gilead Sciences, Inc. | Métodos para la preparación de profármacos de fosforoamidato diastereoméricamente puros |
WO2012012776A1 (fr) | 2010-07-22 | 2012-01-26 | Gilead Sciences, Inc. | Procédés et composés pour traiter des infections à virus paramyxoviridae |
TW201305185A (zh) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之2’-氟取代之碳-核苷類似物 |
AP3699A (en) | 2010-09-20 | 2016-05-31 | Gilead Sciences Inc | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
ES2657687T3 (es) | 2010-10-15 | 2018-03-06 | Biocryst Pharmaceuticals, Inc. | Derivados de pirrolopirimidina para uso en el tratamiento de infecciones virales |
-
2009
- 2009-04-22 KR KR1020107026265A patent/KR101645742B1/ko active IP Right Grant
- 2009-04-22 PL PL09735162T patent/PL2280973T3/pl unknown
- 2009-04-22 US US12/428,176 patent/US8008264B2/en active Active
- 2009-04-22 PT PT97351621T patent/PT2280973E/pt unknown
- 2009-04-22 LT LTEP15155479.7T patent/LT2937350T/lt unknown
- 2009-04-22 AU AU2009240642A patent/AU2009240642B2/en active Active
- 2009-04-22 TW TW102115415A patent/TW201334784A/zh unknown
- 2009-04-22 EP EP15155479.7A patent/EP2937350B9/fr active Active
- 2009-04-22 EA EA201071170A patent/EA020659B1/ru unknown
- 2009-04-22 MX MX2010011661A patent/MX2010011661A/es active IP Right Grant
- 2009-04-22 DK DK15155479.7T patent/DK2937350T3/en active
- 2009-04-22 EP EP09734175.4A patent/EP2268642B1/fr active Active
- 2009-04-22 CN CN201410408008.1A patent/CN104262345B/zh active Active
- 2009-04-22 CN CN2009801202188A patent/CN102046626A/zh active Pending
- 2009-04-22 SI SI200931153T patent/SI2268642T1/sl unknown
- 2009-04-22 US US12/428,234 patent/US8012941B2/en active Active
- 2009-04-22 NZ NZ588670A patent/NZ588670A/xx not_active IP Right Cessation
- 2009-04-22 CA CA2722084A patent/CA2722084C/fr active Active
- 2009-04-22 CA CA2722177A patent/CA2722177C/fr active Active
- 2009-04-22 PT PT97341754T patent/PT2268642E/pt unknown
- 2009-04-22 KR KR1020167033059A patent/KR101856404B1/ko active IP Right Grant
- 2009-04-22 SI SI200930503T patent/SI2280973T1/sl unknown
- 2009-04-22 CN CN200980114224.2A patent/CN102015714B/zh active Active
- 2009-04-22 AU AU2009240630A patent/AU2009240630B2/en active Active
- 2009-04-22 PL PL15155479T patent/PL2937350T3/pl unknown
- 2009-04-22 RS RS20150348A patent/RS54008B1/en unknown
- 2009-04-22 HU HUE09734175A patent/HUE025528T2/en unknown
- 2009-04-22 JP JP2011506429A patent/JP5425186B2/ja active Active
- 2009-04-22 WO PCT/US2009/041432 patent/WO2009132123A1/fr active Application Filing
- 2009-04-22 DK DK09735162.1T patent/DK2280973T3/da active
- 2009-04-22 ES ES15155479.7T patent/ES2665272T3/es active Active
- 2009-04-22 AP AP2010005414A patent/AP3237A/xx active
- 2009-04-22 NO NO15155479A patent/NO2937350T3/no unknown
- 2009-04-22 JP JP2011506435A patent/JP5425187B2/ja active Active
- 2009-04-22 EA EA201071128A patent/EA019883B1/ru not_active IP Right Cessation
- 2009-04-22 KR KR1020107026178A patent/KR101681559B1/ko active IP Right Grant
- 2009-04-22 PT PT151554797T patent/PT2937350T/pt unknown
- 2009-04-22 ME MEP-2018-95A patent/ME03089B/fr unknown
- 2009-04-22 WO PCT/US2009/041447 patent/WO2009132135A1/fr active Application Filing
- 2009-04-22 ES ES09734175.4T patent/ES2536193T3/es active Active
- 2009-04-22 EP EP09735162A patent/EP2280973B1/fr active Active
- 2009-04-22 SI SI200931823T patent/SI2937350T1/en unknown
- 2009-04-22 HU HUE15155479A patent/HUE038946T2/hu unknown
- 2009-04-22 MX MX2010011659A patent/MX2010011659A/es active IP Right Grant
- 2009-04-22 AR ARP090101420A patent/AR071395A1/es active IP Right Grant
- 2009-04-22 ES ES09735162T patent/ES2398684T3/es active Active
- 2009-04-22 BR BRPI0911410A patent/BRPI0911410A2/pt not_active Application Discontinuation
- 2009-04-22 BR BRPI0910455A patent/BRPI0910455B8/pt active IP Right Grant
- 2009-04-22 TW TW098113324A patent/TWI401084B/zh active
- 2009-04-22 NZ NZ588400A patent/NZ588400A/xx unknown
- 2009-04-22 DK DK09734175.4T patent/DK2268642T3/en active
- 2009-04-22 PL PL09734175T patent/PL2268642T3/pl unknown
- 2009-04-22 RS RS20180408A patent/RS57092B1/sr unknown
- 2009-04-22 AP AP2010005439A patent/AP3076A/xx active
-
2010
- 2010-09-30 CO CO10121513A patent/CO6321235A2/es not_active Application Discontinuation
- 2010-10-06 IL IL208515A patent/IL208515A/en active IP Right Grant
- 2010-10-14 IL IL208701A patent/IL208701A/en active IP Right Grant
- 2010-10-22 CO CO10131479A patent/CO6300958A2/es not_active Application Discontinuation
- 2010-10-28 ZA ZA2010/07713A patent/ZA201007713B/en unknown
- 2010-11-09 ZA ZA2010/08008A patent/ZA201008008B/en unknown
- 2010-11-15 EC EC2010010609A patent/ECSP10010609A/es unknown
- 2010-11-19 EC EC2010010618A patent/ECSP10010618A/es unknown
-
2011
- 2011-07-05 HK HK11106883.4A patent/HK1152709A1/xx unknown
- 2011-08-02 US US13/196,117 patent/US8318682B2/en active Active
- 2011-08-09 HK HK11108347.0A patent/HK1154010A1/xx unknown
-
2012
- 2012-10-11 US US13/649,511 patent/US8853171B2/en not_active Ceased
-
2013
- 2013-01-21 HR HRP20130048AT patent/HRP20130048T1/hr unknown
- 2013-02-08 CY CY20131100119T patent/CY1113647T1/el unknown
- 2013-10-21 JP JP2013218139A patent/JP2014012739A/ja not_active Withdrawn
- 2013-10-21 JP JP2013218129A patent/JP2014040471A/ja not_active Withdrawn
-
2015
- 2015-03-30 HR HRP20150359TT patent/HRP20150359T1/hr unknown
- 2015-05-11 CY CY20151100412T patent/CY1116425T1/el unknown
-
2016
- 2016-04-27 HK HK16104808.6A patent/HK1216750A1/zh unknown
- 2016-10-07 US US15/288,271 patent/USRE46762E1/en active Active
-
2018
- 2018-04-04 CY CY20181100377T patent/CY1120366T1/el unknown
- 2018-04-10 HR HRP20180572TT patent/HRP20180572T1/hr unknown
-
2020
- 2020-12-18 LT LTPA2020539C patent/LTC2937350I2/lt unknown
- 2020-12-18 HU HUS2000055C patent/HUS2000055I1/hu unknown
- 2020-12-18 CY CY2020044C patent/CY2020044I2/el unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000056734A1 (fr) * | 1999-03-20 | 2000-09-28 | Aventis Cropscience Gmbh | Heterocycles bicycliques, leur procede de production et leur utilisation comme herbicides et produits pharmaceutiques |
WO2002057287A2 (fr) * | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Derives de nucleoside servant d'inhibiteurs de l'arn polymerase virale arn dependante |
WO2008005542A2 (fr) * | 2006-07-07 | 2008-01-10 | Gilead Sciences, Inc., | Composés antiviraux à base de phosphinate |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1216750A1 (zh) | ' - 用於抗病毒治療的 '替代咔核苷類似物 | |
AP2922A (en) | Carbra-nucleoside analogs for antiviral treatment | |
HRP20170197T1 (hr) | 2' -fluoro supstituirani karba-nukleozidni analozi za antiviralno liječenje | |
ZA201104638B (en) | Nucleoside analogs | |
AP3699A (en) | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment | |
EP2285379A4 (fr) | Analogues de 1-méthylnicotinamide | |
GB0816600D0 (en) | Antiviral compounds | |
IL192335A0 (en) | Antiviral compounds | |
GB0819528D0 (en) | Antiviral compounds |