AP1967A - Thiazolidinone compounds as inhibitors of Hyak3 - Google Patents

Thiazolidinone compounds as inhibitors of Hyak3

Info

Publication number
AP1967A
AP1967A AP2005003304A AP2005003304A AP1967A AP 1967 A AP1967 A AP 1967A AP 2005003304 A AP2005003304 A AP 2005003304A AP 2005003304 A AP2005003304 A AP 2005003304A AP 1967 A AP1967 A AP 1967A
Authority
AP
ARIPO
Prior art keywords
hyak3
inhibitors
thiazolidinone compounds
thiazolidinone
compounds
Prior art date
Application number
AP2005003304A
Other languages
English (en)
Other versions
AP2005003304A0 (en
Inventor
Masaichi Hasegawa
Jun Tang
Hideyuki Sato
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AP2005003304A0 publication Critical patent/AP2005003304A0/xx
Application granted granted Critical
Publication of AP1967A publication Critical patent/AP1967A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AP2005003304A 2002-11-22 2003-11-18 Thiazolidinone compounds as inhibitors of Hyak3 AP1967A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42838402P 2002-11-22 2002-11-22
PCT/US2003/037658 WO2004047760A2 (en) 2002-11-22 2003-11-18 Novel chemical compounds

Publications (2)

Publication Number Publication Date
AP2005003304A0 AP2005003304A0 (en) 2005-06-30
AP1967A true AP1967A (en) 2009-03-10

Family

ID=32393394

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2005003304A AP1967A (en) 2002-11-22 2003-11-18 Thiazolidinone compounds as inhibitors of Hyak3

Country Status (30)

Country Link
US (1) US7767701B2 (no)
EP (1) EP1567112B1 (no)
JP (1) JP2006509765A (no)
KR (1) KR20050085115A (no)
CN (1) CN100579978C (no)
AP (1) AP1967A (no)
AR (1) AR045407A1 (no)
AT (1) ATE411302T1 (no)
AU (1) AU2003298693B2 (no)
BR (1) BR0316502A (no)
CA (1) CA2507256A1 (no)
CY (1) CY1108655T1 (no)
DE (1) DE60324178D1 (no)
DK (1) DK1567112T3 (no)
EA (1) EA008865B1 (no)
EC (1) ECSP055808A (no)
ES (1) ES2315566T3 (no)
IS (1) IS2659B (no)
MA (1) MA27701A1 (no)
MX (1) MXPA05005406A (no)
MY (1) MY140132A (no)
NO (1) NO20052928L (no)
NZ (1) NZ539873A (no)
OA (1) OA12963A (no)
PL (1) PL377564A1 (no)
PT (1) PT1567112E (no)
SI (1) SI1567112T1 (no)
TW (1) TWI309648B (no)
UA (1) UA80572C2 (no)
WO (1) WO2004047760A2 (no)

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PL220952B1 (pl) 2002-01-22 2016-01-29 Warner Lambert Co 2-(Pirydyn-2-yloamino)pirydo[2,3-d]pirymidyn-7-ony
ATE412650T1 (de) * 2003-07-11 2008-11-15 Warner Lambert Co Isethionat salz eines selektiven cdk4 inhibitors
EP1648452B1 (en) * 2003-07-28 2009-07-22 Merck Serono SA 2-imino-4-(thio)oxo-5-polycyclovinylazolines for use as pi3 kinase inhibitors
CN100567275C (zh) 2003-11-21 2009-12-09 埃科特莱茵药品有限公司 作为免疫抑制剂的5-(苯基-(z)-亚基)-噻唑烷-4-酮衍生物
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
JP2007523957A (ja) * 2004-02-25 2007-08-23 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
TW200616967A (en) 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
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CN1984909A (zh) * 2004-07-01 2007-06-20 霍夫曼-拉罗奇有限公司 噻唑啉酮未取代的喹啉
US7241893B2 (en) * 2004-09-17 2007-07-10 Hoffman-La Roche Inc. Thiazolinone 2-substituted quinolines
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WO2006133381A2 (en) * 2005-06-08 2006-12-14 Smithkline Beecham Corporation (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,4,6-trichlorophenyl)amino]-1,3-thiazol-4(5h)-one
TW200745066A (en) * 2005-09-16 2007-12-16 Torrent Pharmaceuticals Ltd Novel PTP1B inhibitors
JP2009514984A (ja) * 2005-11-08 2009-04-09 スミスクライン・ビーチャム・コーポレイション 新規化合物
US20100216801A1 (en) * 2006-03-02 2010-08-26 Dashyant Dhanak Thiazolones for use as pi3 kinase inhibitors
WO2007103754A2 (en) * 2006-03-02 2007-09-13 Smithkline Beecham Corporation Thiazolones for use as pi3 kinase inhibitors
KR100752757B1 (ko) * 2006-04-05 2007-08-29 한국과학기술연구원 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물
CN101460471A (zh) * 2006-04-25 2009-06-17 克里夫兰诊所基金会 活化RNaseL的抗病毒剂
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
CN103087004A (zh) * 2006-11-23 2013-05-08 埃科特莱茵药品有限公司 一种制备2-亚氨基-四氢噻唑-4-酮衍生物的新方法
US20100286041A1 (en) * 2007-03-22 2010-11-11 Smithkline Beecham Corporation (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one
CN101274918A (zh) * 2007-03-30 2008-10-01 中国科学院上海药物研究所 一类取代五元杂环化合物,其制备方法和医学用途
JPWO2010122979A1 (ja) 2009-04-20 2012-10-25 Ｓｂｉバイオテック株式会社 チアゾリジノン誘導体
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FR1604530A (no) * 1967-06-06 1971-11-29

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 68, no. 19, 1968, Columbus, Ohio, US; abstract no.: 87228f *

Also Published As

Publication number Publication date
KR20050085115A (ko) 2005-08-29
CA2507256A1 (en) 2004-06-10
JP2006509765A (ja) 2006-03-23
EP1567112B1 (en) 2008-10-15
ATE411302T1 (de) 2008-10-15
WO2004047760A3 (en) 2004-10-21
US20060293338A1 (en) 2006-12-28
AU2003298693B2 (en) 2010-09-30
CY1108655T1 (el) 2014-04-09
UA80572C2 (en) 2007-10-10
HK1083443A1 (en) 2006-07-07
AU2003298693A1 (en) 2004-06-18
ECSP055808A (es) 2005-09-20
MXPA05005406A (es) 2005-08-03
DK1567112T3 (da) 2009-02-09
PT1567112E (pt) 2009-01-08
CN1742010A (zh) 2006-03-01
NZ539873A (en) 2008-09-26
IS7879A (is) 2005-06-02
EP1567112A4 (en) 2006-11-15
EA200500856A1 (ru) 2005-10-27
NO20052928D0 (no) 2005-06-15
IS2659B (is) 2010-08-15
US7767701B2 (en) 2010-08-03
ES2315566T3 (es) 2009-04-01
MA27701A1 (fr) 2006-01-02
TW200418819A (en) 2004-10-01
AP2005003304A0 (en) 2005-06-30
SI1567112T1 (sl) 2009-02-28
DE60324178D1 (de) 2008-11-27
TWI309648B (en) 2009-05-11
NO20052928L (no) 2005-08-17
EP1567112A2 (en) 2005-08-31
OA12963A (en) 2006-10-13
EA008865B1 (ru) 2007-08-31
AR045407A1 (es) 2005-10-26
CN100579978C (zh) 2010-01-13
PL377564A1 (pl) 2006-02-06
WO2004047760A2 (en) 2004-06-10
MY140132A (en) 2009-11-30
BR0316502A (pt) 2005-10-04

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