ZA831651B - Dihydropyridine anti-ischaemic and antihypertensives agents,processes for their production,and pharmaceutical compositions containing them - Google Patents

Dihydropyridine anti-ischaemic and antihypertensives agents,processes for their production,and pharmaceutical compositions containing them

Info

Publication number
ZA831651B
ZA831651B ZA831651A ZA831651A ZA831651B ZA 831651 B ZA831651 B ZA 831651B ZA 831651 A ZA831651 A ZA 831651A ZA 831651 A ZA831651 A ZA 831651A ZA 831651 B ZA831651 B ZA 831651B
Authority
ZA
South Africa
Prior art keywords
processes
production
pharmaceutical compositions
compositions containing
ischaemic
Prior art date
Application number
ZA831651A
Other languages
English (en)
Inventor
Simon Fraser Campbell
Peter Edward Cross
John Kendrick Stubbs
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10528947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA831651(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of ZA831651B publication Critical patent/ZA831651B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Registering, Tensioning, Guiding Webs, And Rollers Therefor (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA831651A 1982-03-11 1983-03-10 Dihydropyridine anti-ischaemic and antihypertensives agents,processes for their production,and pharmaceutical compositions containing them ZA831651B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8207180 1982-03-11

Publications (1)

Publication Number Publication Date
ZA831651B true ZA831651B (en) 1983-12-28

Family

ID=10528947

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA831651A ZA831651B (en) 1982-03-11 1983-03-10 Dihydropyridine anti-ischaemic and antihypertensives agents,processes for their production,and pharmaceutical compositions containing them

Country Status (37)

Country Link
US (1) US4572909A (cs)
EP (1) EP0089167B1 (cs)
JP (1) JPS58167569A (cs)
KR (1) KR870000809B1 (cs)
AT (1) ATE22884T1 (cs)
AU (1) AU540769B2 (cs)
BA (2) BA97147B1 (cs)
BG (1) BG60658B2 (cs)
CA (1) CA1253865A (cs)
CS (3) CS240954B2 (cs)
DD (2) DD209622A5 (cs)
DE (2) DE3366920D1 (cs)
DK (1) DK161312C (cs)
EG (1) EG16987A (cs)
ES (2) ES8503654A1 (cs)
FI (1) FI81090C (cs)
GR (1) GR77429B (cs)
HK (1) HK16288A (cs)
HR (2) HRP930369B1 (cs)
HU (1) HU187868B (cs)
IE (2) IE54667B1 (cs)
IL (1) IL68091A (cs)
KE (1) KE3778A (cs)
LU (1) LU88332I2 (cs)
LV (2) LV5236A3 (cs)
MY (1) MY101985A (cs)
NL (1) NL930063I2 (cs)
NO (3) NO162818C (cs)
NZ (1) NZ203521A (cs)
PL (3) PL141830B1 (cs)
PT (1) PT76370B (cs)
SG (1) SG98687G (cs)
SI (2) SI8310586A8 (cs)
SU (2) SU1238730A3 (cs)
UA (2) UA7082A1 (cs)
YU (2) YU43541B (cs)
ZA (1) ZA831651B (cs)

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL140069B1 (en) * 1982-12-21 1987-03-31 Pfizer Method of obtaining new derivatives of dihydropiridine
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
EP0125803A3 (en) * 1983-04-27 1987-01-21 FISONS plc Pharmaceutically active dihydropyridines
EP0168841B1 (en) * 1983-12-19 1988-09-28 Pfizer Limited Dihydropyridine intermediate
JPS60156671A (ja) * 1984-01-25 1985-08-16 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体およびその製造法
GB8414518D0 (en) * 1984-06-07 1984-07-11 Pfizer Ltd Therapeutic agents
GR851819B (cs) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
GB8421039D0 (en) * 1984-08-17 1984-09-19 Wyeth John & Brother Ltd Heterocyclic compounds
IL77843A (en) * 1985-02-11 1989-07-31 Syntex Inc Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them
EP0200524A3 (en) * 1985-05-03 1987-06-16 Pfizer Limited Dihydropyridine calcium antagonists
DE3531498A1 (de) * 1985-09-04 1987-03-05 Bayer Ag Dihydropyridin-2-hydroxyamine, verfahren zur herstellung und ihre verwendung in arzneimitteln
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US4983740A (en) * 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2649395B1 (fr) * 1989-07-04 1992-11-06 Adir Nouveau derive de la dihydro-1,4 pyridine denomme (-) Ÿi1Ÿ(((amino-2 ethoxy)-2 ethoxy) methylŸi1Ÿ) -2 (dichloro-2,3 phenyl)-4 ethoxycarbonyl-3 methoxycarbonyl-5 methyl-6 dihydro-1,4 pyridine, son procede de preparation et les compositions qui le contiennent
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
IT1213555B (it) * 1986-12-11 1989-12-20 Boehringer Biochemia Srl 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.
JPS63196564A (ja) * 1987-02-10 1988-08-15 Agency Of Ind Science & Technol イミドオリゴマ−の製造方法
IT1215381B (it) * 1987-03-12 1990-02-08 Boehringer Biochemia Srl Farmaceutiche che le contengono. carbonil- e solfonil- derivati di 2-(aminoalchiltio)metil-1,4-diidropiridine, un metodo per la loro preparazione e composizioni
GB8709447D0 (en) * 1987-04-21 1987-05-28 Pfizer Ltd Dihydropyridines
GB8710493D0 (en) * 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
DE3906406C1 (cs) * 1989-03-01 1990-10-25 Goedecke Ag, 1000 Berlin, De
US5234943A (en) * 1989-04-13 1993-08-10 Bayer Aktiengesellschaft Fungicidal 3-(2-chloro-3-trifluoromethylphenyl)-4-cyanopyrrole
DE4128132A1 (de) * 1991-08-24 1993-02-25 Bayer Ag 3-(2-chlor-3-trifluormethylphenyl)-4-cyanopyrrol, dessen herstellung und verwendung und neue zwischenprodukte
FR2652083B1 (fr) * 1989-09-20 1992-01-24 Ador Cie Nouveau procede de separation d'isomeres optiques des derives de la dihydro-1,4 pyridine.
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
US6057344A (en) 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
JPH07501547A (ja) * 1991-11-26 1995-02-16 セプラコア，インコーポレーテッド 光学的に純粋な（−）アムロジピンを用いる，高血圧，狭心症および他の疾患を治療するための方法および組成物
US6162802A (en) * 1992-03-10 2000-12-19 Papa; Joseph Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor
EP1614420A3 (en) * 1992-11-25 2006-04-19 Sepracor Inc. Treatment of hypertension, angina and other disorders using (-) amlodipine
US5389654A (en) * 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
SI9200344B (sl) * 1992-11-26 1998-06-30 Lek, Postopek za pripravo amlodipin benzensulfonata
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
DE69626958T2 (de) 1995-03-16 2004-03-18 Pfizer Inc. Verwendung von amlodipin, eines seiner salze oder felodipin in kombination mit einem ace-hemmer zur herstellung eines arzneimittels zur behandlung von nicht ischämischer kongestiver herzinsuffizienz
NZ280378A (en) * 1995-11-01 1998-04-27 Apotex Inc 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid compounds, preparation, intermediate compounds
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
GT199800127A (es) 1997-08-29 2000-02-01 Combinaciones terapeuticas.
ZA9810319B (en) * 1997-11-14 2000-05-11 Gea Farmaceutisk Fabrik As Process for the preparation of acetal derivatives of 1,4-dihydropyridines, novel acetal derivatives and the use of the acetal derivatives for the preparation of other 1,4-dihydropyridines.
ZA9810320B (en) * 1997-11-14 2000-05-11 Gea Farmaceutisk Fabrik As Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose.
ES2151850B1 (es) * 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
RU2142942C1 (ru) * 1999-04-28 1999-12-20 Дж. Б.Кемикалс энд Фармасьютикалс Лтд. Способ получения монобензолсульфоната 3-этил-5-метилового эфира 2-[(2-аминоэтокси)метил]-4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5-пиридинди карбоновой кислоты
HN2000000050A (es) 1999-05-27 2001-02-02 Pfizer Prod Inc Sal mutua de amlodipino y atorvastatina
PL353483A1 (en) 1999-05-27 2003-11-17 Pfizer Products Inc. Mutual prodrugs of amlodipine and atorvastatin
UA72768C2 (en) * 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
RU2146672C1 (ru) * 1999-10-13 2000-03-20 Др.Редди'С Лабораторис Лтд. Способ получения 3-этил-5-метил(±)2[2-аминоэтокси)-метил]-4-(2-хлорфенил)-1,4-дигидро- 6-метил-3,5-пиридиндикарбоксилат монобензолсульфоната
CN1091441C (zh) * 1999-12-04 2002-09-25 昆明赛诺制药有限公司 甲磺酸氨氯地平及其制法和应用
US6521647B2 (en) 2000-04-04 2003-02-18 Pfizer Inc. Treatment of renal disorders
CZ301790B6 (cs) * 2000-04-11 2010-06-23 Sankyo Company Limited Farmaceutický prípravek obsahující blokátor vápníku
AU2001284413A1 (en) * 2000-08-30 2002-03-13 Sankyo Company Limited Medicinal compositions for preventing or treating heart failure
US6737430B2 (en) 2000-11-09 2004-05-18 Pfizer, Inc. Mutual prodrug of amlodipine and atorvastatin
GB0027410D0 (en) * 2000-11-09 2000-12-27 Pfizer Ltd Mutual prodrug of amlodipine and atorvastatin
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
ATE315026T1 (de) * 2000-12-29 2006-02-15 Pfizer Ltd Amlodipin-hemimaleat
EP1345901A2 (en) * 2000-12-29 2003-09-24 Bioorganics B.V. Process for making amlodipine, derivatives thereof, and precursors therefor
WO2002054062A2 (en) 2000-12-29 2002-07-11 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
KR20030066782A (ko) * 2000-12-29 2003-08-09 화이자 리미티드 암로디핀 말레에이트를 제조하는 방법
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
BR0116553A (pt) * 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão
CA2433193C (en) 2000-12-29 2006-01-31 Pfizer Limited Amide derivative of amlodipine
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
CA2433181C (en) * 2000-12-29 2005-11-22 Pfizer Limited Amlodipine hemifumarate
RS53403A (en) * 2000-12-29 2006-10-27 Pfizer Limited Process for making amlodipine maleate
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
KR100374767B1 (ko) * 2001-03-13 2003-03-03 한미약품공업 주식회사 개선된 암로디핀의 제조 방법
KR100452491B1 (ko) * 2001-03-29 2004-10-12 한미약품 주식회사 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법
WO2003004025A1 (en) * 2001-07-06 2003-01-16 Lek Pharmaceutical And Chemical Company D.D. High purity amlodipine benzenesulfonate and a process for its preparation
GB0120808D0 (en) * 2001-08-28 2001-10-17 Pfizer Ltd Crystalline material
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US20030180354A1 (en) * 2001-10-17 2003-09-25 Dr. Reddy's Laboratories Limited Amlodipine maleate formulations
US20040001886A1 (en) * 2001-10-17 2004-01-01 Dr. Reddy's Laboratories Limited Stabilized pharmaceutical formulations containing amlodipine maleate
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US6562983B1 (en) * 2002-03-18 2003-05-13 Council Of Scientific And Industrial Research Process for the preparation of alkyl 4[2-(phthalimido)ethoxy]-acetoacetate
US20070135488A1 (en) * 2002-04-13 2007-06-14 Chung You S Amlodipine nicotinate and process for the preparation thereof
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
KR100496436B1 (ko) 2002-07-30 2005-06-20 씨제이 주식회사 암로디핀의 유기산염
KR100538641B1 (ko) * 2002-07-30 2005-12-22 씨제이 주식회사 암로디핀의 유기산염
KR100462304B1 (ko) * 2002-07-30 2004-12-17 씨제이 주식회사 암로디핀의 유기산염
KR20040011751A (ko) * 2002-07-30 2004-02-11 씨제이 주식회사 암로디핀의 유기산염
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
KR100467669B1 (ko) * 2002-08-21 2005-01-24 씨제이 주식회사 암로디핀의 유기산염
US6784297B2 (en) * 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
WO2004024690A1 (en) * 2002-09-11 2004-03-25 Hanlim Pharmaceutical Co., Ltd. S-(-)-amlodipine nicotinate and process for the preparation thereof
AU2003253460A1 (en) 2002-09-19 2004-04-08 Cj Corporation Crystalline organic acid salt of amlodipine
KR100596369B1 (ko) 2002-09-19 2006-07-03 씨제이 주식회사 결정형의 암로디핀 유기산염
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
WO2004058711A1 (en) * 2002-12-30 2004-07-15 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
DE10335027A1 (de) * 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Angiotensin II Rezeptor Antagonisten
WO2004067003A1 (ja) * 2003-01-31 2004-08-12 Sankyo Company, Limited 動脈硬化及び高血圧症の予防及び治療のための医薬
CA2559670A1 (en) * 2003-04-14 2004-10-28 Gabor Pragai Stable amlodipine maleate formulations
US20050159403A1 (en) * 2003-04-22 2005-07-21 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage
WO2004093813A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
GB2415696B (en) * 2003-04-25 2007-06-20 Cipla Ltd Process for preparing amlodipine mesylate monohydrate
US20040242673A1 (en) * 2003-05-16 2004-12-02 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
CN1812983A (zh) * 2003-05-30 2006-08-02 兰贝克赛实验室有限公司 取代的吡咯衍生物及其作为hmg－co抑制剂的用途
US20050043391A1 (en) * 2003-07-17 2005-02-24 Fong Benson M. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
CH697952B1 (de) * 2003-07-25 2009-03-31 Siegfried Generics Int Ag Verfahren zur Reinigung der freien Amlodipinbase.
WO2005023769A1 (en) * 2003-09-04 2005-03-17 Cipla Limited Process for the preparation of amlodipine salts
EP1663227A2 (en) * 2003-09-10 2006-06-07 Synta Pharmaceuticals Corporation Dihydropyridine compounds for treating or preventing metabolic disorders
KR100841409B1 (ko) 2003-12-16 2008-06-25 에스케이케미칼주식회사 암로디핀 겐티세이트 염과 이의 제조방법
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20060035940A1 (en) * 2004-03-16 2006-02-16 Sepracor Inc. (S)-Amlodipine malate
US7244765B2 (en) * 2004-06-25 2007-07-17 Cytokine Pharmasciences, Inc Guanylhydrazone salts, compositions, processes of making and methods of using
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
WO2006003672A1 (en) * 2004-07-02 2006-01-12 Matrix Laboratories Ltd Process for the preparation of pure amlodipine
MX2007000979A (es) * 2004-07-26 2007-07-11 Cotherix Inc Tratamiento de la hipertension pulmonar por iloprost inhalado con una formulacion microparticulada.
UA89065C2 (ru) * 2004-11-05 2009-12-25 Бёрингэр Ингэльхайм Интэрнациональ Гмбх Двухслойная таблетка, которая содержит телмисартан и амлодипин
ATE439347T1 (de) * 2004-11-23 2009-08-15 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
EP1833466A1 (en) * 2004-12-28 2007-09-19 Ranbaxy Laboratories Limited Methods for the preparation of stable pharmaceutical solid dosage forms of atorvastatin and amlodipine
US20080268049A1 (en) * 2005-02-11 2008-10-30 Dhaliwal Mona Stable Solid Dosage Forms of Amlodipine and Benazepril
BRPI0612674B8 (pt) * 2005-06-27 2021-05-25 Daiichi Sankyo Co Ltd preparação farmacêutica, uso de um antagonista do receptor de angiotensina ii e um bloqueador do canal de cálcio
US20080200533A1 (en) * 2005-07-04 2008-08-21 Ramu Krishnan Drug or Pharmaceutical Compounds and a Preparation Thereof
ES2265781B1 (es) * 2005-08-04 2007-12-01 Ercros Industrial, S.A. Procedimiento para la obtencion de besilato de amlodipina.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
WO2007050783A2 (en) 2005-10-26 2007-05-03 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
KR101329112B1 (ko) * 2005-11-08 2013-11-14 랜박시 래보러터리스 리미티드 (3ｒ,5ｒ)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
TW200744583A (en) * 2006-03-14 2007-12-16 Ranbaxy Lab Ltd Statin stabilizing dosage formulations
US20070260065A1 (en) * 2006-05-03 2007-11-08 Vijayabhaskar Bolugoddu Process for preparing amlodipine
EP2049102A4 (en) * 2006-07-14 2010-12-22 Ranbaxy Lab Ltd POLYMORPHIC FORMS OF AN HMG COA REDUCTASE HEATHER AND USE
WO2008023869A1 (en) * 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
TWI399223B (zh) 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd 奧美沙坦酯及氨氯地平之固體劑型
US20080096863A1 (en) * 2006-10-19 2008-04-24 Torrent Pharmaceuticals Limited Stable pharmaceutical compositions of calcium channel blocker and an ACE inhibitor
CN101167724B (zh) * 2006-10-25 2012-08-22 北京华安佛医药研究中心有限公司 含有氨氯地平的药物组合物在制备治疗下尿路疾病药物中的用途
KR100830003B1 (ko) 2006-10-31 2008-05-15 씨제이제일제당 (주) 결정성 ｓ-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
CN101230035B (zh) * 2007-03-23 2010-11-03 浙江尖峰药业有限公司 门冬氨酸氨氯地平系列盐及其制备方法和其组合物、制剂以及片剂
EP1975167A1 (en) * 2007-03-30 2008-10-01 Esteve Quimica, S.A. Acetone solvate of phthaloyl amlodipine
US20080249141A1 (en) * 2007-04-06 2008-10-09 Palepu Nageswara R Co-therapy with and combinations of statins and 1,4-dihydropyridine-3,5-dicarboxydiesters
US20090062352A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched amlodipine
WO2009032286A2 (en) 2007-09-06 2009-03-12 Nektar Therapeutics Al, Corporation Oligomer-calcium channel blocker conjugates
PE20091156A1 (es) * 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
BRPI0821455A2 (pt) * 2007-12-31 2015-06-16 Lupin Ltd Composições farmacêuticas de amlopidina e valsartan
ES2510866T3 (es) 2008-03-13 2014-10-21 Daiichi Sankyo Company, Limited Mejora de la solubilidad de una preparación que contiene olmesartán medoxomilo
CN101560181B (zh) * 2008-04-16 2013-02-27 北京万全阳光医学技术有限公司 一种氨氯地平游离碱的制备方法
CN101367759B (zh) * 2008-10-06 2011-03-16 北京赛科药业有限责任公司 一种高纯度苯磺酸氨氯地平的合成方法
JP2010100562A (ja) * 2008-10-23 2010-05-06 Daito Kk アムロジピン製造中間体の精製方法
CN102573811A (zh) 2009-06-02 2012-07-11 陶氏环球技术有限责任公司 缓释剂型
EP2509596B1 (en) 2009-12-08 2019-08-28 Case Western Reserve University Gamma aminoacids for treating ocular disorders
WO2011117876A1 (en) 2010-03-26 2011-09-29 Fdc Limited An improved process for the preparation of amlodipine free base and acid addition salts thereof
IT1400309B1 (it) * 2010-05-10 2013-05-24 Menarini Int Operations Lu Sa Associazione di inibitori della xantina ossidasi e calcio antagonisti e loro uso.
EP2575808A1 (en) 2010-05-28 2013-04-10 Mahmut Bilgic Combination of antihypertensive agents
WO2011152803A1 (en) 2010-06-03 2011-12-08 Mahmut Bilgic Water soluble formulation comprising a combination of amlodipine and a statin
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
WO2012055941A1 (en) 2010-10-27 2012-05-03 Krka,Tovarna Zdravil, D. D., Novo Mesto Multilayer pharmaceutical composition comprising telmisartan and amlodipine
TR201100152A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Amlodipin içeren efervesan bileşimler.
CN102070516A (zh) * 2011-02-22 2011-05-25 广东东阳光药业有限公司 一种制备氨氯地平的方法
WO2012123966A1 (en) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Process for the preparation of 4 -substituted -1, 4-dihydropyridines
AU2011365756B2 (en) 2011-04-12 2015-07-30 Boryung Pharmaceutical Co., Ltd. Antihypertensive pharmaceutical composition
US9446032B2 (en) 2011-08-26 2016-09-20 Wockhardt Limited Methods for treating cardiovascular disorders
CN102382041B (zh) * 2011-12-02 2016-01-20 东北制药集团股份有限公司 一种马来酸氨氯地平的制备方法
PL236001B1 (pl) 2012-12-21 2020-11-30 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Złożona kompozycja farmaceutyczna zawierająca kandesartan cyleksetylu oraz amlodypinę, sposób jej wytwarzania oraz jednostkowa postać dawkowania zawierająca tę kompozycję
CN103044314A (zh) * 2013-01-06 2013-04-17 先声药业有限公司 马来酸氨氯地平的制备方法
JP5952748B2 (ja) * 2013-01-25 2016-07-13 東和薬品株式会社 フタロイルアムロジピンの新規結晶形態およびそれを用いる高純度なアムロジピンベシル酸塩の製造方法
US20150374713A1 (en) 2013-02-08 2015-12-31 Wockhardt Limited Stable pharmeceutical composition of amlodipine and benazepril or salts thereof
CA2909442A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
EP3025711B1 (en) 2013-07-23 2020-11-18 Daiichi Sankyo Company, Limited Medicine for preventing or treating hypertension
CN104262237A (zh) * 2014-09-28 2015-01-07 常州瑞明药业有限公司 氨氯地平自由碱的合成方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN104529877A (zh) * 2015-01-22 2015-04-22 华东理工常熟研究院有限公司 氨氯地平-癸酸离子液体及其制备方法和用途
CZ2015687A3 (cs) 2015-10-02 2017-04-12 Zentiva, K.S. Farmaceutická kompozice obsahující kombinaci kandesartanu, amlodipinu a hydrochlorthiazidu
WO2017068532A1 (en) 2015-10-23 2017-04-27 Ftf Pharma Private Limited Oral solution of dihydropyridine derivatives
JP6934859B2 (ja) 2016-03-24 2021-09-15 第一三共株式会社 腎疾患の治療のための医薬
WO2017207375A1 (en) 2016-05-30 2017-12-07 Boehringer Ingelheim International Gmbh Fixed dose combination of telmisartan, hydrochlorothiazide and amlodipine
EP3960158B1 (en) 2016-10-07 2025-05-21 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
US10350171B2 (en) 2017-07-06 2019-07-16 Dexcel Ltd. Celecoxib and amlodipine formulation and method of making the same
CA3096101A1 (en) 2018-04-11 2019-10-17 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
WO2019241580A1 (en) 2018-06-14 2019-12-19 Astrazeneca Uk Limited Methods for treating and preventing symptoms of asthma with a corticosteroid pharmaceutical composition
JP7470647B2 (ja) * 2018-06-14 2024-04-18 アストラゼネカ・ユーケイ・リミテッド ジヒドロピリジン型カルシウムチャネル遮断薬医薬組成物を用いて血圧を低下させるための方法
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
JP7558193B2 (ja) 2019-05-21 2024-09-30 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 食品用ブチレート
GB2595203A (en) 2020-03-03 2021-11-24 Alkaloid Ad Skopje Formulation
GB202102575D0 (en) 2021-02-23 2021-04-07 Teva Pharmaceutical Industries Ltd Fixed-dose pharmaceutical compositions
GB2636158A (en) 2023-12-01 2025-06-11 Novumgen Ltd An orally disintegrating tablet containing amlodipine or pharmaceutically acceptable salts thereof and the process of preparing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
JPS5547656A (en) * 1978-09-29 1980-04-04 Dainippon Pharmaceut Co Ltd 2-(2-substituted aminoethyl)-1,4-dihydropyridine derivative and its derivative
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DE3739854A1 (de) * 1987-11-25 1989-06-08 Philips Patentverwaltung Verfahren zur herstellung von titandioxid-pulver

Also Published As

Publication number Publication date
PT76370B (en) 1986-03-27
IE863092L (en) 1983-09-11
NO162818B (no) 1989-11-13
DK161312C (da) 1991-12-09
PL140575B1 (en) 1987-05-30
BA97147B1 (bs) 1998-12-28
YU58683A (en) 1986-06-30
EP0089167A2 (en) 1983-09-21
SI8511419A8 (sl) 1996-10-31
KE3778A (en) 1987-11-27
PT76370A (en) 1983-04-01
NZ203521A (en) 1985-09-13
SU1227110A3 (ru) 1986-04-23
PL140278B1 (en) 1987-04-30
EP0089167A3 (en) 1984-07-11
UA7082A1 (uk) 1995-06-30
CS159284A2 (en) 1985-06-13
PL240854A1 (en) 1985-04-09
NO864435L (no) 1983-09-12
DE3366920D1 (en) 1986-11-20
US4572909A (en) 1986-02-25
YU43417B (en) 1989-06-30
HU187868B (en) 1986-02-28
KR870000809B1 (ko) 1987-04-20
NO1994020I1 (no) 1994-11-02
FI81090C (fi) 1990-09-10
DD209622A5 (de) 1984-05-16
BG60658B2 (en) 1995-11-30
ES8505201A1 (es) 1985-05-16
CS240998B2 (en) 1986-03-13
NO830847L (no) 1983-09-12
HRP930369B1 (en) 1996-02-29
NL930063I2 (nl) 1993-10-01
NL930063I1 (nl) 1993-09-01
ATE22884T1 (de) 1986-11-15
CS240954B2 (en) 1986-03-13
CA1253865A (en) 1989-05-09
DK161312B (da) 1991-06-24
PL250767A1 (en) 1985-12-17
YU43541B (en) 1989-08-31
DD218887A5 (de) 1985-02-20
EP0089167B1 (en) 1986-10-15
YU141985A (en) 1986-06-30
NO864435D0 (no) 1986-11-06
JPS58167569A (ja) 1983-10-03
MY101985A (en) 1992-02-29
DK81383A (da) 1983-09-12
SI8310586A8 (sl) 1996-02-29
FI830789A0 (fi) 1983-03-09
HRP930370B1 (en) 1996-02-29
AU1235183A (en) 1983-09-22
DK81383D0 (da) 1983-02-23
LV5236A3 (lv) 1993-10-10
LU88332I2 (fr) 1994-05-04
IE830520L (en) 1983-09-11
NO170275C (no) 1992-09-30
ES520389A0 (es) 1985-03-16
DE19375111I2 (de) 2001-06-13
SG98687G (en) 1988-09-23
PL141830B1 (en) 1987-08-31
NO162818C (no) 1990-02-21
SU1238730A3 (ru) 1986-06-15
FI830789L (fi) 1983-09-12
IE54667B1 (en) 1990-01-03
IL68091A (en) 1986-11-30
NO170275B (no) 1992-06-22
FI81090B (fi) 1990-05-31
ES526459A0 (es) 1985-05-16
BA98207B1 (bs) 1999-08-02
KR840004073A (ko) 1984-10-06
CS149983A2 (en) 1985-06-13
LV5235A3 (lv) 1993-10-10
AU540769B2 (en) 1984-12-06
UA7083A1 (uk) 1995-06-30
IE54765B1 (en) 1990-01-31
CS418891A3 (en) 1992-09-16
HK16288A (en) 1988-03-11
EG16987A (en) 1991-03-30
JPS626703B2 (cs) 1987-02-13
IL68091A0 (en) 1983-06-15
GR77429B (cs) 1984-09-14
ES8503654A1 (es) 1985-03-16

Similar Documents

Publication Publication Date Title
DE3366920D1 (en) Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
PL243130A1 (en) Process for preparing novel derivatives of 1,4-dihydropyridine