ZA200602347B - Controlled release sterile injectable aripiprazole formulation and method - Google Patents
Controlled release sterile injectable aripiprazole formulation and method Download PDFInfo
- Publication number
- ZA200602347B ZA200602347B ZA200602347A ZA200602347A ZA200602347B ZA 200602347 B ZA200602347 B ZA 200602347B ZA 200602347 A ZA200602347 A ZA 200602347A ZA 200602347 A ZA200602347 A ZA 200602347A ZA 200602347 B ZA200602347 B ZA 200602347B
- Authority
- ZA
- South Africa
- Prior art keywords
- aripiprazole
- formulation
- sterile
- freeze
- particle size
- Prior art date
Links
- 229960004372 aripiprazole Drugs 0.000 title claims description 186
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 title claims description 166
- 239000000203 mixture Substances 0.000 title claims description 79
- 238000009472 formulation Methods 0.000 title claims description 70
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- 239000007972 injectable composition Substances 0.000 claims description 18
- 238000002347 injection Methods 0.000 claims description 15
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51361803P | 2003-10-23 | 2003-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200602347B true ZA200602347B (en) | 2007-09-26 |
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| ZA200602347A ZA200602347B (en) | 2003-10-23 | 2004-10-18 | Controlled release sterile injectable aripiprazole formulation and method |
Country Status (33)
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|---|---|
| US (11) | US7807680B2 (ko) |
| EP (1) | EP1675573B2 (ko) |
| JP (2) | JP4836797B2 (ko) |
| KR (1) | KR100931784B1 (ko) |
| CN (1) | CN1870980B (ko) |
| AR (2) | AR046141A1 (ko) |
| AT (1) | ATE411797T2 (ko) |
| AU (1) | AU2004285448C1 (ko) |
| BR (1) | BRPI0415531B8 (ko) |
| CA (1) | CA2543242C (ko) |
| CO (1) | CO5690539A2 (ko) |
| CY (2) | CY1109040T1 (ko) |
| DE (1) | DE602004017342D1 (ko) |
| DK (1) | DK1675573T4 (ko) |
| EC (2) | ECSP066512A (ko) |
| ES (1) | ES2315721T5 (ko) |
| FR (1) | FR14C0039I1 (ko) |
| GE (1) | GEP20115205B (ko) |
| HK (1) | HK1095266A1 (ko) |
| IL (1) | IL175072A (ko) |
| LU (1) | LU92427I2 (ko) |
| MX (1) | MXPA06004489A (ko) |
| MY (1) | MY146093A (ko) |
| NO (2) | NO334919B1 (ko) |
| NZ (1) | NZ546063A (ko) |
| PE (1) | PE20050811A1 (ko) |
| PL (1) | PL1675573T4 (ko) |
| PT (1) | PT1675573E (ko) |
| SI (1) | SI1675573T2 (ko) |
| TW (2) | TWI421101B (ko) |
| UA (1) | UA82561C2 (ko) |
| WO (1) | WO2005041937A2 (ko) |
| ZA (1) | ZA200602347B (ko) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| US20050032811A1 (en) * | 2003-08-06 | 2005-02-10 | Josiah Brown | Methods for administering aripiprazole |
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- 2007-10-31 US US11/979,149 patent/US8030313B2/en active Active
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2008
- 2008-12-31 CY CY20081101518T patent/CY1109040T1/el unknown
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2011
- 2011-01-14 JP JP2011006037A patent/JP5372032B2/ja active Active
- 2011-12-28 US US13/338,827 patent/US8952013B2/en active Active
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2012
- 2012-01-20 EC EC2012006512A patent/ECSP12006512A/es unknown
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2013
- 2013-09-19 US US14/031,571 patent/US20140018369A1/en not_active Abandoned
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2014
- 2014-04-11 LU LU92427C patent/LU92427I2/fr unknown
- 2014-05-13 CY CY2014021C patent/CY2014021I2/el unknown
- 2014-05-13 FR FR14C0039C patent/FR14C0039I1/fr active Active
- 2014-10-06 US US14/507,303 patent/US9763935B2/en active Active
- 2014-10-27 NO NO2014027C patent/NO2014027I1/no not_active IP Right Cessation
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2016
- 2016-10-21 AR ARP160103230A patent/AR106449A2/es not_active Application Discontinuation
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2017
- 2017-08-18 US US15/680,291 patent/US20170348308A1/en not_active Abandoned
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2019
- 2019-10-30 US US16/668,008 patent/US20200061057A1/en not_active Abandoned
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2021
- 2021-07-16 US US17/377,898 patent/US20210338663A1/en not_active Abandoned
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