ZA200508280B - Pharmaceutical compositions comprising bispecific anti-CD3, Anti-CD19 antibody constructs for the treatment of B-cell related disorders - Google Patents
Pharmaceutical compositions comprising bispecific anti-CD3, Anti-CD19 antibody constructs for the treatment of B-cell related disorders Download PDFInfo
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- ZA200508280B ZA200508280B ZA200508280A ZA200508280A ZA200508280B ZA 200508280 B ZA200508280 B ZA 200508280B ZA 200508280 A ZA200508280 A ZA 200508280A ZA 200508280 A ZA200508280 A ZA 200508280A ZA 200508280 B ZA200508280 B ZA 200508280B
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Public Health (AREA)
- Engineering & Computer Science (AREA)
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- Communicable Diseases (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- Biophysics (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03012136 | 2003-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200508280B true ZA200508280B (en) | 2007-04-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200508280A ZA200508280B (en) | 2003-05-31 | 2005-10-13 | Pharmaceutical compositions comprising bispecific anti-CD3, Anti-CD19 antibody constructs for the treatment of B-cell related disorders |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7635472B2 (fr) |
| EP (1) | EP1629012B1 (fr) |
| JP (3) | JP2008501621A (fr) |
| CN (1) | CN100509850C (fr) |
| AU (1) | AU2004242846A1 (fr) |
| CA (1) | CA2522586C (fr) |
| RU (1) | RU2005141512A (fr) |
| WO (1) | WO2004106381A1 (fr) |
| ZA (1) | ZA200508280B (fr) |
Families Citing this family (312)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL138857A0 (en) * | 1998-04-21 | 2001-10-31 | Micromet Ges For Biomedizinisc | Cd19xcd3 specific polypeptides and uses thereof |
| US20080260731A1 (en) * | 2002-03-01 | 2008-10-23 | Bernett Matthew J | Optimized antibodies that target cd19 |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| NZ546173A (en) | 2003-10-16 | 2009-04-30 | Micromet Ag | Multispecific deimmunized CD3-binders |
| US8101722B2 (en) * | 2004-02-16 | 2012-01-24 | Micromet Ag | Less immunogenic binding molecules |
| CN101031655A (zh) | 2004-07-26 | 2007-09-05 | 陶氏环球技术公司 | 通过株工程改进蛋白表达的方法 |
| WO2006114115A1 (fr) | 2005-04-26 | 2006-11-02 | Trion Pharma Gmbh | Combinaison d'anticorps et de glucocorticoides destinee au traitement du cancer |
| CN101379085B (zh) | 2005-06-30 | 2013-03-27 | Abbvie公司 | Il-12/p40结合蛋白 |
| AU2006301492B2 (en) | 2005-10-11 | 2011-06-09 | Amgen Research (Munich) Gmbh | Compositions comprising cross-species-specific antibodies and uses thereof |
| AU2013202375B2 (en) * | 2005-12-16 | 2016-10-27 | Amgen Research (Munich) Gmbh | Means and Methods for the Treatment of Tumorous Diseases |
| CA2633594C (fr) * | 2005-12-16 | 2021-10-26 | Micromet Ag | Moyens et procedes pour le traitement de maladies tumorales |
| ES2457072T3 (es) * | 2006-08-14 | 2014-04-24 | Xencor, Inc. | Anticuerpos optimizados que seleccionan como diana CD19 |
| CN101512008B (zh) | 2006-09-08 | 2015-04-01 | 艾伯维巴哈马有限公司 | 白介素-13结合蛋白 |
| WO2008031056A2 (fr) * | 2006-09-08 | 2008-03-13 | Medimmune, Llc | Anticorps anti-cd19 humanisés, et leur utilisation dans le traitement de l'oncologie, de la transplantation et de la maladie auto-immune |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| WO2008134461A2 (fr) | 2007-04-27 | 2008-11-06 | Dow Global Technologies, Inc. | Procédé pour rapidement cribler des hôtes microbiens et identifier certaines souches ayant un rendement et/ou une qualité d'expression des protéines hétérologues améliorés |
| EP2014680A1 (fr) * | 2007-07-10 | 2009-01-14 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Dérivés d'anticorps bi-spécifiques ou tri-spécifiques trivalents, recombinants, à simple chaîne |
| KR101658083B1 (ko) * | 2007-10-19 | 2016-09-30 | 시애틀 지네틱스, 인크. | 씨디19 결합제 및 그의 용도 |
| JP5490714B2 (ja) * | 2007-11-28 | 2014-05-14 | メディミューン，エルエルシー | タンパク質製剤 |
| US9029508B2 (en) * | 2008-04-29 | 2015-05-12 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| PE20100092A1 (es) | 2008-06-03 | 2010-03-12 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
| PE20100054A1 (es) * | 2008-06-03 | 2010-03-03 | Abbott Lab | Inmunoglobulina con dominio variable dual |
| RU2011104348A (ru) * | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение |
| PE20140852A1 (es) | 2008-07-18 | 2014-07-14 | Bristol Myers Squibb Co | Composiciones monovalentes para union a cd28 |
| EP2352763B2 (fr) | 2008-10-01 | 2022-09-21 | Amgen Research (Munich) GmbH | Anticorps monocaténaires bispécifiques spécifiques d'antigènes cibles de masse moléculaire élevée |
| EP2370467B1 (fr) | 2008-10-01 | 2016-09-07 | Amgen Research (Munich) GmbH | Anticorps monocaténaire bispécifique pscaxcd3 (cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 ou fapalpha xcd3), spécifique d'espèces croisées |
| CA2738565C (fr) * | 2008-10-01 | 2023-10-10 | Micromet Ag | Anticorps monocatenaire bispecifique psmaxcd3, specifique d'especes croisees |
| EP2352765B1 (fr) * | 2008-10-01 | 2018-01-03 | Amgen Research (Munich) GmbH | Anticorps monocaténaire bispécifique à domaine unique, spécifique d'espèces croisées |
| DK2342227T3 (en) * | 2008-11-07 | 2016-02-15 | Amgen Res Munich Gmbh | TREATMENT OF ACUTE Lymphoblastic Tissue Leukemia |
| SI3330293T1 (sl) | 2008-11-07 | 2019-10-30 | Amgen Res Munich Gmbh | Zdravljenje pediatrične akutne limfoblastne levkemije z bispecifičnimi protitelesi proti CD3XCD19 |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5239062A (en) | 1986-03-20 | 1993-08-24 | Dana-Farber Cancer Institute, Inc. | Blocked lectins, methods and affinity support for making same using affinity ligands, and method of killing selected cell populations having reduced nonselective cytotoxicity |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| CA2063035A1 (fr) | 1991-03-27 | 1992-09-28 | Klaus Karjalainen | Anticorps chimeriques contenant le domaine de ligand de cd4 |
| US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| JPH11505704A (ja) | 1995-05-17 | 1999-05-25 | リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | アンチｃｄ−１９抗体の単鎖可変領域フラグメントを含む免疫コンジュゲート |
| DE19531348A1 (de) | 1995-08-25 | 1997-02-27 | Gsf Forschungszentrum Umwelt | Antikörper mit zwei oder mehr Spezifitäten zur selektiven Eliminierung von Zellen in vivo |
| IL138857A0 (en) | 1998-04-21 | 2001-10-31 | Micromet Ges For Biomedizinisc | Cd19xcd3 specific polypeptides and uses thereof |
| EP1311549A2 (fr) | 2000-08-22 | 2003-05-21 | Micromet AG | Composition destinee a l'elimination des cellules b autoreactives |
| ES2276735T3 (es) * | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | Anticuerpos fv multimericos de cadena sencilla en tandem. |
-
2004
- 2004-05-26 WO PCT/EP2004/005685 patent/WO2004106381A1/fr active Application Filing
- 2004-05-26 CA CA2522586A patent/CA2522586C/fr not_active Expired - Lifetime
- 2004-05-26 EP EP04739378.0A patent/EP1629012B1/fr not_active Expired - Lifetime
- 2004-05-26 CN CNB2004800145132A patent/CN100509850C/zh not_active Expired - Lifetime
- 2004-05-26 RU RU2005141512/13A patent/RU2005141512A/ru unknown
- 2004-05-26 AU AU2004242846A patent/AU2004242846A1/en not_active Abandoned
- 2004-05-26 JP JP2006529929A patent/JP2008501621A/ja not_active Withdrawn
- 2004-05-26 US US10/554,852 patent/US7635472B2/en active Active
-
2005
- 2005-10-13 ZA ZA200508280A patent/ZA200508280B/en unknown
-
2012
- 2012-10-26 JP JP2012236443A patent/JP6025502B2/ja not_active Expired - Lifetime
-
2015
- 2015-02-02 JP JP2015018323A patent/JP2015110628A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN100509850C (zh) | 2009-07-08 |
| EP1629012B1 (fr) | 2018-11-28 |
| JP6025502B2 (ja) | 2016-11-16 |
| JP2008501621A (ja) | 2008-01-24 |
| JP2015110628A (ja) | 2015-06-18 |
| AU2004242846A1 (en) | 2004-12-09 |
| US7635472B2 (en) | 2009-12-22 |
| CA2522586A1 (fr) | 2004-12-09 |
| US20070123479A1 (en) | 2007-05-31 |
| EP1629012A1 (fr) | 2006-03-01 |
| CA2522586C (fr) | 2017-02-21 |
| WO2004106381A1 (fr) | 2004-12-09 |
| RU2005141512A (ru) | 2007-07-20 |
| JP2013063981A (ja) | 2013-04-11 |
| CN1795208A (zh) | 2006-06-28 |
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