ZA200507954B - Pl-3 kinase inhibitor prodrugs - Google Patents
Pl-3 kinase inhibitor prodrugs Download PDFInfo
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- ZA200507954B ZA200507954B ZA200507954A ZA200507954A ZA200507954B ZA 200507954 B ZA200507954 B ZA 200507954B ZA 200507954 A ZA200507954 A ZA 200507954A ZA 200507954 A ZA200507954 A ZA 200507954A ZA 200507954 B ZA200507954 B ZA 200507954B
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Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Neurosurgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
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| US8651113B2 (en) * | 2003-06-18 | 2014-02-18 | Swr&D Inc. | Magnetically responsive nanoparticle therapeutic constructs and methods of making and using |
| US20050043239A1 (en) * | 2003-08-14 | 2005-02-24 | Jason Douangpanya | Methods of inhibiting immune responses stimulated by an endogenous factor |
| US20050054614A1 (en) * | 2003-08-14 | 2005-03-10 | Diacovo Thomas G. | Methods of inhibiting leukocyte accumulation |
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| CA2598409A1 (en) * | 2005-02-17 | 2006-08-24 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
| WO2007086943A2 (en) * | 2005-09-01 | 2007-08-02 | Beth Israel Deaconess Medical Center | Wortmannin conjugates and uses thereof |
| WO2007035395A2 (en) * | 2005-09-16 | 2007-03-29 | Virginia Commonwealth University Intellectual Property Foundation | Therapeutic compositions comprising chorionic gonadotropins and hmg coa reductase inhibitors |
| CN101394865B (zh) * | 2005-12-01 | 2013-02-13 | 都柏林伊丽莎白女皇神学院院长、研究员及专家协会 | 癌症和传染病治疗的组合物及方法 |
| TWI426905B (zh) * | 2006-02-09 | 2014-02-21 | Enzon Pharmaceuticals Inc | 用於乳癌、大腸直腸癌、胰臟癌、卵巢癌及肺癌之治療的７-乙基-１０羥喜樹鹼之多臂聚合性共軛物 |
| US8329683B2 (en) * | 2006-06-02 | 2012-12-11 | Nexgenix Pharmaceuticals, Llc | Treatment of neurofibromatosis with radicicol and its derivatives |
| WO2007143630A2 (en) * | 2006-06-02 | 2007-12-13 | Nexgenix Pharmaceuticals | Treatment of neurofibromatosis with hsp90 inhibitors |
| PE20090717A1 (es) * | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| EP2231152B1 (en) * | 2008-01-24 | 2014-01-01 | SignalRX Pharmaceuticals, Inc. | Thienopyranones as kinase inhibitors |
| WO2009108704A1 (en) * | 2008-02-25 | 2009-09-03 | Semafore Pharmaceuticals, Inc. | O-alkylated pi-3 kinase inhibitor prodrug combination |
| DE102008001855A1 (de) * | 2008-05-19 | 2009-11-26 | Evonik Degussa Gmbh | Zweikomponenten-Zusammensetzung zur Herstellung von flexiblen Polyurethan-Gelcoats |
| WO2009141823A2 (en) | 2008-05-22 | 2009-11-26 | Ramot At Tel Aviv University Ltd. | Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases |
| WO2010019511A2 (en) | 2008-08-13 | 2010-02-18 | Targanta Therapeutics Corp. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| CN104042618B (zh) | 2008-11-13 | 2018-02-16 | 吉利德卡利斯托加公司 | 恶性血液病的治疗 |
| CA2793263C (en) | 2009-03-17 | 2015-12-15 | Woodway Usa, Inc. | Power generating manually operated treadmill |
| WO2010111432A1 (en) | 2009-03-24 | 2010-09-30 | Calistoga Pharmaceuticals Inc. | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
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| KR20010033811A (ko) | 1997-12-31 | 2001-04-25 | 토마스 안 빅토리아 | 2차 및 3차 아민을 함유하는 약제의 물에 용해가능한프로드럭 및 그것의 제조방법 |
| JP2000169372A (ja) * | 1998-09-29 | 2000-06-20 | Takeda Chem Ind Ltd | 抗真菌薬組成物 |
| CA2398163C (en) * | 2000-01-24 | 2011-02-22 | Kinacia Pty Ltd. | Therapeutic morpholino-substituted compounds |
| AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
-
2004
- 2004-04-03 JP JP2006509693A patent/JP2006523237A/ja active Pending
- 2004-04-03 CN CNA2004800092262A patent/CN1826331A/zh active Pending
- 2004-04-03 CA CA002518916A patent/CA2518916A1/en not_active Abandoned
- 2004-04-03 KR KR1020057018781A patent/KR20070087266A/ko not_active Application Discontinuation
- 2004-04-03 SG SG200716544-2A patent/SG160211A1/en unknown
- 2004-04-03 EP EP04758869A patent/EP1611119A1/en not_active Withdrawn
- 2004-04-03 WO PCT/US2004/010399 patent/WO2004089925A1/en active Application Filing
- 2004-04-03 BR BRPI0409063-2A patent/BRPI0409063A/pt not_active IP Right Cessation
- 2004-04-03 AU AU2004228668A patent/AU2004228668B2/en not_active Expired - Fee Related
- 2004-04-03 NZ NZ542475A patent/NZ542475A/en not_active IP Right Cessation
- 2004-04-03 EA EA200501563A patent/EA012240B1/ru not_active IP Right Cessation
- 2004-04-03 MX MXPA05010471A patent/MXPA05010471A/es unknown
- 2004-04-05 US US10/818,145 patent/US6949537B2/en not_active Expired - Fee Related
-
2005
- 2005-04-20 US US11/111,201 patent/US7396828B2/en not_active Expired - Fee Related
- 2005-09-30 ZA ZA200507954A patent/ZA200507954B/en unknown
-
2007
- 2007-12-21 US US11/962,612 patent/US7662977B2/en not_active Expired - Fee Related
-
2010
- 2010-10-20 JP JP2010235985A patent/JP2011057686A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EA200501563A1 (ru) | 2006-06-30 |
| WO2004089925A1 (en) | 2004-10-21 |
| US20050203173A1 (en) | 2005-09-15 |
| US20080188423A1 (en) | 2008-08-07 |
| KR20070087266A (ko) | 2007-08-28 |
| JP2011057686A (ja) | 2011-03-24 |
| CA2518916A1 (en) | 2004-10-21 |
| NZ542475A (en) | 2009-04-30 |
| US6949537B2 (en) | 2005-09-27 |
| US7662977B2 (en) | 2010-02-16 |
| CN1826331A (zh) | 2006-08-30 |
| JP2006523237A (ja) | 2006-10-12 |
| US7396828B2 (en) | 2008-07-08 |
| EA012240B1 (ru) | 2009-08-28 |
| MXPA05010471A (es) | 2006-05-25 |
| EP1611119A1 (en) | 2006-01-04 |
| US20040242631A1 (en) | 2004-12-02 |
| SG160211A1 (en) | 2010-04-29 |
| AU2004228668A1 (en) | 2004-10-21 |
| BRPI0409063A (pt) | 2006-03-28 |
| AU2004228668B2 (en) | 2011-10-27 |
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