ZA200305759B - Isoindole-imide compounds compositions and uses thereof - Google Patents
Isoindole-imide compounds compositions and uses thereof Download PDFInfo
- Publication number
- ZA200305759B ZA200305759B ZA2003/05759A ZA200305759A ZA200305759B ZA 200305759 B ZA200305759 B ZA 200305759B ZA 2003/05759 A ZA2003/05759 A ZA 2003/05759A ZA 200305759 A ZA200305759 A ZA 200305759A ZA 200305759 B ZA200305759 B ZA 200305759B
- Authority
- ZA
- South Africa
- Prior art keywords
- dioxo
- alkyl
- piperidyl
- dioxoisoindolin
- piperidin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 110
- 125000000217 alkyl group Chemical group 0.000 claims description 101
- 125000003118 aryl group Chemical group 0.000 claims description 91
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 84
- 125000001072 heteroaryl group Chemical group 0.000 claims description 79
- 229910052799 carbon Inorganic materials 0.000 claims description 76
- 125000003342 alkenyl group Chemical group 0.000 claims description 67
- 125000000304 alkynyl group Chemical group 0.000 claims description 65
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 49
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 33
- 238000004519 manufacturing process Methods 0.000 claims description 30
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- 241000124008 Mammalia Species 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 11
- 229910052736 halogen Inorganic materials 0.000 claims description 11
- 150000002367 halogens Chemical class 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- 229910052717 sulfur Inorganic materials 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000012453 solvate Substances 0.000 claims description 10
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- 125000004076 pyridyl group Chemical group 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 125000001544 thienyl group Chemical group 0.000 claims description 4
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- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
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- TYFWVUHGEDGFCZ-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-4-(pyridin-3-ylmethylamino)isoindole-1,3-dione Chemical compound O=C1C(C(=CC=C2)NCC=3C=NC=CC=3)=C2C(=O)N1C1CCC(=O)NC1=O TYFWVUHGEDGFCZ-UHFFFAOYSA-N 0.000 claims 1
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