YU51398A - Polihidroksifenol derivati i preventivni i terapeutski agensi za oboljenja kosti i hrskavice koji sadrže iste - Google Patents

Polihidroksifenol derivati i preventivni i terapeutski agensi za oboljenja kosti i hrskavice koji sadrže iste

Info

Publication number
YU51398A
YU51398A YU51398A YU51398A YU51398A YU 51398 A YU51398 A YU 51398A YU 51398 A YU51398 A YU 51398A YU 51398 A YU51398 A YU 51398A YU 51398 A YU51398 A YU 51398A
Authority
YU
Yugoslavia
Prior art keywords
optionally substituted
preventive
alkyl
alkenyl
substituted benzyl
Prior art date
Application number
YU51398A
Other languages
English (en)
Inventor
Kunikazu Sakai
Yusuke Satoh
Kazuyuki Doi
Kazuyuki Kitamura
Original Assignee
Hoechst Marion Roussel Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Ltd. filed Critical Hoechst Marion Roussel Ltd.
Publication of YU51398A publication Critical patent/YU51398A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Jedinjenja korisna kao preventivni i terapeutski agensi za obolenja kosti i hskavice; i preparate leka koji ih sadrže. Jedinjenja su polifidroksifenol derivati opšte formule (I) i hinon analognih derivata od (gde R1 je alkil, opcionalno supstituisan benzil, ili opcionalno supstituisan aril; R2 je vodonik, alkil, alkenil ili opcionalno supstituisan benzil; R3 je vodonik, alkil, alkenil, opcionalno supstituisan benzil, hidroksil, alkoksi, alkeniloksi ili opcionalno supstituisan benziloksi; R4 je vodonik, alkil, alkenil, opcionalno supstituisan benzil ili hidroksil; i R5 i R6 su svaki nezavisno vodonik, alkil, alkenil ili opcionalno supstituisan benzil. Polihidroksifenol kinon analog ne pokazuju jaku inhibitornu aktivnost protiv resorpcije kosti, i korisni su kao preventivni i terapeutski agensti za obolenja kosti i hrskavice.
YU51398A 1996-05-14 1997-05-14 Polihidroksifenol derivati i preventivni i terapeutski agensi za oboljenja kosti i hrskavice koji sadrže iste YU51398A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8154710A JPH09301916A (ja) 1996-05-14 1996-05-14 ポリヒドロキシフェノール誘導体およびそれらからなる骨・軟骨疾患予防・治療剤

Publications (1)

Publication Number Publication Date
YU51398A true YU51398A (sh) 2000-03-21

Family

ID=15590273

Family Applications (1)

Application Number Title Priority Date Filing Date
YU51398A YU51398A (sh) 1996-05-14 1997-05-14 Polihidroksifenol derivati i preventivni i terapeutski agensi za oboljenja kosti i hrskavice koji sadrže iste

Country Status (21)

Country Link
US (1) US6177474B1 (sh)
EP (1) EP0994093B1 (sh)
JP (1) JPH09301916A (sh)
CN (1) CN1178889C (sh)
AT (1) ATE314339T1 (sh)
AU (1) AU737890B2 (sh)
BR (1) BR9709074A (sh)
CA (1) CA2255589A1 (sh)
CZ (1) CZ355498A3 (sh)
DE (1) DE69735008D1 (sh)
EA (1) EA001172B1 (sh)
HU (1) HUP9904402A3 (sh)
IL (1) IL126797A (sh)
NO (1) NO312892B1 (sh)
NZ (1) NZ332722A (sh)
PL (1) PL188398B1 (sh)
SK (1) SK283956B6 (sh)
TR (1) TR199802290T2 (sh)
UA (1) UA66759C2 (sh)
WO (1) WO1997043235A1 (sh)
YU (1) YU51398A (sh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3942759B2 (ja) 1999-01-25 2007-07-11 興和株式会社 電子透かしの埋め込み方法，復号方法およびその装置
EP2364083A4 (en) * 2008-12-10 2012-10-31 Metaproteomics Llc A METHOD FOR PURIFYING SUBSTITUTED CYCLOPENT-2-EN-1-ON-CONGENERS AND SUBSTITUTED 1,3-CYCLOPENTADION-CONGENERS FROM A COMPLEX MIXTURE WITH PRESENT DEPOSITION
WO2023278394A1 (en) * 2021-06-28 2023-01-05 Firmenich Incorporated Polycationic salts of phenolic compounds and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU168744B (sh) * 1971-12-02 1976-07-28
JPS5515443A (en) * 1978-07-19 1980-02-02 Kirin Brewery Co Ltd Antibacterial agent
JPS5581814A (en) * 1978-12-15 1980-06-20 Kirin Brewery Co Ltd Antifungal agent
JPS56140943A (en) * 1980-04-07 1981-11-04 Takeda Chem Ind Ltd Preparation of organic compound
JPS59175448A (ja) * 1983-03-25 1984-10-04 Sanko Kaihatsu Kagaku Kenkyusho:Kk フエノ−ル系化合物
JPS60155111A (ja) 1983-10-20 1985-08-15 Hisamitsu Pharmaceut Co Inc 安定なケトプロフェン含有外用経皮製剤
JPS6176433A (ja) * 1984-09-21 1986-04-18 Toyobo Co Ltd 新規なカルコン誘導体
JPS61176548A (ja) * 1985-01-31 1986-08-08 Nippon Zeon Co Ltd アルキル（ジヒドロキシフエニル）ケトンの製造法
JPS61180738A (ja) * 1985-02-06 1986-08-13 Nippon Zeon Co Ltd アルキル（ジヒドロキシフエニル）ケトンの製造法
JPS61293945A (ja) * 1985-06-05 1986-12-24 Sumitomo Chem Co Ltd ポリヒドロキシベンゾフェノンの製造方法
JPH0629182B2 (ja) * 1986-12-20 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPH0629185B2 (ja) * 1986-12-22 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPH0629184B2 (ja) * 1986-12-22 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPS63264543A (ja) * 1987-04-17 1988-11-01 Toyo Gosei Kogyo Kk ポリヒドロキシベンゾフエノン類の製造方法
JPH01242540A (ja) * 1988-03-22 1989-09-27 Tsumura & Co 新規カルコン誘導体および該誘導体を有効成分とする抗潰瘍剤
DE3936592A1 (de) * 1989-11-03 1991-05-08 Basf Ag Verfahren zur herstellung und reinigung von 2-hydroxy-4-(2'-hydroxy-ethoxy)phenylarylketonen
JP2627349B2 (ja) * 1989-11-13 1997-07-02 株式会社大塚製薬工場 ３―アルキルフラボン誘導体及び５―リポキシゲナーゼ阻害剤
ES2125267T3 (es) 1991-07-15 1999-03-01 Steiner Inc S S Agentes estabilizantes de espuma y que proporcionan amargor derivados del lupulo.
JPH0625081A (ja) * 1992-02-27 1994-02-01 Asahi Breweries Ltd 抗酸化作用を有するβ酸（ルプロン類）アシル誘導体
JPH06312924A (ja) 1993-04-28 1994-11-08 Asahi Breweries Ltd 抗酸化作用を有するフムロン類の利用
JP3814309B2 (ja) * 1994-04-12 2006-08-30 リポプロテイン・テクノロジーズ・インコーポレイテッド 骨粗鬆症治療剤
JPH0827057A (ja) * 1994-07-19 1996-01-30 Asahi Breweries Ltd 抗酸化作用を有する新規物質およびその製造方法
JP3525267B2 (ja) * 1994-07-19 2004-05-10 アサヒビール株式会社 抗酸化作用を有するマロフェノンの利用およびその製造方法
FR2729387B1 (fr) * 1995-01-13 1997-03-21 Great Lakes Chemical France Procede pour la fabrication d'hydroxy-alcoxy-benzophenones
JPH08277241A (ja) * 1995-04-04 1996-10-22 Nippon Kayaku Co Ltd ヒドロキシフェニルベンジルケトン類の製造方法と結晶変態

Also Published As

Publication number Publication date
BR9709074A (pt) 1999-08-03
PL329885A1 (en) 1999-04-12
UA66759C2 (en) 2004-06-15
AU737890B2 (en) 2001-09-06
EA001172B1 (ru) 2000-10-30
DE69735008D1 (de) 2006-02-02
JPH09301916A (ja) 1997-11-25
CA2255589A1 (en) 1997-11-20
US6177474B1 (en) 2001-01-23
AU2788797A (en) 1997-12-05
EA199801012A1 (ru) 1999-06-24
NO985298L (no) 1999-01-13
EP0994093A1 (en) 2000-04-19
NO985298D0 (no) 1998-11-13
HUP9904402A2 (hu) 2000-09-28
WO1997043235A1 (fr) 1997-11-20
EP0994093B1 (en) 2005-12-28
PL188398B1 (pl) 2005-01-31
EP0994093A4 (en) 2000-05-17
IL126797A0 (en) 1999-08-17
TR199802290T2 (xx) 2001-09-21
CN1225082A (zh) 1999-08-04
NO312892B1 (no) 2002-07-15
SK283956B6 (sk) 2004-06-08
HUP9904402A3 (en) 2002-07-29
CN1178889C (zh) 2004-12-08
NZ332722A (en) 2001-07-27
SK153198A3 (en) 1999-06-11
CZ355498A3 (cs) 1999-04-14
ATE314339T1 (de) 2006-01-15
IL126797A (en) 2004-06-20

Similar Documents

Publication Publication Date Title
ES2164657T3 (es) Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
MY125749A (en) Aralkyl and aralkylidene heterocyclic lactams and imides
NZ505453A (en) Hypolipidemic benzothiazepine compounds
ATE427936T1 (de) Substituierte piperidin-verbindungen als modulatoren der chemokine receptor aktivitat
HUP0002353A2 (hu) IV típusú foszfodiészteráz inhibitor hatású 1-cikloalkil-1,8-naftiridin-4-on-származékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
HUP0002272A2 (hu) Piperazinszármazékok, eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
FR2712591B1 (fr) Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
YU4795A (sh) Derivati indola koji se mogu koristiti kao 5ht agonisti, farmaceutski preparati koji ih sadrže i postupci njihovog dobijanja
ATE201671T1 (de) Chinolon und acridinon derivate zur behandlung der harninkontinenz
NO308654B1 (no) Amid-derivater, fremgangsmÕter og mellomprodukter for fremstilling derav, deres anvendelse og farmasøytiske blandinger som inneholdende dem
DE69819539D1 (de) Antithrombotische mittel
DE69418035T2 (de) Hiv-proteaseinhibitoren
YU51398A (sh) Polihidroksifenol derivati i preventivni i terapeutski agensi za oboljenja kosti i hrskavice koji sadrže iste
ES2094545T3 (es) Derivados n-substituidos del 3-azabiciclo(3.2.0)heptano, como neurolepticos etc..
EP1027051A4 (en) ANTITHROMBOTIC AGENTS
NO950177L (no) Farmakologisk aktive erivater
ES2175337T3 (es) Compuesto bifenilicos y su utilizacion como agentes estrogenicos.
ES2095058T3 (es) Derivados del 3-azabiciclo(3.2.0)heptano substituidos como productos intermedios.
DE69914563D1 (de) Azaindol derivate und ihre Verwendung als antithrombotische Wirkstoffe
HUP0101505A2 (hu) Barbitursavszármazékok és ezeket tartalmazó gyógyszerkészítmények csont- és porcbetegségek kezelésére és megelőzésére
ATE268768T1 (de) Antithrombosemittel
IL139317A0 (en) Benzimdazole and benzoxazole derivatives and pharmaceutical compositions contining the same