EA199801012A1 - Производные полигидроксифенола, содержащие их лекарственные композиции и применение указанных веществ для профилактики и лечения заболеваний костей и хрящей - Google Patents

Производные полигидроксифенола, содержащие их лекарственные композиции и применение указанных веществ для профилактики и лечения заболеваний костей и хрящей

Info

Publication number
EA199801012A1
EA199801012A1 EA199801012A EA199801012A EA199801012A1 EA 199801012 A1 EA199801012 A1 EA 199801012A1 EA 199801012 A EA199801012 A EA 199801012A EA 199801012 A EA199801012 A EA 199801012A EA 199801012 A1 EA199801012 A1 EA 199801012A1
Authority
EA
Eurasian Patent Office
Prior art keywords
optionally substituted
alkyl
diseases
substituted benzyl
alkenyl
Prior art date
Application number
EA199801012A
Other languages
English (en)
Other versions
EA001172B1 (ru
Inventor
Куниказу Сакай
Юсуке Сатох
Казуюки Китамура
Казуюки Дой
Original Assignee
Хехст Марион Руссел Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Марион Руссел Лтд. filed Critical Хехст Марион Руссел Лтд.
Publication of EA199801012A1 publication Critical patent/EA199801012A1/ru
Publication of EA001172B1 publication Critical patent/EA001172B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Производные полигидроксифенола и средства профилактики и лечения заболеваний костей и хрящей. Предложены соединения полезные для профилактики и лечения заболеваний костей и хрящей, а также композиции их содержащие. Указанные соединения представляют собой производные полигидроксифенола общей формулы (I) и его хиноновые производные:где R- алкил, необязательно замещенный бензил или необязательно замещенный арил;R- водород, алкил, алкенил, необязательно замещенный бензил;R- водород; алкил, алкенил, необязательно замещенный бензил, гидроксил, алкокси, алкенилокси или необязательно замещенный бензилокси;R- водород, алкил, алкенил, необязательно замещенный бензил или гидроксил;Rи R- каждый независимо водород, алкил, алкенил, необязательно замещенный бензил.Соединения (I) обладают сильной активностью подавления костной резорбции и полезны как средства профилактики и лечения заболеваний хрящей и костей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199801012A 1996-05-14 1997-05-14 Производные полигидроксифенола, содержащие их лекарственные композиции и применение указанных веществ для профилактики и лечения заболеваний костей и хрящей EA001172B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8154710A JPH09301916A (ja) 1996-05-14 1996-05-14 ポリヒドロキシフェノール誘導体およびそれらからなる骨・軟骨疾患予防・治療剤
PCT/JP1997/001625 WO1997043235A1 (fr) 1996-05-14 1997-05-14 Derives polyhydroxyphenols et agents les contenant, destines a la prevention et a la therapie de maladies de l'os et du cartilage

Publications (2)

Publication Number Publication Date
EA199801012A1 true EA199801012A1 (ru) 1999-06-24
EA001172B1 EA001172B1 (ru) 2000-10-30

Family

ID=15590273

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199801012A EA001172B1 (ru) 1996-05-14 1997-05-14 Производные полигидроксифенола, содержащие их лекарственные композиции и применение указанных веществ для профилактики и лечения заболеваний костей и хрящей

Country Status (21)

Country Link
US (1) US6177474B1 (ru)
EP (1) EP0994093B1 (ru)
JP (1) JPH09301916A (ru)
CN (1) CN1178889C (ru)
AT (1) ATE314339T1 (ru)
AU (1) AU737890B2 (ru)
BR (1) BR9709074A (ru)
CA (1) CA2255589A1 (ru)
CZ (1) CZ355498A3 (ru)
DE (1) DE69735008D1 (ru)
EA (1) EA001172B1 (ru)
HU (1) HUP9904402A3 (ru)
IL (1) IL126797A (ru)
NO (1) NO312892B1 (ru)
NZ (1) NZ332722A (ru)
PL (1) PL188398B1 (ru)
SK (1) SK283956B6 (ru)
TR (1) TR199802290T2 (ru)
UA (1) UA66759C2 (ru)
WO (1) WO1997043235A1 (ru)
YU (1) YU51398A (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3942759B2 (ja) 1999-01-25 2007-07-11 興和株式会社 電子透かしの埋め込み方法，復号方法およびその装置
EP2364083A4 (en) * 2008-12-10 2012-10-31 Metaproteomics Llc A METHOD FOR PURIFYING SUBSTITUTED CYCLOPENT-2-EN-1-ON-CONGENERS AND SUBSTITUTED 1,3-CYCLOPENTADION-CONGENERS FROM A COMPLEX MIXTURE WITH PRESENT DEPOSITION
JP2024525438A (ja) * 2021-06-28 2024-07-12 フィルメニッヒ インコーポレイテッド フェノール系化合物のポリカチオン塩およびその使用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU168744B (ru) * 1971-12-02 1976-07-28
JPS5515443A (en) 1978-07-19 1980-02-02 Kirin Brewery Co Ltd Antibacterial agent
JPS5581814A (en) 1978-12-15 1980-06-20 Kirin Brewery Co Ltd Antifungal agent
JPS56140943A (en) * 1980-04-07 1981-11-04 Takeda Chem Ind Ltd Preparation of organic compound
JPS59175448A (ja) * 1983-03-25 1984-10-04 Sanko Kaihatsu Kagaku Kenkyusho:Kk フエノ−ル系化合物
JPS60155111A (ja) 1983-10-20 1985-08-15 Hisamitsu Pharmaceut Co Inc 安定なケトプロフェン含有外用経皮製剤
JPS6176433A (ja) * 1984-09-21 1986-04-18 Toyobo Co Ltd 新規なカルコン誘導体
JPS61176548A (ja) * 1985-01-31 1986-08-08 Nippon Zeon Co Ltd アルキル（ジヒドロキシフエニル）ケトンの製造法
JPS61180738A (ja) * 1985-02-06 1986-08-13 Nippon Zeon Co Ltd アルキル（ジヒドロキシフエニル）ケトンの製造法
JPS61293945A (ja) * 1985-06-05 1986-12-24 Sumitomo Chem Co Ltd ポリヒドロキシベンゾフェノンの製造方法
JPH0629182B2 (ja) 1986-12-20 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPH0629185B2 (ja) 1986-12-22 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPH0629184B2 (ja) 1986-12-22 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPS63264543A (ja) * 1987-04-17 1988-11-01 Toyo Gosei Kogyo Kk ポリヒドロキシベンゾフエノン類の製造方法
JPH01242540A (ja) 1988-03-22 1989-09-27 Tsumura & Co 新規カルコン誘導体および該誘導体を有効成分とする抗潰瘍剤
DE3936592A1 (de) * 1989-11-03 1991-05-08 Basf Ag Verfahren zur herstellung und reinigung von 2-hydroxy-4-(2'-hydroxy-ethoxy)phenylarylketonen
JP2627349B2 (ja) 1989-11-13 1997-07-02 株式会社大塚製薬工場 ３―アルキルフラボン誘導体及び５―リポキシゲナーゼ阻害剤
WO1993002177A1 (en) * 1991-07-15 1993-02-04 S.S. Steiner, Inc. Hops-derived foam stabilizing and bittering agents
JPH0625081A (ja) 1992-02-27 1994-02-01 Asahi Breweries Ltd 抗酸化作用を有するβ酸（ルプロン類）アシル誘導体
JPH06312924A (ja) * 1993-04-28 1994-11-08 Asahi Breweries Ltd 抗酸化作用を有するフムロン類の利用
JP3814309B2 (ja) 1994-04-12 2006-08-30 リポプロテイン・テクノロジーズ・インコーポレイテッド 骨粗鬆症治療剤
JPH0827057A (ja) 1994-07-19 1996-01-30 Asahi Breweries Ltd 抗酸化作用を有する新規物質およびその製造方法
JP3525267B2 (ja) 1994-07-19 2004-05-10 アサヒビール株式会社 抗酸化作用を有するマロフェノンの利用およびその製造方法
FR2729387B1 (fr) * 1995-01-13 1997-03-21 Great Lakes Chemical France Procede pour la fabrication d'hydroxy-alcoxy-benzophenones
JPH08277241A (ja) * 1995-04-04 1996-10-22 Nippon Kayaku Co Ltd ヒドロキシフェニルベンジルケトン類の製造方法と結晶変態

Also Published As

Publication number Publication date
CA2255589A1 (en) 1997-11-20
ATE314339T1 (de) 2006-01-15
HUP9904402A2 (hu) 2000-09-28
EP0994093A4 (en) 2000-05-17
WO1997043235A1 (fr) 1997-11-20
TR199802290T2 (xx) 2001-09-21
IL126797A0 (en) 1999-08-17
AU737890B2 (en) 2001-09-06
EP0994093B1 (en) 2005-12-28
PL188398B1 (pl) 2005-01-31
EA001172B1 (ru) 2000-10-30
NO312892B1 (no) 2002-07-15
UA66759C2 (en) 2004-06-15
AU2788797A (en) 1997-12-05
DE69735008D1 (de) 2006-02-02
CN1178889C (zh) 2004-12-08
SK153198A3 (en) 1999-06-11
IL126797A (en) 2004-06-20
CZ355498A3 (cs) 1999-04-14
HUP9904402A3 (en) 2002-07-29
NO985298D0 (no) 1998-11-13
EP0994093A1 (en) 2000-04-19
CN1225082A (zh) 1999-08-04
US6177474B1 (en) 2001-01-23
JPH09301916A (ja) 1997-11-25
NZ332722A (en) 2001-07-27
BR9709074A (pt) 1999-08-03
SK283956B6 (sk) 2004-06-08
PL329885A1 (en) 1999-04-12
YU51398A (sh) 2000-03-21
NO985298L (no) 1999-01-13

Similar Documents

Publication Publication Date Title
TR200001816T2 (tr) Hipolipidemik benzotiyazepin bileşikleri
EA200400023A1 (ru) Ингибиторы вич-протеазы, содержащие их композиции, их фармацевтическое использование и материалы для их синтеза
MX9702865A (es) Agentes estrogenicos.
BR9813360A (pt) Derivados de ácido hidroxâmico como inibidores de metaloprotease de matriz (mmp)
RU2203274C2 (ru) Спироциклические ингибиторы металлопротеаз
EA200000298A1 (ru) Агонисты простагландинов и их применение для лечения заболеваний костей
DE69831506D1 (en) 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
DE69628019D1 (de) Chinolone und deren therapeutische verwendung
TR199800585T2 (xx) COX-2 �nhibit�rleri Olarak (Metils�lfonil)Fenil-2-(5H)-Furanonlar.
EA199800268A1 (ru) Замещенные имидазолы, обладающие антиканцерогенной и цитокин-ингибирующей активностью
ATE321548T1 (de) Verwendung von statin zur behandlung von hauterkrankungen
RU95106821A (ru) Циклопептиды, способ их получения, фармацевтическая композиция и способ ее получения
EA200200625A1 (ru) Антипикорнавирусные соединения и композиции, их фармацевтическое применение и вещества для их синтеза
BR9916046A (pt) Composto, composição farmacêutica, e, processos para inibir a replicação de um vìrus herpes e para tratamento de um paciente que sofra de uma infecção do vìrus herpes
ATE244565T1 (de) Verwendung von 2-aryl-3-aroylbenzo(b)thiophene zur behandlung des oestrogenenthaltungssyndroms
EA199801012A1 (ru) Производные полигидроксифенола, содержащие их лекарственные композиции и применение указанных веществ для профилактики и лечения заболеваний костей и хрящей
FR2744445B1 (fr) Composes biphenyles nouveaux et/ou a titre de medicament, compositions pharmaceutiques les contenant, leur procede de preparation et les intermediaires de ce procede
EA200100639A1 (ru) Производные тиомочевины, содержащие гетероциклический карбоксамид и защитную группу фенилэтиленамина, в качестве ингибиторов вирусов герпеса
ES543802A0 (es) Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo n-carbamiloxi sustituido
ATE100439T1 (de) 2-(2-hydroxy-3-phenoxypropylamino)-ethoxybenzol derivate.
PT1120415E (pt) Compostos de isoxazoliltiofeno substituido
DE69713648D1 (de) Benzopyranderivate und ihre Verwendung zur Behandlung von Herzkrankheiten
ATE265854T1 (de) Azasteroidverbindung zur behandlung oder vorbeugung von prostatakrebs
EA200001028A1 (ru) Производные 2"-деоксигигромицина
EA200001157A3 (ru) Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU