ATE314339T1 - Polyhydroxyphenolderivate und mittel zur vorbeugung und therapie von knochen- und knorpelkrankheiten die diese enthalten - Google Patents

Polyhydroxyphenolderivate und mittel zur vorbeugung und therapie von knochen- und knorpelkrankheiten die diese enthalten

Info

Publication number
ATE314339T1
ATE314339T1 AT97922050T AT97922050T ATE314339T1 AT E314339 T1 ATE314339 T1 AT E314339T1 AT 97922050 T AT97922050 T AT 97922050T AT 97922050 T AT97922050 T AT 97922050T AT E314339 T1 ATE314339 T1 AT E314339T1
Authority
AT
Austria
Prior art keywords
optionally substituted
alkyl
bone
substituted benzyl
alkenyl
Prior art date
Application number
AT97922050T
Other languages
English (en)
Inventor
Kunikazu Discovery Resea Sakai
Ltd - - Minamidai Roussel
Yusuke Discovery Researc Satoh
Kazuyuki Information Techn Doi
Kazuyuki Discovery Re Kitamura
Original Assignee
Hoechst Marion Roussel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Ltd filed Critical Hoechst Marion Roussel Ltd
Application granted granted Critical
Publication of ATE314339T1 publication Critical patent/ATE314339T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
AT97922050T 1996-05-14 1997-05-14 Polyhydroxyphenolderivate und mittel zur vorbeugung und therapie von knochen- und knorpelkrankheiten die diese enthalten ATE314339T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8154710A JPH09301916A (ja) 1996-05-14 1996-05-14 ポリヒドロキシフェノール誘導体およびそれらからなる骨・軟骨疾患予防・治療剤
PCT/JP1997/001625 WO1997043235A1 (fr) 1996-05-14 1997-05-14 Derives polyhydroxyphenols et agents les contenant, destines a la prevention et a la therapie de maladies de l'os et du cartilage

Publications (1)

Publication Number Publication Date
ATE314339T1 true ATE314339T1 (de) 2006-01-15

Family

ID=15590273

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97922050T ATE314339T1 (de) 1996-05-14 1997-05-14 Polyhydroxyphenolderivate und mittel zur vorbeugung und therapie von knochen- und knorpelkrankheiten die diese enthalten

Country Status (21)

Country Link
US (1) US6177474B1 (de)
EP (1) EP0994093B1 (de)
JP (1) JPH09301916A (de)
CN (1) CN1178889C (de)
AT (1) ATE314339T1 (de)
AU (1) AU737890B2 (de)
BR (1) BR9709074A (de)
CA (1) CA2255589A1 (de)
CZ (1) CZ355498A3 (de)
DE (1) DE69735008D1 (de)
EA (1) EA001172B1 (de)
HU (1) HUP9904402A3 (de)
IL (1) IL126797A (de)
NO (1) NO312892B1 (de)
NZ (1) NZ332722A (de)
PL (1) PL188398B1 (de)
SK (1) SK283956B6 (de)
TR (1) TR199802290T2 (de)
UA (1) UA66759C2 (de)
WO (1) WO1997043235A1 (de)
YU (1) YU51398A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3942759B2 (ja) 1999-01-25 2007-07-11 興和株式会社 電子透かしの埋め込み方法，復号方法およびその装置
EP2364083A4 (de) * 2008-12-10 2012-10-31 Metaproteomics Llc Verfahren zur aufreinigung von substituierten cyclopent-2-en-1-on-congeneren und substituierten 1,3-cyclopentadion-congeneren aus einer komplexen mischung mit gegenläufiger abscheidung
WO2023278394A1 (en) * 2021-06-28 2023-01-05 Firmenich Incorporated Polycationic salts of phenolic compounds and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU168744B (de) * 1971-12-02 1976-07-28
JPS5515443A (en) * 1978-07-19 1980-02-02 Kirin Brewery Co Ltd Antibacterial agent
JPS5581814A (en) * 1978-12-15 1980-06-20 Kirin Brewery Co Ltd Antifungal agent
JPS56140943A (en) * 1980-04-07 1981-11-04 Takeda Chem Ind Ltd Preparation of organic compound
JPS59175448A (ja) * 1983-03-25 1984-10-04 Sanko Kaihatsu Kagaku Kenkyusho:Kk フエノ−ル系化合物
JPS60155111A (ja) 1983-10-20 1985-08-15 Hisamitsu Pharmaceut Co Inc 安定なケトプロフェン含有外用経皮製剤
JPS6176433A (ja) * 1984-09-21 1986-04-18 Toyobo Co Ltd 新規なカルコン誘導体
JPS61176548A (ja) * 1985-01-31 1986-08-08 Nippon Zeon Co Ltd アルキル（ジヒドロキシフエニル）ケトンの製造法
JPS61180738A (ja) * 1985-02-06 1986-08-13 Nippon Zeon Co Ltd アルキル（ジヒドロキシフエニル）ケトンの製造法
JPS61293945A (ja) * 1985-06-05 1986-12-24 Sumitomo Chem Co Ltd ポリヒドロキシベンゾフェノンの製造方法
JPH0629182B2 (ja) * 1986-12-20 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPH0629185B2 (ja) * 1986-12-22 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPH0629184B2 (ja) * 1986-12-22 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPS63264543A (ja) * 1987-04-17 1988-11-01 Toyo Gosei Kogyo Kk ポリヒドロキシベンゾフエノン類の製造方法
JPH01242540A (ja) * 1988-03-22 1989-09-27 Tsumura & Co 新規カルコン誘導体および該誘導体を有効成分とする抗潰瘍剤
DE3936592A1 (de) * 1989-11-03 1991-05-08 Basf Ag Verfahren zur herstellung und reinigung von 2-hydroxy-4-(2'-hydroxy-ethoxy)phenylarylketonen
JP2627349B2 (ja) * 1989-11-13 1997-07-02 株式会社大塚製薬工場 ３―アルキルフラボン誘導体及び５―リポキシゲナーゼ阻害剤
ES2125267T3 (es) 1991-07-15 1999-03-01 Steiner Inc S S Agentes estabilizantes de espuma y que proporcionan amargor derivados del lupulo.
JPH0625081A (ja) * 1992-02-27 1994-02-01 Asahi Breweries Ltd 抗酸化作用を有するβ酸（ルプロン類）アシル誘導体
JPH06312924A (ja) 1993-04-28 1994-11-08 Asahi Breweries Ltd 抗酸化作用を有するフムロン類の利用
JP3814309B2 (ja) * 1994-04-12 2006-08-30 リポプロテイン・テクノロジーズ・インコーポレイテッド 骨粗鬆症治療剤
JPH0827057A (ja) * 1994-07-19 1996-01-30 Asahi Breweries Ltd 抗酸化作用を有する新規物質およびその製造方法
JP3525267B2 (ja) * 1994-07-19 2004-05-10 アサヒビール株式会社 抗酸化作用を有するマロフェノンの利用およびその製造方法
FR2729387B1 (fr) * 1995-01-13 1997-03-21 Great Lakes Chemical France Procede pour la fabrication d'hydroxy-alcoxy-benzophenones
JPH08277241A (ja) * 1995-04-04 1996-10-22 Nippon Kayaku Co Ltd ヒドロキシフェニルベンジルケトン類の製造方法と結晶変態

Also Published As

Publication number Publication date
BR9709074A (pt) 1999-08-03
PL329885A1 (en) 1999-04-12
UA66759C2 (en) 2004-06-15
AU737890B2 (en) 2001-09-06
EA001172B1 (ru) 2000-10-30
DE69735008D1 (de) 2006-02-02
JPH09301916A (ja) 1997-11-25
CA2255589A1 (en) 1997-11-20
US6177474B1 (en) 2001-01-23
AU2788797A (en) 1997-12-05
EA199801012A1 (ru) 1999-06-24
NO985298L (no) 1999-01-13
EP0994093A1 (de) 2000-04-19
NO985298D0 (no) 1998-11-13
HUP9904402A2 (hu) 2000-09-28
WO1997043235A1 (fr) 1997-11-20
EP0994093B1 (de) 2005-12-28
PL188398B1 (pl) 2005-01-31
EP0994093A4 (de) 2000-05-17
IL126797A0 (en) 1999-08-17
TR199802290T2 (xx) 2001-09-21
CN1225082A (zh) 1999-08-04
NO312892B1 (no) 2002-07-15
SK283956B6 (sk) 2004-06-08
HUP9904402A3 (en) 2002-07-29
CN1178889C (zh) 2004-12-08
NZ332722A (en) 2001-07-27
YU51398A (sh) 2000-03-21
SK153198A3 (en) 1999-06-11
CZ355498A3 (cs) 1999-04-14
IL126797A (en) 2004-06-20

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